20,308 results match your criteria included 101


Risk Factors Associated With Poor Outcomes Following Temporomandibular Joint Discectomy and Fat Graft.

J Oral Maxillofac Surg 2021 May 19. Epub 2021 May 19.

Melbourne Dental School, University of Melbourne, Parkville, Australia; Maxillofacial Surgery Unit, Epworth-Freemasons Hospital East Melbourne, Melbourne, Australia.

Purpose: Temporomandibular joint (TMJ) discectomy is performed for patients with degenerative joint disease with an unsalvageable disc, but with a salvageable condylar head and glenoid fossa. The purpose of this study was to estimate the incidence and risk factors associated with poor postoperative outcomes following TMJ discectomy and abdominal fat grafting.

Methods: A retrospective cohort study was conducted on patients who underwent TMJ discectomy. Read More

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What Is the Mid-Term Survivorship of Infected Rotating-Hinge Implants Treated with One-stage-exchange?

Clin Orthop Relat Res 2021 Jun 21. Epub 2021 Jun 21.

Department of Orthopedic Surgery, Helios ENDO-Klinik, Hamburg, Germany.

Background: Despite the growing number of studies reporting on periprosthetic joint infection (PJI), there is little information on one-stage exchange arthroplasty for the revision of infected rotating-hinge prostheses, which can be among the most difficult PJI presentations to treat.

Questions/purposes: After one-stage direct exchange revision for an infected rotating-hinge TKA prosthesis, and using a multimodal approach for infection control, we asked: (1) What is the survivorship free from repeat revision for infection and survivorship free from reoperation for any cause? (2) What is the clinical outcome, based on the Oxford Knee Score, of these patients at the latest follow-up?

Methods: Between January 2011 and December 2017, we treated 101 patients with infected rotating-hinge knee prostheses at our hospital. All patients who underwent a one-stage exchange using another rotating-hinge implant were potentially eligible for this retrospective study. Read More

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The Role of Type III Interferons in Human Disease.

Clin Invest Med 2021 Jun 14;44(2):E5-18. Epub 2021 Jun 14.

Division of Immunology, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.

Purpose: This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules.

Source: Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020. N=101 articles were included in this review. Read More

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High Prevalence of Right Ventricular/Left Ventricular Ratio ≥1 Among Patients Undergoing Computed Tomography Pulmonary Angiography.

J Thorac Imaging 2021 Jul;36(4):231-235

Departments of Radiology.

Aim: Increased ratio between the right and left ventricular (RV/LV) diameters ≥1 is considered an important imaging marker for risk stratification among patients diagnosed with acute pulmonary embolism (PE). Our goal was to assess the prevalence of RV/LV≥1 among consecutive patients undergoing computed tomography pulmonary angiography, and to compare the prevalence of RV/LV≥1 between patients with and without PE.

Methods: Retrospective analysis of consecutive patients who underwent computed tomography pulmonary angiography due to clinical suspicion of PE between January 1, 2014 and December 31, 2014. Read More

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Admission Blood Glucose in the Emergency Department is Associated with Increased In-Hospital Mortality in Nontraumatic Critically Ill Patients.

J Emerg Med 2021 Jun 17. Epub 2021 Jun 17.

Emergency Department, University Hospital of Leipzig, Leipzig, Germany.

Background: Abnormal admission blood glucose was reported as a useful predictor of outcome in critically ill patients.

Objectives: To identify patients at higher risk, this study aimed to evaluate the relationship between admission blood glucose levels and patient mortality during the management of nontraumatic critically ill patients in the emergency department (ED).

Methods: In this prospective, single-center observational study in a German university ED, all adult patients admitted to the resuscitation room of the ED were included between September 1, 2014 and August 31, 2015. Read More

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Antibiotics in pediatric Inflammatory Bowel Diseases: a systematic review.

Expert Rev Gastroenterol Hepatol 2021 Jun 21. Epub 2021 Jun 21.

Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The Netherlands.

Introduction: : Current available therapies in pediatric Inflammatory Bowel Disease (IBD) target the immune system and often fail to sustain long term remission. Therefore, there is a high need for development of alternative treatment strategies such as antibiotics in pediatric IBD.

Areas Covered: : This study systematically assessed efficacy and safety of antibiotics in pediatric IBD. Read More

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The burden of central line-associated bloodstream infections in children with medical complexity.

J Vasc Access 2021 Jun 21:11297298211027468. Epub 2021 Jun 21.

Bambino Gesù Pediatric Hospital, Rome, Italy.

Background: Central line-associated bloodstream infections (CLABSI) are significant cause of complications in pediatric intensive care units (PICUs). An emerging challenge are CLABSIs in children with medical complexity (CMC) admitted to PICU. CMC are patients with chronic conditions with or without neurological impairment needing for tracheostomy and/or home mechanical or non-invasive ventilation and/or gastrostomy/jejunostomy. Read More

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The association between sleep quality and quality of life: a population-based study.

Sleep Med 2021 May 27;84:121-126. Epub 2021 May 27.

Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea. Electronic address:

Objectives: This study aimed to evaluate the association between sleep quality and quality of life (QoL).

Methods: This cross-sectional study included 225,541 adults (101,133 men, 124,408 women) who participated in the 2018 Korean Community Health Survey. Multiple sociodemographic and psychosocial variables were evaluated and compared between participants with poor (n = 67,619) and good sleep quality (n = 157,922); sleep quality was subjectively determined using the Pittsburgh Sleep Quality Index (PSQI). Read More

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Urinary Dickkopf-3 (uDKK3): a new biomarker for CKD progression and mortality?

Nephrol Dial Transplant 2021 Jun 17. Epub 2021 Jun 17.

Department of Nephrology., Hospital Universitario Fundación Alcorcón, Madrid, Spain.

Background: Kidney fibrosis has been reported to be a prognostic factor in CKD progression. Previous studies have shown that the assessment of urinary Dickkopf-3 (uDKK3), a stress induced tubular epithelial-derived profibrotic glycoprotein, might be a potential tubulointerstitial fibrosis biomarker and might identify patients at short-term risk of eGFR loss. We aim to evaluate uDKK3 as a potential biomarker for progression of CKD in a cohort with various etiologies of CKD, and subsequently in an overt diabetic nephropathy cohort. Read More

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Normal intraocular pressure in Egyptian children and meta-analysis.

Eye (Lond) 2021 Jun 18. Epub 2021 Jun 18.

Ophthalmic Department, Cairo University, Cairo, Egypt.

Objective: To determine the normal intraocular pressure in a sample of Egyptian children 0-12 years of age, and compare it to that recorded in previous studies.

Methods: This is a prospective cross-sectional study, including 345 eyes. All children underwent complete history taking and ophthalmic examination. Read More

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Estimation of Tacrolimus Clearance in Saudi Adult Kidney Transplant Recipients.

Saudi J Kidney Dis Transpl 2021 Jan-Feb;32(1):101-110

Department of Clinical Pharmacy, College of Pharmacy; Clinical Pharmacokinetics and Pharmacodynamics Unit, King Saud University Medical City, Riyadh, Saudi Arabia.

Tacrolimus is commonly used in adult kidney transplant patients. Only few studies have so far described the pharmacokinetics of tacrolimus in the Saudi population. Thus, the goal of this study is to determine the population pharmacokinetics of tacrolimus in Saudi adult kidney transplant recipients and to identify the factors that explain variability. Read More

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Diffusion-weighted MR imaging in pancreatic ductal adenocarcinoma: prediction of next-generation sequencing-based tumor cellularity and prognosis after surgical resection.

Abdom Radiol (NY) 2021 Jun 18. Epub 2021 Jun 18.

