16,626 results match your criteria incidence biliary

Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk.

Front Genet 2021 30;12:693933. Epub 2021 Aug 30.

Blood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Children's Hospital, Florence, Italy.

Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. Read More

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The influences of obesity in laparoscopic and open distal gastrectomy patients for early gastric cacer.

J Nippon Med Sch 2021 Sep 14. Epub 2021 Sep 14.

Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School.

Background: A recent increase in the number of surgeries performed on obese patents has raised several issues. In this study, we examined the effects of obesity on laparoscopic and open distal gastrectomy.

Methods: A totalof 262 patients with gastric cancer (cStageI) who underwent distal gastrectomy were classified into open distal gastrectomy (ODG) (145 patients) and laparoscopic distal gastrectomy (LDG) (117 patients) groups. Read More

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September 2021

Genetic polymorphisms involved in mitochondrial metabolism and pancreatic cancer risk.

Cancer Epidemiol Biomarkers Prev 2021 Sep 15. Epub 2021 Sep 15.

Division of Gastroenterology and Research Laboratory, Casa Sollievo della Sofferenza, IRCCS Casa Sollievo della Sofferenza.

Background: The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC aetiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNPs) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported. Read More

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September 2021

Isolated pancreatic injury in an adolescent treated with Roux-en-Y pancreatojejunostomy: a case report and review of the literature.

J Med Case Rep 2021 Sep 16;15(1):474. Epub 2021 Sep 16.

Department of Gastrointestinal and Hepato-Pancreatic-Biliary Surgery, Ibn Sina Specialized Hospital, Khartoum, Sudan.

Background: Pancreatic injury presented as isolated injury in the pediatric population is exceptionally rare, with a conveyed incidence of less than 2% of all abdominal trauma injuries cases and a very controversial management approach for grade III injuries.

Case Presentation: A 16-year-old adolescent Sudanese boy was referred to our emergency department with a 5-day history of upper and left hypochondrial pain after blunt abdominal trauma to the epigastric region with a solid object. Grade III pancreatic body trauma with major duct involvement can be successfully treated operatively. Read More

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September 2021

Identification of causal metabolites related to multiple autoimmune diseases.

Hum Mol Genet 2021 Sep 15. Epub 2021 Sep 15.

Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou, China.

Object: Observational studies provide evidence that metabolites may be involved in the development of autoimmune diseases (ADs), but whether it is causal is still unknown.

Methods: Based on the large-scale GWAS summary statistics, two-sample Mendelian randomization (MR) was performed to evaluate the causal association between human serum metabolites and multiple ADs, which were inflammatory bowel disease (IBD), ulcerative Colitis (UC), crohn's disease (CD), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), multiple sclerosis (MS), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Comprehensive sensitive analysis was used to validate the robustness of MR results and multivariable MR analysis was conducted to avoid potential pleiotropic effect of other complex traits. Read More

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September 2021

Incidence And Predictors Of Textbook Outcome After Simultaneous Liver And Rectal Surgeries For Stage Iv Rectal Cancer.

Colorectal Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy.

Aim: Textbook outcome [TO] is a new surgical quality measure that combines structure, process, and surgical outcomes into a single element. Our study aimed to determine the incidence of TO after simultaneous rectal and liver surgery and to use the achievement of TO as a tool to identify the best candidates for these complex procedures.

Methods: In total, 256 patients who underwent simultaneous liver and rectal surgery for stage IV rectal cancer between January 2004 and August 2019 at five tertiary centers were enrolled. Read More

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September 2021

Postoperative adjuvant chemotherapy for resectable cholangiocarcinoma.

Cochrane Database Syst Rev 2021 Sep 13;9:CD012814. Epub 2021 Sep 13.

Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

Background: Cholangiocarcinoma (cancer in the bile duct) is an aggressive tumour for which surgical resection is a mainstay of treatment. Despite complete resection, recurrences of the cancer are common and lead to poor prognosis in patients. Postoperative adjuvant chemotherapy given after surgical resection may reduce the risk of cancer recurrence by eradicating residual cancer and micrometastatic lesions. Read More

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September 2021

Impact of COVID-19 on Liver Transplantation in Hong Kong and Singapore: A Modelling Study.

Lancet Reg Health West Pac 2021 Nov 7;16:100262. Epub 2021 Sep 7.

Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.

Background: Liver transplantation (LT) activities during the COVID-19 pandemic have been curtailed in many countries. The impact of various policies restricting LT on outcomes of potential LT candidates is unclear.

Methods: We studied all patients on the nationwide LT waitlists in Hong Kong and Singapore between January 2016 and May 2020. Read More

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November 2021

Impact of COVID-19 on presentation, management, and outcomes of acute care surgery for gallbladder disease and acute appendicitis.

