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Human herpesvirus-encoded MicroRNA in host-pathogen interaction.

Adv Biol Regul 2021 Sep 16;82:100829. Epub 2021 Sep 16.

Department of Periodontics, College of Dentistry, University of Illinois at Chicago, United States. Electronic address:

Human herpesviruses (HHV) are ubiquitous, linear dsDNA viruses that establish lifelong latency, disrupted by sporadic reactivation. HHV have evolved diverse ingenious mechanisms to evade robust host defenses. Incorporation of unique stem loop sequences that generate viral microRNAs (v-miRs) exemplifies one such evolutionary adaptation in HHV. Read More

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September 2021

Case report: incessant ventricular fibrillation in a conscious left ventricular assist device patient.

Eur Heart J Case Rep 2021 Sep 7;5(9):ytab337. Epub 2021 Sep 7.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.

Background : Ventricular arrhythmia in left ventricular assist device (LVAD) recipients represents a challenging clinical scenario and the optimal treatment strategy in this unique patient population still needs to be defined.

Case Summary : We report on a 61-year-old LVAD patient with incessant ventricular fibrillation (VF) despite multiple unsuccessful attempts to restore normal rhythm with external defibrillation and antiarrhythmic medication. He remained initially stable as an outpatient and subsequently developed secondary organ failure. Read More

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September 2021

Development of the Bone Phenotype and microRNA Profile in Adults With Low-Density Lipoprotein Receptor-Related Protein 5-High Bone Mass (LRP5-HBM) Disease.

JBMR Plus 2021 Sep 1;5(9):e10534. Epub 2021 Sep 1.

Department of Endocrinology and Metabolism Odense University Hospital Odense Denmark.

Pathogenic variants in the Wnt-pathway co-receptor low-density lipoprotein (LDL) receptor-related protein 5 (LRP5) cause high bone mass (LRP5-HBM) due to insensitivity to the endogenous antagonist of Wnt-signaling. Although indicating incessant progression of BMD and biomarkers reflecting bone formation, this has not been confirmed in individuals with LRP5-HBM. We investigated how the LRP5-HBM bone phenotype changes with age in adults and is associated with quantitative changes of bone turnover markers and bone-related microRNAs (miRNAs) in the circulation. Read More

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September 2021

Molecular phylogenetics and evolutionary analysis of a highly recombinant begomovirus, Cotton leaf curl Multan virus, and associated satellites.

Virus Evol 2021 4;7(2):veab054. Epub 2021 Jun 4.

Plant Protection Research Institute and Guangdong Provincial Key Laboratory of High Technology for Plant Protection, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, P.R. China.

(CLCuMuV) and its associated satellites are a major part of the cotton leaf curl disease (CLCuD) caused by the begomovirus species complex. Despite the implementation of potential disease management strategies, the incessant resurgence of resistance-breaking variants of CLCuMuV imposes a continuous threat to cotton production. Here, we present a focused effort to map the geographical prevalence, genomic diversity, and molecular evolutionary endpoints that enhance disease complexity by facilitating the successful adaptation of CLCuMuV populations to the diversified ecosystems. Read More

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Basal cell carcinoma-not always the 'good guy': Case report of a life-threatening basosquamous carcinoma and review of the literature.

Exp Ther Med 2021 Oct 10;22(4):1158. Epub 2021 Aug 10.

Department of Urology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Cutaneous basosquamous carcinoma is a variant of basal cell carcinoma that is characterized by histopathological features of both basal and squamous cell carcinoma. Due to its local invasiveness, high frequency of recurrence, and its metastatic potential, it is considered to be one of the most aggressive subtypes of basal cell carcinoma. We present the case of an 81-year-old male who was admitted to the hospital with incessant hemorrhage arising from a cutaneous tumor that later proved to be a basosquamous carcinoma. Read More

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October 2021

Incessant multiform ectopy in a young woman: What is the mechanism and treatment?

