231,734 results match your criteria incidence median

A Clinically Applicable Gene Expression based Score predicts Resistance to Induction Treatment in Acute Myeloid Leukemia.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Research Unit Apoptosis in Hematopoietic Stem Cells, Helmholtz Zentrum München, German Center for Environmental Health (HMGU), Germany.

Prediction of resistant disease at initial diagnosis of acute myeloid leukemia (AML) can be achieved with high accuracy by using cytogenetic data and 29 gene expression markers (PS29MRC). Our aim was to establish PS29MRC as a clinically usable assay by using the widely implemented NanoString platform and further validate the classifier in a more recently treated patient cohort. 351 patients with newly diagnosed AML intensively treated within the AMLCG registry were analyzed. Read More

View Article and Full-Text PDF
September 2021

Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Institute of Immunology, Hannover Mecial School, Germany.

Donor lymphocyte infusion (DLI) is a standard of care for relapse of AML after allogeneic hematopoietic stem cell transplantation (aHSCT). Currently it is poorly understood how and when CD8+ αβ T cells exert graft-versus-leukemia (GvL) activity after DLI. Also, there is no reliable biomarker to monitor GvL activity of the infused CD8+ T cells. Read More

View Article and Full-Text PDF
September 2021

Associations of metabolomic profiles with circulating vitamin E and urinary vitamin E metabolites in middle-aged individuals.

Nutrition 2021 Jul 29;93:111440. Epub 2021 Jul 29.

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

Vitamin E (α-tocopherol [α-TOH]) is transported in lipoprotein particles in blood, but little is known about the transportation of its oxidized metabolites. In the Netherlands Epidemiology of Obesity Study, we aimed to investigate the associations of 147 circulating metabolomic measures obtained through targeted nuclear magnetic resonance with serum α-TOH and its urinary enzymatic (α-CEHC) and oxidized (α-TLHQ) metabolites from 24-h urine quantified by liquid chromatography with tandem mass spectrometry. Multivariable linear regression analyses, in which multiple testing was taken into account, were performed to assess associations between metabolomic measures (determinants; standardized to mean = 0, SD = 1) and vitamin E metabolites (outcomes), adjusted for demographic factors. Read More

View Article and Full-Text PDF

A multicenter study to evaluate the pharmacokinetics and safety of liposomal bupivacaine for postsurgical analgesia in pediatric patients aged 6 to less than 17 years (PLAY).

J Clin Anesth 2021 Sep 14;75:110503. Epub 2021 Sep 14.

Cleveland Clinic, Cleveland, OH, United States of America.

Study Objective: To evaluate the pharmacokinetics and safety of liposomal bupivacaine in pediatric patients undergoing spine or cardiac surgery.

Design: Multicenter, open-label, phase 3, randomized trial (PLAY; NCT03682302).

Setting: Operating room. Read More

View Article and Full-Text PDF
September 2021

Serum catalytic iron and progression of chronic kidney disease: findings from the ICKD study.

Nephrol Dial Transplant 2021 Sep 17. Epub 2021 Sep 17.

George Institute for Global Health India, New Delhi.

Background: The non-transferrin bound catalytic iron moiety catalyses production of toxic reactive oxygen species and is associated with adverse outcomes. We hypothesized that serum catalytic iron (SCI) is associated with progression of chronic kidney disease (CKD).

Methods: Baseline samples of the Indian Chronic Kidney Disease participants with at least one follow up visit were tested for total iron, iron binding capacity, transferrin saturation, SCI, ferritin and hepcidin. Read More

View Article and Full-Text PDF
September 2021

Differences in outcomes of mandatory motorcycle helmet legislation by country income level: A systematic review and meta-analysis.

PLoS Med 2021 Sep 17;18(9):e1003795. Epub 2021 Sep 17.

Program in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

Background: The recent Lancet Commission on Legal Determinants of Global Health argues that governance can provide the framework for achieving sustainable development goals. Even though over 90% of fatal road traffic injuries occur in low- and middle-income countries (LMICs) primarily affecting motorcyclists, the utility of helmet laws outside of high-income settings has not been well characterized. We sought to evaluate the differences in outcomes of mandatory motorcycle helmet legislation and determine whether these varied across country income levels. Read More

View Article and Full-Text PDF
September 2021

Local Recurrence Outcomes of Colorectal Cancer Oligometastases Treated With Stereotactic Ablative Radiotherapy.

