785,028 results match your criteria included diagnostic


Population-based mammography screening attendance in Sweden 2017-2018: A cross-sectional register study to assess the impact of sociodemographic factors.

Breast 2021 Jun 2;59:16-26. Epub 2021 Jun 2.

Department of Translational Medicine, Diagnostic Radiology, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden.

Sweden has a population-based mammography screening programme for women aged 40-74. The objective of this study was to examine the association between mammography screening attendance and sociodemographic factors in 15 of Sweden's 21 health care regions. Register-based information was collected on all mammography screening invitations and attendance during 2017 and 2018, and linked to individual-level sociodemographic data from Statistics Sweden. Read More

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Establishing paediatric diagnostic reference levels using reference curves - A feasibility study including conventional and CT examinations.

Phys Med 2021 Jun 9;87:65-72. Epub 2021 Jun 9.

Department of Radiation Protection and Measurement Services, Norwegian Radiation and Nuclear Safety Authority, Bærum, Norway; Department of Health Sciences, Norwegian University of Science and Technology, Gjøvik, Norway.

Purpose: To derive Regional Diagnostic Reference Levels (RDRL) for paediatric conventional and CT examinations using weight-based DRL curves and compare the outcome with DRL derived using the weight groups.

Methods: Data from 1722 examinations performed at 29 hospitals in four countries were included. DRL was derived for four conventional x-ray (chest, abdomen, pelvis, hips/joints) and two types of CT examinations (thorax, abdomen). Read More

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Impact of a pharmacist-led substance use disorder transitions of care clinic on postdischarge medication treatment retention.

J Subst Abuse Treat 2021 Apr 28;130:108440. Epub 2021 Apr 28.

VA Tennessee Valley Healthcare System, 1310 24th Avenue South, Nashville, TN 37212, United States.

Background: The Veterans Health Administration (VHA) has made significant improvements in increasing prescribing of medication treatment for opioid use disorder (MOUD) and medication treatment for alcohol use disorder (MAUD); however, several barriers to treatment retention remain. In an effort to improve MOUD/MAUD retention, a Veterans Affairs (VA) facility established a pharmacist-led substance use disorder (SUD) transitions of care telephone clinic for patients discharged from an inpatient hospitalization on MOUD/MAUD, including buprenorphine/naloxone (BUP/NAL) and extended-release (ER) naltrexone injections. Pharmacists within the clinic assess aspects of treatment retention such as medication tolerability, perceived barriers to continuing treatment, status of current prescriptions, and appointment coordination. Read More

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Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease.

Neuroimage Clin 2021 Jun 4;31:102712. Epub 2021 Jun 4.

Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

This work validates the generalizability of MRI-based classification of Alzheimer's disease (AD) patients and controls (CN) to an external data set and to the task of prediction of conversion to AD in individuals with mild cognitive impairment (MCI). We used a conventional support vector machine (SVM) and a deep convolutional neural network (CNN) approach based on structural MRI scans that underwent either minimal pre-processing or more extensive pre-processing into modulated gray matter (GM) maps. Classifiers were optimized and evaluated using cross-validation in the Alzheimer's Disease Neuroimaging Initiative (ADNI; 334 AD, 520 CN). Read More

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Accelerometry-derived respiratory index estimating apnea-hypopnea index for sleep apnea screening.

Comput Methods Programs Biomed 2021 May 31;207:106209. Epub 2021 May 31.

Grenoble Alpes University, CNRS, CHU Grenoble Alpes, Grenoble INP, TIMC, Grenoble, France. Electronic address:

Background And Objective: Sleep Apnea Syndrome (SAS) is a multimorbid chronic disease with individual and societal deleterious consequences. Polysomnography (PSG) is the multi-parametric reference diagnostic tool that allows a manual quantification of the apnea-hypopnea index (AHI) to assess SAS severity. The burden of SAS is affecting nearly one billion people worldwide explaining that SAS remains largely under-diagnosed and undertreated. Read More

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Impact of inappropriate empirical antibiotic treatment on clinical outcomes of urinary tract infections caused by Escherichia coli: a retrospective cohort study.