Heart Rhythm 2021 Sep;18(9):1615-1616

Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California. Electronic address:

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September 2021

Efficacy and landscape of Covid-19 vaccines: a review article.

Rev Assoc Med Bras (1992) 2021 Jan;67(3):474-478

Centro Universitário Cesmac - Maceió (AL), Brazil.

Introduction: The rapid advance of Coronavirus disease 2019 (Covid-19) has led to the incessant search for therapeutic and prophylactic measures to fight the pandemic. Because it is a viral infection, the safest long-term prophylactic form, in addition to social distance and hygiene, is the vaccine.

Objective: Thus, this study aimed at conducting a review of the efficacy and landscape of Covid-19 vaccines. Read More

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January 2021

Cost benefit analysis of a municipal solid waste recycling facility in Soweto, South Africa.

Waste Manag 2021 Oct 26;134:263-269. Epub 2021 Aug 26.

Chemical, Materials and Metallurgical Engineering Department, Faculty of Engineering and Technology, Botswana International University of Science and Technology, Private Mail Bag 16, Palapye, Botswana.

Rapid population and economic growth, changes in consumption pattern etc. have become major contributing factors to severe municipal solid waste generation globally. Thus, various methods are being employed to manage the incessant municipal solid waste generation for a sustainable solid waste management and one of the viable approaches is the recycling option. Read More

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October 2021

Proteomic Advances in Cereal and Vegetable Crops.

Molecules 2021 Aug 14;26(16). Epub 2021 Aug 14.

Centro Tecnológico de la Carne de Galicia, Adva. Galicia n° 4, Parque Tecnológico de Galicia, San Cibrao das Viñas, 32900 Ourense, Spain.

The importance of vegetables in human nutrition, such as cereals, which in many cases represent the main source of daily energy for humans, added to the impact that the incessant increase in demographic pressure has on the demand for these plant foods, entails the search for new technologies that can alleviate this pressure on markets while reducing the carbon footprint of related activities. Plant proteomics arises as a response to these problems, and through research and the application of new technologies, it attempts to enhance areas of food science that are fundamental for the optimization of processes. This review aims to present the different approaches and tools of proteomics in the investigation of new methods for the development of vegetable crops. Read More

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Magnetic Resonance Features of a Recent Catheter Ablation of Left Posterior Fascicular Ventricular Tachycardia.

Cureus 2021 Jul 22;13(7):e16555. Epub 2021 Jul 22.

Cardiology, McLaren Health Care, Flint/Michigan State University, Flint, USA.

A 71-year-old male patient with a past medical history of hypertension, hyperlipidemia, and chronic kidney disease stage II presented with a complaint of intermittent palpitations for three months and was found to have wide complex tachycardia on the electrocardiogram (ECG). The patient was given adenosine and amiodarone, following which he underwent synchronized cardioversion at 150 Joules followed by 200 Joules without successful conversion. He was subsequently initiated on lidocaine drip at the rate of 1 to 4 mg/minute to maintain adequate rhythm control, which converted him to sinus rhythm and relieved his symptoms. Read More

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Case Report: A Novel Variant c.2262+3A>T of the Gene Results in Intron Retention Associated With Incessant Ventricular Tachycardias.

Front Med (Lausanne) 2021 4;8:659119. Epub 2021 Aug 4.

Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.

Voltage-gated sodium channel Na1.5 encoded by the gene plays crucial roles in cardiac electrophysiology. Previous genetic studies have shown that mutations in are associated with multiple inherited cardiac arrhythmias. Read More

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To the Surface and Back: Exo- and Endocytic Pathways in .

Front Cell Dev Biol 2021 6;9:720521. Epub 2021 Aug 6.

Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.

is one of only a few unicellular pathogens that thrives extracellularly in the vertebrate host. Consequently, the cell surface plays a critical role in both immune recognition and immune evasion. The variant surface glycoprotein (VSG) coats the entire surface of the parasite and acts as a flexible shield to protect invariant proteins against immune recognition. Read More

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An unusual incessant long RP tachycardia-What is the mechanism?

