116 results match your criteria incessant increase


Proteomic Advances in Cereal and Vegetable Crops.

Molecules 2021 Aug 14;26(16). Epub 2021 Aug 14.

Centro Tecnológico de la Carne de Galicia, Adva. Galicia n° 4, Parque Tecnológico de Galicia, San Cibrao das Viñas, 32900 Ourense, Spain.

The importance of vegetables in human nutrition, such as cereals, which in many cases represent the main source of daily energy for humans, added to the impact that the incessant increase in demographic pressure has on the demand for these plant foods, entails the search for new technologies that can alleviate this pressure on markets while reducing the carbon footprint of related activities. Plant proteomics arises as a response to these problems, and through research and the application of new technologies, it attempts to enhance areas of food science that are fundamental for the optimization of processes. This review aims to present the different approaches and tools of proteomics in the investigation of new methods for the development of vegetable crops. Read More

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How we treat primary central nervous system lymphoma.

ESMO Open 2021 Aug 13;6(4):100213. Epub 2021 Jul 13.

Lymphoma Unit, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan. Electronic address:

Primary diffuse large B-cell (DLBCL) lymphoma of the central nervous system (CNS) (PCNSL) is a new lymphoma entity, recognized by the 2017 WHO classification of hematopoietic and lymphoid tumors. Unlike systemic DLBCL, the use of anthracycline-based chemotherapy combinations is associated with disappointing outcomes, due to low CNS bioavailability of related drugs. Therefore, international researchers investigated alternative strategies, mostly including drugs able to cross the blood-brain-barrier at low or high doses, with a progressive improvement in survival. Read More

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The incessant increase curve during oral glucose tolerance tests in Chinese adults with type 2 diabetes and its association with gut hormone levels.

Peptides 2021 Sep 8;143:170595. Epub 2021 Jun 8.

Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.

Glucose curve shapes during oral glucose tolerance tests (OGTTs) are mainly classified as incessant increase, monophasic and biphasic. Youth with an incessant increase curve have worse β-cell function. The aim of this paper was to investigate the incessant increase curve in Chinese adults with type 2 diabetes (T2DM), and its association with β-cell function and gut hormone levels. Read More

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September 2021

The Shape of the Oral Glucose Tolerance Test-Glucose Response Curve in Islet Cell Antibody-Positive vs. -Negative Obese Youth Clinically Diagnosed with Type 2 Diabetes.

J Obes Metab Syndr 2021 Jun;30(2):178-183

Center for Pediatric Research in Obesity and Metabolism, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Background: The oral glucose tolerance test (OGTT)-glucose response curves (GRCs; incessant increase, monophasic, and biphasic) reflect insulin sensitivity and β-cell function, being worse in the former and superior in the latter. Here, we examined if the OGTT-GRC pattern is worse in obese antibody (glutamic acid decarboxylase 65-kDa [GAD65] and insulinoma-associated protein-2 [IA-2])-positive (Ab) vs. -negative (Ab) youth clinically diagnosed with type 2 diabetes (CDX-T2D). Read More

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Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19.

Free Radic Biol Med 2021 May 28;175:56-64. Epub 2021 May 28.

Pathways Bioscience, Aurora, CO, 80045, USA; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address:

PB125® is a phytochemical composition providing potent Nrf2 activation as well as a number of direct actions that do not involve Nrf2. Nrf2 is a transcription actor that helps maintain metabolic balance by providing redox-sensitive expression of numerous genes controlling normal day-to-day metabolic pathways. When ordinary metabolism is upset by extraordinary events such as injury, pathogenic infection, air or water pollution, ingestion of toxins, or simply by the slow but incessant changes brought about by aging and genetic variations, Nrf2 may also be called into action by the redox changes resulting from these events, whether acute or chronic. Read More

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Ecological analysis and environmental niche modelling of (D. Don) Soo: A conservation approach for critically endangered medicinal orchid.

Saudi J Biol Sci 2021 Apr 1;28(4):2109-2122. Epub 2021 Feb 1.

Department of Botany, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185234, J&K, India.

