535,281 results match your criteria in-hospital mortality

Continuous metabolic syndrome severity score and the risk of CVD and all-cause mortality.

Eur J Clin Invest 2022 May 22:e13817. Epub 2022 May 22.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: The dualistic diagnostic criteria for metabolic syndrome overlooked the severity of metabolic syndrome, and the relationships between the severity of metabolic syndrome and adverse health conditions are poorly characterized. We therefore aimed to investigate the associations of metabolic syndrome severity with incident cardiovascular disease (CVD)/all-cause mortality.

Methods: A total of 116772 participants from the Kailuan study were followed up biennially between 2006 and 2018. Read More

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Splenic artery aneurysm in pregnancy: a systematic review.

Int J Gynaecol Obstet 2022 May 22. Epub 2022 May 22.

Department of Metabolism, Digestion and Reproduction, Imperial College London.

Background: Splenic artery aneurysms (SAA) are associated with significant maternal and fetal mortality when ruptured in pregnancy. However, there is no consensus on the optimal obstetric management of both ruptured and asymptomatic SAA.

Objective: To evaluate risk factors, presentation, investigation and management of SAA in pregnancy and puerperium. Read More

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A Clinical Profile of Patients with Hyperuricemia and the Relationship between Hyperuricemia and Metabolic Syndrome: A Cross-sectional Study at a Tertiary Hospital in the Indian Population.

J Assoc Physicians India 2022 05;70(5):11-12

Assistant Professor, Department of General Medicine, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra.

Introduction: Metabolic syndrome is a constellation of interrelated risk factors that increase the risk of cardiovascular diseases (CVD) and diabetes mellitus. The increase in prevalence of hyperuricemia was considered to be directly related to increasing incidence of obesity and Metabolic Syndrome in developing and developed countries. Hyperuricemia is defined as serum uric acid of 6. Read More

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Circulatory Cytokine Levels as a Predictor of Disease Severity in COVID-19: A Study from Western India.

J Assoc Physicians India 2022 May;70(5):11-12

Assistant Professor, Department of General Medicine, SMS Medical College and Hospital, Jaipur, Rajasthan.

Inflammatory response in COVID-19 responsible for acute respiratory distress syndrome (ARDS) and multiorgan failure and play a major role in morbidity and mortality of patients. The present study was undertaken to assess serum level of cytokines and its association with other inflammatory markers and disease severity in COVID-19 and hence their prognostic significance.

Methods: This was a retrospective observational study of 175 admitted COVID-19 patients. Read More

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Serum Magnesium Levels in Critically Ill Patients on Admission in ICU and its Correlation with Outcome.

J Assoc Physicians India 2022 May;70(5):11-12

Research Consultant, Poona Hospital & Research Centre, Pune, Maharashtra.

Background: Many studies found that only hypomagnesemia, but not hypermagnesemia is linked with increased mortality. However, reports of mortality due to magnesium dysregulation in the critical care setting are controversial.

Objectives: To study serum magnesium levels in critically ill patients on admission in intensive care unit (ICU) and its correlation with patient's need and duration for ventilator support, duration of ICU stay, incidence of cardiac arrhythmias and mortality Methods: Two hundred forty six critically ill patients admitted in ICU with Acute Physiology and Chronic Health Evaluation (APACHE) II scores>10, were included for this prospective observational study. Read More

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AGEs-RAGE axis mediates myocardial fibrosis via activation of cardiac fibroblasts induced by autophagy in heart failure.

Exp Physiol 2022 May 22. Epub 2022 May 22.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

New Findings: What is the central question of this study? Does the AGEs-RAGE axis mediate myocardial fibrosis in heart failure? What is the main finding and its importance? The AGEs-RAGE axis is involved in the pathogenesis of myocardial fibrosis through CFs activation induced by autophagy in heart failure. Inhibiting AGEs-RAGE axis attenuates dysfunction in the heart and attenuates myocardial fibrosis in mice with TAC via suppressing CFs activation.

