33,095 results match your criteria include reduction

Successful pregnancy in morbidly obese lady with polycystic ovary syndrome after bariatric surgery: A case report.

Int J Surg Case Rep 2021 Jul 24;85:106235. Epub 2021 Jul 24.

Department of Surgery, Faculty of Medicine and Science Health, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia. Electronic address:

Introduction: Obesity has been proven to have adverse effects on fertility and is one of the predisposing factors for delay in pregnancy even with the use of assisted reproductive technique. There are many pathways in which obesity can affect fertility such as anovulation, poor implantation and low-quality oocyte.

Case Presentation: We report a case of a 40-year-old lady with primary infertility for six years with underlying polycystic ovary syndrome (PCOS) and BMI 45. Read More

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A Dictyostelium model for BPAN disease reveals a functional relationship between the WDR45/WIPI4 homolog Wdr45l and Vmp1 in the regulation of autophagy-associated PtdIns3P and ER stress.

Autophagy 2021 Jul 27:1-17. Epub 2021 Jul 27.

C.S.I.C./U.A.M., Instituto De Investigaciones Biomédicas Alberto Sols, Madrid, Spain.

PROPPINs are conserved PtdIns3P-binding proteins required for autophagosome biogenesis that fold into a characteristic group of seven-bladed beta-propellers. Mutations in WDR45/WIPI4, a human member of this family, lead to BPAN, a rare form of neurodegeneration. We have generated mutants for the two PROPPIN proteins present in the model system (Atg18 and Wdr45l) and characterized their function. Read More

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Care of the Postpartum Patient in the Emergency Department: A Systematic Review with Implications for Maternal Mortality.

Am J Perinatol 2021 Jul 29. Epub 2021 Jul 29.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama.

Objective:  Approximately one-third of maternal deaths occur postpartum. Little is known about the intersection between the postpartum period, emergency department (ED) use, and opportunities to reduce maternal mortality. The primary objectives of this systematic review are to explore the incidence of postpartum ED use, identify postpartum disease states that are evaluated in the ED, and summarize postpartum ED use by race/ethnicity and payor source. Read More

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Top 10 dietary strategies for atherosclerotic cardiovascular risk reduction.

Am J Prev Cardiol 2020 Dec 19;4:100106. Epub 2020 Nov 19.

Oregon Health and Science University, USA.

Poor dietary quality has surpassed all other mortality risk factors, accounting for 11 million deaths and half of CVD deaths globally. Implementation of current nutrition recommendations from the American Heart Association (AHA), American College of Cardiology (ACC) and the National Lipid Association (NLA) can markedly benefit the primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD). These include: 1) incorporate nutrition screening into medical visits; 2) refer patients to a registered dietitian nutritionist (RDN) for medical nutrition therapy, when appropriate, for prevention of ASCVD; 3) follow ACC/AHA Nutrition and Diet Recommendations for ASCVD prevention and management of overweight/obesity, type 2 diabetes and hypertension; 4) include NLA nutrition goals for optimizing low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) and reducing ASCVD risk; 5) utilize evidence-based heart-healthy eating patterns for improving cardiometabolic risk factors, dyslipidemia and ASCVD risk; 6) implement ACC/AHA/NLA nutrition and lifestyle recommendations for optimizing triglyceride levels; 7) understand the impact of saturated fats, trans fats, omega-3 and omega-6 polyunsaturated fats and monounsaturated fats on ASCVD risk; 8) limit excessive intake of dietary cholesterol for those with dyslipidemia, diabetes and at risk for heart failure; 9) include dietary adjuncts such as viscous fiber, plant sterols/stanols and probiotics; and 10) implement AHA/ACC and NLA physical activity recommendations for the optimization of lipids and prevention of ASCVD. Read More

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December 2020

Modeling the Effects of Future Hydroclimatic Conditions on Microbial Water Quality and Management Practices in Two Agricultural Watersheds.

Trans ASABE 2020 Jan;63(3):753-770

Physical Scientist, Office of Research and Development, U.S. Environmental Protection Agency, Washington, D.C., USA.

