905,846 results match your criteria incidence proportion


Pediatric Ocular Injury Due to Hand Sanitizer Exposure An Emerging Hazard.

Pediatr Emerg Care 2021 Jun 11. Epub 2021 Jun 11.

From the Department of Ophthalmology, Shaare Zedek Medical Center, Jerusalem Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel Hashomer Pediatric Emergency Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Objectives: The objective of this study was to describe the incidence and severity of ocular exposure to alcohol-based hand rub (ABHR) in children presenting to a tertiary medical center during the severe acute respiratory syndrome coronavirus 2 pandemic.

Methods: A retrospective single-center observational study conducted from February 21, 2020, to October 11, 2020. Subjects 10 years or younger who presented with ABHR-induced ocular injury were included. Read More

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COVID-19 pandemic in Africa: Is it time for water, sanitation and hygiene to climb up the ladder of global priorities?

Sci Total Environ 2021 Jun 3;791:148252. Epub 2021 Jun 3.

Universidad de Granada, Campus de Cartuja, s/n, 18071 Granada, Spain.

In the current pandemic context, it is necessary to remember the lessons learned from previous outbreaks in Africa, where the incidence of other diseases could rise if most resources are directed to tackle the emergency. Improving the access to water, sanitation and hygiene (WASH) could be a win-win strategy, because the lack of these services not only hampers the implementation of preventive measures against SARS-CoV-2 (e.g. Read More

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Use of available crop by-products as alternative bedding materials to wheat straw for rearing broilers.

Animal 2021 Jun 8;15(7):100260. Epub 2021 Jun 8.

Poultry Production Department, Agriculture College, Damietta University, Damietta 34517, Egypt.

The provision of suitable bedding for rearing broilers is an ongoing challenge for poultry producers. The aim of the present study was to evaluate the effect of using different types of crop residues as alternative bedding materials to wheat straw on growth performance, carcass traits, health, and welfare of broilers; moreover, the effects on the bedding and air quality were analyzed. We randomly assigned 180 1-day-old chickens (Cobb 500) across six bedding groups (three replicates of 10 birds each). Read More

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Incidence of abnormal uterine bleeding in a multicenter implementation study using apixaban and rivaroxaban to treat venous thromboembolism.

Thromb Res 2021 May 26;204:29-31. Epub 2021 May 26.

Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, United States of America. Electronic address:

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Middle ear effusion prevalence at time of tympanostomy before and during COVID-19 pandemic.

Int J Pediatr Otorhinolaryngol 2021 Jun 8;147:110785. Epub 2021 Jun 8.

Nemours Children's Hospital, Orlando, FL, USA.

Background: Management of pediatric otitis media with effusion (OME) and recurrent otitis media typically includes observation up to 3 months. Bilateral myringotomy and tube (BMT) placement is performed due to persistent effusion with associated symptoms such as decreased hearing. With the COVID-19 pandemic and mandatory stay at home orders (MSHO), children were quarantined at home and many remained home after MSHO. Read More

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Development and validation of signature sequence-based PCR for improved molecular diagnosis of tuberculosis.

J Mol Diagn 2021 Jun 8. Epub 2021 Jun 8.

ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi. Electronic address:

Reliable, fast, and affordable diagnosis for TB remains a challenge to reduce disease incidence in resource-poor countries. Tests based on nucleotide sequences that are 'signature' to M. tuberculosis (M. Read More

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Age-related amyloidosis outside the brain: A state-of-the-art review.

Ageing Res Rev 2021 Jun 8:101388. Epub 2021 Jun 8.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. Electronic address:

Inside and outside the brain, accumulation of amyloid fibrils plays key roles in the pathogenesis of fatal age-related diseases such as Alzheimer's and Parkinson's diseases and wild-type transthyretin amyloidosis. Although the incidence of all amyloidoses increases with age, for some types of amyloidosis aging is known as the main direct risk factor, and these types are typically diseases of elderly people. More than 10 different precursor proteins are known to cause age-associated amyloidosis; these proteins include amyloid β protein, α-synuclein, transthyretin, islet amyloid polypeptide, atrial natriuretic factor, and the newly discovered epidermal growth factor-containing fibulin-like extracellular matrix protein 1. Read More

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Metformin and primary bone cancer risk in Taiwanese patients with type 2 diabetes mellitus.

Authors:
Chin-Hsiao Tseng

Bone 2021 Jun 8:116037. Epub 2021 Jun 8.

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Division of Environmental Health and Occupational Medicine of the National Health Research Institutes, Zhunan, Taiwan. Electronic address:

Background: The effect of metformin on primary bone cancer risk has not been researched. This retrospective cohort study investigated the risk of primary bone cancer between metformin initiators and non-metformin initiators in patients with type 2 diabetes mellitus.