Heart Rhythm 2021 Aug 19. Epub 2021 Aug 19.

Division of Cardiology, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.

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Refractory Ventricular Tachycardia Originating From an Intracardiac Metastasis Treated With Catheter Ablation.

JACC Case Rep 2021 Aug 23;3(9):1231-1235. Epub 2021 Jun 23.

Department of Cardiology, Center for Arrhythmia Care, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.

A 45-year-old man with stage IV melanoma presented with incessant nonsustained wide complex tachycardia. He was found to have a right ventricular intracardiac metastasis that created a nidus for ventricular tachycardia refractory to multiple therapeutic interventions. The patient underwent catheter ablation for this rare indication, with successful arrhythmia control by direct ablation over the tumor surface. Read More

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Incessant threat of COVID-19 variants: Highlighting need for a mix of FDA-approved artificial intelligence tools and community pharmacy services.

Res Social Adm Pharm 2021 Jul 21. Epub 2021 Jul 21.

Ziauddin University, Karachi, Pakistan. Electronic address:

Seamless integration of artificial intelligence (AI) technology, especially FDA-approved AI tools, in community pharmacies can build increasingly effective and easy care pathways, thereby minimizing burden on healthcare system, and ensuring compliance to preventive measure through limiting hospital visits. In this regard, the WHO needs to enlist and provide guidance on most promising AI tools that can be implemented in community pharmacy settings. Read More

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Stabilizing the Solid-Electrolyte Interphase with Polyacrylamide for High-Voltage Aqueous Lithium-Ion Batteries.

Angew Chem Int Ed Engl 2021 Aug 11. Epub 2021 Aug 11.

Helmholtz-Institute Muenster (HI MS), IEK-12, Forschungszentrum Juelich GmbH, Corrensstr. 46, 48149, Muenster, Germany.

The introduction of "water-in-salt" electrolyte (WiSE) concept opens a new horizon to aqueous electrochemistry that is benefited from the formation of a solid-electrolyte interphase (SEI). However, such SEI still faces multiple challenges, including dissolution, mechanical damaging, and incessant reforming, which result in poor cycling stability. Here, we report a polymeric additive, polyacrylamide (PAM) that effectively stabilizes the interphase in WiSE. Read More

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Tackling Virulence of by the Natural Furanone Sotolon.

Antibiotics (Basel) 2021 Jul 17;10(7). Epub 2021 Jul 17.

Department of Microbiology and Biotechnology, Faculty of Pharmacy, Delta University for Science and Biotechnology, Gamasa 35712, Egypt.

The bacterial resistance development due to the incessant administration of antibiotics has led to difficulty in their treatment. Natural adjuvant compounds can be co-administered to hinder the pathogenesis of resistant bacteria. Sotolon is the prevailing aromatic compound that gives fenugreek its typical smell. Read More

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An unusual tachycardia - Tale of a hidden P wave.

J Electrocardiol 2021 Jul 27;68:53-55. Epub 2021 Jul 27.

Section of Cardiac Electrophysiology, Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Traditional rules of arrhythmia mechanisms may not apply in altered anatomical states such as heart transplantation. We present a case of a young man presenting with incessant tachycardia that violates routine electrocardiographic criteria for rhythm analysis. Meticulous attention to surgical techniques and anastomotic sites is crucial when approaching post-operative arrhythmias. Read More

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Incessant Atrial Tachycardia as First Presentation of Cardiac Angiosarcoma.

JACC Case Rep 2021 Apr 21;3(4):619-624. Epub 2021 Apr 21.

UCLA Cardiac Arrhythmia Center, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.