The natural populations of have been greatly affected due to incessant exploitation. As such, studies on its population attributes together with habitat suitability and environmental factors affecting its distribution are needed to be undertaken for its conservation in nature. Present study aimed at accessing an impact of anthropogenic pressure on population structure and locate suitable habitats for the conservation of this critically endangered orchid. Read More

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Oral glucose tolerance response curve predicts disposition index but not other cardiometabolic risk factors in healthy adolescents.

J Pediatr Endocrinol Metab 2021 May 5;34(5):599-605. Epub 2021 Apr 5.

Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, USA.

Objectives: In obese adults the shape of the glucose response curve during an oral glucose tolerance test (OGTT) predicts future type 2 diabetes. Patients with an incessant increase or monophasic curves have increased risk compared to those with biphasic curves. Since type 2 diabetes is associated with increased cardiometabolic risk, we studied whether differences in OGTT response curve are associated with differences in cardiometabolic risk factors in healthy adolescents across a wide body mass index (BMI) range. Read More

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The Continuous Surveillance of InSTI Resistance Could be an Important Public Health Tool in the Fight Against HIV Infection.

Curr HIV Res 2021 ;19(4):358-367

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.

Aims: To evaluate the frequency of the InSTIs mutations in a large cohort of HIV-infected people.

Background: The Highly Active Anti-Retroviral Therapy (HAART) allows turning HIV infection from a fatal disease to chronic infection, and Integrase Strand Transfer Inhibitors (InSTIs) represent the cornerstone of this treatment. However, the spread of HIV-1 drug resistance mutations represents an emerging threat to the long-term success of HIV treatment programs. Read More

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January 2021

Count Models Analysis of Factors Associated with Under-Five Mortality in Ethiopia.

Glob Pediatr Health 2021 10;8:2333794X21989538. Epub 2021 Feb 10.

Salale University, Oromia, Ethiopia.

. Under-five mortality has continued a key challenge to public health in Ethiopia, and other sub-Saharan Africa countries. The threat of under-five mortality is incessant and more studies are needed to generate new scientific evidence. Read More

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February 2021

OGTT Glucose Response Curves, Insulin Sensitivity, and β-Cell Function in RISE: Comparison Between Youth and Adults at Randomization and in Response to Interventions to Preserve β-Cell Function.

Diabetes Care 2021 03 12;44(3):817-825. Epub 2021 Jan 12.

VA Puget Sound Health Care System and University of Washington, Seattle, WA.

Objective: We examined the glucose response curves (biphasic [BPh], monophasic [MPh], incessant increase [IIn]) during an oral glucose tolerance test (OGTT) and their relationship to insulin sensitivity (IS) and β-cell function (βCF) in youth versus adults with impaired glucose tolerance or recently diagnosed type 2 diabetes.RESEARCH DESIGN AND METHODSThis was both a cross-sectional and a longitudinal evaluation of participants in the RISE study randomized to metformin alone for 12 months or glargine for 3 months followed by metformin for 9 months. At baseline/randomization, OGTTs (85 youth, 353 adults) were categorized as BPh, MPh, or IIn. Read More

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In vitro and in vivo hypolipidemic properties of the aqueous extract of , cultivated in colored flasks under artificial illumination.

PeerJ 2020 1;8:e10366. Epub 2020 Dec 1.

Department of Biology, Faculty of Sciences and Arts Khulais, University of Jeddah, Jeddah, Saudi Arabia.

Background: is blue-green algae that grows mainly in tropical and subtropical lakes and is commonly used due to its nutritional features including high concentrations of protein, vitamins, mineral salts, carotenoids and antioxidants. This study aimed to investigate the anti-hypercholesterolemic potential of aqueous extract of cultivated in different colored flasks under artificial illumination; in vitro and in the diet induced hypercholesterolemic Swiss albino mice.

Methods: was cultivated in red, blue, green and colorless Erlenmeyer flasks containing Zarrouk's medium under aerobic conditions, with incessant illumination by artificial cool white fluorescent with light intensity of 2500 lux (35 µmol photon m s). Read More

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December 2020

A Critical Review on the Properties and Applications of Sulfur-Based Concrete.

Materials (Basel) 2020 Oct 22;13(21). Epub 2020 Oct 22.

Higher School of Industrial, Civil and Road Construction, Peter the Great St. Petersburg Polytechnic University, 195251 St. Petersburg, Russia.

