225,613 results match your criteria included cases

Prevalence of sarcopenic obesity and association with metabolic syndrome in an adult Iranian cohort: The Fasa PERSIAN cohort study.

Clin Obes 2021 May 4:e12459. Epub 2021 May 4.

Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.

Sarcopenic obesity (SO) is characterised by a concomitant high fat mass (FM) and low fat free mass (FFM) leading to an increased cardio-metabolic risk. This analysis aims to estimate the SO prevalence in Iranian adults and evaluate the association of SO with metabolic syndrome (MetS) risk. This cross-sectional analysis included 4296 subjects (age 35-70 years, 55. Read More

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Does the length of the plate affect the failure rate of hallux MTP joint arthrodesis for severe hallux valgus?

Foot (Edinb) 2021 Jan 2;47:101773. Epub 2021 Jan 2.

Division of Foot and Ankle Surgery, Department of Orthopaedic Surgery, University of Virginia Health System, PO Box 801016 Charlottesville, VA, USA. Electronic address:

Purpose: The purpose of this study was to investigate the effect of the length of the dorsal locking plate on the failure rate of first MTP joint arthrodesis for severe hallux valgus deformities.

Methods: A retrospective review was conducted for all patients who underwent first MTP joint arthrodesis using solely a specific locked plating system (Depuy-Synthes, Raynham, MA) for severe hallux valgus deformities between January 2014 to June 2017. Patients were divided into subgroups according to the length of the plate and the failure rate was investigated. Read More

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January 2021

Cost-effectiveness of feedback-informed psychological treatment: Evidence from the IAPT-FIT trial.

Behav Res Ther 2021 Apr 24;142:103873. Epub 2021 Apr 24.

Department of Health Sciences and Hull York Medical School, University of York, United Kingdom; Department of Epidemiology and Biostatistics, Western University, Canada.

Background: Feedback-informed treatment (FIT) involves using computerized routine outcome monitoring technology to alert therapists to cases that are not responding well to psychotherapy, prompting them to identify and resolve obstacles to improvement. In this study, we present the first health economic evaluation of FIT, compared to usual care, to enable decision makers to judge whether this approach represents a good investment for health systems.

Methods: This randomised controlled trial included 2233 patients clustered within 77 therapists who were randomly assigned to a FIT group (n = 1176) or a usual care control group (n = 1057). Read More

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Emergency department bounceback characteristics for patients diagnosed with COVID-19.

Am J Emerg Med 2021 Apr 19;47:239-243. Epub 2021 Apr 19.

NorthShore University HealthSystem, 2650 Ridge Ave, Evanston, IL 60201, USA; University of Chicago Pritzker School of Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA.

Background: The global healthcare burden of COVID-19 continues to rise. There is currently limited information regarding the disease progression and the need for hospitalizations in patients who present to the Emergency Department (ED) with minimal or no symptoms.

Objectives: This study identifies bounceback rates and timeframes for patients who return to the ED due to COVID-19 after initial discharge on the date of testing. Read More

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Technical in-depth comparison of two massive parallel DNA-sequencing methods for formalin-fixed paraffin-embedded tissue from victims of sudden cardiac death.

Forensic Sci Int Genet 2021 Apr 26;53:102522. Epub 2021 Apr 26.

Department of Laboratory Medicine, Örebro University Hospital, Sweden; Faculty of Medicine and Health, Örebro University, Örebro Sweden.

Sudden cardiac death (SCD) is a tragic and traumatic event. SCD is often associated with hereditary genetic disease and in such cases, sequencing of stored formalin fixed paraffin embedded (FFPE) tissue is often crucial in trying to find a causal genetic variant. This study was designed to compare two massive parallel sequencing assays for differences in sensitivity and precision regarding variants related to SCD in FFPE material. Read More

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Reliability of CT angiography scoring systems used for brain death and the effect of cranial interventions on the results.

Clin Imaging 2021 Apr 29;79:142-147. Epub 2021 Apr 29.

Department of Radiology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.

Objective: To assess vascular opacifications, the efficiency, and interobserver agreement (IOA) of five different computed tomography angiography (CTA) brain death (BD) scoring systems in patients with and without cranial interventions, for determining alternative findings correctly supporting BD diagnosis by CTA even in cranial intervention presence.

Methods: 45 patients clinically identified with BD and evaluated with CTA were included. IOA of five different scoring systems used for CTA BD diagnosis, the effect of intracranial interventions on scoring systems, and vascular opacification were evaluated. Read More

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Surgical management of deep pelvic endometriosis in France: do we need to be a pelvic surgeon to deal with DPE?

J Gynecol Obstet Hum Reprod 2021 May 1:102158. Epub 2021 May 1.

Gynaecology Unit, Hautepierre Hospital, University Hospitals of Strasbourg, 1 avenue Molière, 67000 Strasbourg France.