J Glob Antimicrob Resist 2021 Jun 9. Epub 2021 Jun 9.

Jiangxi Provincial Key Laboratory of Medicine, Clinical Laboratory of the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China. Electronic address:

Objective: We aimed to determine the clinical impact of inappropriate empirical antibiotic treatment (IEAT) compared with appropriate empirical antibiotic treatment (AEAT) in hospitalised patients with urinary tract infections (UTIs) caused by Escherichia coli (E. coli).

Methods: This retrospective cohort study included adult patients with a primary diagnosis of UTI who were treated with empirical antibiotics at a tertiary hospital in southern China over a 2-year period. Read More

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Inflammatory bowel disease in primary immunodeficiency disorders is a heterogeneous clinical entity requiring an individualized treatment strategy: A systematic review.

Autoimmun Rev 2021 Jun 9:102872. Epub 2021 Jun 9.

Department of Internal Medicine, Division of Allergy and Clinical Immunology, Erasmus Medical Center, Rotterdam, The Netherlands.

Objective: To describe the prevalence, clinical presentation and current treatment regimens of inflammatory bowel disease (IBD) in patients with primary immunodeficiency disorders (PIDs).

Methods: A systematic review was conducted. The following databases were searched: MEDLINE, Embase, Web of Science, the Cochrane Library and Google Scholar. Read More

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Prevalence of Polycystic Ovary Syndrome in Patients with McCune Albright Syndrome.

J Pediatr Adolesc Gynecol 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas; Texas Children's Hospital, Houston, Texas.

Study Objective: To identify PCOS in a population of female patients with MAS by retrospective chart review DESIGN: : Retrospective study SETTING: : Academic setting PARTICIPANTS: : All females with a prior diagnosis of MAS who were older than 12 years of age at the time of chart review. Only complete medical records from January 2009 to January 2020 were included in the analysis.

Interventions: None MAIN OUTCOME MEASURE(S): : Diagnosis of PCOS based on the Rotterdam 2003 criteria. Read More

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Analysis and comparison of autologous platelet-rich plasma preparation systems used in the treatment of enthesopathies: A preliminary study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Trauma and Hand Surgery, Wroclaw Medical University, Poland.

Background: Autologous platelet-rich plasma (PRP) injection is an alternative but widely accepted method for the treatment of degenerative changes in tendon attachments known as enthesopathies. The PRP is considered a safe source for high concentrations of the growth factors involved in the healing process. Despite initial promising outcomes, many recent studies report conflicting results for this treatment. Read More

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Pathological findings in horses with lumbosacral region pain.

Equine Vet J 2021 Jun 12. Epub 2021 Jun 12.

Centre for Equine Studies, Animal Health Trust, Lanwades Park, Newmarket, Suffolk, CB8 7UU, UK.

Background: There is a lack of understanding of the pathological and/or physiological nature of lumbosacral region pain.

Objectives: To describe the gross variations of the osseous and soft tissues of the lumbosacral region and report the histological findings of sections of nerve tissue in affected and control horses.

Study Design: Descriptive post-mortem case series. Read More

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Appendicular skeletal muscle mass and quality estimated by bioelectrical impedance analysis in the assessment of frailty syndrome risk in older individuals.

Aging Clin Exp Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Biostructure, University School of Physical Education in Wroclaw, Al. I. J. Paderewskiego 35, 51-612, Wroclaw, Poland.

Background And Aim: The rising aging index of many populations necessitates the continuous evolution of geriatric assessment methods, especially the ones used to identify frailty and the risk of frailty. An appropriately early diagnosis of adverse changes in skeletal muscles can reduce the risk of functional limitations in elderly persons. The aim of this study was to assess the correlation between the appendicular skeletal muscle mass and quality, estimated by the bioelectrical impedance analysis method, and the risk of prevalence of the pre-frailty state in elderly persons. Read More

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Exploring the Clinical Utility of Metagenomic Next-Generation Sequencing in the Diagnosis of Pulmonary Infection.