Abstract: Background: Heart failure is the end stage of cardiovascular diseases, and is a critical medical condition that poses an important therapeutic challenge for physicians due to its high morbidity and mortality. Read More

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Risk Factors and Outcomes for COVID-19 in Autoimmune Inflammatory Diseases during the SARS-CoV-2 Pandemic: A Comparative Study.

Isr Med Assoc J 2022 May;24(5):299-305

Department of Postgraduate Studies, Faculty of Medicine, National University Autonomous of Mexico, México City, México.

Background: Patients with autoimmune disease (AID) and coronavirus disease 2019 (COVID-19) could have higher mortality due to the co-morbidity and the use of immunosuppressive therapy.

Objectives: To analyze the risk factors and outcomes of patients with AID and COVID-19 versus a control group.

Methods: A prospective cohort study included patients with and without AID and COVID-19. Read More

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Early Postoperative Complications and Ambulation in Patients Treated for Hip Fractures, the Unexpected Positive Influence of the COVID-19 Pandemic: A Comparison Study.

Isr Med Assoc J 2022 May;24(5):293-298

Department of Orthopedic Surgery, Sheba Medical Center, Tel Hashomer, Israel.

Background: The influence of the coronavirus disease 2019 (COVID-19) pandemic caused countries worldwide to implement lockdowns. Elective surgeries were temporarily suspended, with surgeries being performed only for emergent/urgent medical conditions such as hip fractures where early surgical intervention has shown decreased rates of morbidity/mortality.

Objectives: To assess the indirect influence of the COVID-19 pandemic and associated lockdown on hip fracture patients, considering factors such as time to surgery, early postoperative complications, and ambulation status. Read More

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Critically ill COVID-19 patients in northeast Brazil: mortality predictors during the first and second waves including SAPS 3.

Trans R Soc Trop Med Hyg 2022 May 22. Epub 2022 May 22.

University of Fortaleza, Av. Washington Soares, 1321, Fortaleza, CE, 60811-905, Brazil.

Background: The Simplified Acute Physiology Score (SAPS) 3 is a reliable score to predict mortality. This study aims to investigate the predictive values of SAPS 3 and other clinical parameters for death in critically ill coronavirus disease 2019 (COVID-19) patients.

Methods: This is a prospective study in a tertiary hospital for patients who required intensive care due to COVID-19 infection in northeast Brazil. Read More

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Microbiologically confirmed infections and antibiotic-resistance in a national surveillance study of hospitalised patients who died with COVID-19, Italy 2020-2021.

Antimicrob Resist Infect Control 2022 May 21;11(1):74. Epub 2022 May 21.

Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore Di Sanità, Rome, Italy.

Background: Patients hospitalised for COVID-19 may present with or acquire bacterial or fungal infections that can affect the course of the disease. The aim of this study was to describe the microbiological characteristics of laboratory-confirmed infections in hospitalised patients with severe COVID-19.

Methods: We reviewed the hospital charts of a sample of patients deceased with COVID-19 from the Italian National COVID-19 Surveillance, who had laboratory-confirmed bacterial or fungal bloodstream infections (BSI) or lower respiratory tract infections (LRTI), evaluating the pathogens responsible for the infections and their antimicrobial susceptibility. Read More

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Direct oral anticoagulant versus low molecular weight heparin for the treatment of cancer-associated venous thromboembolism: 2022 updated systematic review and meta-analysis of randomized controlled trials.

J Hematol Oncol 2022 May 21;15(1):69. Epub 2022 May 21.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

International clinical practice guidelines have progressively endorsed direct oral anticoagulants (DOACs) as an alternative to low-molecular-weight heparins (LMWHs) monotherapy for the initial and long-term treatment of cancer-associated thrombosis (CAT). Several new randomized controlled trials (RCTs) have recently reported additional results on the safety and efficacy of DOACs in this setting. We performed an updated meta-analysis of all publicly available data from RCTs comparing DOACs with LMWHs for the treatment of CAT. Read More

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Effects of different doses of methylprednisolone on clinical outcomes in patients with severe community-acquired pneumonia: a study protocol for a randomized controlled trial.