Introduction: Endometriosis is a common disease in women, which requires a medical and surgical approach. Surgical societies recommend a multidisciplinary management in tertiary referral centers. The objective of our study is to assess the surgical management of endometriosis in France by studying the surgeons' attitude for bowel and urinary endometriosis. Read More

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Bone union status of all osteotomy sites one year after curved periacetabular osteotomy based on computed tomography.

Orthop Traumatol Surg Res 2021 May 1:102955. Epub 2021 May 1.

Department of Orthopaedic Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Electronic address:

Background: Curved periacetabular osteotomy (CPO) is a joint-preservation surgery to treat acetabular dysplasia. It is performed via an anterior approach with the osteotomy of the anterosuperior iliac spine (ASIS). One of the complications associated with CPO includes non-union of the osteotomy sites. Read More

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Mitral Surgery after Transcatheter Edge-to-Edge Repair: Society of Thoracic Surgeons Database Analysis.

J Am Coll Cardiol 2021 Apr 27. Epub 2021 Apr 27.

Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Transcatheter edge-to-edge (TEER) mitral repair may be complicated by residual or recurrent mitral regurgitation. Increasing need for surgical reintervention has been reported but operative outcomes are ill-defined.

Objectives: This study evaluated national outcomes of mitral surgery after TEER. Read More

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Influenza season 2020-2021 did not begin in Finland despite the looser social restrictions during the second wave of COVID-19: A nationwide register study.

Ilari Kuitunen

J Med Virol 2021 May 4. Epub 2021 May 4.

University of Eastern Finland, School of Medicine, Yliopistonranta 1, PL 1627, 70211, Kuopio, Finland; Mikkeli Central Hospital, Department of Pediatrics, Porrassalmenkatu 35-37, 50100, Mikkeli, Finland.

Background: The nationwide lockdowns ended influenza seasons rapidly in Northern hemisphere in spring 2020. Strategy during second wave was to minimize the restrictions set for children. Children spread influenza and therefore simultaneous influenza and COVID-19 surges were feared. Read More

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Cause-specific mortality prediction in older residents of São Paulo, Brazil: a machine learning approach.

Age Ageing 2021 May 3. Epub 2021 May 3.

School of Public Health, University of São Paulo, São Paulo, Brazil.

Background: Populational ageing has been increasing in a remarkable rate in developing countries. In this scenario, preventive strategies could help to decrease the burden of higher demands for healthcare services. Machine learning algorithms have been increasingly applied for identifying priority candidates for preventive actions, presenting a better predictive performance than traditional parsimonious models. Read More

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Contrast-enhanced ultrasound for the assessment of focal nodular hyperplasia - results of a multicentre study.

Med Ultrason 2021 Apr 22. Epub 2021 Apr 22.

Regional Institute of Gastroenterology and Hepatology "Prof. Dr. Octavian Fodor", "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj Napoca, Cluj Napoca, Romania.

Aim: Contrast-enhanced ultrasound (CEUS) has become a relevant imaging method for the evaluation of focal liver le-sions (FLL). The aim of this study was to evaluate the performance of CEUS for the assessment of focal nodular hyperplasia (FNH) in a large study group.

Material And Methods: We performed a multicentre prospective observational study, which included successive CEUS examinations from fourteen Romanian centres. Read More

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Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.

PLoS One 2021 4;16(5):e0250525. Epub 2021 May 4.

Department of Veterinary Sciences, Microbiology and Antibiotic Resistance Team (MicroART), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal.

Klebsiella pneumoniae is a major pathogen implicated in nosocomial infections. Extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae isolates are a public health concern. Read More

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Genomic epidemiology of tuberculosis in eastern Malaysia: insights for strengthening public health responses.

Microb Genom 2021 May;7(5)

Queensland Mycobacterium Reference Laboratory, Brisbane, Australia.

Tuberculosis is a leading public health priority in eastern Malaysia. Knowledge of the genomic epidemiology of tuberculosis can help tailor public health interventions. Our aims were to determine tuberculosis genomic epidemiology and characterize resistance mutations in the ethnically diverse city of Kota Kinabalu, Sabah, located at the nexus of Malaysia, Indonesia, Philippines and Brunei. Read More

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Research trends in rabies vaccine in the last three decades: a bibliometric analysis of global perspective.

Hum Vaccin Immunother 2021 May 4:1-9. Epub 2021 May 4.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

: Rabies is an infectious zoonotic viral disease which mainly occurs in Africa and Asia. Dogs are predominantly responsible for rabies transmission contributing up to 99% of all human rabies cases. Rabies is a vaccine preventable disease in both animals and humans. Read More

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genetic testing in melanoma-prone families in Sweden in the years 2015-2020: implications for novel national recommendations.