Am J Clin Oncol 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN.

Purpose: The aim of this study was to report local failure (LF) outcomes and associated predictors in patients with oligometastatic colorectal cancer (CRC) treated with stereotactic ablative radiotherapy (SABR).

Materials And Methods: We retrospectively reviewed patients with CRC metastases to the brain, liver, spine, or lung treated with SABR between 2001 and 2016. Time to LF was summarized using cumulative incidence of LF curves with death as a competing risk. Read More

View Article and Full-Text PDF
September 2021

Descriptive Epidemiology and Outcomes of Nonventilated Hospital-Acquired, Ventilated Hospital-Acquired, and Ventilator-Associated Bacterial Pneumonia in the United States, 2012-2019.

Crit Care Med 2021 Sep 16. Epub 2021 Sep 16.

Division of Health Services Research, EviMed Research Group, LLC, Goshen, MA. OptiStatim, LLC, Longmeadow, MA. Merck, Kenilworth, NJ. Department of Pulmonary and Critical Care Medicine, Washington Hospital Center, Washington, DC.

Objectives: Multiple randomized controlled trials exploring the outcomes of patients with ventilator-associated bacterial pneumonia and hospital-acquired bacterial pneumonia have noted that hospital-acquired bacterial pneumonia patients who require subsequent ventilated hospital-acquired bacterial pneumonia suffered higher mortality than either those who did not (nonventilated hospital-acquired bacterial pneumonia) or had ventilator-associated bacterial pneumonia. We examined the epidemiology and outcomes of all three conditions in a large U.S. Read More

View Article and Full-Text PDF
September 2021

Heterotopic Ossifications after Fractures of the Anterior Pelvic Segment: Overview of Morphology and Clinical Correlations.

Acta Chir Orthop Traumatol Cech 2021 ;88(4):253-259

Centre for Integrated Studies of the Pelvis, Third Faculty of Medicine, Charles University, Prague.

PURPOSE OF THE STUDY In certain patients after treated pelvic fractures, heterotopic ossifications can be observed in the area of the pubic bone, which protrude ventrally, and often also laterally and distally into surrounding soft tissues of the groin or even medially into the proximal thigh. These ossifications are shaped like sharp spikes of various lengths, which is why the authors refer to them as "spicules". In some patients, these ossifications are also associated with pain. Read More

View Article and Full-Text PDF
January 2021

Safety and efficacy of large balloon dilatation under fluoroscopy.

Ann N Y Acad Sci 2021 Sep 17. Epub 2021 Sep 17.

Department of Interventional Radiology, the First Affiliated Hospital of Zhengzhou University, Henan, China.

The maximum diameter of the balloon used for balloon dilatation(BD) of esophagogastric anastomotic stricture (EAS) is generally 20 millimeters. This study aimed to evaluate the safety and efficacy of BD under fluoroscopy, using balloons with a diameter of 25-30 millimeters. We retrospectively analyzed the data of patients with benign EAS treated by large BD (balloon diameter, 25-30 mm) under fluoroscopy. Read More

View Article and Full-Text PDF
September 2021

Combined association of cognitive impairment and poor oral health on mortality risk in older adults: results from the NHANES with 15 years of follow-up.

J Periodontol 2021 Sep 17. Epub 2021 Sep 17.

Center for Dentistry and Oral Hygiene, University Medical Center Groningen, University of Groningen, China.

Background: Cognitive impairment and poor oral health are frequently seen among older adults. Both conditions have been identified as risk factors for mortality. However, the combined associations of cognitive impairment and poor oral health with mortality have not been well studied and are therefore the aim of this cohort study. Read More

View Article and Full-Text PDF
September 2021

Association of age with the timing of acute spine surgery-effects on neurological outcome after traumatic spinal cord injury.

Eur Spine J 2021 Sep 17. Epub 2021 Sep 17.

Clinical and Experimental Spinal Cord Injury Research (Neuroparaplegiology), Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Purpose: To investigate the association of age with delay in spine surgery and the effects on neurological outcome after traumatic spinal cord injury (SCI).

