1,687 results match your criteria include pol

Genetic basis of hereditary hypophosphataemic rickets and phenotype presentation in children and adults.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Paediatrics, Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia.

Hypophosphataemic rickets (HR) is a genetic disorder causing defects in the renal handling of phosphorus, resulting in rickets. HR can be classified into two groups. First- those with excess fibroblast growth factor 23(FGF23) levels, which are due to gene mutations in extrarenal factors and include X-linked dominant hypophosphataemic rickets (XLHR), autosomal dominant hypophosphataemic rickets (ADHR), autosomal recessive hypophosphataemic rickets (ARHR), and hypophosphataemic rickets with hyperparathyroidism. Read More

View Article and Full-Text PDF

Determination of neuron-specific enolase in patients with midgut-type tumour treated with somatostatin analogues.

Endokrynol Pol 2021 Jul 22. Epub 2021 Jul 22.

Department of Endocrinology, Metabolism, and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

Introduction: The biochemical diagnosis of neuroendocrine tumours (NETs) uses assays of specific and nonspecific markers. Nonspecific markers include, among others, neuron-specific enolase (NSE). The aim of this study was to evaluate NSE in patients with midgut type tumours treated with somatostatin analogues. Read More

View Article and Full-Text PDF

Selective Caries Removal in Permanent Teeth (SCRiPT) for the treatment of deep carious lesions: a randomised controlled clinical trial in primary care.

BMC Oral Health 2021 Jul 9;21(1):336. Epub 2021 Jul 9.

Dental Health Services Research Unit, Dundee Dental School, The University of Dundee, 9th Floor, Park Place, Dundee, DD1 4HN, UK.

Background: Dental caries is one of the most prevalent non-communicable disease globally and can have serious health sequelae impacting negatively on quality of life. In the UK most adults experience dental caries during their lifetime and the 2009 Adult Dental Health Survey reported that 85% of adults have at least one dental restoration. Conservative removal of tooth tissue for both primary and secondary caries reduces the risk of failure due to tooth-restoration, complex fracture as well as remaining tooth surfaces being less vulnerable to further caries. Read More

View Article and Full-Text PDF

An expert opinion of the Polish Cardiac Society Working Group on Pulmonary Circulation and the Polish Society for Rheumatology on the diagnosis and treatment of pulmonary hypertension in patients with connective tissue disease.

Kardiol Pol 2021 Jul 6. Epub 2021 Jul 6.

Department of Internal Medicine, Rheumatology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.

Systemic connective tissue diseases (CTDs) comprise a large group of diseases that are auto-immune in nature and characterized by the involvement of multiple systems and organs. Pul-monary hypertension (PH) of various etiologies may develop in the course of CTD, including pulmonary arterial hypertension (PAH), PH secondary to the lung disease, postcapillary PH in the course of left heart disease, and chronic thromboembolic pulmonary hypertension (CTEPH). In addition, the different forms of PH may coexist with each other. Read More

View Article and Full-Text PDF

[Mental health protection associated with COVID-19].

Ewa A Ogłodek

Pol Merkur Lekarski 2021 Jun;49(291):235-237

Faculty of Health Science, Jan Dlugosz University in Czestochowa, Poland.

Mental health is a state of mental well-being in which people are able to cope with stressful situations in life and can bring their life potential to their communities. Good mental health enables people to fulfill their roles in both family and society. When crises affect social life, people should be expected to experience high levels of stress. Read More

View Article and Full-Text PDF

Is elimination of HCV realistic by 2030: France.

Liver Int 2021 06;41 Suppl 1:45-49

Université Paris Centre, Département d'Hépatologie, Hôpital Cochin, APHP; INSERM U1223, Institut Pasteur, Paris, France.