Trials 2022 May 21;23(1):423. Epub 2022 May 21.

Department of Intensive Care Unit, Shengli Oilfield Central Hospital, Dongying, China.

Background: The specific use of methylprednisolone in severe community-acquired pneumonia (SCAP) has not yet formed a consensus. It is not clear whether the clinical efficacy of methylprednisolone in SCAP is dose-dependent, and how to balance the best efficacy with the least complications. The aim of this study is to evaluate the efficacy and safety of different doses of methylprednisolone in the adjuvant treatment for patients with SCAP. Read More

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Pancreatic surgery during the COVID-19 pandemic 2020-2021: an observational cohort study from a third level referral center.

BMC Surg 2022 May 21;22(1):200. Epub 2022 May 21.

Department of Surgery and Transplantation, Rigshospitalet Copenhagen University Hospital, 2100, Copenhagen, Denmark.

Background: During the COVID pandemic there has been limited access to elective surgery including oncologic surgery in several countries world-wide. The aim of this study was to investigate if there was any lockdown effect on pancreatic surgery with special focus on malignant pancreatic and periampullary tumours.

Methods: Patients who underwent pancreatic surgery during the two Danish lockdown periods from 11. Read More

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Recurrent heart failure hospitalizations increase the risk of mortality in heart failure patients with atrial fibrillation and type 2 diabetes mellitus in the United Kingdom: a retrospective analysis of Clinical Practice Research Datalink database.

BMC Cardiovasc Disord 2022 May 21;22(1):234. Epub 2022 May 21.

Novartis Pharma AG, 4056, Basel, Switzerland.

Background: Heart failure (HF) is a global illness and is a leading cause of hospitalizations. Recurrent HF hospitalization (HFH) is associated with increased risk of cardiovascular (CV) and all-cause mortality, thereby burdening the health system. Type 2 diabetes mellitus (T2DM) and atrial fibrillation (AF) are two important comorbidities in patients living with HF. Read More

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Clinical characteristics and mortality associated with COVID-19 at high altitude: a cohort of 5161 patients in Bogotá, Colombia.

Int J Emerg Med 2022 May 21;15(1):22. Epub 2022 May 21.

Grupo de Investigación Clínica, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Background: There are few data on the clinical outcomes of patients with coronavirus disease 2019 (COVID-19) in cities over 1000 m above sea level (masl).

Objectives: To describe the clinical characteristics and mortality of patients with COVID-19 treated at a high complexity hospital in Bogotá, Colombia, at 2640 masl.

Methods: This was an observational study of a cohort including 5161 patients with confirmed COVID-19 infection from 19 March 2020 to 30 April 2021. Read More

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Surgeon specialty effect on early outcomes of elective posterior spinal fusion for adolescent idiopathic scoliosis: a propensity-matched analysis of 965 patients.

Eur Spine J 2022 May 21. Epub 2022 May 21.

Department of Neurosurgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 5-109, Baltimore, MD, 21287, USA.

Background And Objective: Comparative effectiveness research plays a vital role in health care delivery. Specialty training is one of these variables; surgeons who are trained in different specialties may have different outcomes performing the same procedure. The objective of this study was to investigate the impact of spine surgeon specialty (neurosurgery vs orthopedic surgery) on early perioperative outcome measures of elective posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS). Read More

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Gene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapy.

Br J Cancer 2022 May 21. Epub 2022 May 21.

Department of General, Visceral and Pediatric Surgery, University Medical Center, Göttingen, Germany.

Purpose: Preoperative (neoadjuvant) chemoradiotherapy (CRT) and total mesorectal excision is the standard treatment for rectal cancer patients (UICC stage II/III). Up to one-third of patients treated with CRT achieve a pathological complete response (pCR). These patients could be spared from surgery and its associated morbidity and mortality, and assigned to a "watch and wait" strategy. Read More

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Biomarker-Based Assessment for Infectious Risk Before and After Heart Transplantation.

Curr Heart Fail Rep 2022 May 21. Epub 2022 May 21.