Anticipated future hydroclimatic changes are expected to alter the transport and survival of fecally-sourced waterborne pathogens, presenting an increased risk of recreational water quality impairments. Managing future risk requires an understanding of interactions between fecal sources, hydroclimatic conditions and best management practices (BMPs) at spatial scales relevant to decision makers. In this study we used the Hydrologic Simulation Program FORTRAN to quantify potential fecal coliform (FC - an indicator of the potential presence of pathogens) responses to a range of mid-century climate scenarios and assess different BMP scenarios (based on reduction factors) for reducing the risk of water quality impairment in two, small agricultural watersheds - the Chippewa watershed in Minnesota, and the Tye watershed in Virginia. Read More

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January 2020

The early hunting dog from Dmanisi with comments on the social behaviour in Canidae and hominins.

Sci Rep 2021 Jul 29;11(1):13501. Epub 2021 Jul 29.

Earth Science Department, Paleo[Fab]Lab, University of Florence, Via G. La Pira 4, 50121, Firenze, Italy.

The renowned site of Dmanisi in Georgia, southern Caucasus (ca. 1.8 Ma) yielded the earliest direct evidence of hominin presence out of Africa. Read More

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The efficacy and safety of MR-HIFU and US-HIFU in treating uterine fibroids with the volume <300 cm: a meta-analysis.

Int J Hyperthermia 2021 ;38(1):1126-1132

Department of Gynecology, Jiangsu Province Hospital, Nanjing, China.

Background: High-intensity focused ultrasound (HIFU) is a promising and non-invasive therapy for symptomatic uterine fibroids. Currently, the main image-guided methods for HIFU include magnetic resonance-guided (MR-HIFU) and ultrasound-guided (US-HIFU). However, there are few comparative studies on the therapeutic efficacy and safety of MR-HIFU and US-HIFU in treating symptomatic uterine fibroids with a volume <300 cm. Read More

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January 2021

Experiences of people with opioid use disorder during the COVID-19 pandemic: A qualitative study.

PLoS One 2021 29;16(7):e0255396. Epub 2021 Jul 29.

Department of Emergency Medicine, St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

Aim: To capture pandemic experiences of people with opioid use disorder (OUD) to better inform the programs that serve them.

Design: We designed, conducted, and analyzed semi-structured qualitative interviews using grounded theory. We conducted interviews until theme saturation was reached and we iteratively developed a codebook of emerging themes. Read More

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Modified ultrafiltration and postoperative course in patients undergoing repair of tetralogy of fallot.

J Card Surg 2021 Jul 29. Epub 2021 Jul 29.

Departments of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Expected benefits of modified ultrafiltration (MUF) include increased hematocrit, reduction of total body water and inflammatory mediators, improved left ventricular systolic function, and improved systolic blood pressure and cardiac index (CI) following cardiopulmonary bypass (CPB). This prospective randomized trial tested this hypothesis.

Methods: Seventy-nine patients undergoing intracardiac repair of tetralogy of fallot were randomized to conventional ultrafiltration (CUF) + MUF (n = 39) or only CUF group (n = 40). Read More

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Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic.

JAMA Netw Open 2021 Jul 1;4(7):e2118433. Epub 2021 Jul 1.

SWOG Cancer Research Network Group Chair's Office, Portland, Oregon.

Importance: During the initial outbreak of the COVID-19 pandemic, cancer clinical trial participation decreased precipitously. Given the continued pandemic-especially the severe wave of new cases and deaths in winter 2020 to 2021-a vital question is whether trial enrollments have remained low or even worsened.

Objective: To examine the experience of cancer clinical trial enrollment 1 year after the COVID-19 outbreak. Read More

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Evaluation and Management of Posterior Wall Acetabulum Fractures.

J Am Acad Orthop Surg 2021 Jul 23. Epub 2021 Jul 23.

From the Department of Orthopaedic Surgery (Perdue, Toney), Christiana Hospital, Newark, DE (Tainter) Virginia Commonwealth University, Richmond, VA, and the Department of Orthopaedic Surgery (Lee), University of California, Los Angeles, Los Angeles, CA.

