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Locked-In Syndrome: A Systematic Review of Long-Term Management and Prognosis.

Cureus 2021 Jul 29;13(7):e16727. Epub 2021 Jul 29.

General Medicine, Universidad Católica de Santiago de Guayaquil, Guayaquil, ECU.

Locked-in syndrome (LIS) is a neurological disorder in which there is damage to the ventral pons and caudal midbrain. An ischemic cause, such as basilar artery occlusion, can often lead to LIS. LIS has three subtypes: classical, partial, and total. Read More

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Simple and precise characterization of differential modal group delay arising in few-mode fiber.

Opt Lett 2021 Jun;46(12):2856-2859

In this Letter, we propose a simple and high-precision differential modal group delay (DMGD) characterization method for few-mode fibers (FMF) by using the frequency-modulated continuous wave. Since the detected signals are located at the low-frequency range, our DMGD characterization method waives the use of expensive equipment, such as vector network or optical spectrum analyzers. Due to the high linearity of the used Mach-Zehnder modulator, our DMGD measurement is free from the complex auxiliary interferometer, leading to an improvement of characterization precision. Read More

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Characteristics and Prevalence of Lifetime Sexual Victimization Among a Sample of Men and Women with Intellectual Disabilities.

J Interpers Violence 2021 Apr 18:8862605211006373. Epub 2021 Apr 18.

Universitat de Barcelona, Spain.

This study examines the prevalence and characteristics of sexual victimization experiences suffered by people with intellectual disabilities (ID). The sample consisted of 260 adults with an ID diagnosis (154 men and 106 women), ranging in age from 20 to 71 years (M = 41.69, SD = 12. Read More

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Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments.

J Vis Exp 2021 02 12(168). Epub 2021 Feb 12.

Department of Cell Biology, Duke University; Department of Biochemistry, Duke University.

Neuronal axon initial segments (AIS) are sites of initiation of action potentials and have been extensively studied for their molecular structure, assembly and activity-dependent plasticity. Giant ankyrin-G, the master organizer of AIS, directly associates with membrane-spanning voltage gated sodium (VSVG) and potassium channels (KCNQ2/3), as well as 186 kDa neurofascin, a L1CAM cell adhesion molecule. Giant ankyrin-G also binds to and recruits cytoplasmic AIS molecules including beta-4-spectrin, and the microtubule-binding proteins, EB1/EB3 and Ndel1. Read More

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February 2021

Geometrically Editable Face Image Translation With Adversarial Networks.

IEEE Trans Image Process 2021 12;30:2771-2783. Epub 2021 Feb 12.

Recently, image-to-image translation has received increasing attention, which aims to map images in one domain to another specific one. Existing methods mainly solve this task via a deep generative model that they focus on exploring the bi-directional or multi-directional relationship between specific domains. Those domains are often categorized by attribute-level or class-level labels, which do not incorporate any geometric information in learning process. Read More

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February 2021

Probabilistic Structure Learning for EEG/MEG Source Imaging With Hierarchical Graph Priors.

IEEE Trans Med Imaging 2021 01 29;40(1):321-334. Epub 2020 Dec 29.

Brain source imaging is an important method for noninvasively characterizing brain activity using Electroencephalogram (EEG) or Magnetoencephalography (MEG) recordings. Traditional EEG/MEG Source Imaging (ESI) methods usually assume the source activities at different time points are unrelated, and do not utilize the temporal structure in the source activation, making the ESI analysis sensitive to noise. Some methods may encourage very similar activation patterns across the entire time course and may be incapable of accounting the variation along the time course. Read More

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January 2021

Right single lung transplantation using an inverted left donor lung: interposition of pericardial conduit for pulmonary venous anastomosis - a case report.

BMC Pulm Med 2020 Feb 19;20(1):46. Epub 2020 Feb 19.

Organ Transplant Center, Okayama University Hospital, Okayama, Japan.

Background: Lung transplantation (LTx) is still limited by the shortage of suitable donor lungs. Developing flexible surgical procedures can help to increase the chances of LTx by unfolding recipient-to-donor matching options based on the pre-existing organ allocation concept. We report a case in which a successful left-to-right inverted LTx was completed using the interposition of a pericardial conduit for pulmonary venous anastomosis. Read More

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February 2020

Network capacity with probit-based stochastic user equilibrium problem.

PLoS One 2017 8;12(2):e0171158. Epub 2017 Feb 8.

Jiangsu Province Collaborative Innovation Center for Modern Urban Traffic Technologies, Nanjing, China.