Methods: Ambispective cohort study (2011-2017) in n = 213 patients consecutively enrolled in a Level I trauma center with SCI care in a metropolitan region in Germany. Age-related differences in the injury to surgery interval and conditions associated with its delay (> 12 h after SCI) were explored using age categories or continuous variables and natural cubic splines. Read More

View Article and Full-Text PDF
September 2021

Liver surface nodularity on non-contrast MRI identifies advanced fibrosis in patients with NAFLD.

Eur Radiol 2021 Sep 17. Epub 2021 Sep 17.

INSERM U1149 "Centre de Recherche Sur L'inflammation", CRI, Université de Paris, 75018, Paris, France.

Objectives: To evaluate the diagnostic performance of liver surface nodularity (LSN) for the assessment of advanced fibrosis in patients with non-alcoholic fatty liver disease (NAFLD).

Methods: We retrospectively analysed patients with pathologically proven NAFLD who underwent liver MRI. Demographic, clinical, and laboratory data (including FIB-4 scores) were gathered. Read More

View Article and Full-Text PDF
September 2021

Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry.

ESC Heart Fail 2021 Sep 17. Epub 2021 Sep 17.

Division of Infectious Diseases, Azienda ULSS 9, M. Magalini Hospital, Verona, Italy.

Aims: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations.

Methods And Results: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). Read More

View Article and Full-Text PDF
September 2021

Comparison of Routine Replacement With Clinically Indicated Replacement of Peripheral Intravenous Catheters.

JAMA Intern Med 2021 Sep 17. Epub 2021 Sep 17.

Infection Control Program and World Health Organization Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.

Importance: Peripheral intravenous catheters (PVCs) are the most frequently used indwelling devices in hospitals worldwide. Peripheral intravenous catheter bloodstream infections (PVC-BSIs) are rare, but severe and preventable, adverse events.

Objective: To investigate the incidence of PVC-BSIs after changing the policy of routine PVC replacement every 96 hours to clinically indicated replacement. Read More

View Article and Full-Text PDF
September 2021

Joint Infection Rates After and before A National Infection Control Program: A Study of 45,438 Primary Total Knee Arthroplasties.

Acta Orthop 2021 Sep 17:1-7. Epub 2021 Sep 17.

Department of Clinical Sciences Lund, Lund University, Division of Orthopedics.

Background and purpose - Strenuous efforts to minimize postoperative infection rates have been made, including the Swedish nationwide initiative Prosthesis Related Infections Shall be Stopped (PRISS). This study calculated the incidence rate of periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) before and after PRISS.Patients and methods - All 45,438 primary TKAs registered in the Swedish Knee Arthroplasty Register (SKAR) during 2007-2008 and 2012-2013 were included. Read More

View Article and Full-Text PDF
September 2021

Newly Diagnosed Atrial Fibrillation in Acute Myocardial Infarction.

J Am Heart Assoc 2021 Sep 17:e021417. Epub 2021 Sep 17.

Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan.

Background It remains controversial whether long-term clinical impact of newly diagnosed atrial fibrillation (AF) in the acute phase of acute myocardial infarction (AMI) is different from that of prior AF diagnosed before the onset of AMI. Methods and Results The current study population from the CREDO-Kyoto AMI (Coronary Revascularization Demonstrating Outcome Study in Kyoto Acute Myocardial Infarction) Registry Wave-2 consisted of 6228 patients with AMI who underwent percutaneous coronary intervention. The baseline characteristics and long-term clinical outcomes were compared according to AF status (newly diagnosed AF: N=489 [7. Read More

View Article and Full-Text PDF
September 2021

Prognostic Value of Ventricular-Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes.

J Am Heart Assoc 2021 Sep 17:e019267. Epub 2021 Sep 17.

Department of Cardiology Keio University School of Medicine Tokyo Japan.

Background Ventricular-arterial coupling predicts outcomes in patients with heart failure. The arterial elastance to end-systolic elastance ratio (Ea/Ees) is a noninvasively assessed index that reflects ventricular-arterial coupling. We aimed to determine the prognostic value of ventricular-arterial coupling assessed through Ea/Ees after transcatheter aortic valve replacement to predict clinical events. Read More

View Article and Full-Text PDF
September 2021

Ultrasensitive Assay for Hepatitis B Core-Related Antigen Predicts Hepatocellular Carcinoma Incidences During Entecavir.