The incessant demand for concrete is predicted to increase due to the fast construction developments worldwide. This demand requires a huge volume of cement production that could cause an ecological issue such as increasing the rates of CO emissions in the atmosphere. This motivated several scholars to search for various alternatives for cement and one of such alternatives is called sulfur-based concrete. Read More

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October 2020

Impacts and social implications of landuse-environment conflicts in a typical Mediterranean watershed.

Sci Total Environ 2021 Apr 9;764:142853. Epub 2020 Oct 9.

Economic and Environmental Geology and Hydrology Group, University of Barcelona, Barcelona, Spain. Electronic address:

In coastal watersheds, services and landuse favour coastal tourism and urbanization, depriving rural upstream of infrastructure and attention. This unbalanced management leads to an intensification of socioeconomic changes that generate a structural heterogeneity of the landscape and a reduction in the livelihoods of the rural population. The incessant dissociation between the objectives of the stakeholders triggers landuse-environment-economy conflicts which threaten to mutate large-scale development programs. Read More

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Long-Lasting Ventricular Fibrillation in Humans ECG Characteristics and Effect of Radiofrequency Ablation.

Circ Arrhythm Electrophysiol 2020 10 10;13(10):e008639. Epub 2020 Sep 10.

LIRYC Institute/INSERM 1045, Bordeaux University, France (J.D., M. Hocini, F.S., P.J., O.B., M. Haïssaguerre, R.D.).

Background: Studies of ventricular fibrillation (VF) in humans are limited because of the short available duration. We sought to study surface ECG waveforms and effect of ablation in long-lasting VF in patients with left assist devices.

Methods: Continuous 12-lead ECG of 5 episodes of long-lasting VF occurring in 3 patients with left ventricular assist device were analyzed. Read More

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October 2020

Exploring the Role of Bacterial Extracellular Polymeric Substances for Sustainable Development in Agriculture.

Curr Microbiol 2020 Nov 2;77(11):3224-3239. Epub 2020 Sep 2.

Department of Chemical Technology, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata 700009, West Bengal, India.

The incessant need to increase crop yields has led to the development of many chemical fertilizers containing NPK (nitrogen-phosphorous-potassium) which can degrade soil health in the long term. In addition, these fertilizers are often leached into nearby water bodies causing algal bloom and eutrophication. Bacterial secondary metabolites exuded into the extracellular space, termed extracellular polymeric substances (EPS) have gained commercial significance because of their biodegradability, non-toxicity, and renewability. Read More

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November 2020

COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases.

J Clin Med 2020 Aug 22;9(9). Epub 2020 Aug 22.

Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.

Background: Lysosomal storage disorders (LSDs) are rare, chronic, progressive multisystem diseases implying severe medical issues and psychological burden. Some of these disorders are susceptible to a treatment, which is administered weekly or every other week, in a hospital. During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Read More

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Improved Thermophysical Properties and Energy Efficiency of Aqueous Ionic Liquid/MXene Nanofluid in a Hybrid PV/T Solar System.

Nanomaterials (Basel) 2020 Jul 14;10(7). Epub 2020 Jul 14.

Department of Mechanical Engineering, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, Perak Darul Ridzuan 32610, Malaysia.

In recent years, solar energy technologies have developed an emerging edge. The incessant research to develop a power source alternative to fossil fuel because of its scarcity and detrimental effects on the environment is the main driving force. In addition, nanofluids have gained immense interest as superior heat transfer fluid in solar technologies for the last decades. Read More

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Impact of heavy rains of 2018 in western Japan: disaster-induced health outcomes among the population of Innoshima Island.

Heliyon 2020 May 25;6(5):e03942. Epub 2020 May 25.

Department of Public Health, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Southwestern Japan suffered its worst rains in 2018 causing floods and mudslides, claiming 225 lives and forcing millions for evacuations. Referred as "Heisei san-jū-nenshichi-gatsugōu", the disaster was the result of incessant precipitation caused by the interaction of typhoon "Prapiroon" with the seasonal rain front "Baiu". The present epidemiological study aims to investigate disaster-induced health issues in 728 residents of Innoshima island in the Hiroshima Prefecture by comparing their clinical data in pre-disaster (2017) and disaster-hit (2018) years which was obtained from annual health screening. Read More

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Expression of Meiothermus ruber luxS in E. coli alters the antibiotic susceptibility and biofilm formation.