Posterior wall acetabulum fractures typically result from high-energy mechanisms and can be associated with various orthopaedic and nonorthopaedic injuries. They range from isolated simple patterns to multifragmentary with or without marginal impaction. Determination of hip stability, which can depend on fragment location, size, and displacement, directs management. Read More

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Natural bioactive molecules: An alternative approach to the treatment and control of glioblastoma multiforme.

Biomed Pharmacother 2021 Jul 19;141:111928. Epub 2021 Jul 19.

Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address:

Glioblastoma multiforme is one of the most deadly malignant tumors, with more than 10,000 cases recorded annually in the United States. Various clinical analyses and studies show that certain chronic diseases, including cancer, interact between cell-reactive radicals rise and pathogenesis. Reactive oxygen and nitrogenous sources include endogenous (physiological processes), and exogenous sources contain reactive oxygen and nitrogen (xenobiotic interaction). Read More

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Quadratus Lumborum Block is an Effective Postoperative Analgesic Technique in Pediatric Patients Undergoing Lower Abdominal Surgery: A Meta-Analysis.

Pain Physician 2021 Aug;24(5):E555-E563

Department of Anesthesiology, Hangzhou Women's Hospital (Hangzhou First People's Hospital Qianjiang New City Campus, The Affiliated Women's Hospital of Hangzhou Normal University), Hangzhou, China.

Background: Quadratus lumborum (QL) block has shown promising analgesic efficacy in the adult population in previous meta-analyses. However, the response of the pediatric group to pain stimulation is stronger than that in the adult population, and the management of pediatric pain is constrained by limited available analgesia agents. All data analyzed during this study are collected from published articles. Read More

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Registered report: A pilot investigation of acute exercise response among girls and young women with and without eating disorders.

Int J Eat Disord 2021 Jul 29. Epub 2021 Jul 29.

Department of Psychiatry and Behavioral Sciences, University of California - San Francisco, San Francisco, California, USA.

Objective: Driven exercise (DEx) is a serious and common feature of eating disorders (EDs), but current understanding of factors that give rise to and maintain DEx is limited. DEx may be reinforced through its effects on the threat reduction and reward systems. The current protocol is designed to evaluate acute psychobiological response to exercise among female participants (age 16-22) with and without EDs. Read More

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[Shapes or icons from the dietary guidelines. A reality going beyond healthy food].

Nutr Hosp 2021 Jul 29. Epub 2021 Jul 29.

Departamento de Nutrición y Dietética. Facultad de Enfermería. Universidad de Valladolid.

Background: icons or shapes represent the development and approval of dietary guidelines including recommendations of food consumption and nutrient intakes according to the behavioral models of countries worldwide. The Food and Agriculture Organization (FAO) collected and recognized them.

Methods: websites of food-based dietary guidelines of the FAO. Read More

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APE1/Ref-1 as a Novel Target for Retinal Diseases.

J Cell Signal 2021 ;2(2):133-138

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN 46202, USA.

APE1/Ref-1 (also called Ref-1) has been extensively studied for its role in DNA repair and reduction-oxidation (redox) signaling. The review titled: " by Caston et. al. Read More

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January 2021

Comprehensive Review and Update of Burning Eye Syndrome.

J Patient Cent Res Rev 2021 19;8(3):255-260. Epub 2021 Jul 19.

Valley Anesthesiology and Pain Consultants - Envision Physician Services, Phoenix, AZ.

Keratoconjunctivitis sicca ("dry eye") is a common (14%-30% of adults over age 48) though difficult to treat condition that causes both discomfort and disability with associated dryness, pain, and visual disturbances. Etiology is not clearly understood but is likely varied, with a subset of patients suffering from chronic neuropathic pain referred to as "burning eye syndrome." This review of existing literature summarizes the clinical presentation, natural history, pathophysiology, and treatment modalities of burning eye syndrome. Read More

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Enhanced Recovery Components for Posterior Lumbar Spine Fusion: Harnessing National Data to Compare Protocols.