World J Gastrointest Surg 2021 Aug;13(8):859-870

Department of Surgery, Stanford University School of Medicine, Palo Alto, CA 94305, United States.

Background: The ongoing coronavirus disease 2019 (COVID-19) pandemic has significantly disrupted both elective and acute medical care. Data from the early months suggest that acute care patient populations deferred presenting to the emergency department (ED), portending more severe disease at the time of presentation. Additionally, care for this patient population trended towards initial non-operative management. Read More

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Georgian Med News 2021 Jul-Aug(316-317):16-21

1National Institute of Surgery and Transplantology of the NAMS of Ukraine name after А.А. Shalimov, Kyiv; Ukraine.

The goal of this study was to analyze the effectiveness of pancreatogastrostomy at the stage of reconstruction by assessing its technical aspects and analysis of the frequency of postoperative complications. The article represents results of the study held with a total of 35 pancreatoduodenectomies performed, followed by reconstruction pancreatogastrostomy. The average patients age was 53. Read More

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September 2021

Integration of public health measures for NAFLD into India's national programme for NCDs.

Lancet Gastroenterol Hepatol 2021 Oct;6(10):777-778

Department of Clinical Epidemiology, Institute of Liver and Biliary Sciences, New Delhi, India.

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October 2021

Epidemiology and risk factors for pyogenic liver abscess in the Calgary Health Zone revisited: a population-based study.

BMC Infect Dis 2021 Sep 10;21(1):939. Epub 2021 Sep 10.

Department of Medicine, University of Calgary, Calgary, Canada.

Background: Pyogenic liver abscess (PLA), although uncommon in North America, is associated with significant morbidity and mortality. We sought to re-examine the epidemiology, risk factors, and outcomes of PLA in a large, diverse Canadian health zone.

Methods: All Calgary Health Zone (CHZ) residents aged ≥20 with PLA between 2015 and 2017 were identified. Read More

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September 2021

Dynamic Risk Prediction of Response to Ursodeoxycholic Acid Among Patients with Primary Biliary Cholangitis in the USA.

Dig Dis Sci 2021 Sep 9. Epub 2021 Sep 9.

Department of Gastroenterology and Hepatology, Henry Ford Health System, and Wayne State University School of Medicine, Detroit, MI, USA.

Background: Ursodeoxycholic acid (UDCA) remains the first-line therapy for primary biliary cholangitis (PBC); however, inadequate treatment response (ITR) is common. The UK-PBC Consortium developed the modified UDCA Response Score (m-URS) to predict ITR (using alkaline phosphatase [ALP] > 1.67 times the upper limit of normal [*ULN]) at 12 months post-UDCA initiation). Read More

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September 2021

Portojejunostomy: A Salvage Technique for Extrahepatic Bile Ducts Surgery.

Chirurgia (Bucur) 2021 Aug;116(4):480-483

As laparoscopic surgery has evolved, open cholecystectomy has been replaced with a new minimally invasive approach which is considered nowadays the gold-standard technique. Laparoscopic cholecystectomy has brought multiple advantages in terms of outcomes; however, the incidence of complex biliary injuries has been noticed. The portojejunostomy was first performed for pediatric patients with biliary atresia, involving the attachment of a Roux-en- Y loop to the porta hepatis in order to restore the bilioenteric continuity. Read More

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The Importance of Route Anatomic Variants of the Common Hepatic Artery.

Chirurgia (Bucur) 2021 Aug;116(4):466-472

Variants of vascularization in the celiac and upper mesenteric artery are described in the dedicated literature. The anatomy of this area is a subject of interest, considering the potential techniques and the risk of generating intraoperative incidents/accidents or complications. Material and method: We have conducted a unicentric retrospective study, in the Surgery Clinic No. Read More

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Prognosis of patients with liver cirrhosis: a multi-center retrospective observational study.

Hepatol Res 2021 Sep 7. Epub 2021 Sep 7.

Clinical Research Center, National Hospital Organization Nagasaki Medical Center, Omura, Japan.

Aim: Despite advances in the management of liver diseases and changes in the etiology of cirrhosis, few studies have updated the prognosis of cirrhosis. This study aimed to clarify the recent prognosis of cirrhosis and identify risk factors for death.

Methods: In this retrospective observational study by the Hepatic Disease Network of the National Hospital Organization in Japan, chart reviews were performed to follow patients with cirrhosis beginning in 2011. Read More

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September 2021

Laparoscopic cholecystectomy in a swine model using a novel near-infrared fluorescent IV dye (BL-760).