Methods: A total of 673,532 patients with newly diagnosed type 2 diabetes mellitus and had been prescribed antidiabetic drugs for 2 or more times during 1999-2009 were enrolled from Taiwan's National Health Insurance. Read More

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External validation of a predictive model of adverse events following spine surgery.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA.

Background Context: We lack models that reliably predict 30-day postoperative adverse events (AEs) following spine surgery.

Purpose: We externally validated a previously developed predictive model for common 30-day adverse events (AEs) after spine surgery.

Study Design/setting: This prospective cohort study utilizes inpatient and outpatient data from a tertiary academic medical center. Read More

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Efficacy and safety of ciprofol for the sedation/anesthesia in patients undergoing colonoscopy: Phase IIa and IIb multi-center clinical trials.

Eur J Pharm Sci 2021 Jun 8:105904. Epub 2021 Jun 8.

Department of Anesthesiology, West China Hospital, Sichuan University & The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences Chengdu, China. Electronic address:

Objective: Ciprofol is a new intravenous anesthetic agent similar to propofol that has the pharmacodynamic characteristics of a rapid rate of onset and recovery in pre-clinical experiments. The aims of the present clinical trials were to compare the efficacy and safety of ciprofol emulsion for sedation or general anesthesia during colonoscopy and to define optimal doses for a subsequent phase III clinical trial.

Methods: A phase IIa multi-center, open-label, non-randomized, positive control, dose-escalating study was performed to determine a recommended phase IIb dose (RP2D) of ciprofol to induce sedation or anesthesia in patients undergoing colonoscopy. Read More

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Is Melanoma Overdiagnosed? A Review of the Evidence.

J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT; University of Florida Dermatology Department, Gainesville, FL. Electronic address:

Background: Melanoma is one of the most commonly diagnosed malignancies in the United States (US) and is responsible for the majority of deaths from skin cancer.

Objective: Since the 1970s, the incidence of melanoma has risen appreciably while melanoma-specific mortality has remained stable. This has raised a debate about potential overdiagnosis of melanoma. Read More

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Non-Ventilator Associated Hospital Acquired Pneumonia Incidence and Health Outcomes Among U.S. Veterans from 2016-2020.

Am J Infect Control 2021 Jun 8. Epub 2021 Jun 8.

Research and Development, Salem VA Medical Center, Salem, VA, USA. Electronic address:

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Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.

J Obstet Gynecol Neonatal Nurs 2021 Jun 8. Epub 2021 Jun 8.

Objective: To critically review and summarize current knowledge regarding the assessment of newborns with neonatal abstinence syndrome (NAS).

Data Sources: We searched the following databases for articles on the assessment of newborns with NAS that were published in English between January 2014 and June 2020: PubMed, CINAHL, and PsycINFO. Keywords and Medical Subject Heading terms used to identify relevant research articles included neonatal abstinence syndrome; Finnegan Scale; eat, sleep, console; epigenetics; genetics; pharmacokinetics; and measurement. Read More

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ASIC1a promotes acidic microenvironment-induced HCC cells migration and invasion by inducing autophagy.

Eur J Pharmacol 2021 Jun 8:174252. Epub 2021 Jun 8.

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, 230032,China. Electronic address:

Hepatocellular carcinoma (HCC) is one of the most common types of liver cancer with high incidence and metastatic rate. Recent studies have shown that the high metastasis of HCC is closely related to the acidic microenvironment of HCC cells. Acid-sensing ion Channel 1a (ASIC1a) plays an important role in HCC development, which can mediate tumor cell migration and invasion. Read More

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Hydrogeochemistry and health hazards of fluoride-enriched groundwater in the Tarim Basin, China.

Environ Res 2021 Jun 8:111476. Epub 2021 Jun 8.

College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:

Fluoride (F) enrichment reduces the availability of groundwater resources in the arid region, and it is thus important to investigate the hydrogeochemistry and health hazards of fluoride-enriched groundwater. Seventy-two groundwater samples (20 unconfined samples from the piedmont plain, 22 unconfined samples and 30 shallow confined samples from the alluvial plain) were collected in the Tarim Basin of China to illustrate the geochemical processes driving the F enrichment and the incidence of dental fluorosis. The patterns of average ions contents in groundwater are Na > Ca > Mg > K and SO > Cl > HCO > NO > F. Read More

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Valve Sparing Root Replacement versus Bio-Bentall: Inverse Propensity Weighting of 796 Patients.

Ann Thorac Surg 2021 Jun 8. Epub 2021 Jun 8.

Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Division of Cardiothoracic and Vascular Surgery, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY. Electronic address:

Background: This large cohort, single center study aims to compare the 10-year survival and freedom from aortic valve reintervention between valve sparing root replacement (VSRR) and bioprosthetic Bentall (bio-Bentall).

Methods: All patients undergoing elective VSRR or bio-Bentall for aortic root aneurysm between March 2005 through October 2019 were retrospectively reviewed (n=796 [VSRR = 360]). Inverse probability of treatment weighting (IPTW) balanced clinical variables between groups. Read More

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Gastroschisis annual incidence, mortality, and trends in extreme Southern Brazil.

J Pediatr (Rio J) 2021 Jun 8. Epub 2021 Jun 8.

Universidade Estadual de Maringá, Centro de Ciências da Saúde, Maringá, PR, Brazil.

Objective: To analyze gastroschisis annual incidence, mortality rates, and trends in the Brazilian state of Rio Grande do Sul from the year 2000 to the year 2017.

Method: Population-based study with the analysis of the temporal trend of gastroschisis annual incidence and mortality rates. Data were obtained from the Live Birth Information System and the Mortality Information System, with the analysis performed by polynomial regression modeling. Read More

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Larvicidal potential of cell wall degrading enzymes from Trichoderma asperellum against Aedes aegypti (Diptera: Culicidae).

Biotechnol Prog 2021 Jun 11. Epub 2021 Jun 11.

Laboratório de Química de Polímeros (LQP) - ICB2 - Universidade Federal de Goiás, Goiânia, GO, Brazil.

Background: Aedes aegypti is a mosquito vector of arboviruses such as Dengue, Chikungunya, Zika and Yellow Fever that cause important public health diseases. The incidence and gravity of these diseases justifies the search for effective measures to reduce the presence of this vector in the environment. Bioinsecticides are an effective alternative method for insect control, with added ecological benefits such as biodegradability. Read More

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Systematic review and meta-analysis: the incidence and prevalence of paediatric coeliac disease across Europe.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Swansea, UK.

Background: Coeliac disease is one of the most prevalent immune-mediated gastrointestinal disorders in children.

Aim: To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis.

Methods: Systematic review and meta-analysis from January 1, 1950 to December 31, 2019, based on PubMed, CINAHL and the Cochrane Library, searches of grey literature and websites and hand searching of reference lists. Read More

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Tetanus presenting as painful muscle spasms, dysphagia and delirium in an older adult.

Age Ageing 2021 Jun 12. Epub 2021 Jun 12.

Geriatric Medicine Consultant, Harrogate District Hospital Foundation Trust, Harrogate, UK.

While tetanus is now a rare disease in the UK, it remains an important differential diagnosis for trismus and muscle spasms. Even more so in older adults, as this population is less likely to have received full vaccination. Hence, the highest incidence of tetanus in England is seen in older adults. Read More

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Prevalence of active tuberculosis disease among healthcare workers and support staff in healthcare settings of the Amhara region, Ethiopia.

PLoS One 2021 11;16(6):e0253177. Epub 2021 Jun 11.

KNCV Tuberculosis Foundation, The Hague, The Netherlands.

Background: Health care workers (HCWs) are at an increased risk of acquiring tuberculosis (TB) compared to the general population, because of the frequent face to face contact or potential exposure to TB through shared air or space with infectious patient(s), regardless of economic setting and local TB incidence. Information on the burden of active TB disease among HCWs will help guide control measures, can be utilized to evaluate the effectiveness of TB infection prevention programs in the health care setting, and guide necessary actions. However, data on TB among HCW in Ethiopia is limited. Read More

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REM-related obstructive sleep apnea and vertigo: A retrospective case-control study.

PLoS One 2021 11;16(6):e0252844. Epub 2021 Jun 11.

Sleep Centre, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

Background: In recent population-based case-control studies, sleep apnea was significantly associated with a higher incidence (hazard ratio, 1.71) of vertigo and the risk of tinnitus was found to increase 1.36 times in patients with sleep apnea. Read More

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The effect of the combined use of silver diamine fluoride and potassium iodide in disrupting the plaque biofilm microbiome and alleviating tooth discoloration: A systematic review.

PLoS One 2021 11;16(6):e0252734. Epub 2021 Jun 11.

Department of Preventive and Restorative Dentistry, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.

Silver diamine fluoride (SDF) is used in minimally invasive dentistry for arresting dental caries. However, discoloration of teeth is a significant side effect that has limited the use of SDF. Hence, the application of potassium iodide (KI) following SDF has been proposed to ameliorate the staining. Read More

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General health of patients with diabetic macular edema-The LIPSIA study.

PLoS One 2021 11;16(6):e0252321. Epub 2021 Jun 11.

Department of Ophthalmology, University Hospital Leipzig, Leipzig, Germany.