Acta Oncol 2021 May 4:1-9. Epub 2021 May 4.

Department of Oncology and Pathology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

Inherited pathogenic variants (PVs) in the gene are among the strongest known risk factors for cutaneous melanoma. Carriers are at high risks to develop multiple primary melanomas and other cancers, in particular pancreatic cancer. In this study, the testing, carried out in Sweden in the years 2015-2020, was evaluated. Read More

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Monocentric study of 28 cases of chronic inflammatory demyelinating polyneuropathy: first Tunisian study.

Neurol Sci 2021 May 4. Epub 2021 May 4.

Department of Neurology, Military Hospital, Tunis, Tunisia.

Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare affection of the peripheral nervous system. Its diagnostic criteria have evolved since 1975. The aim of our work is to study the epidemiological, clinical, and paraclinical aspects of CIDP. Read More

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Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review and meta-analysis.

Int J Colorectal Dis 2021 May 4. Epub 2021 May 4.

Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Background: There is increasing evidence to support the use of neoadjuvant chemotherapy (NAC) in locally advanced colon cancer (LACC). However, its safety, efficacy and side effect profile is yet to be completely elucidated. This review aims to assess NAC regimens, duration, compare completion rates, intra-operative and post-operative complication profiles and oncological outcomes, in order to provide guidance for clinical practice and further research. Read More

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Missense and truncating variants in CHD5 in a dominant neurodevelopmental disorder with intellectual disability, behavioral disturbances, and epilepsy.

Hum Genet 2021 May 4. Epub 2021 May 4.

CHU Sainte-Justine Research Center, Montreal, QC, H3T 1C5, Canada.

Located in the critical 1p36 microdeletion region, the chromodomain helicase DNA-binding protein 5 (CHD5) gene encodes a subunit of the nucleosome remodeling and deacetylation (NuRD) complex required for neuronal development. Pathogenic variants in six of nine chromodomain (CHD) genes cause autosomal dominant neurodevelopmental disorders, while CHD5-related disorders are still unknown. Thanks to GeneMatcher and international collaborations, we assembled a cohort of 16 unrelated individuals harboring heterozygous CHD5 variants, all identified by exome sequencing. Read More

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Giant hemorrhagic trochanteric bursitis mimicking a high-grade soft tissue sarcoma: report of two cases.

Acta Biomed 2021 Apr 30;92(S1):e2021043. Epub 2021 Apr 30.

Rizzoli-Sicilia Department, IRCCS Istituto Ortopedico Rizzoli.

Background: The giant haemorrhagic bursitis of the hip joint is a rare clinical condition that requires evidence-based guidelines for adequate diagnosis and management. Usually, this pathology requires conservative treatment; however, when abnormal size or clinical symptoms of compression of the surrounding noble structures are reported, an accurate differential diagnosis is required, in order to exclude other malignant conditions that can be included into differential diagnosis, and a surgical approach should be considered. The purpose of this work is to provide an appropriate description of the diagnostic and therapeutic path, providing an accurate analysis of the possible differential diagnoses. Read More

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Drastic reduction of orthopaedic services at an urban tertiary hospital in South Africa during COVID-19: Lessons for the future response to the pandemic.

S Afr Med J 2021 Mar 2;111(3):240-244. Epub 2021 Mar 2.

Orthopaedic Research Unit, Division of Orthopaedic Surgery, Groote Schuur Hospital, Cape Town, South Africa; Division of Orthopaedic Surgery, Groote Schuur Hospital, Cape Town, South Africa; Wellcome Centre for Infectious Disease Research in Africa (CIDRI-Africa), Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.

Background: The COVID-19 pandemic has impacted on the global surgery landscape.

Objectives: To analyse and describe the initial impact of the COVID-19 pandemic on orthopaedic surgery at Groote Schuur Hospital, a tertiary academic hospital in South Africa.

Methods: The number of orthopaedic surgical cases, emergency theatre patient waiting times, and numbers of outpatient clinic visits, ward admissions, bed occupancies and total inpatient days for January - April 2019 (pre-COVID-19) were compared with the same time frame in 2020 (COVID-19). Read More

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Circumferential esophageal hiatal rim reconstruction for treatment of persistent regurgitation in brachycephalic dogs: 29 cases (2016-2019).

J Am Vet Med Assoc 2021 May;258(10):1091-1097

Objective: To describe a technique for circumferential esophageal hiatal rim reconstruction and to report outcomes in brachycephalic dogs with persistent regurgitation treated with the technique.

Animals: 29 client-owned brachycephalic dogs.

Procedures: Dogs that had undergone circumferential esophageal hiatal rim reconstruction between January 1, 2016, and December 31, 2019, for treatment of persistent regurgitation were identified through a search of the medical record database of The Animal Hospital at Murdoch University. Read More

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Acute urticaria in children: from pediatric emergency department to allergology consultation at a central hospital.