Infect Dis Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Respiratory, The Affiliated Wuxi Second People's Hospital of Nanjing Medical University, Wuxi, China.

Introduction: We aimed to explore the real-world clinical application value and challenges of metagenomic next-generation sequencing (mNGS) for pulmonary infection diagnosis.

Methods: We retrospectively reviewed the results of mNGS and conventional tests from 140 hospitalized patients with suspected pulmonary infections from January 2019 to December 2020. The sample types included bronchoalveolar lavage fluid, lung tissue by transbronchial lung biopsy, pleural effusion, blood, and bronchial sputum. Read More

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Human papillomavirus in Italy: retrospective cohort analysis and preliminary vaccination effect from real-world data.

Eur J Health Econ 2021 Jun 12. Epub 2021 Jun 12.

Institute for Leadership and Management in Health, Kingston University London, London, UK.

Introduction: The objective of this study was to estimate the lifetime risk of hospitalization associated with all major human papillomavirus (HPV)-related diseases in Italy. Moreover, a preliminary vaccination effect was also performed.

Methods: A retrospective, nonrandomized, observational study was developed based on patients hospitalized between 2006 and 2018 in Italy. Read More

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Noninfectious Intermediate, Posterior, or Panuveitis: Results from the Retrospective, Observational, International EyeCOPE Study.

Ophthalmol Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Ophthalmology, Faculty of Medicine, Gazi University, 13th Floor, Besevler, Cankaya, 06500, Ankara, Turkey.

Introduction: The EyeCOPE study characterized noninfectious intermediate posterior, or panuveitis (NIIPPU) before biologic agents were widely available.

Methods: This retrospective, observational study included adults with NIIPPU attending a routine ophthalmological visit. Data were collected from the study visit and medical records. Read More

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Prescribing Antibiotics in Adults with Respiratory Tract Infections in Lebanon.

Int J Clin Pract 2021 Jun 12:e14514. Epub 2021 Jun 12.

Department of Family Medicine, American University of Beirut Medical Center (AUBMC, Beirut, Lebanon.

Background: Antibiotic resistance is a global concern that has significant health and economic burden. The inappropriate use of antibiotics is a major cause of antibiotic resistance; this includes both unnecessary and incorrect prescriptions. Most antibiotics are prescribed in primary care, mainly for respiratory tract infections. Read More

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Comparison and validation of FDG-PET/CT scores for polymyalgia rheumatica.

Rheumatology (Oxford) 2021 Jun 12. Epub 2021 Jun 12.

Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Objectives: To compare and validate the diagnostic accuracy of FDG-PET/CT scores for polymyalgia rheumatica (PMR); and to explore their relationship with clinical factors.

Methods: This retrospective study included 39 consecutive patients diagnosed with PMR and 19 PMR comparators. The final clinical diagnosis was established after 6 months follow-up. Read More

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N-ammonia positron emission tomography-derived endocardial strain for the assessment of ischemia using feature-tracking in high-resolution cine imaging.

J Nucl Cardiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Assessing endocardial strain using a single N-ammonia positron emission tomography (PET) scan would be clinically useful, given the association between ischemia and myocardial deformation. However, no software has been developed for strain analysis using PET. We evaluated the clinical potential of feature tracking-derived strain values measured using PET, based on associations with the myocardial flow reserve (MFR). Read More

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Disease Behaviour During the Peri-Diagnostic Period in Patients with Suspected Interstitial Lung Disease: The STARLINER Study.

Adv Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical and Experimental Medicine, Regional Referral Centre for Rare Lung Diseases, University Hospital Policlinico "G. Rodolico-San Marco", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.

Introduction: Disease behaviour may guide diagnosis and treatment decisions in patients with interstitial lung disease (ILD). STARLINER aimed to characterise disease behaviour in patients with suspected ILD during the peri-diagnostic period using real-time home-based assessments.

Methods: STARLINER (NCT03261037) was an international, multicentre study. Read More

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Different threshold levels of circulating total and free 25-hydroxyvitamin D for the diagnosis of vitamin D deficiency in obese adolescents.