Clin Spine Surg 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurological Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx Department of Orthopedics Department of Population Health Science and Policy, Institute for Healthcare Delivery Science, Icahn School of Medicine at Mount Sinai Department of Anesthesiology, Critical Care, and Pain Management, Hospital for Special Surgery, New York, NY.

Study Design: This was a retrospective cohort study.

Objective: The aim of this study was to assess the most commonly used components of enhanced recovery after surgery (ERAS) combinations and their relative effectiveness.

Summary Of Background Data: Data is lacking on use and effectiveness of various ERAS combinations which are increasingly used in spine surgery. Read More

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Awareness of and reactions to health and environmental harms of red meat among parents in the United States.

Public Health Nutr 2021 Jul 29:1-32. Epub 2021 Jul 29.

Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.

Objective: Evidence of the health and environmental harms of red meat is growing, yet little is known about which harms may be most impactful to include in meat reduction messages. This study examined which harms consumers are most aware of and which most discourage them from wanting to eat red meat.

Design: Within-subjects randomized experiment. Read More

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Preoperative stereotactic radiosurgery for brain metastases: the STEP study protocol for a multicentre, prospective, phase-II trial.

BMC Cancer 2021 Jul 28;21(1):864. Epub 2021 Jul 28.

INSERM U1240 IMoST, University of Clermont Auvergne, Clermont-Ferrand, France.

Background: Surgery is an important therapeutic option for brain metastases. Currently, postoperative stereotactic radiosurgery (SRT) leads to 6-month and 1-year local control estimated at 70 and 62% respectively. However, there is an increased risk of radio-necrosis and leptomeningeal relapse. Read More

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Impact of pharmacist involvement on medication safety in interprofessional transfer of care activity.

N Z Med J 2021 Jul 30;134(1539):9-20. Epub 2021 Jul 30.

Associate Dean Medical Education, University of Otago, Christchurch, Specialist Respiratory Physician, Canterbury District Health Board.

Aim: Any transition of patient care is a high-risk time for communication error. This paper explores whether the presence of a pharmacist as part of an interprofessional group provides additional benefit and safety in transitions of care.

Method: Six pharmacy interns and newly qualified pharmacists joined participants from seven other health professional training programmes to take part in an interprofessional education activity. Read More

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Differential structure and functional gene response to geochemistry associated with the suspended and attached shallow aquifer microbiomes from the Illinois Basin, IL.

Water Res 2021 Jul 14;202:117431. Epub 2021 Jul 14.

Illinois State Geological Survey, IL, USA. Electronic address:

Despite the clear ecological significance of the microbiomes inhabiting groundwater and connected ecosystems, our current understanding of their habitats, functionality, and the ecological processes controlling their assembly have been limited. In this study, an efficient pipeline combining geochemistry, high-throughput Fluidigm functional gene amplification and sequencing was developed to analyze the suspended and attached microbial communities inhabiting five groundwater monitoring wells in the Illinois Basin, USA. The dominant taxa in the suspended and the attached microbial communities exhibited significantly different spatial and temporal changes in both alpha- and beta-diversity. Read More

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The injectable composite resin technique: biocopy of a natural tooth - advantages of digital planning.

Int J Esthet Dent 2021 Aug;16(3):280-299

The injectable composite resin technique is a minimally invasive and purely additive procedure that uses a transparent silicone index and flowable composite resin to translate the restorative plan from the wax-up to the final restoration. Its minimally invasive nature means that it can preserve tooth structure as it may not require hard tissue reduction. It is also an indirect/direct molding technique that allows the clinician to perform a direct restoration based on a proper analysis and planning. Read More

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Effect of routine first trimester combined screening for pre-eclampsia on small for gestational age birth: a secondary interrupted time series analysis.

Ultrasound Obstet Gynecol 2021 Jul 28. Epub 2021 Jul 28.

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, London, SW17 0RE, UK.