Among different stochastic user equilibrium (SUE) traffic assignment models, the Logit-based stochastic user equilibrium (SUE) is extensively investigated by researchers. It is constantly formulated as the low-level problem to describe the drivers' route choice behavior in bi-level problems such as network design, toll optimization et al. The Probit-based SUE model receives far less attention compared with Logit-based model albeit the assignment result is more consistent with drivers' behavior. Read More

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Integrating gastrocnemius force-length properties, activation and operating lengths reveals how deal with ecological challenges.

J Exp Biol 2017 Mar 15;220(Pt 5):796-806. Epub 2016 Dec 15.

Department of Biology, University of California, 900 University Avenue, Riverside, CA 92521, USA.

A central question in biology is how animals successfully behave under complex natural conditions. Although changes in locomotor behaviour, motor control and force production in relation to incline are commonly examined, a wide range of other factors, including a range of perch diameters, pervades arboreal habitats. Moving on different substrate diameters requires considerable alteration of body and limb posture, probably causing significant shifts in the lengths of the muscle-tendon units powering locomotion. Read More

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Multicriteria assessment of advanced treatment technologies for micropollutants removal at large-scale applications.

Sci Total Environ 2016 Sep 16;563-564:1050-67. Epub 2016 May 16.

Environmental Engineering and Management Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.

With the introduction and discharge of thousands of new micropollutants (MPs) every year, traditional water and wastewater treatment plants may be incapable of tackling them all. With their low concentrations and diversity in nature, MP removal encounters numerous challenges. Although some MPs are effectively eliminated via conventional treatment methods, most of them can easily escape and are retained in the discharged effluent. Read More

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September 2016

Multiple-Layer Visibility Propagation-Based Synthetic Aperture Imaging through Occlusion.

Sensors (Basel) 2015 Aug 4;15(8):18965-84. Epub 2015 Aug 4.

ShaanXi Provincial Key Lab of Speech and Image Information Processing, School of Computer Science, Northwestern Polytechnical University, Xi\'an 710129, China.

Heavy occlusions in cluttered scenes impose significant challenges to many computer vision applications. Recent light field imaging systems provide new see-through capabilities through synthetic aperture imaging (SAI) to overcome the occlusion problem. Existing synthetic aperture imaging methods, however, emulate focusing at a specific depth layer, but are incapable of producing an all-in-focus see-through image. Read More

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Performance variation in motor imagery brain-computer interface: a brief review.

J Neurosci Methods 2015 Mar 8;243:103-10. Epub 2015 Feb 8.

School of Information and Communications, Gwangju Institute of Science and Technology, Gwangju 500-712, South Korea. Electronic address:

Brain-computer interface (BCI) technology has attracted significant attention over recent decades, and has made remarkable progress. However, BCI still faces a critical hurdle, in that performance varies greatly across and even within subjects, an obstacle that degrades the reliability of BCI systems. Understanding the causes of these problems is important if we are to create more stable systems. Read More

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Joint analysis of differential gene expression in multiple studies using correlation motifs.

Biostatistics 2015 Jan 19;16(1):31-46. Epub 2014 Aug 19.

Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA

The standard methods for detecting differential gene expression are mostly designed for analyzing a single gene expression experiment. When data from multiple related gene expression studies are available, separately analyzing each study is not ideal as it may fail to detect important genes with consistent but relatively weak differential signals in multiple studies. Jointly modeling all data allows one to borrow information across studies to improve the analysis. Read More

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January 2015

An evidential reasoning based model for diagnosis of lymph node metastasis in gastric cancer.

BMC Med Inform Decis Mak 2013 Nov 6;13:123. Epub 2013 Nov 6.

School of Computer Science and Technology, Xidian University, Xi'an 710071, P, R, China.

Background: Lymph node metastasis (LNM) in gastric cancer is a very important prognostic factor affecting long-term survival. Currently, several common imaging techniques are used to evaluate the lymph node status. However, they are incapable of achieving both high sensitivity and specificity simultaneously. Read More

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November 2013

Automatic removal of manually induced artefacts in ultrasound images of thyroid gland.

Annu Int Conf IEEE Eng Med Biol Soc 2013 ;2013:3399-402

Manually induced artefacts, like caliper marks and anatomical labels, render an ultrasound (US) image incapable of being subjected to further processes of Computer Aided Diagnosis (CAD). In this paper, we propose a technique to remove these artefacts and restore the image as accurately as possible. The technique finds application as a pre-processing step when developing unsupervised segmentation algorithms for US images that deal with automatic estimation of the number of segments and clustering. Read More

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Alternate copies of D1 are used by cyanobacteria under different environmental conditions.

Photosynth Res 2012 Dec 11;114(2):133-5. Epub 2012 Nov 11.

