5,462 results match your criteria incidence delirium


Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: a prospective observational study.

BMC Pulm Med 2021 May 11;21(1):157. Epub 2021 May 11.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Yuzhong District, Chongqing, 400016, China.

Background: Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and outcomes of delirium in NIV patients.

Methods: A prospective observational study was performed in an intensive care unit (ICU) of a teaching hospital. Read More

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The influence of age on EEG-based anaesthesia indices.

J Clin Anesth 2021 May 8;73:110325. Epub 2021 May 8.

Department of Anesthesiology and Intensive Care Medicine, Technical University of Munich, School of Medicine, Munich, Germany. Electronic address:

Study Objective: In the upcoming years there will be a growing number of elderly patients requiring general anaesthesia. As age is an independent risk factor for postoperative delirium (POD) the incidence of POD will increase concordantly. One approach to reduce the risk of POD would be to avoid excessively high doses of anaesthetics by using neuromonitoring to guide anaesthesia titration. Read More

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Geriatric fracture centre vs usual care after proximal femur fracture in older patients: what are the benefits? Results of a large international prospective multicentre study.

BMJ Open 2021 May 10;11(5):e039960. Epub 2021 May 10.

Paracelsus Medizinischen Privatuniversität für Geriatrie, Paracelsus Universitat Nurnberg, Nurnberg, Germany.

Objective: The aim of this study was to determine the effect of treatment in geriatric fracture centres (GFC) on the incidence of major adverse events (MAEs) in patients with hip fractures compared with usual care centres (UCC). Secondary objectives included hospital-workflow and mobility-related outcomes.

Design: Cohort study recruiting patients between June 2015 and January 2017. Read More

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Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study.

Front Oncol 2021 22;11:627726. Epub 2021 Apr 22.

Department of Pediatrics, Weill Cornell Medical College, New York, NY, United States.

Delirium occurs frequently in adults undergoing hematopoietic cell transplantation, with significant associated morbidity. Little is known about the burden of delirium in children in the peri-transplant period. This study was designed to determine delirium rates, define risk factors (demographic and treatment related), and establish feasibility of multi-institutional bedside screening for delirium in children undergoing hematopoietic cell transplant. Read More

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The perioperative application of continuous cerebral autoregulation monitoring for cerebral protection in elderly patients.

Ann Palliat Med 2021 Apr;10(4):4582-4592

Department of Anesthesiology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

Background: The majority of surgical patients aged 65 years and over are accompanied with underlying conditions, making them susceptible to perioperative cerebral complications. Here, we investigated the clinical value of continuous cerebral autoregulation (CA) monitoring in protecting against cerebral dysfunction in elderly patients undergoing surgery.

Methods: This study enrolled 40 elderly patients (aged ≥65 years) and 40 middle-aged patients (aged 45 to 64 years) selected to undergo robotic-assisted laparoscopic radical prostatectomy. Read More

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The performance of the Dutch Safety Management System frailty tool to predict the risk of readmission or mortality in older hospitalised cardiac patients.

BMC Geriatr 2021 May 8;21(1):299. Epub 2021 May 8.

Department of Cardiology, Amsterdam UMC, Amsterdam, the Netherlands.

Background: Early identification of older cardiac patients at high risk of readmission or mortality facilitates targeted deployment of preventive interventions. In the Netherlands, the frailty tool of the Dutch Safety Management System (DSMS-tool) consists of (the risk of) delirium, falling, functional impairment, and malnutrition and is currently used in all older hospitalised patients. However, its predictive performance in older cardiac patients is unknown. Read More

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Orthogeriatric co-management reduces incidence of delirium in hip fracture patients.

Osteoporos Int 2021 May 8. Epub 2021 May 8.

Oslo Delirium Research Group, Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

Hip fracture patients often display an acute confusional state (delirium) which is associated with worse outcomes. In this observational study, we found that co-management of hip fracture patients by a multidisciplinary team including a geriatrician and an orthopaedic surgeon could reduce the incidence of delirium.

Introduction: Delirium after hip fracture is common and is associated with negative outcomes. Read More

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Derivation and validation of actionable quality indicators targeting reductions in complications for injury admissions.