Lasers Surg Med 2021 Sep 7. Epub 2021 Sep 7.

Department of Surgery, Dong-A University College of Medicine, Seo-Gu, Busan, South Korea.

Background And Objectives: Bile duct injury during laparoscopic cholecystectomy has an incidence rate of 1%-2% and commonly appears under conditions of severe inflammation, adhesion, or unexpected anatomical variations. Despite the difficulties and rising concerns of identifying bile duct during surgeries, surgeons do not have a specific modality to identify bile duct except intraoperative cholangiography. While no biliary-specific fluorescent dye exists for clinical use, our team has previously described the development of a preclinical biliary-specific dye, BL-760. Read More

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September 2021

Proof-of-concept study to evaluate the safety and efficacy of saroglitazar in patients with primary biliary cholangitis.

J Hepatol 2021 Sep 3. Epub 2021 Sep 3.

Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine. Electronic address:

Background & Aim: Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with dual agonistic properties (α/γ). Due to a strong mechanistic rationale, we aimed to test the safety and efficacy of saroglitazar in patients with primary biliary cholangitis (PBC) who were either ursodeoxycholic acid (UDCA) resistant or intolerant.

Methods: In this double-blind, phase 2 proof-of-concept trial, 37 PBC patients were randomized to saroglitazar 4 mg (n=13), saroglitazar 2 mg (n=14), or placebo (n=10) daily for 16 weeks. Read More

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September 2021

Interleukin 23 Produced by Hepatic Monocyte-Derived Macrophages Is Essential for the Development of Murine Primary Biliary Cholangitis.

Front Immunol 2021 13;12:718841. Epub 2021 Aug 13.

The Research Center for Digestive Tract and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background And Aims: Primary Biliary Cholangitis (PBC) is an organ-specific autoimmune liver disease. Mononuclear phagocytes (MNPs), comprise of monocyte, dendritic cells and monocyte-derived macrophages, constitute major arm of the innate immune system known to be involved in the pathogenesis of autoimmune disorders. MNPs were shown to accumulate around intra-hepatic bile ducts in livers of PBC patients. Read More

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Impact of Kasai procedure and the length of native liver survival time on outcomes of liver transplantation for biliary atresia.

Liver Transpl 2021 Sep 5. Epub 2021 Sep 5.

Liver Transplant Center, Clinical Center for Pediatric liver transplantation, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Objective: To explore the impact of the Kasai procedure (KP) and the length of native liver survival time (NLST) on outcomes of liver transplantation (LT).

Methods: Patients with biliary atresia (BA), who underwent LT in Beijing Friendship Hospital from January 2017 to December 2019, were enrolled and divided into non-KP (N-KP) and post-KP (P-KP) groups. The patients in the P-KP group were further divided into early failure (KP-EF) defined by NLST <1 year, medium failure (KP-MF; NLST 1-5 years), and late failure (KP-LF, NLST >5 years) subgroups. Read More

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September 2021

Effects of the COVID-19 Pandemic on Solid Organ Transplantation During 2020 in Poland Compared with Countries in Western Europe, Asia, and North America: A Review.

Med Sci Monit 2021 Sep 4;27:e932025. Epub 2021 Sep 4.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

The coronavirus disease 2019 (COVID-19) pandemic, due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which began in March 2020, affected organ donor acceptance and rates of heart, lung, kidney, and liver transplants worldwide. According to data reported to POLTRANSPLANT, the number of solid organ transplants decreased by over 35% and the number of patients enlisted de novo for organ transplantation was reduced to 70% of its pre-COVID-19 volume in Poland. Most transplant centers in Western Europe and the USA have also drastically reduced their activity when compared to the pre-pandemic era. Read More

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September 2021

Incidence and computed tomography findings of lenvatinib-induced pancreatobiliary inflammation: A single-center, retrospective study.

Medicine (Baltimore) 2021 Sep;100(35):e27182

Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Abstract: In this single-center retrospective study, we intended to evaluate the frequencies and characteristics of computed tomography findings of pancreatobiliary inflammation (PBI) in patients treated with lenvatinib and the relationship of these findings with treatment-planning changes.We included 78 patients (mean ± standard deviation, 69.8 ± 9. Read More

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September 2021

Successful Removal of a Biliary Stent in the Jejunum Using Double-Balloon Enteroscopy.

Galen Med J 2020 18;9:e1809. Epub 2020 Dec 18.

Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Plastic biliary stent placement has been widely used as a safe approach for the management of hilar neoplasms or the dilation of benign biliary obstruction. Despite the complexity of this procedure, this approach is followed by a few complications. The incidence rate of stent migration is about 10%. Read More

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December 2020

Value of Low-Mechanical-Index Contrast-Enhanced Transabdominal Ultrasound for Diagnosis of Pancreatic Cancer: A Meta-analysis.