Eur J Pediatr 2021 Jun 11. Epub 2021 Jun 11.

Department of Biostatistics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

The total serum 25-hydroxyvitamin D [25(OH)D] level is lower in obese individuals than in their nonobese peers, despite similar bone turnover markers and bone mineral density. This study aimed to investigate whether the threshold level of 25(OH)D for the diagnosis of vitamin D deficiency (VDD) in obese adolescents was lower than that in controls and to compare 25(OH)D, free [25(OH)D] and bioavailable [25(OH)D] vitamin D with VDBP levels in obese individuals and their controls. A total of 173 adolescents (90 obese individuals and 83 controls) aged 12-18 years were included in the study. Read More

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Prognostic impact of histological review of high-grade endometrial carcinomas in a large Danish cohort.

Virchows Arch 2021 Jun 11. Epub 2021 Jun 11.

Department of Pathology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Copenhagen University, Borgmester Ib Juuls Vej 73, 2730, Herlev, Denmark.

The aim of this study was to investigate the outcome of histological subtype review of high-grade endometrial carcinoma (EC) and its prognostic impact in a large well-documented Danish nationwide cohort. From the Danish Gynecological Cancer Database (DGCD) 2005-2012 cohort, we included 425 patients with an original diagnosis of high-grade EC, independent of histologic subtype. Of these, at least one hematoxylin and eosin (H&E)-stained slide from 396 cases (93. Read More

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Decreasing Chlamydial Reinfections in a Female Urban Population.

Sex Transm Dis 2021 Jun 11. Epub 2021 Jun 11.

Department of Pharmacy, Parkland Health & Hospital System Center for Innovation and Value, Parkland Health & Hospital System Department of Internal Medicine - Div. Infectious Diseases, University of Texas Southwestern Medical Center Department of Obstetrics & Gynecology - Div. Maternal-Fetal Medicine, University of Texas Southwestern Medical Center.

Background: Chlamydia is the most reported bacterial sexually transmitted infection (STI). The rates of chlamydia rose by 19 percent between 2011 and 2018. The STI National Strategic Plan (2021-2025), encourages coordinated solutions to address STIs and reduce disparities in disadvantaged populations. Read More

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Deletion of and causes abnormal skull morphology and global developmental delay.

Cold Spring Harb Mol Case Stud 2021 Jun 11;7(3). Epub 2021 Jun 11.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

The ETS2 repressor factor (ERF) is a transcription factor in the RAS-MEK-ERK signal transduction cascade that regulates cell proliferation and differentiation, and pathogenic sequence variants in the gene cause variable craniosynostosis inherited in an autosomal dominant pattern. The reported variants are largely loss-of-function, implying haploinsufficiency as a primary disease mechanism; however, gene deletions have not been reported previously. Here we describe three probands with macrocephaly, craniofacial dysmorphology, and global developmental delay. Read More

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Statin therapy for patients with aortic stenosis who underwent transcatheter aortic valve implantation: a report from a Japanese multicentre registry.

BMJ Open 2021 Jun 11;11(6):e044319. Epub 2021 Jun 11.

Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Japan.

Objective: Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients.

Design: Observational study. Read More

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A Multicenter Preliminary Study of Cangrelor following Thrombectomy Failure for Refractory Proximal Intracranial Occlusions.

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

Neurology (I.S.), Bordeaux University Hospital, Bordeaux, France.

Background And Purpose: Rescue endovascular and pharmacologic approaches are increasingly being adopted after recanalization failure of acute large-vessel occlusion strokes with mechanical thrombectomy, with encouraging results. The safety and efficacy of glycoprotein IIb/IIIa inhibitors in ischemic stroke have been investigated, though cangrelor, a recent intravenous P2Y12-receptor inhibitor with a rapid onset/offset of action and a short half-life, may be a valuable option. We compared the safety and efficacy of cangrelor with those of glycoprotein IIb/IIIa inhibitors for refractory occlusions. Read More

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Diagnostic Accuracy and Failure Mode Analysis of a Deep Learning Algorithm for the Detection of Cervical Spine Fractures.