Eur J Trauma Emerg Surg 2021 May 7. Epub 2021 May 7.

Axe Santé des Populations et Pratiques Optimales en Santé (Population Health and Optimal Health Practices Research Unit), Traumatologie-Urgence-Soins Intensifs (Trauma-Emergency-Critical Care Medicine), Centre de Recherche du CHU de Québec (Hôpital de l'Enfant-Jésus), Université Laval, Québec, QC, Canada.

Purpose: Approximately, one out of five patients hospitalized following injury will develop at least one hospital complication, more than three times that observed for general admissions. We currently lack actionable Quality Indicators (QI) targeting specific complications in this population. We aimed to derive and validate QI targeting hospital complications for injury admissions and develop algorithms to identify patient charts to review. Read More

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The impact of loco-regional anaesthesia on postoperative opioid use in elderly hip fracture patients: an observational study.

Eur J Trauma Emerg Surg 2021 May 7. Epub 2021 May 7.

Department of Anesthesiology, Luzerner Kantonsspital, Luzern, Switzerland.

Purpose: Hip fractures are a common health problem among the elderly with an increasing incidence. They are associated with high mortality and morbidity. Optimal pain management remains challenging and inadequate pain control is known for negatively affecting outcomes. Read More

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The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial.

Anaesthesia 2021 May 7. Epub 2021 May 7.

Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Delirium occurs commonly following major non-cardiac and cardiac surgery and is associated with: postoperative mortality; postoperative neurocognitive dysfunction; increased length of hospital stay; and major postoperative complications and morbidity. The aim of this study was to investigate the effect of peri-operative administration of dexmedetomidine on the incidence of postoperative delirium in non-cardiac and cardiac surgical patients. In this randomised, double-blind placebo-controlled trial we included 63 patients aged ≥ 60 years undergoing major open abdominal surgery or coronary artery bypass graft surgery with cardiopulmonary bypass. Read More

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Predictors of delirium in older patients at the emergency department: a prospective multicentre derivation study.

CJEM 2021 May 4;23(3):330-336. Epub 2021 Jan 4.

Université Laval, Québec, Canada.

Objective: The objective of this study was to identify the predictors of incident delirium in this high-risk population.

Methods: This study was a planned sub-analysis of the INDEED multicentre cohort study. We recruited patients aged ≥ 65, independent/semi-independent, with an emergency department (ED) length of stay ≥ 8 h and admitted to any hospital ward. Read More

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Prospective Randomized Controlled Pilot Study of High-Intensity Lightbox Phototherapy to Prevent ICU-Acquired Delirium Incidence.

Cureus 2021 Apr 1;13(4):e14246. Epub 2021 Apr 1.

Pulmonary, Critical Care and Sleep Medicine Section, Department of Medicine, Virginia Tech Carilion School of Medicine, Roanoke, USA.

Background This study aimed to evaluate the role of disturbed circadian rhythm in potentiating intensive care unit (ICU)-acquired delirium.Previous studies have demonstrated bright light therapy (BLT) as an effective modality to improve sleeping patterns and cognitive function in non-critically ill patients. However, its benefit in the ICU has not been clearly established. Read More

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Platelet aggregometry for hip fracture surgery in patients treated with clopidogrel: a pilot study.

J Clin Monit Comput 2021 May 6. Epub 2021 May 6.

Anesthesia and Intensive Care Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.

Surgery for hip fractures should be performed within 48 h from patient's admission. However, several factors including chronic antiplatelet therapy could delay operation. Among the totality of patients taking clopidogrel, up to 30% are resistant to the drug and have a normal platelets reactivity. Read More

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Multi-Component Care Bundle in Geriatric Fracture Hip for Reducing Post-Operative Delirium.

Geriatr Orthop Surg Rehabil 2021 16;12:21514593211004530. Epub 2021 Apr 16.

Department of Anaesthesiology, Queen Mary Hospital, Hong Kong.