Division of Cardiology, University of Texas Southwestern Medical Center, 5959 Harry Hines Jr. Blvd, Dallas, TX, 75235, USA.

Purpose Of Review: Survival outcomes for heart transplant recipients have improved in recent decades, but infection remains a significant cause of morbidity and mortality. In this review, we discuss several biological markers, or biomarkers, that may be used to monitor immunologic status in this patient population.

Recent Findings: While modest, data on the utility of immune biomarkers in heart transplant recipients suggest correlation between low level of immune response and increased infection risk. Read More

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Definition of factors associated with negative antibody response after COVID-19 vaccination in patients with hematological diseases.

Ann Hematol 2022 May 21. Epub 2022 May 21.

Department of Hematology and Oncology, III. Medical Clinic, University Hospital Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

COVID-19 in patients with hematological diseases is associated with a high mortality. Moreover, preventive vaccination demonstrated reduced efficacy and the knowledge on influencing factors is limited. In this single-center study, antibody levels of the SARS-CoV-2 spike protein were measured ≥ 2 weeks after 2nd COVID-19 vaccination with a concentration ≥ 0. Read More

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[Troponin-T and n-terminal pro-brain type natriuretic peptide plasma levels and its relationship with mortality in COVID-19].

Hipertens Riesgo Vasc 2022 Apr 28. Epub 2022 Apr 28.

Hospital Escuela Eva Perón, Granadero Baigorria, Santa Fe, Argentina.

Introduction: Cardiovascular compromise in coronavirus disease 2019 (COVID-19) does not necessarily present with the classic symptoms described in myocarditis. There is growing evidence demonstrating subclinical cardiovascular compromise in the context of the intense inflammation unleashed, the cytokine storm involved, the baseline prothrombotic state, and the consequent endothelial dysfunction. We set out to analyse whether Troponin-T (TT) and the amino-terminal fraction of pro-brain natriuretic peptide (NT-proBNP) determined at hospital admission, are related to mortality during the hospitalization of these patients. Read More

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Outcome of early cholecystectomy compared to percutaneous drainage of gallbladder and delayed cholecystectomy for patients with acute cholecystitis: systematic review and meta-analysis.

HPB (Oxford) 2022 May 6. Epub 2022 May 6.

The Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen, UK; Department of General Surgery, Aberdeen Royal Infirmary, NHS Grampian, UK.

Background: Compare outcomes of early laparoscopic cholecystectomy (ELC) and percutaneous trans-hepatic drainage of gallbladder (PTGBD) as an initial intervention for AC and to compare operative outcomes of ELC and delayed laparoscopic cholecystectomy (DLC).

Methods: English-language studies published until December 2020 were searched. Randomised controlled trials (RCTs) and observational studies compared EC and PTGBD with delayed cholecystectomy for patients presented with acute cholecystitis were considered. Read More

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[Mortality in patients with dementia admitted in critical care units].

Rev Esp Geriatr Gerontol 2022 May 18. Epub 2022 May 18.

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Objective: To determine the mortality and comorbidities associated of patients with dementia admitted to the Intensive Care Unit (ICU) on the hospitalization and at one year of follow-up.

Materials And Methods: A retrospective observational cohort study was carried out between 2012 and 2017 at the Hospital Italiano de San Justo, of patients who were admitted to the ICU, these were observed up to hospitalary death, out hospital death one year of hospitalization, the disenrollment from the institution's health plan or the end of the follow-up.

Results: A total of 163 patients were included for analysis. Read More

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Risk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation.

Am J Cardiol 2022 May 18. Epub 2022 May 18.

Department of Medicine, Division of Cardiology, University Hospitals Harrington Heart & Vascular Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address:

Previous studies reported that new-onset persistent left bundle branch block (NOP-LBBB) was related to worse outcomes after transcatheter aortic valve implantation (TAVI). However, these results can be confounded by the presence of permanent pacemaker (PPM) implantation before and after TAVI. Long-term outcomes and the risk stratification of NOP-LBBB not having PPM implantation before and after TAVI have not been fully investigated. Read More

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Timing of Repair in Postinfarction Ventricular Septal Defect.