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology (M.E.L., J.W.G., J.-P.J.Y.), University of Wisconsin-Madison, Madison, Wisconsin

Background And Purpose: Artificial intelligence decision support systems are a rapidly growing class of tools to help manage ever-increasing imaging volumes. The aim of this study was to evaluate the performance of an artificial intelligence decision support system, Aidoc, for the detection of cervical spinal fractures on noncontrast cervical spine CT scans and to conduct a failure mode analysis to identify areas of poor performance.

Materials And Methods: This retrospective study included 1904 emergent noncontrast cervical spine CT scans of adult patients (60 [SD, 22] years, 50. Read More

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Burden and quality of life in caregivers of cancer patients at the beginning of palliative care. CUIDPALCOSTASOL Study.

Enferm Clin (Engl Ed) 2021 Jun 8. Epub 2021 Jun 8.

Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain; Departamento de Enfermería, Facultad de Ciencias de la Salud, Universidad de Málaga, Málaga, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.

Objectives: To describe the quality of life and caregiver burden of family caregivers of cancer patients at the beginning of palliative care.

Method: Cross-sectional descriptive study in the CUIDPACOSTASOL cohort of family caregivers of palliative phase cancer patients, included between February 2017 and December 2019 from health centres of the Costa del Sol and Malaga-Valle del Guadalhorce Primary Care District, and Cudeca Foundation. Sociodemographic data on caregivers and patients, specific questionnaires related to family caregiver burden as well as satisfaction (Zarit and FAMCARE), quality of life (SF-36) and nursing diagnoses (NANDA), and patient characteristics (PPI, PPSv2) were collected. Read More

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Diagnostic delay and misdiagnosis in eosinophilic oesophagitis.

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. Electronic address:

Background: Eosinophilic oesophagitis (EoE) may lead to severe complications if not promptly recognised.

Aims: To assess the diagnostic delay in patients with EoE and to explore its risk factors.

Methods: EoE patients followed-up at eight clinics were included via retrospective chart review. Read More

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Combined stoma reversal and liver resection for rectal metastatic cancer: A single center retrospective analysis.

J Visc Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Digestive Surgery and Transplantation, Lille University Hospital, Lille, France.

Goal Of The Study: Concomitant liver metastases are discovered at the time of diagnosis in 25% of patients with colorectal cancers. The appropriate time to restore digestive continuity after stoma creation during rectal surgery has not yet been established. The objective of this study is to assess the morbidity of stoma reversal during the secondary hepatectomy procedure. Read More

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Tumors masquerading as type 2 papillary renal cell carcinoma: pathologists' ever-expanding differential diagnosis for a heterogeneous group of entities.

Urol Oncol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI. Electronic address:

Although papillary renal cell carcinoma has historically been classified as either type 1 or type 2, data from The Cancer Genome Atlas (TCGA) has demonstrated significant genomic heterogeneity in tumors classified as "type 2 papillary renal cell carcinoma" (T2PRCC). Papillary renal cell carcinoma is expected to have a favorable clinical course compared to clear cell renal cell carcinoma (CCRCC). However, tumors with poor outcome more similar to CCRCC were included in the T2PRCC cohort studied by the TCGA. Read More

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Maternal gut microbiota displays minor changes in overweight and obese women with GDM.

Nutr Metab Cardiovasc Dis 2021 Apr 18. Epub 2021 Apr 18.

Mater Research Institute-The University of Queensland, Brisbane, Australia; Department of Endocrinology, Mater Health, Australia. Electronic address:

Background And Aims: Previous literature have shown a diversity of findings regarding the relationship between the maternal gut microbiota and gestational diabetes mellitus (GDM). We investigated the gut microbiota of overweight and obese women with gestational diabetes mellitus (GDM) against matched euglycaemic women at 16 and 28-weeks' gestation.

Methods And Results: This study included women from the SPRING (Study of PRobiotics IN Gestational diabetes) cohort. Read More

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