Objective: Evaluate the effect of first trimester combined Fetal Medicine Foundation (FMF) based pre-eclampsia screening on rates of fetal small for gestational age (SGA) birth and adverse pregnancy outcome.

Methods: A retrospective cohort study in a London tertiary hospital between January 2017 to March 2019. Secondary analysis of first trimester screening for pre-eclampsia: 7720 screened according to NICE risk-based approach and 4841 by FMF multimodal approach combining risk factors, blood pressure, PAPP-A and uterine Doppler indices. Read More

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Benefits of Dietary Management in Breast Cancer Patients: A Systematic Review and Meta-Analysis.

Nutr Cancer 2021 Jul 28:1-13. Epub 2021 Jul 28.

Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

The World Cancer Research Fund/American Institute of Cancer Research recommendations include guidance on diet, nutrition, and weight management for people with cancer. However, for women diagnosed with breast cancer there is a lack of comprehensive analyses on the effects of dietary interventions. The purpose of this study was to investigate the impact of changes in dietary behavior and body composition on breast cancer development. Read More

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Impact of behavioral side effects on the management of Parkinson patients treated with dopamine agonists.

Clin Park Relat Disord 2021 2;4:100091. Epub 2021 Mar 2.

Center for Neurological Restoration, Neurological Institute, Cleveland Clinic, USA.

Dopamine agonists are one of the main stay of treatment option for Parkinson disease (PD). Side effects that develop from their use are generally categorized into and . Behavioral side effects include: impulse control behavior disorder (ICD), psychosis and cognitive impairment. Read More

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Microbial Interventions to Control and Reduce Blood Pressure in Australia (MICRoBIA): rationale and design of a double-blinded randomised cross-over placebo controlled trial.

Trials 2021 Jul 27;22(1):496. Epub 2021 Jul 27.

Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University, 25 Rainforest Walk, Clayton, Victoria, 3800, Australia.

Background: Hypertension is a prevalent chronic disease worldwide that remains poorly controlled. Recent studies support the concept that the gut microbiota is involved in the development of hypertension and that dietary fibre intake may act through the gut microbiota to lower blood pressure (BP). Resistant starch is a type of prebiotic fibre which is metabolised by commensal bacteria in the colon to produce short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate. Read More

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The safety and efficacy of botanicals with nootropic effects.

Curr Neuropharmacol 2021 Jul 26. Epub 2021 Jul 26.

Personal Healthcare Division, The Procter & Gamble Company, 8700 Mason-Montgomery Road, Mason, OH, 45040, United States.

Recent estimates for the global brain health supplement category, i.e. nootropic market size, will grow to nearly $5. Read More

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Evaluating and Managing the Painful Total Ankle Replacement.

Foot Ankle Int 2021 Jul 27:10711007211027273. Epub 2021 Jul 27.

Hospital for Special Surgery, New York, NY, USA.

The number of total ankle replacements (TARs) performed in the United States has dramatically increased in the past 2 decades due to improvements in implant design and surgical technique. Yet as the prevalence of TAR increases, so does the likelihood of encountering complications and the need for further surgery. Patients with new-onset or persistent pain after TAR should be approached systematically to identify the cause: infection, fracture, loosening/subsidence, cysts/osteolysis, impingement, and nerve injury. Read More

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Assessing the impact of medically tailored meals and medical nutrition therapy on type 2 diabetes: Protocol for Project MiNT.

Contemp Clin Trials 2021 Jul 24:106511. Epub 2021 Jul 24.

Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street, Suite 300, Philadelphia, PA 19107, USA; Center for Connected Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut St, Suite 704, Philadelphia, PA 19107, United States of America.

Background: Research has shown that among people with type 2 diabetes mellitus, reduction in hemoglobin A1c (HbA1c) prevents long term complications. Medically tailored meals (MTM) and telehealth-delivered medical nutrition therapy (tele-MNT) are promising strategies for patient-centered diabetes care.

Objectives: Project MiNT will determine whether provision of MTM with and without the addition of telehealth-delivered medical nutrition therapy improves HbA1c and is cost effective for patients with type 2 diabetes mellitus. Read More

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