Am J Cardiol 2022 May 18. Epub 2022 May 18.

Harrington Heart and Vascular Institute, Case Western Reserve University, Cleveland, Ohio. Electronic address:

The optimal timing of postinfarction ventricular septal defect (PI-VSD) repair is subject to debate. Patients with ventricular septal defect (VSD) and ST-elevation myocardial infarction (STEMI) were queried using appropriate International Classification of Diseases, Ninth and Tenth Revision Clinical Modification codes from the National Inpatient Sample (2003 to 2018). VSD repair was identified using appropriate International Classification of Diseases, Ninth and Tenth Revision Procedure Coding System codes. Read More

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Comparison of different metrics of cerebral autoregulation in association with major morbidity and mortality after cardiac surgery.

Br J Anaesth 2022 May 18. Epub 2022 May 18.

Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Background: Cardiac surgery studies have established the clinical relevance of personalised arterial blood pressure management based on cerebral autoregulation. However, variabilities exist in autoregulation evaluation. We compared the association of several cerebral autoregulation metrics, calculated using different methods, with outcomes after cardiac surgery. Read More

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Use of tranexamic acid in major trauma: a sex-disaggragated analysis of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH-2 and CRASH-3) trials and UK trauma registry (Trauma and Audit Research Network) data.

Br J Anaesth 2022 May 17. Epub 2022 May 17.

Emergency Department, Lausanne University Hospital, Lausanne, Switzerland.

Background: Women are less likely than men to receive some emergency treatments. This study examines whether the effect of tranexamic acid (TXA) on mortality in trauma patients varies by sex and whether the receipt of TXA by trauma patients varies by sex.

Methods: First, we conducted a sex-disaggregated analysis of data from the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH)-2 and CRASH-3 trials. Read More

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Derivation and external validation of a 30-day mortality risk prediction model for older patients having emergency general surgery.

Br J Anaesth 2022 May 18. Epub 2022 May 18.

Department of Anesthesiology and Pain Medicine, University of Ottawa, Ottawa, Canada; ICES-Ottawa, Ottawa, ON, Canada; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Background: Older people (≥65 yr) are at increased risk of morbidity and mortality after emergency general surgery. Risk prediction models are needed to guide decision making in this high-risk population. Existing models have substantial limitations and lack external validation, potentially limiting their applicability in clinical use. Read More

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Sex Differences in the Immune System in Relation to Hypertension and Vascular Disease.

Can J Cardiol 2022 May 18. Epub 2022 May 18.

Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research; Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

Hypertension is the leading risk factor for cardiovascular disease and mortality worldwide. Despite intensive research into the mechanisms underlying the development of hypertension, it remains difficult to control blood pressure in a large proportion of patients. Young men have a higher prevalence of hypertension compared to age-matched women, and this holds true until approximately the fifth decade of life. Read More

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Outcomes in LVAD Patients Undergoing Simultaneous Heart-Kidney Transplantation.

J Card Fail 2022 May 18. Epub 2022 May 18.

Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC. Electronic address:

Background: Multiple studies have shown better outcomes for simultaneous heart kidney transplant (sHKT) compared with isolated orthotopic heart transplant (iOHT) in recipients with chronic kidney disease (CKD). However, outcomes in patients supported by durable LVAD have not been well studied.

Methods: Patients with durable LVADs and stage 3 or greater CKD (eGFR <60ml/min/1. Read More

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Sex differences in time trends in acute coronary syndrome management and in 12-month lethality: Data from the French MONICA registries.

Int J Cardiol 2022 May 18. Epub 2022 May 18.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.. Electronic address:

Background: Sex differences in clinical presentation, patient care and fatal outcomes after an acute coronary syndrome (ACS) have been reported. However, recent improvements in the care and treatment of ACSs have not been assessed with regard to possible sex differences.

Aim: To assess sex differences in trends between 2006 and 2016 in the characteristics of ACSs, their management, and the associated mortality. Read More

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