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Purpose: To identify features on preoperative MR imaging with diffusion-weighted imaging (DWI) for predicting next-generation sequencing (NGS)-based tumor cellularity and patient outcome after surgical resection of pancreatic ductal adenocarcinoma (PDAC).

Methods: This retrospective study included 105 patients with surgically resected PDAC who underwent preoperative MR imaging with DWI. Tumor cellularity was measured using molecular techniques and bioinformatics methods. Read More

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[Analysis of the effect of cognitive stimulation program in older adults with normal cognition: randomized clinical trial].

An Sist Sanit Navar 2021 Jun 18;0(0). Epub 2021 Jun 18.

Departamento de Fisiatría y Enfermería. Facultad de Ciencias de la Salud. Universidad de Zaragoza. Zaragoza. España..

Background: Cognitive stimulation programs in older adults seek cognitive and emotional improvements. The literature makes no reference to programs adapted according to cognitive and occupational levels in older adults with no cognitive impairment. The objective of this study was to analyze the effectiveness of level-adapted cognitive stimulation interven-tion in older adults in terms of cognition and mood. Read More

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Predictors of lead break during transvenous lead extraction.

J Arrhythm 2021 Jun 15;37(3):645-652. Epub 2021 Mar 15.

Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan.

Background: The incidence, predictors, and clinical impact of lead break during transvenous lead extraction (TLE) were previously unknown.

Methods: We included consecutive patients who underwent TLE between September 2013 and July 2019 at our institute. Lead break during removal was defined as lead stretching and becoming misshapen, as assessed by fluoroscopy. Read More

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Carer's Attachment Anxiety, Stressful Life-Events and the Risk of Childhood-Onset Type 1 Diabetes.

Front Psychiatry 2021 25;12:657982. Epub 2021 May 25.

Centre for Mental Health, University Psychiatric Hospital Ljubljana, Ljubljana, Slovenia.

Type 1 diabetes (T1D) is among the most common chronic diseases in children/adolescents, and the incidence continues to rise worldwide. Different environmental factors have been evaluated in the etiology. In the present study, we investigated the role of attachment examining whether insecure attachment to carers or carers' own attachment insecurity was related to a higher risk of T1D in children. Read More

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[Association of cadmium internal exposure with chronic kidney disease in Chinese adults].

Zhonghua Yi Xue Za Zhi 2021 Jun 9;101:1921-1928. Epub 2021 Jun 9.

Key Laboratory of Environment and Population Health, Chinese Center for Disease Control and Prevention, Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China.

To analyze the association of the cadmium internal exposure with chronic kidney disease (CKD) in Chinese adults aged 18 and older. A total of 9 821 adults aged 18-79 from the China National Human Biomonitoring (CNHBM) from 2017 to 2018 were included. Blood and urine cadmium exposure levels were measured by inductively coupled plasma mass spectrometry (ICP-MS), and urine cadmium levels were adjusted with urine creatinine; CKD were defined by estimated glomerular filtration (eGFR) using the chronic kidney disease epidemiology collaboration (CKD-EPI). Read More

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[Relationship between non-medical reading and burnout as well as professional satisfaction among urologists with migrant background: results of the EUTAKD survey study conducted at German hospitals].

Aktuelle Urol 2021 Jun 17. Epub 2021 Jun 17.

Klinik für Urologie und Kinderurologie, Ruppiner Kliniken GmbH, Medizinische Hochschule Brandenburg Theodor Fontane, Neuruppin, Deutschland.

Background: There are no study results on the private and professional satisfaction and the burnout risk of urologists with a migrant background at German hospitals to date. Non-medical reading has been described to have an influence on lower burnout rates among physicians of different specialties.

Material And Methods: A SurveyMonkey questionnaire with 101 items on criteria characterising the study participant, questions on private and professional satisfaction and the complete Maslach Burnout Inventory was opened to urologists with a migrant background at German clinics between August and October 2020. Read More

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Factors influencing maternal healthcare seeking in a highland region of Madagascar: a mixed methods analysis.