Eur Ann Allergy Clin Immunol 2021 May 4. Epub 2021 May 4.

Medical doctor, Allergy Department, Centro Hospitalar Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal.

Summary: Acute urticaria is a common condition in the pediatric emergency department (ED) and no data is available in Portugal. We aimed to characterize the prevalence, etiology and management of acute urticaria in children presenting at an ED of a portuguese central hospital and report the follow-up investigation when drug or food allergy was suspected. Retrospective study of clinical records from children admitted to the ED with acute urticaria during one year period. Read More

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Pooled prevalence of three major cardiovascular risk factors in patients undergoing left main bifurcation stenting: a systematic review and meta-analysis.

Minerva Cardiol Angiol 2021 May 4. Epub 2021 May 4.

Division of Cardiology, Rovigo General Hospital, Rovigo, Italy.

Background: Prevalence of the major risk factors in patients with Left Main (LM) bifurcation disease has not been yet clearly assessed, although it would important for building up bifurcation computational models. We perform a systematic review and metaanalysis on the three major cardiovascular risk factors in patients treated for LM bifurcation disease using either single or 2-stent strategy.

Mehtods: In accordance with the PRISMA guidelines, Cochrane Library, Embase, PubMed and Google Scholar were queried to locate articles published between January 2015 to October 2020, comparing single- versus 2-stent strategy and reporting the prevalence of arterial hypertension (HT), hyperlipidaemia (HyperL) and diabetes mellitus (DM). Read More

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Impact of coronary stenting on top of medical therapy and of inclusion of periprocedural infarctions on hard composite endpoints in patients with chronic coronary syndromes: a meta-analysis of randomized controlled trials.

Minerva Cardiol Angiol 2021 May 4. Epub 2021 May 4.

IRCCS Ospedale Policlinico San Martino, Italian IRCCS Cardiovascular Network, Genoa, Italy -

Background: Composite endpoints are pivotal when assessing rare outcomes over relatively short follow-ups. Most randomized controlled trials (RCTs) comparing percutaneous coronary intervention (PCI) with stent implantation to optimal medical therapy (OMT) in chronic coronary syndromes (CCS) patients included both hard and soft outcomes in their primary endpoint, with periprocedural myocardial infarctions (MIs) systematically allocated to the PCI arm. We metaanalysed the above RCTs for composite hard endpoints, with and without periprocedural MIs. Read More

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Clinics and pathology of Krukenberg Tumor: a systematic review and meta-analysis.

Minerva Obstet Gynecol 2021 May 4. Epub 2021 May 4.

Minimal Invasive Oncological and General Surgery, Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Background: Krukenberg tumor (KT) is defined as a secondary neoplasm of the ovary. While ovarian metastases account for about 30% of ovarian tumors, KTs are rare, accounting for about 1-2% of the total. The rarity of KT is at least in part responsible for the lack of a precise clinic-pathological characterization of these tumors. Read More

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Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An study.

Investig Clin Urol 2021 May;62(3):354-360

Department of Urology, Fertility Center, CHA Gangnam Medical Center, CHA University, Seoul, Korea.

Purpose: Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We investigated the effect of PDE5 inhibitors on sperm function by analyzing sperm motility and acrosome reaction. Read More

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Analysis of clinicopathological features of primary diaphragm tumors: A single-center study.

Thorac Cancer 2021 May 4. Epub 2021 May 4.

Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background And Objectives: Primary diaphragm tumors are rare. The aim of this study was to explore the clinicopathological features of primary diaphragm tumor patients who underwent surgical treatment in our center to improve the diagnosis and treatment of this disease.

Methods: Clinical data of patients with primary diaphragm tumor who underwent surgery in our hospital from 2004 to 2019 were reviewed and analyzed. Read More

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Hospital-level compliance with the commission on cancer's quality of care measures and the association with patient survival.

Cancer Med 2021 May 4. Epub 2021 May 4.

Department of Surgery, Duke University, Duke Cancer Institute, Durham, NC, USA.

Background: Quality measurement has become a priority for national healthcare reform, and valid measures are necessary to discriminate hospital performance and support value-based healthcare delivery. The Commission on Cancer (CoC) is the largest cancer-specific accreditor of hospital quality in the United States and has implemented Quality of Care Measures to evaluate cancer care delivery. However, none has been formally tested as a valid metric for assessing hospital performance based on actual patient outcomes. Read More

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Salmonella Osteomyelitis in Adults: A Systematic Review.

Orthop Surg 2021 May 4. Epub 2021 May 4.

First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

The aim of this systematic review was to characterize the clinical features of adults with Salmonella osteomyelitis and summarize diagnosis and treatment methods to provide guidance for clinicians. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We conducted a literature search in the PubMed, EMBASE, and Cochrane Library databases. Read More

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