The World Health Organization (WHO) has proposed a plan for the elimination of viral hepatitis with a goal of reducing new hepatitis infections by 30% and 90% in 2020 and 2030, and associated mortality by 10% and 65% respectively. Actions and targets to reach these goals include improving hepatitis B virus (HBV) vaccination programs, the prevention of mother-to-child transmission of HBV, improving the safety of blood products and injections, risk reduction policies and optimizing the diagnosis and treatment of hepatitis. The goal of eliminating hepatitis C virus (HCV) by 2030 is based on three main actions: increased screening, strengthening access to care and the prevention of infections and re-infections. Read More

View Article and Full-Text PDF

Post-operative computed tomography imaging evaluation of ascending aorta surgery.

Pol J Radiol 2021 28;86:e246-e254. Epub 2021 Apr 28.

Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties - ProMISE, University of Palermo, Palermo, Italy.

Ascending thoracic aorta disease is often a life-threatening condition. Aortic aneurysm and aortic dissection are the most frequent ascending aorta diseases requiring surgical intervention. Surgical repair techniques of the ascending aorta are various; they include reconstruction of the ascending aorta by using a graft with or without a prosthetic valve, reconstruction with a composite artificial graft or using a biological graft, and reconstruction of the ascending aorta with a composite graft preserving the native valve and arch repair. Read More

View Article and Full-Text PDF

Movement disorders associated with chromosomal aberrations diagnosed in adult patients.

Neurol Neurochir Pol 2021 26;55(3):300-305. Epub 2021 May 26.

Department of Neurology, Faculty of Health Science, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland.

Introduction: Chromosomal aberrations are rare but important causes of various movement disorders. In cases of movement disorders associated with dysmorphic features, multiorgan involvement and/or intellectual disability, the identification of causative chromosomal aberrations should be considered.

Aim Of The Study: The purpose of this article was to summarise clinical findings in six patients with dystonia and two with parkinsonism and identified chromosomal aberrations in a single-centre prospective study. Read More

View Article and Full-Text PDF

Laboratory assessment of the direct oral anticoagulants: who can benefit?

Kardiol Pol 2021 24;79(6):622-630. Epub 2021 May 24.

Department of Medicine and Department of Pathology & Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.

Direct oral anticoagulants (DOACs), apixaban, dabigatran, edoxaban, and rivaroxaban, are widely used for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation as well as for prevention and treatment of venous thromboembolism. Although DOACs do not require routine laboratory monitoring of anticoagulant effect, there are special situations in which laboratory assessment may be warranted. Laboratory tests include quantitative assays, which measure plasma DOAC levels, and qualitative or semi-quantitative assays, which may be used to screen for the presence of clinically relevant DOAC levels. Read More

View Article and Full-Text PDF

Overexpression of oncogenic H-Ras in hTERT-immortalized and SV40-transformed human cells targets replicative and specialized DNA polymerases for depletion.

PLoS One 2021 7;16(5):e0251188. Epub 2021 May 7.

Department of Pathology, The Jake Gittlen Laboratories for Cancer Research, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America.

DNA polymerases play essential functions in replication fork progression and genome maintenance. DNA lesions and drug-induced replication stress result in up-regulation and re-localization of specialized DNA polymerases η and κ. Although oncogene activation significantly alters DNA replication dynamics, causing replication stress and genome instability, little is known about DNA polymerase expression and regulation in response to oncogene activation. Read More

View Article and Full-Text PDF

Multiple roles of H2A.Z in regulating promoter chromatin architecture in human cells.

Nat Commun 2021 05 5;12(1):2524. Epub 2021 May 5.

The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.

Chromatin accessibility of a promoter is fundamental in regulating transcriptional activity. The histone variant H2A.Z has been shown to contribute to this regulation, but its role has remained poorly understood. Read More

View Article and Full-Text PDF

Magnetic resonance imaging of the inner ear in the diagnostics of Ménière's disease.

Otolaryngol Pol 2020 Dec;75(2):1-8

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland; Head: Prof. Kazimierz Niemczyk MD PhD.