BMC Pregnancy Childbirth 2021 Jun 16;21(1):428. Epub 2021 Jun 16.

USAID ACCESS - Management Sciences for Health, Institut Pasteur, Antananarivo, Madagascar.

Background: In Madagascar, maternal mortality remains stable and high (426 deaths per 100,000 live births). This situation is mainly due to a delay or lack of use of maternal healthcare services. Problems related to maternal healthcare services are well documented in Madagascar, but little information related to maternal healthcare seeking is known. Read More

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Exogenous Ketone Ester Delays CNS Oxygen Toxicity Without Impairing Cognitive and Motor Performance in Male Sprague Dawley Rats.

Am J Physiol Regul Integr Comp Physiol 2021 06 16. Epub 2021 Jun 16.

Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, United States.

Hyperbaric oxygen (HBO) is breathing greater than 1 ATA (101.3 kPa) O and is used in HBO therapy and undersea medicine. What limits the use of HBO is the risk of developing CNS oxygen toxicity (CNS-OT). Read More

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Minimally Invasive Esophagectomy in Semi-Prone Position (Pawar Technique): Technical Aspects and Outcome in 224 Patients.

South Asian J Cancer 2020 Oct 12;9(4):213-221. Epub 2021 Jun 12.

Department of Medicine, HBT Medical College, and Dr. R N Cooper Municipal General Hospital, Juhu, Mumbai, Maharashtra, India.

 There are two patient positions described for minimally invasive esophagectomy (MIE) for esophageal cancer, viz., left lateral and prone positions. To retain the benefits and overcome the disadvantages of these positions, a semi-prone position was developed by us. Read More

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October 2020

[Malnutrition in geriatric patients: risk factor residential nursing home?]

HeilberufeScience 2021 Jun 11:1-9. Epub 2021 Jun 11.

Fakultät Soziale Arbeit, Bildung und Pflege, Institut für Gesundheits- und Pflegewissenschaften, Hochschule Esslingen - University of Applied Sciences, Flandernstraße 101, 73732 Esslingen am Neckar, Deutschland.

Background: Malnutrition remains a challenging problem in hospitals, especially among geriatric patients. The background and causes are actually well known but still underestimated in clinical practice.

Aim And Methods: This study evaluated possible differences in rates of malnutrition risk and malnutrition in geriatric patients living at home and geriatric patients living in residential nursing homes. Read More

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Antegrade intramedullary fixation for adolescent fifth metacarpal neck fracture and its impact on epiphyseal growth.

BMC Musculoskelet Disord 2021 Jun 15;22(1):546. Epub 2021 Jun 15.

Department of Surgical Center, Karamay Central Hospital of Xinjiang, 834000, Karamay, China.

Background: Antegrade intramedullary nailing (AIMN) with Kirschner wire (K-wire) is a minimally invasive osteosynthesis technique. This procedure has been widely performed to treat the fifth metacarpal neck fracture (FMNF) in adults. This study was performed to determine whether using AIMN with a single K-wire to treat FMNF in adolescents would have good clinical and radiographic outcomes. Read More

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Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography.

Eur Radiol 2021 Jun 15. Epub 2021 Jun 15.

Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Objectives: To compare the detection of relevant extracardiac findings (ECFs) on coronary computed tomography angiography (CTA) and invasive coronary angiography (ICA) and evaluate the potential clinical benefit of their detection.

Methods: This is the prespecified subanalysis of ECFs in patients presenting with a clinical indication for ICA based on atypical angina and suspected coronary artery disease (CAD) included in the prospective single-center randomized controlled Coronary Artery Disease Management (CAD-Man) study. ECFs requiring immediate therapy and/or further workup including additional imaging were defined as clinically relevant. Read More

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Aripiprazole Lauroxil 2-Month Formulation With 1-Day Initiation for Acute Schizophrenia: ALPINE Exploratory Efficacy and Patient-Reported Outcomes.