Appl Microbiol Biotechnol 2020 May 25;104(10):4457-4469. Epub 2020 Mar 25.

Department of Microbiology, Panjab University, Chandigarh, India.

Quorum sensing (QS) and signal molecules used for interspecies communication are well defined in mesophiles, but there is still a plethora of microorganisms in which existence and mechanisms of QS need to be explored, thermophiles being among them. In silico analysis has revealed the presence of autoinducer-2 (AI-2) class of QS signaling molecules in thermophiles, synthesized by LuxS (AI-2 synthase), though the functions of this system are not known. In this study, LuxS of Meiothermus ruber was used for understanding the mechanism and functions of AI-2 based QS among thermophilic bacteria. Read More

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Subchronic exposure to ; its neurotoxic potentials in young adult female Wistar rats.

Heliyon 2020 Mar 12;6(3):e03514. Epub 2020 Mar 12.

Department of Pharmacology and Therapeutic, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Background: (camphor) {CHO} is a chemical substance used mostly amongst the Yoruba ethnic group in Western Nigeria to treat infantile colic during early childhood. This study assess the neurotoxic potentials of following sub-chronic exposure in female albino Wistar rats.

Methods: Twenty-eight female rats (mean weight of 130 g) were randomly selected and assigned into four (4) groups. Read More

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Screening and Prevention for High-Grade Serous Carcinoma of the Ovary Based on Carcinogenesis-Fallopian Tube- and Ovarian-Derived Tumors and Incessant Retrograde Bleeding.

Diagnostics (Basel) 2020 Feb 22;10(2). Epub 2020 Feb 22.

Department of Obstetrics and Gynecology, Kameda Medical Center, Kamogawa 296-8602, Japan.

High-grade serous carcinoma (HGSC) is the most common and lethal subtype of ovarian carcinoma. Many HGSCs are now believed to originate in the fallopian tube epithelium; ovarian surface epithelium is another possible origin. Thus, current screening methods, i. Read More

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February 2020

Physiological, Biochemical and Reproductive Studies on a Critically Endangered Medicinal Plant of the Himalayan Region Grown under In-Situ and Ex-Situ Conditions.

Plants (Basel) 2020 Jan 21;9(2). Epub 2020 Jan 21.

Department of Botany and Microbiology, College of Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.

, a perennial herb belonging to family Valerianaceae, is an important medicinal herb of the Himalayan region. The incessant exploitation of nature for meeting the demands of the pharmaceutical industry has put unbearable pressure on its natural habitats. A study on its physiological, biochemical, growth and reproductive attributes was planned. Read More

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January 2020

The effects of persistent audible seat belt reminders and a speed-limiting interlock on the seat belt use of drivers who do not always use a seat belt.

J Safety Res 2019 12 12;71:13-24. Epub 2019 Nov 12.

Westat, Inc., 1600 Research Blvd, Rockville, MD 20850, United States.

Introduction: Vehicle technologies that increase seat belt use can save thousands of lives each year. Kidd, Singer, Huey, and Kerfoot (2018) found that a gearshift interlock was more effective for increasing seat belt use than an intermittent audible reminder, but interlocks may not be more effective than persistent audible reminders lasting at least 90 seconds.

Method: Forty-nine part-time belt users with a recent seat belt citation who self-reported not always using a seat belt drove two vehicles for 1 week each. Read More

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December 2019

Combating colorectal cancer with immunotherapy: Where are we?

Drugs Today (Barc) 2019 Aug;55(8):513-528

Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India.

Despite incessant advancement in the therapeutic regimens against colorectal cancer (CRC), treatment failure, metastasis and serious side effects associated with the available therapeutic options demand specific targeted therapies that could help in improving the survival rate with significantly less toxicity, fewer untoward effects and improved efficacy. In-depth studies highlighted the potential of CRC to be immune-responsive, thereby opening a new door in the development of strategies to combat CRC. Immunotherapy has attracted a myriad of researchers with a hope that it could potentially increase the efficacy of the treatment regimens in parallel to the reduction of toxicity. Read More

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Biventricular Pacing Going Along with Acute Hemodynamic Response in a Patient with Huge Anterior Wall Aneurysm - Importance of Pacing Viable Myocardium.