Background: Delirium in elderly orthopaedic patients poses an enormous medical, social and financial burden to the healthcare system, and causes significant distress to patients and their caregivers. We examined whether a Multi-component Care Bundle (MCB) could reduce the incidence of post-operative delirium (POD) in fractured hip patients.

Methods: An observational study was conducted, analyzing 154 patients (mean age ± SD, 85 ± 7. Read More

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Laparoscopic Surgery Is Acceptable for Elderly Patients With Colorectal Cancer: A Propensity Score-matched Study.

Anticancer Res 2021 May;41(5):2611-2615

Department of Coloproctological Surgery, Faculty of Medicine, and Medical Technology Innovation Center Clinical Research and Trial Center, Juntendo University, Tokyo, Japan.

Background/aim: The study was performed to examine the suitability of laparoscopic surgery for elderly patients with colorectal cancer.

Patients And Methods: The subjects were 242 patients aged ≥80 years who underwent primary tumor resection of colorectal cancer using laparoscopic assisted colectomy (LAC, n=145) or open colectomy (OC, n=97). Propensity score matching used to balance the characteristics of the groups resulted in 76 patients being assigned to each group. Read More

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Dealing with missing delirium assessments in prospective clinical studies of the critically ill: a simulation study and reanalysis of two delirium studies.

BMC Med Res Methodol 2021 May 6;21(1):97. Epub 2021 May 6.

Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: In longitudinal critical care studies, researchers may be interested in summarizing an exposure over time and evaluating its association with a long-term outcome. For example, the number of days a patient has delirium (i.e. Read More

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Perioperative dexmedetomidine reduces emergence agitation without increasing the oculocardiac reflex in children: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(18):e25717

Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, China.

Background: Intravenous dexmedetomidine (DEX) has been used to prevent emergence agitation (EA) in children. The aim of this meta-analysis was to evaluate whether DEX decreases EA incidence without augmenting oculocardiac reflex (OCR) in pediatric patients undergoing strabismus surgery.

Methods: We searched PubMed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), Wan Fang, and the Cochrane Library to collect the randomized controlled trials (RCTs) investigating the effects of intraoperative DEX in children undergoing strabismus surgery from inception to October 2019. Read More

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Depression and anxiety symptoms are related to pain and frailty but not cognition or delirium in older surgical patients.

Brain Behav 2021 May 5:e02164. Epub 2021 May 5.

Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

Objective: In community dwelling older adults, depression and anxiety symptoms can be associated with early cognitive decline. Symptoms of depression and anxiety are common in older adults prior to surgery. However, their significance is unknown. Read More

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Mobilization in the evening to prevent delirium: A pilot randomized trial.

Nurs Crit Care 2021 May 4. Epub 2021 May 4.

Department of Anaesthesiology, University Hospital Mannheim, Heidelberg, Germany.

Background: Delirium is a common complication in patients in Intensive Care Units (ICU). Interventions such as mobilization are effective in the prevention and treatment of delirium, although this is usually completed during the daytime.

Aim: The aim of this study was to assess the feasibility of mobilization in the evening to prevent and treat ICU patients from delirium by an additional mobility team over 2 weeks. Read More

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A randomized double-blind placebo-controlled trial of intravenous thiamine for prevention of delirium following allogeneic hematopoietic stem cell transplantation.

J Psychosom Res 2021 Apr 27;146:110503. Epub 2021 Apr 27.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Objective: To determine if high dose intravenous (IV) thiamine can prevent delirium during hospitalization following allogeneic HSCT. Secondarily, we evaluated the effects of high dose IV thiamine on thiamine levels and explored risk factors for delirium.

Methods: Randomized, double-blind, placebo-controlled trial in patients undergoing allogeneic HSCT at a U. Read More

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COVID-19 and Alzheimer's disease: how one crisis worsens the other.

Transl Neurodegener 2021 04 30;10(1):15. Epub 2021 Apr 30.

Center for Translational Neurodegeneration and Regenerative Therapy, Tenth People's Hospital of Tongji University, Shanghai, 200072, China.