Hepatol Commun 2021 Sep 16. Epub 2021 Sep 16.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Serum hepatitis B core-related antigen (HBcrAg) and surface antigen (HBsAg) are surrogate markers of intrahepatic covalently closed circular DNA. The measurement range of the current HBcrAg assay is relatively narrow. Thus, we examined the potential of HBcrAg and HBsAg measured by ultrasensitive assays for predicting hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B treated with entecavir (ETV). Read More

View Article and Full-Text PDF
September 2021

Exposure-Response Analysis of Acalabrutinib and its Active Metabolite, ACP-5862, in Patients With B-Cell Malignancies.

Br J Clin Pharmacol 2021 Sep 17. Epub 2021 Sep 17.

Quantitative Clinical Pharmacology, AstraZeneca, South San Francisco, USA.

Aim: Examine relationships between the systemic exposure of acalabrutinib, a highly selective, next-generation Bruton tyrosine kinase inhibitor, and its active metabolite (ACP-5862) versus efficacy and safety responses in patients with B-cell malignancies who received acalabrutinib as monotherapy or in combination with obinutuzumab.

Methods: For exposure-efficacy analyses, patients with untreated chronic lymphocytic leukemia (CLL) were assessed for best overall response, progression-free survival (PFS), and tumor regression. For exposure-safety analyses, incidences of grade ≥2 adverse events (AEs), grade ≥3 AEs, and grade ≥2 events of clinical interest were assessed in patients with B-cell malignancies. Read More

View Article and Full-Text PDF
September 2021

Sedentary Behavior and Change in Kidney Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Kidney360 2021 Feb 25;2(2):245-253. Epub 2021 Feb 25.

Department of Medicine, University of Illinois at Chicago, Chicago, Illinois.

Background: There is accumulating evidence linking prolonged sedentary time to adverse health outcomes. The effect of sedentary behavior on kidney function has not been evaluated in US Hispanics/Latinos, a population disproportionately affected by CKD.

Methods: We evaluated the association between accelerometer-measured (1 week) sedentary time at baseline and kidney function among 7134 adults without CKD at entry in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), who completed a baseline visit with accelerometry (2008-2011) and a follow-up visit (2014-2017). Read More

View Article and Full-Text PDF
February 2021

Coronary Artery Disease: Optimal Lipoprotein(a) for Survival-Lower Is Better? A Large Cohort With 43,647 Patients.

Front Cardiovasc Med 2021 31;8:670859. Epub 2021 Aug 31.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

A high level of lipoprotein(a) can lead to a high risk of cardiovascular events or mortality. However, the association of moderately elevated lipoprotein(a) levels (≥15 mg/dL) with long-term prognosis among patients with coronary artery disease (CAD) is still uncertain. Hence, we aim to systematically analyzed the relevance of baseline plasma lipoprotein(a) levels to long-term mortality in a large cohort of CAD patients. Read More

View Article and Full-Text PDF

Ablative radiation therapy for hepatocellular carcinoma is associated with reduced treatment- and tumor-related liver failure and improved survival.

J Gastrointest Oncol 2021 Aug;12(4):1743-1752

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: More than 70% of patients with hepatocellular carcinoma (HCC) are not candidates for curative therapy or recur after curative-intent therapy. There is growing evidence on the use of ablative radiation therapy (RT) for liver tumors. We aimed to analyze outcomes of HCC patients treated with conventional versus ablative RT. Read More

View Article and Full-Text PDF

Clinicopathologic differences and mortality among Latinos and non-Latino whites with gastric cancer at a majority-minority cancer center in South Texas.

J Gastrointest Oncol 2021 Aug;12(4):1301-1307

Division of Hematology/Oncology, Department of Internal Medicine, Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA.

Background: Latino patients have a higher incidence of gastric cancer compared to non-Latino white patients nationwide, with greater disparities in South Texas. However, the impact of Latino ethnicity on mortality in gastric cancer is controversial. We evaluated clinicopathological characteristics and survival outcomes in Latino . Read More

View Article and Full-Text PDF

Inflammation-Immunity-Nutrition Score: A Novel Prognostic Score for Patients with Resectable Colorectal Cancer.