Am J Case Rep 2019 Jun 9;20:810-815. Epub 2019 Jun 9.

Department of Cardiology, University Heart Center Lübeck, Lübeck, Germany.

BACKGROUND Response to cardiac resynchronization therapy (CRT) is variable among patients. Extensive scar tissue burden has been characterized as a negative predictor of significant response. Whereas mid-term and long-term response has been thoroughly investigated in randomized clinical trials; however, little is known about acute hemodynamic effects of biventricular pacing. Read More

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Qualitative Job Insecurity and Informal Learning: A Longitudinal Test of Occupational Self-Efficacy and Psychological Contract Breach as Mediators.

Int J Environ Res Public Health 2019 05 24;16(10). Epub 2019 May 24.

Research group for Work, Organisational, and Personnel Psychology, KU Leuven, 3000 Leuven, Belgium.

Current work life has become increasingly turbulent, which has sparked employees' concern about the loss of valued job features, coined as qualitative job insecurity. No prior research has investigated the relationship between this type of job insecurity and informal learning. However, informal learning might be particularly relevant for qualitatively job-insecure employees, as it might aid them to deal with the incessant changes in their work environment. Read More

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Contemporary Management of Electrical Storm.

Heart Lung Circ 2019 Jan 15;28(1):123-133. Epub 2018 Oct 15.

Department of Cardiology, Westmead Hospital, Westmead Applied Research Centre, University of Sydney, Sydney, NSW, Australia. Electronic address:

Cardiac electrical storm (ES) is characterised by three or more discrete episodes of ventricular arrhythmia within 24hours, or incessant ventricular arrhythmia for more than 12hours. ES is a distinct medical emergency that portends a significant increase in mortality risk and often presages progressive heart failure. ES is also associated with psychological morbidity from multiple implanted cardioverter defibrillator (ICD) shocks and exponential health resource utilisation. Read More

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January 2019

The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in β-Cell Function in TODAY.

Diabetes Care 2019 01 19;42(1):164-172. Epub 2018 Nov 19.

University of Oklahoma Health Sciences Center, Oklahoma City, OK.

Objective: Obese youth without diabetes with monophasic oral glucose tolerance test (OGTT) glucose response curves have lower insulin sensitivity and impaired β-cell function compared with those with biphasic curves. The OGTT glucose response curve has not been studied in youth-onset type 2 diabetes. Here we test the hypothesis that the OGTT glucose response curve at randomization in youth in the TODAY (Treatment Options for Type 2 Diabetes in Adolescents and Youth) study forecasts heightened glycemic failure rates and accelerated decline in β-cell function. Read More

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January 2019

Hypothesis: The Vestibular and Cerebellar Basis of the Mal de Debarquement Syndrome.

Front Neurol 2018 5;9:28. Epub 2018 Feb 5.

Department of Neurology, NYU School of Medicine, New York, NY, United States.

The Mal de Debarquement syndrome (MdDS) generally follows sea voyages, but it can occur after turbulent flights or spontaneously. The primary features are objective or perceived continuous rocking, swaying, and/or bobbing at 0.2 Hz after sea voyages or 0. Read More

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February 2018

Remote sensing appraisal of Lake Chad shrinkage connotes severe impacts on green economics and socio-economics of the catchment area.

R Soc Open Sci 2017 Nov 8;4(11):171120. Epub 2017 Nov 8.

Department of Meteorology and Climate Science, School of Earth and Mineral Sciences, Federal University of Technology Akure, PMB 704, Akure, Nigeria.

Lake Chad commonly serves as a major hub of fertile economic activities for the border communities and contributes immensely to the national growth of all the countries that form its boundaries. However, incessant and multi-decadal drying via climate change pose greater threats to this transnational water resource, and adverse effects on ecological sustainability and socio-economic status of the catchment area. Therefore, this study assessed the extent of shrinkage of Lake Chad using remote sensing. Read More

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November 2017