Department of Biological Sciences, Purdue University, Lilly Hall of Life Sciences, West Lafayette, IN 47907, USA.

All cyanobacteria sequenced to date have multiple psbA genes, encoding the D1 protein. Some of these psbA genes have a series of mutations that would seem to render D1 incapable of binding the Mn(4)CaO(5) metallocluster (Murray, Photosynth Res 110(3):177-184, 2012). Nonetheless, these genes are expressed under specific environmental conditions, such as during N(2) fixation in unicellular diazotrophs of the genes Cyanothece. Read More

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December 2012

Tensor hypercontraction density fitting. I. Quartic scaling second- and third-order Møller-Plesset perturbation theory.

J Chem Phys 2012 Jul;137(4):044103

Department of Chemistry and the PULSE Institute, Stanford University, Stanford, California 94305, USA.

Many approximations have been developed to help deal with the O(N(4)) growth of the electron repulsion integral (ERI) tensor, where N is the number of one-electron basis functions used to represent the electronic wavefunction. Of these, the density fitting (DF) approximation is currently the most widely used despite the fact that it is often incapable of altering the underlying scaling of computational effort with respect to molecular size. We present a method for exploiting sparsity in three-center overlap integrals through tensor decomposition to obtain a low-rank approximation to density fitting (tensor hypercontraction density fitting or THC-DF). Read More

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Are general practitioners prepared to end life on request in a country where euthanasia is legalised?

J Med Ethics 2012 May 10;38(5):274-80. Epub 2012 Jan 10.

Department of General Practice and Primary Health Care, University Hospital 1K3, De Pintelaan 185, 9000 Ghent, Belgium.

Background: In 2002, Belgium set a legal framework for euthanasia, whereby granting and performing euthanasia is entrusted entirely to physicians, and-as advised by Belgian Medical Deontology--in the context of a trusted patient--physician relationship. Euthanasia is, however, rarely practiced, so the average physician will not attain routine in this matter.

Aim: To explore how general practitioners in Flanders (Belgium) deal with euthanasia. Read More

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[Education for self-administered antibiotic therapy: a pragmatic and ethical alternative for the treatment of STDs for the street youth of Kinshasa in the Democratic Republic of the Congo (RDC)].

Sante 2009 Oct-Dec;19(4):217-25. Epub 2010 Feb 26.

IRSS/HELESI, UCL/ Belgique, Clos Chapelle-aux-champs 30, 1200 Woluwe-Saint-Lambert, Belgique.

All healthcare providers decide in someone else's place, for someone else. In doing so, they take their place in a long long tradition, that of medical paternalism. Patients are treated as children, incapable of making decisions about themselves. Read More

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Explanation and relations. How do general practitioners deal with patients with persistent medically unexplained symptoms: a focus group study.

BMC Fam Pract 2009 Sep 24;10:68. Epub 2009 Sep 24.

Department of Primary and Community Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Background: Persistent presentation of medically unexplained symptoms (MUS) is troublesome for general practitioners (GPs) and causes pressure on the doctor-patient relationship. As a consequence, GPs face the problem of establishing an ongoing, preferably effective relationship with these patients. This study aims at exploring GPs' perceptions about explaining MUS to patients and about how relationships with these patients evolve over time in daily practice. Read More

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September 2009

To both be like a captain and fellow worker of the caring team: the meaning of Nurse Assistants' expectations of Registered Nurses in Swedish residential care homes.

Int J Older People Nurs 2008 Mar;3(1):35-45

Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, SwedenProfessor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, SwedenProfessor, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, SwedenProfessor, Department of Caring and Public Health Sciences, Mälardalen University, Västerås, Sweden.

Aim.  To describe the expectations of and to illuminate the meaning of the Nurse Assistants' (NA) expectations of Registered Nurses (RN) who are responsible for the care of older people living in residential care homes in Sweden. Background. Read More

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Image classification using correlation tensor analysis.

IEEE Trans Image Process 2008 Feb;17(2):226-34

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Images, as high-dimensional data, usually embody large variabilities. To classify images for versatile applications, an effective algorithm is necessarily designed by systematically considering the data structure, similarity metric, discriminant subspace, and classifier. In this paper, we provide evidence that, besides the Fisher criterion, graph embedding, and tensorization used in many existing methods, the correlation-based similarity metric embodied in supervised multilinear discriminant subspace learning can additionally improve the classification performance. Read More

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February 2008

A fuzzy analytic network process for multi-criteria evaluation of contaminated site remedial countermeasures.

J Environ Manage 2008 Aug 30;88(3):479-95. Epub 2007 Apr 30.