Primary cardiac angiosarcomas are rare malignant tumors with a very poor prognosis. We present a case of a 48-year-old man with no previous cardiac history who developed an incessant focal atrial tachycardia complicated by tachycardia-mediated cardiomyopathy as a consequence of cardiac angiosarcoma. (). Read More

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A Shocking Case of Far-Field Atrial Oversensing in Giant-Cell Myocarditis.

JACC Case Rep 2021 Apr 21;3(4):603-609. Epub 2021 Apr 21.

Department of Internal Medicine, Division of Cardiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

We report a unique case of delivery of inappropriate implantable cardioverter-defibrillator therapies related to a "perfect storm": presence of an integrated lead, insufficient lead slack related to right heart dilation resulting in shock coil misplacement, myocarditis with loss of R waves, and the concomitant occurrence of an incessant atrial tachycardia. (). Read More

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Epicardial Ablation of Persistent Junctional Reciprocating Tachycardia in an Infant With Tachycardia-Induced Cardiomyopathy.

JACC Case Rep 2021 Mar 17;3(3):512-516. Epub 2021 Mar 17.

Department of Pediatrics, University of Florida School of Medicine, Jacksonville, Florida, USA.

A 3-month-old infant who developed persistent junctional reciprocating tachycardia (PJRT)-induced cardiomyopathy that was successfully treated with radiofrequency ablation. To our knowledge this is the youngest reported patient with a successful epicardial lesion placed in a diverticulum off the coronary sinus and also the first report of a PJRT connection located at an epicardial site distinct from the mitral and tricuspid valve annulus. We use this case to highlight how low-power lesions in the coronary sinus in the youngest of patients can achieve results safely. Read More

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Severe Heart Failure Associated With Tachycardia-Induced Cardiomyopathy Due to Incessant Atrioventricular Re-Entrant Tachycardia.

JACC Case Rep 2021 Mar 3;3(3):479-483. Epub 2021 Feb 3.

Assistance Publique-Hôpitaux de Paris, Henri Mondor Hospital, Cardiology Department, Créteil, France.

Short RP interval atrioventricular re-entrant tachycardias do not typically present as an incessant form. We present 2 cases of incessant atrioventricular re-entrant tachycardias leading to tachycardia-induced cardiomyopathy with severe heart failure presentation in middle-aged adults. Both underwent accessory pathway ablation and recovered normal left ventricle function before hospital discharge. Read More

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Incessant Pericarditis With Recurrent Cardiac Tamponade as the Manifestation of Autoimmune Polyglandular Syndrome Type II.

JACC Case Rep 2020 Aug 19;2(10):1536-1541. Epub 2020 Aug 19.

Cardiology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

A 23-year-old man was admitted for acute pericarditis that evolved to cardiac tamponade and shock with need of emergent pericardiocentesis and inotropic support. Corticosteroid therapy was successful, but despite a gradual tapering, the patient relapsed. Incidentally, the patient developed hyperkalemia with hyponatremia. Read More

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Basin-wide flood depth and exposure mapping from SAR images and machine learning models.

J Environ Manage 2021 Nov 26;297:113367. Epub 2021 Jul 26.

Faculty of Environmental Earth Science, Hokkaido University, Sapporo, 060-0810, Japan. Electronic address:

Recent years recorded an increasing number of short duration - high-intensity rainfall events in the Indian subcontinent consequent with urban and riverine flash floods. Rapid assessments of flooded areas are key for effective mitigation strategies and disaster risk plans, as well as to prepare operative policies for future events. Herein, we present an integrated methodology for rapidly mapping the flood extent, and depths based on Synthetic Aperture Radar (SAR) images and a digital elevation model (DEM). Read More

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November 2021

Effect of a tropical cyclone on the distribution of heavy metals in the marine sediments off Kameswaram, Southeast coast of India.

Mar Pollut Bull 2021 Jul 22;171:112741. Epub 2021 Jul 22.

Department of Applied Geology, University of Madras, Guindy Campus, Chennai 600 025, India.