Ultrasound Med Biol 2021 Aug 28. Epub 2021 Aug 28.

Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan. Electronic address:

The incidence and mortality rates of pancreatic cancer (PC) are increasing. It is important to discriminate PC from the other pancreatic lesions; however, differential diagnosis based on conventional transabdominal ultrasound (US) remains challenging even though US is often the first examination performed. Transabdominal contrast-enhanced ultrasound (CEUS) has high diagnostic accuracy for PC. Read More

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An Analysis of 5 Years of Randomized Trials in Gastroenterology and Hepatology Reveals 52 Medical Reversals.

Dig Dis Sci 2021 Aug 31. Epub 2021 Aug 31.

Division of Gastroenterology, Department of Internal Medicine, Columbia University Irving Medical Center, 180 Fort Washington Avenue, Suite 936, New York, USA.

Background And Aims: One manifestation of low-value medical practice is the medical reversal, a practice in widespread use that, once subjected to a randomized controlled trial (RCT), is found to be no better-or worse-than a prior established standard of care. We aimed to determine the prevalence of medical reversals in gastroenterology (GI) journals and characterize these reversals.

Methods: We searched the American Journal of Gastroenterology, Clinical Gastroenterology and Hepatology, Gastroenterology, Gut, Hepatology, and the Journal of Hepatology, reviewing studies published in 2015-2019. Read More

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Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4.

Cell Death Discov 2021 Aug 28;7(1):224. Epub 2021 Aug 28.

Department of Radiology, The Fourth Affiliated Hospital of Anhui Medical University, 230012, Hefei, China.

Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-derived exosomes possess protective effects against various human diseases by transporting microRNAs (miRNAs or miRs). We aimed to explore the role of exosomal miR-15a derived from MSCs and its related mechanisms in HCC. Read More

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A randomised, multicentre trial of somatostatin to prevent clinically relevant postoperative pancreatic fistula in intermediate-risk patients after pancreaticoduodenectomy.

J Gastroenterol 2021 Aug 28. Epub 2021 Aug 28.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Prophylactic somatostatin to reduce the incidence of clinically relevant postoperative pancreatic fistula after pancreaticoduodenectomy remains controversial. We assessed the preventive efficacy of somatostatin on clinically relevant postoperative pancreatic fistula in intermediate-risk patients who underwent pancreaticoduodenectomy at pancreatic centres in China.

Methods: In this multicentre, prospective, randomised controlled trial, we used the updated postoperative pancreatic fistula classification criteria and cases were confirmed by an independent data monitoring committee to improve comparability between centres. Read More

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Association of type 2 diabetes mellitus with incidences of microvascular invasion and survival outcomes in hepatitis B virus-related hepatocellular carcinoma after liver resection: A multicenter study.

Eur J Surg Oncol 2021 Aug 13. Epub 2021 Aug 13.

Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. Electronic address:

Background: Microvascular invasion (MVI) adversely affects long-term survival in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). This study aimed to examine the association between preoperative type 2 diabetes mellitus (T2DM) with incidences of MVI and prognosis in HBV-related HCC after liver resection (LR).

Material And Methods: Data of HBV-related HCC patients who underwent LR as an initial therapy from four hospitals in China were retrospectively collected. Read More

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Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.

PLoS One 2021 27;16(8):e0256797. Epub 2021 Aug 27.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-Ku, Okayama, Japan.

Objective: The rare incidence of submucosal invasive non-ampullary duodenal carcinoma has led to scant information in literature; therefore, we compared the clinicopathological features between submucosal invasive carcinoma (SM-Ca), mucosal carcinoma (M-Ca), and advanced carcinoma (Ad-Ca).

Materials: We retrospectively analyzed 165 patients with sporadic non-ampullary duodenal carcinomas (SNADCs) from four institutions between January 2003 and December 2018. The SNADCs were divided to three groups according to histological diagnosis: SM-Ca, M-Ca, and Ad-Ca. Read More

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Horizons on the Therapy of Biliary Tract Cancers: A State-of-the-art Review.

J Clin Transl Hepatol 2021 Aug 12;9(4):559-567. Epub 2021 May 12.

Department of Gastroenterology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Biliary tract cancers (BTCs) comprise a group of heterogeneous poor prognosis cancers with increasing incidence recent years. The combination chemotherapy with cisplatin and gemcitabine is the first-line therapy for advanced BTC. There remains no accepted standard treatment in the second-line setting. Read More

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