Ménière's disease is characterized by sudden episodes of vertigo accompanied by tinnitus and/or feeling of fullness in the ear as well as fluctuating sensorineural hearing loss. Despite numerous studies, the etiology of this disease remains unknown. However, the enlargement of the inner ear's endolymphatic spaces, referred to as endolymphatic hydrops, is considered the underlying condition. Read More

View Article and Full-Text PDF
December 2020

The relevance of Short-Term Variation (STV) value measured within 1 hour before delivery in predicting adverse neonatal outcome.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Department of Obstetrics and Perinatology, Jagiellonian University Medical College, Cracow, Poland.

Objectives: Computer CTG analysis (cCTG) included short-term variation (STV) is one of the methods of monitoring fetal condition during delivery. The aim of our study was to define appropriability of STV measured within 1 hour before delivery in prediction of neonatal outcomes.

Material And Methods: The retrospective study included 1014 pregnant women, who gave birth in the Department of Obstetrics and Perinatology. Read More

View Article and Full-Text PDF

[Current nutrition recommendations for chronic kidney disease].

Pol Merkur Lekarski 2021 Apr;49(290):162-165

II Department of Nephrology with Unit of Hypertension Therapy and Unit of Dializotherapy, Medical University of Białystok, Poland.

The paper discusses the current recommendations regarding the supply of individual nutrients in patients with chronic kidney disease (CKD). The recommendations include keeping the energy supply in the range of 25 to 35 kcal per kilogram of proper body weight per day, limiting the consumption of phosphorus to maximum of 1 g per day and limiting sodium to maximum of 2.3 g per day. Read More

View Article and Full-Text PDF

Diagnostic and therapeutic difficulties in patient with cerebral venous thrombosis - a case report.

Pol Merkur Lekarski 2021 Apr;49(290):146-149

Department of Radiological Diagnostics and and Isotope Therapy, University Clinical Hospital of the Military Medical Academy - Central Veterans Hospital, Łódź, Poland.

Cerebral venous infarction also known as cerebral venous thrombosis (CVT) is a rare disease. It is more common in young adults, but three times more common in women than in men. The clinical picture of CVT may vary and non-specific manifestations often delay correct diagnosis. Read More

View Article and Full-Text PDF

Prophylactic medical examination of 15/16 year old from the Warsaw Agglomeration. Evaluation of the implementation of standards in practice.

Pol Merkur Lekarski 2021 Apr;49(290):114-118

Medical University of Warsaw, Department of Social Medicine and Public Health.

Prophylactic medical examinations - called well-child visit - are among the benefits guaranteed under basic health care. The prophylactic visit should include, among others: physical examination and an interview (with the adolescent and the parent), as well as individual pro-health education.

Aim: The aim of the study was to answer the question whether preventive medical visits of 15/16 year olds from the Warsaw Agglomeration are carried out within the scope defined by the Minister of Health and in accordance with standards. Read More

View Article and Full-Text PDF

Effects of inlet temperature and carrier concentration on spray-dried 'cempedak' (Artocarpus integer) fruit powder and its reconstitution properties.

Acta Sci Pol Technol Aliment 2021 Apr-Jun;20(2):135-148

Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia.

Background: 'Cempedak' (Artocarpus integer) is an aromatic fruit which is similar to jackfruit. Although it is rich in vitamin A and is consumed fresh, the fruit has a short shelf life. Hence, it can be converted through a spray-drying process, to form powder, which is more stable. Read More

View Article and Full-Text PDF

Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell.

Nucleic Acids Res 2021 Jul;49(13):e74

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Double strand break (DSB) repair primarily occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and homologous recombination (HR). Typical methods to measure pathway usage include integrated cassette reporter assays or visualization of DNA damage induced nuclear foci. It is now well understood that repair of Cas9-induced breaks also involves NHEJ, Alt-EJ, and HR pathways, providing a new format to measure pathway usage. Read More

View Article and Full-Text PDF

Radiological differences in computed tomography findings and texture analysis between cystic lymph node metastases of human papillomavirus-positive oropharyngeal cancer and second branchial cysts.