J Inflamm Res 2021 10;14:4577-4588. Epub 2021 Sep 10.

Department of Epidemiology and Biostatistics, The Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Purpose: This study was designed to investigate the prognostic value of the combination of high-sensitivity C-reactive protein, lymphocyte, and albumin in patients with resectable colorectal cancer.

Patients And Methods: Seven-hundred-and-nineteen patients who underwent colorectal cancer resection in Hubei Cancer Hospital were included. Inflammation-Immunity-Nutrition score (0-6) was constructed based on preoperative high-sensitivity C-reactive protein, lymphocyte, and albumin. Read More

View Article and Full-Text PDF
September 2021

LncRNA SOX2OT is Upregulated in Gestational Diabetes Mellitus (GDM) and Correlated with Multiple Adverse Events.

Diabetes Metab Syndr Obes 2021 10;14:3989-3995. Epub 2021 Sep 10.

Department of Obstetrics and Gynecology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, 401147, People's Republic of China.

Purpose: LncRNA SOX2OT plays protective roles in high glucose-induced injuries, suggesting its potential involvement in diabetes. Therefore, we analyzed the role of SOX2OT in gestational diabetes mellitus (GDM).

Methods: A total of 216 pregnant women with a gestational age of about 2 months were enrolled in this study. Read More

View Article and Full-Text PDF
September 2021

Social and economic inequality in coronavirus disease 2019 vaccination coverage across Illinois counties.

Tim F Liao

Sci Rep 2021 Sep 16;11(1):18443. Epub 2021 Sep 16.

Department of Sociology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

Prior research has well established the association of ethno-racial and economic inequality with COVID-19 incidence and mortality rates across counties in the US. In this ecological study, a similar association was found between ethno-racial and economic inequality and COVID-19 full vaccination rates across the 102 counties in the American state of Illinois in the early months of vaccination. Among the counties with income inequality below the median, a county's poverty rate had a negative association with the proportion of population fully vaccinated. Read More

View Article and Full-Text PDF
September 2021

A Higher Foci Density of Interstitial Fibrosis and Tubular Atrophy Predicts Progressive CKD after a Radical Nephrectomy for Tumor.

J Am Soc Nephrol 2021 Jun 18. Epub 2021 Jun 18.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota

Background: Chronic tubulointerstitial injury on kidney biopsy is usually quantified by the percentage of cortex with interstitial fibrosis/tubular atrophy (IF/TA). Whether other patterns of IF/TA or inflammation in the tubulointerstitium have prognostic importance beyond percentage IF/TA is unclear.

Methods: We obtained, stained, and digitally scanned full cortical thickness wedge sections of renal parenchyma from patients who underwent a radical nephrectomy for a tumor over 2000-2015, and morphometrically analyzed the tubulointerstitium of the cortex for percentage IF/TA, IF/TA density (foci per mm cortex), percentage subcapsular IF/TA, striped IF/TA, percentage inflammation (both within and outside IF/TA regions), and percentage subcapsular inflammation. Read More

View Article and Full-Text PDF

Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group.

Crit Care 2021 Sep 16;25(1):338. Epub 2021 Sep 16.

Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, Japan.

Background: Trends in the incidence and outcomes of sepsis using a Japanese nationwide database were investigated.

Methods: This was a retrospective cohort study. Adult patients, who had both presumed serious infections and acute organ dysfunction, between 2010 and 2017 were extracted using a combined method of administrative and electronic health record data from the Japanese nationwide medical claim database, which covered 71. Read More

View Article and Full-Text PDF
September 2021

Alcohol drinking and risks of liver cancer and non-neoplastic chronic liver diseases in China: a 10-year prospective study of 0.5 million adults.

BMC Med 2021 Sep 17;19(1):216. Epub 2021 Sep 17.

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Background: Alcohol consumption is an important risk factor for hepatic neoplastic and non-neoplastic diseases. Questions remain, however, about the relevance to disease risk of drinking patterns and alcohol tolerability, which differ appreciably between Chinese and Western populations.

Methods: The prospective China Kadoorie Biobank included 512,715 adults (41% men) aged 30-79 years recruited from ten areas during 2004-2008, recording alcohol intake, drinking patterns, and other characteristics. Read More

View Article and Full-Text PDF
September 2021