CNS Spectr 2021 Apr;26(2):171-172

Alkermes, Inc., Waltham, MA, USA.

Objective: The randomized, controlled, phase 3b ALPINE study evaluated efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) initiated with a 1-day regimen during hospitalization for an acute exacerbation of schizophrenia; paliperidone palmitate (PP) was included as an active control. The primary efficacy outcome, within-group change from baseline in PANSS total score at 4 weeks, was previously reported. Here we report additional exploratory PANSS subscale endpoints and patient-reported outcomes (PROs). Read More

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Efficacy and safety of normobaric hyperoxia combined with intravenous thrombolysis on acute ischemic stroke patients.

Neurol Res 2021 Jun 15:1-6. Epub 2021 Jun 15.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Intravenous thrombolysis elevates the prognostic level of acute ischemic stroke (AIS) patients. Normobaric hyperoxia (NBO) delays the progression of the infarct core and promotes neurological recovery. However, it is uncertain whether NBO can further raise the prognostic level of AIS patients based on intravenous thrombolysis. Read More

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[Utility of the type 3 portable monitor for the diagnosis of sleep disordered breathing in patients with stable heart failure].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(22):1676-1682

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.

To evaluate the utility of a type 3 portable monitor (PM) at home for the diagnosis of sleep disordered breathing (SDB) in patients with stable congestive heart failure (CHF). Seventy-six consecutive patients with CHF (61 males, 15 females, mean±standard deviation age (57.0±16. Read More

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Identification of genes related to stress affecting thymus immune function in a chicken stress model using transcriptome analysis.

Res Vet Sci 2021 Jun 7;138:90-99. Epub 2021 Jun 7.

College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China; Henan Key Laboratory for Innovation and Utilization of Chicken Germplasm Resources, Zhengzhou 450046, China. Electronic address:

With the rapid development of the poultry breeding industry and highly intensive production management, the losses caused by stress responses are becoming increasingly serious. To screen candidate genes related to chicken stress and provide a basis for future research on the molecular mechanisms governing the effects of stress on chicken immune function, we successfully constructed a chicken stress model by exogenously introducing corticosterone (CORT). RNA-seq technology was used to identify and analyze the mRNA and enrichment pathways of the thymus in the stress model group and the control group. Read More

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A Determinants-of-Fertility Ontology for Detecting Future Signals of Fertility Issues From Social Media Data: Development of an Ontology.

J Med Internet Res 2021 Jun 14;23(6):e25028. Epub 2021 Jun 14.

Department of Health Management, Samyook University, Seoul, Republic of Korea.

Background: South Korea has the lowest fertility rate in the world despite considerable governmental efforts to boost it. Increasing the fertility rate and achieving the desired outcomes of any implemented policies requires reliable data on the ongoing trends in fertility and preparations for the future based on these trends.

Objective: The aims of this study were to (1) develop a determinants-of-fertility ontology with terminology for collecting and analyzing social media data; (2) determine the description logics, content coverage, and structural and representational layers of the ontology; and (3) use the ontology to detect future signals of fertility issues. Read More

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Sulfonylureas Use Is Not Associated With Increased Infarct Size in Patients With Type 2 Diabetes and ST-Segment Elevation Myocardial Infarction.

Front Cardiovasc Med 2021 28;8:658059. Epub 2021 May 28.

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

This retrospective study assessed the association between sulfonylureas use and infarct size in patients with type 2 diabetes (T2DM) and ST-segment elevation myocardial infarction (STEMI) by myocardial enzymology indexes and cardiac magnetic resonance (CMR) imaging. Patients presenting STEMI between July 2013 and August 2019 were included in a retrospective database at our institution. Antidiabetic agents used before STEMI were recorded. Read More

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