Cyclones and heavy rainfalls are the main reasons for incessant environmental aggravation in the coastal regions and the distribution of pollutants from the contaminated terrestrial areas to the offshore regions. Twenty-five surface sediment samples were collected off Kameswaram, SE coast of India, and assessed for their geochemical and sedimentological characteristics post Cyclone Gaja. Sediment texture and various geochemical analyses were carried out to assess the metal distribution in the study area. Read More

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Automated Localization of Focal Ventricular Tachycardia From Simulated Implanted Device Electrograms: A Combined Physics-AI Approach.

Front Physiol 2021 1;12:682446. Epub 2021 Jul 1.

King's College London, London, United Kingdom.

Focal ventricular tachycardia (VT) is a life-threating arrhythmia, responsible for high morbidity rates and sudden cardiac death (SCD). Radiofrequency ablation is the only curative therapy against incessant VT; however, its success is dependent on accurate localization of its source, which is highly invasive and time-consuming. The goal of our study is, as a proof of concept, to demonstrate the possibility of utilizing electrogram (EGM) recordings from cardiac implantable electronic devices (CIEDs). Read More

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How we treat primary central nervous system lymphoma.

ESMO Open 2021 Aug 13;6(4):100213. Epub 2021 Jul 13.

Lymphoma Unit, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milan. Electronic address:

Primary diffuse large B-cell (DLBCL) lymphoma of the central nervous system (CNS) (PCNSL) is a new lymphoma entity, recognized by the 2017 WHO classification of hematopoietic and lymphoid tumors. Unlike systemic DLBCL, the use of anthracycline-based chemotherapy combinations is associated with disappointing outcomes, due to low CNS bioavailability of related drugs. Therefore, international researchers investigated alternative strategies, mostly including drugs able to cross the blood-brain-barrier at low or high doses, with a progressive improvement in survival. Read More

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Stellate ganglion block as rescue therapy in drug-resistant electrical storm.

Ann Card Anaesth 2021 Jul-Sep;24(3):415-418

Department of Cardiology, HealthWorld Hospitals, Durgapur, West Bengal, India.

Electrical storm or incessant ventricular tachycardia is a life-threatening condition and is associated with high morbidity and mortality. Often patients respond to traditional anti-arrhythmia treatment. However, some patients are resistant to the drug therapy and thus, pose huge challenges in effective management. Read More

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Epicardial ablation of incessant left atrial appendage tachycardia in a case with tachycardiomyopathy.

J Interv Card Electrophysiol 2021 Jul 8. Epub 2021 Jul 8.

Electrocardiology Department, National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico.

Atrial tachycardias originated at the left atrial appendage (LAA) are uncommon; often they are incessant and might induce tachycardiomyopathy, as discussed by Hillock et al. (Heart Rhythm;3(4):467-469, 2006). A case of a 21-year-old woman with incessant atrial tachycardia is presented, refractory to medical therapy, echocardiography showed global dilation with LV ejection fraction of 20%. Read More

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Radiofrequency catheter ablation of cranial vena cava flutter in four dogs.

J Vet Cardiol 2021 Aug 9;36:123-130. Epub 2021 Jun 9.

Cardiology Department, Clinica Veterinaria Malpensa - AniCura, Viale Marconi 27, Samarate, Varese, 21017, Italy; Department of Clinical Sciences, Cornell College of Veterinary Medicine, Ithaca, NY, 14853-6401, USA. Electronic address:

Four dogs were referred to our institution for incessant supraventricular tachycardias causing weakness; congestive heart failure was present in one dog. At admission, all dogs had a surface electrocardiogram showing a narrow QRS complex tachycardia with a ventricular rate ranging from 80 to 300 bpm, variable atrioventricular conduction ratio from 1:1 to 3:1, and positive atrial depolarizations in inferior leads (II, II, III, and aVF), with isoelectric lines between them. Three of four dogs had a dilated cardiomyopathy phenotype; one dog had a heart base tumor involving the cranial vena cava wall. Read More

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