Purpose: Cardiovascular risk factors such as hypertension or dyslipidemia can influence the incidence and progression of diabetic retinopathy (DR) and diabetic macular edema (DME). The aim of this study is to describe the comorbidities in patients with DME.

Methods: Prospective, monocentric observational study. Read More

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Integrated bioinformatics analysis and screening of hub genes in papillary thyroid carcinoma.

PLoS One 2021 11;16(6):e0251962. Epub 2021 Jun 11.

Department of Operational Medicine, Tianjin Institute of Environmental and Operational Medicine, Tianjin, PR China.

Background: With the increasing incidence of papillary thyroid carcinoma (PTC), PTC continues to garner attention worldwide; however its pathogenesis remains to be elucidated. The purpose of this study was to explore key biomarkers and potential new therapeutic targets for, PTC.

Methods: GEO2R and Venn online software were used for screening of differentially expressed genes. Read More

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Real-world safety and effectiveness of rivaroxaban using Japan-specific dosage during long-term follow-up in patients with atrial fibrillation: XAPASS.

PLoS One 2021 11;16(6):e0251325. Epub 2021 Jun 11.

Medical Affairs and Pharmacovigilance, Bayer Yakuhin, Ltd., Osaka, Japan.

Background: The Xarelto Post-Authorization Safety and Effectiveness Study in Japanese Patients with Atrial Fibrillation (XAPASS) was designed to investigate safety and effectiveness during long-term follow-up of rivaroxaban treatment, using reduced doses compared with other global regions, in Japanese patients with non-valvular atrial fibrillation in real-world clinical practice.

Methods: In this prospective, open-label, single-arm, observational study, 11,308 patients with non-valvular atrial fibrillation newly prescribed rivaroxaban (15/10 mg once daily) at 1416 sites across Japan were enrolled and followed for a mean of 2.5 years. Read More

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Cost of illness for severe and non-severe diarrhea borne by households in a low-income urban community of Bangladesh: A cross-sectional study.

PLoS Negl Trop Dis 2021 Jun 11;15(6):e0009439. Epub 2021 Jun 11.

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

The illness cost borne by households, known as out-of-pocket expenditure, was 74% of the total health expenditure in Bangladesh in 2017. Calculating economic burden of diarrhea of low-income urban community is important to identify potential cost savings strategies and prioritize policy decision to improve the quality of life of this population. This study aimed to estimate cost of illness and monthly percent expenditure borne by households due diarrhea in a low-income urban settlement of Dhaka, Bangladesh. Read More

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A qualitative assessment of the context and enabling environment for the control of Taenia solium infections in endemic settings.

PLoS Negl Trop Dis 2021 Jun 11;15(6):e0009470. Epub 2021 Jun 11.

Animal and Human Health Program, International Livestock Research Institute, Nairobi, Kenya.

Background: Taenia solium (T. solium), is a zoonotic helminth causing three diseases namely; taeniasis (in humans), neurocysticercosis (NCC, in humans) and porcine cysticercosis (PCC, in pigs) and is one of the major foodborne diseases by burden. The success or failure of control options against this parasite in terms of reduced prevalence or incidence of the diseases may be attributed to the contextual factors which underpin the design, implementation, and evaluation of control programmes. Read More

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Hypotony-associated Complications after Deep Sclerectomy: Incidence, Risk Factors, and Long-Term Outcomes.

J Glaucoma 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy Department of Ophthalmology, Calderdale and Huddersfield NHS Trust, Huddersfield, UK.

Precis: Chronic hypotony is not uncommon following deep sclerectomy, but only a minor proportion of patients develop hypotony-associated complications. Numerical hypotony does not affect the visual outcomes. This study identifies factors associated with hypotony. Read More

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Inter-rater reliability and predictive accuracy of the Shkuratova Assessment of Falls-risk in Rehabilitation (SAFER) tool.

Int J Rehabil Res 2021 Jun 10. Epub 2021 Jun 10.

Peninsula Health, The Mornington Center Deakin University Geelong, Centre for Quality and Patient Safety Research-Epworth HealthCare Partnership, Melbourne Deakin University Geelong, School of Nursing and Midwifery, Victoria Deakin University Geelong, Centre for Quality and Patient Safety Research-Monash Health Partnership, Monash Health, Clayton, Melbourne, Australia.

Despite the recognised importance of falls prevention in rehabilitation settings, there is limited research focusing on falls risk assessment tools designed to guide both patient screening and therapy. This study evaluated the predictive accuracy and inter-rater reliability of the Shkuratova Assessment of Falls-risk in Rehabilitation settings (SAFER) tool. The study was conducted at a subacute rehabilitation facility in Australia. Read More

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