Pol J Radiol 2021 25;86:e177-e182. Epub 2021 Mar 25.

Department of Radiology, The Jikei University School of Medicine, Japan.

Purpose: The study aimed to analyse radiological differences in computed tomography (CT) findings and texture analysis between cystic lymph node metastases (CNM) in human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) and second branchial cleft cysts (2 BC).

Material And Methods: Patients with pathological evidence of CNM-HPV-OPC and 2 BC, who underwent contrast-enhanced CT, were retrospectively evaluated. The evaluated characteristics include age, sex, and CT findings. Read More

View Article and Full-Text PDF

Picornaviruses: A View from 3A.

Viruses 2021 03 11;13(3). Epub 2021 Mar 11.

Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.

Picornaviruses are comprised of a positive-sense RNA genome surrounded by a protein shell (or capsid). They are ubiquitous in vertebrates and cause a wide range of important human and animal diseases. The genome encodes a single large polyprotein that is processed to structural (capsid) and non-structural proteins. Read More

View Article and Full-Text PDF

Nonhomologous end joining: new accessory factors fine tune the machinery.

Trends Genet 2021 06 27;37(6):582-599. Epub 2021 Mar 27.

Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India. Electronic address:

Nonhomologous DNA end joining (NHEJ) is one of the major DNA double-strand break (DSB) repair pathways in eukaryotes. The well-known critical proteins involved in NHEJ include Ku70/80, DNA-PKcs, Artemis, DNA pol λ/μ, DNA ligase IV-XRCC4, and XLF. Recent studies have added a number of new proteins to the NHEJ repertoire namely paralog of XRCC4 and XLF (PAXX), modulator of retroviral infection (MRI)/ cell cycle regulator of NHEJ (CYREN), transactivation response DNA-binding protein (TARDBP) of 43 kDa (TDP-43), intermediate filament family orphan (IFFO1), ERCC excision repair 6 like 2 (ERCC6L2), and RNase H2. Read More

View Article and Full-Text PDF

Providing new insights into the endometriosisassociated cancer arising in episiotomy scars.

Ginekol Pol 2021 10;92(3):220-225. Epub 2021 Mar 10.

Universitary Clinic of Gynecology, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Coimbra, Portugal.

Endometriosis-associated malignancy in an episiotomy scar is rare. The predictive factors are poorly understood as are the mechanisms and pathways associated with implantation and malignant transformation. In this study we describe the cases reported in the literature of malignancies arising in endometriosis foci of an episiotomy scar. Read More

View Article and Full-Text PDF

Pituitary transcription factors in the immunohistochemical and molecular diagnosis of pituitary tumours - a systematic review.

Endokrynol Pol 2021 ;72(1):53-63

C.I. Parhon" National Institute of Endocrinology, Bucuresti, Romania, Romania.

Introduction: Although histopathology remains in the first line of the diagnosis of pituitary pathology, immunohistochemistry and molecular biology are currently in charge of providing a more accurate characterisation of tumours in this field.

Material And Methods: A systematic review of the literature was performed, using the PubMed and SCOPUS databases, with terms that included transcription factors involved in the development of pituitary tumours: T-PIT, PIT-1, and SF-1.

Results: The results showed different perspectives, but the evidence is in favour of a multifold immunohistochemical analysis that must include pituitary transcription factors for a highly accurate diagnosis, prognosis, and guidance of (multimodal) therapy. Read More

View Article and Full-Text PDF
January 2021

Sexual activity in patients after proctocolectomy with ileal pouch-anal anastomosis.

Pol Przegl Chir 2020 Nov;93(1):19-24

General and Colorectal Surgery Clinic, Medical University of Lodz.