Alzheimer's disease (AD) has emerged as a key comorbidity of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The morbidity and mortality of COVID-19 are elevated in AD due to multiple pathological changes in AD patients such as the excessive expression of viral receptor angiotensin converting enzyme 2 and pro-inflammatory molecules, various AD complications including diabetes, lifestyle alterations in AD, and drug-drug interactions. Meanwhile, COVID-19 has also been reported to cause various neurologic symptoms including cognitive impairment that may ultimately result in AD, probably through the invasion of SARS-CoV-2 into the central nervous system, COVID-19-induced inflammation, long-term hospitalization and delirium, and post-COVID-19 syndrome. Read More

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USE OF REGIONAL ANALGESIA AND RISK OF DELIRIUM IN OLDER ADULTS WITH MULTIPLE RIB FRACTURES: AN EAST MULTICENTER STUDY.

J Trauma Acute Care Surg 2021 Apr 29. Epub 2021 Apr 29.

Harborview Injury Prevention and Research Center University of Washington Department of Surgery University of Washington University of Washington University of Washington Medical College of Wisconsin Gundersen Health System Mercy Health, Muskegon, MI St. Vincent Indianapolis Hospital University of Utah University of Utah Oregon Health and Science University Oregon Health and Science University Mission Trauma Services, Asheville, NC Loma Linda University Loma Linda University Harborview Injury Prevention and Research Center University of Washington University of Washington University of Washington.

Background: Single center data demonstrates that regional analgesia (RA) techniques are associated with reduced risk of delirium in older patients with multiple rib fractures. We hypothesized that a similar effect between RA and delirium would be identified in a larger cohort of patients from multiple Level I trauma centers.

Methods: Retrospective data from seven Level-I trauma centers were collected for ICU patients ≥65 years old with ≥3 rib fractures from 1/2012-12/2016. Read More

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Agitation and Dementia: Prevention and Treatment Strategies in Acute and Chronic Conditions.

Front Neurol 2021 16;12:644317. Epub 2021 Apr 16.

Department of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.

Agitation is a behavioral syndrome characterized by increased, often undirected, motor activity, restlessness, aggressiveness, and emotional distress. According to several observations, agitation prevalence ranges from 30 to 50% in Alzheimer's disease, 30% in dementia with Lewy bodies, 40% in frontotemporal dementia, and 40% in vascular dementia (VaD). With an overall prevalence of about 30%, agitation is the third most common neuropsychiatric symptoms (NPS) in dementia, after apathy and depression, and it is even more frequent (80%) in residents of nursing homes. Read More

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Does performance-based remuneration improve outcomes in the treatment of hip fracture?

Bone Joint J 2021 May;103-B(5):881-887

Oxford Trauma and Emergency Care, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK.

Aims: The aim of this study was to determine whether national standards of best practice are associated with improved health-related quality of life (HRQoL) outcomes in hip fracture patients.

Methods: This was a multicentre cohort study conducted in 20 acute UK NHS hospitals treating hip fracture patients. Patients aged ≥ 60 years treated operatively for a hip fracture were eligible for inclusion. Read More

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Perioperative dexmedetomidine administration to prevent delirium in adults after non-cardiac surgery: A systematic review and meta-analysis.

J Clin Anesth 2021 Apr 28;73:110308. Epub 2021 Apr 28.

Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, PR China. Electronic address:

Study Objective: To evaluate the efficacy of perioperative dexmedetomidine (DEX) administration for preventing delirium in adults after non-cardiac surgery.

Design: Systematic review and meta-analysis of randomized controlled trials (RCTs).

Interventions: Perioperative administration of DEX to prevent delirium in adults following non-cardiac surgery. Read More

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Incidence and risk factors for postoperative delirium after liver transplantation: a systematic review and meta-analysis.

Eur Rev Med Pharmacol Sci 2021 Apr;25(8):3246-3253

Department of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.

Objective: Postoperative delirium (POD) is a common complication after surgery. The incidence of POD and delirium risk factors after liver transplantation (LT) have not been systematically summarized.

Materials And Methods: Databases, such as PubMed, Cochrane Library, and EMBASE were searched up to September 15, 2019. Read More

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