Laboratory of Sound Material-Cycle Systems Planning, Graduate School of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo 060-8628, Hokkaido, Japan.

The Analytic Network Process (ANP) has been proposed to incorporate interdependence and feedback effect in the prioritization of remedial countermeasures using a hierarchical network decision model, but this approach seems to be incapable of capturing the vagueness and fuzziness during value judgment elicitation. The aim of this paper is to present an evaluation method using a fuzzy ANP (FANP) approach to address this shortcoming. Triangular fuzzy numbers (TFN) and their degree of fuzziness are used in the semantic scale as human judgment expressed in natural language is most often vague and fuzzy. Read More

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[Professional ethics and institutional ethics: convergence or conflict?].

Authors:
Diego Gracia

Rev Esp Salud Publica 2006 Sep-Oct;80(5):457-67

Unidad de Historia de la Medicina, Departamento de Medicina Preventiva, Salud Pública e Historia de la Ciencia, Facultad de Medicina, Universidad Complutense de Madrid.

During the last decades, an important debate about professions in general, and particularly about the medical profession, has taken place. The classic idea that professionals do have a "special mora lity", different from the common morality, which among other things give them legal impunity, came to a head. This causes a great deal of confusion among the professionals, incapable of reacting and redefining precisely their own identity. Read More

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January 2007

Multiagent scheduling method with earliness and tardiness objectives in flexible job shops.

IEEE Trans Syst Man Cybern B Cybern 2005 Apr;35(2):293-301

Department of Industrial and Management Systems Engineering, University of South Florida, Tampa, FL 33620, USA.

Flexible job-shop scheduling problems are an important extension of the classical job-shop scheduling problems and present additional complexity. Such problems are mainly due to the existence of a considerable amount of overlapping capacities with modern machines. Classical scheduling methods are generally incapable of addressing such capacity overlapping. Read More

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The case of K.C.: contributions of a memory-impaired person to memory theory.

Neuropsychologia 2005 12;43(7):989-1021. Epub 2005 Jan 12.

Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont., Canada M6A 2E1.

K.C. has been investigated extensively over some 20 years since a motorcycle accident left him with widespread brain damage that includes large bilateral hippocampal lesions, which caused a remarkable case of memory impairment. Read More

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September 2005

[A device for feminine urinary incontinence].

Rev Enferm 2004 Jan;27(1):52-4

Centro de Salud "Pinillo Chico", Puerto de Santa María, Distrito Sanitario Bahía de Cádiz la Janda. Cádiz.

Urinary incontinence is grave health problem which causes severe repercussions in the quality of life of those patients which suffer it and it is a serious risk factor in the development of pressure sores or ulcers. Urinary collecting sacks provide an option to deal with this problem even though up to present time these collecting sacks were only available for male patients. In this instrument usage article, the authors introduce a new device, VILUC, commercialized by Lauclar Laboratories in Spain, for feminine urinary incontinence as a possible alternate treatment for women affected by this problem who are incapable of maintaining a progressive and complete vesicle reeducation. Read More

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January 2004

Compounding TPN admixtures: then and now.

Authors:
David F Driscoll

JPEN J Parenter Enteral Nutr 2003 Nov-Dec;27(6):433-8; quiz 439

Department of Medicine, B.l. Deaconess Medical Center and, Harvard Medical School, Boston, Massachusetts, USA.

Compounding TPN admixtures has significantly developed since the first clinical reports by Dr. Dudrick and colleagues from the University of Pennsylvania approximately 35 years ago. Today, the responsibility for the compounding of sage parenteral nutrition admixtures for patients incapable of oral or enteral nutrition primarily rests with the pharmacy department. Read More

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New developments in STIs and SIT.

Authors:

Proj Inf Perspect 2000 Oct(31)

As more and more researchers have come to acknowledge that current treatments are incapable of eradicating HIV, growing attention has been focused on structured treatment interruptions (STIs) and structured intermittent therapy (SIT). New strategies will apparently be required to deal with issues around long-term use of anti-HIV therapies, including side effects, adherence, treatment fatigue and the lifetime costs of the anti-HIV drugs. If ways can be found to make treatment a temporary or intermittent requirement, many of these problems might be resolved. Read More

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October 2000

Stem cells and neuropoiesis in the adult human brain.

Lancet 2002 Mar;359(9311):1047-54

Department of Neuroscience, McKnight Brain Institute and Shands Cancer Center, University of Florida Program in Stem Cell Biology, College of Medicine, Gainesville, FL 32610, USA.

Stem cells in adult tissues have attracted a great deal of interest. These cells are self-renewing and can give rise to diverse progeny. An extraordinary finding was the presence of stem cells in the mature human brain. Read More

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