<b>Introduction:</b> Proctocolectomy with ileal pouch-anal anastomosis is the gold standard in the surgical treatment of patients with ulcerative colitis, familial adenomatous polyposis and other colorectal diseases requiring colectomy. The treatment consists in removing the large intestine and creating an intestinal reservoir from the last ileum loop and then anastomosing the intestinal reservoir with the anal canal. Like any surgical procedure, RPC-IPAA also carries the risk of complications, both early and late. Read More

View Article and Full-Text PDF
November 2020

Thoracic imaging tests for the diagnosis of COVID-19.

Cochrane Database Syst Rev 2021 03 16;3:CD013639. Epub 2021 Mar 16.

NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust and University of Birmingham, Birmingham, UK.

Background: The respiratory illness caused by SARS-CoV-2 infection continues to present diagnostic challenges. Our 2020 edition of this review showed thoracic (chest) imaging to be sensitive and moderately specific in the diagnosis of coronavirus disease 2019 (COVID-19). In this update, we include new relevant studies, and have removed studies with case-control designs, and those not intended to be diagnostic test accuracy studies. Read More

View Article and Full-Text PDF

[Surgery first as an alternative approach in patients treated for dentofacial deformities].

Pol Merkur Lekarski 2021 Feb;49(289):84-87

Department of Nutrition and Epidemiology, Medical University of Łódź, Poland.

Recently surgery first became more popular alternative for treatment of dentofacial deformities. In this approach treatment starts from orthognathic surgery. Immediately after othognathic surgery facial aesthetics and oral function are improved. Read More

View Article and Full-Text PDF
February 2021

Cystinuria poorly responding to treatment - the risk of chronic kidney disease.

Pol Merkur Lekarski 2021 Feb;49(289):60-63

Department of Internal Medicine, Nephrology and Dialysis, Military Institute of Medicine. Warsaw, Poland.

Cystinuria is the genetic condition for the increased excretion of cystine in the urine. Patients mainly suffer from afflictions related to the presence and passage of kidney stones. The currently available treatment methods include conservative treatment based on increased fluid intake, appropriate diet, medications and urological procedures. Read More

View Article and Full-Text PDF
February 2021

Hypercalcemia in the nephrology department patients - incidence, etiology and impact on renal function.

Pol Merkur Lekarski 2021 Feb;49(289):9-12

Department of Internal Medicine, Nephrology and Dialysis Therapy, Military Institute of Medicine, Warsaw, Poland.

Hypercalcemia (HCM) is predominantly caused by primary hyperparathyroidism (PHPT) or malignancy. It's incidence varies from 0.17% to 4. Read More

View Article and Full-Text PDF
February 2021

Does the anterolateral ligament protect the anterior cruciate ligament in the most common injury mechanisms? A human knee model study.

Knee 2021 Mar 9;29:381-389. Epub 2021 Mar 9.

Department of Orthopedic Sports Medicine and Arthroscopic Surgery, Hessing Stiftung Augsburg, Augsburg, Germany.

Background: Anterior cruciate ligament (ACL) reconstruction still has a risk of re-rupture and persisting rotational instability. Thus, extra-articular structures such as the anterolateral ligament (ALL) are increasingly treated. The ALL however prevents the internal rotation of the tibia and it must be doubted that the ALL protects the ACL in other common injury mechanisms which primarily include tibial external rotation. Read More

View Article and Full-Text PDF

A high-resolution protein architecture of the budding yeast genome.

Nature 2021 Apr 10;592(7853):309-314. Epub 2021 Mar 10.

Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.

The genome-wide architecture of chromatin-associated proteins that maintains chromosome integrity and gene regulation is not well defined. Here we use chromatin immunoprecipitation, exonuclease digestion and DNA sequencing (ChIP-exo/seq) to define this architecture in Saccharomyces cerevisiae. We identify 21 meta-assemblages consisting of roughly 400 different proteins that are related to DNA replication, centromeres, subtelomeres, transposons and transcription by RNA polymerase (Pol) I, II and III. Read More

View Article and Full-Text PDF