4,495 results match your criteria ims analysis

Neurosurgical anatomy of the floor of the third ventricle and related vascular structures.

Surg Radiol Anat 2021 Jun 14. Epub 2021 Jun 14.

Unit of Anatomy, Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Purpose: Anatomical knowledge of the floor of the third ventricle (FTV) is essential in avoiding surgical complications during endoscopic third ventriculostomy. The purpose of this study was to characterize the morphometry of FTV and related arteries, particularly the basilar artery (BA), as well as the factors that influence it.

Methods: Twenty-six formalin-fixed adult brains and two hundred adult brain MRIs were studied focusing on FTV and related arteries. Read More

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High-throughput screening of TRPV1 ligands in the light of the Bioluminescence Resonance Energy Transfer technique.

Mol Pharmacol 2021 Jun 14. Epub 2021 Jun 14.

IMS laboratory / CNRS UMR 5218, Bordeaux University, France

Ion channels are attractive drug targets for many therapeutic applications. However, high-throughput screening (HTS) of drug candidates is difficult and remains very expensive. We thus assessed the suitability of the Bioluminescence Resonance Energy Transfer (BRET) technique as a new HTS method for ion-channel studies by taking advantage of our recently characterized intra- and intermolecular BRET probes targeting the TRPV1 ion channel. Read More

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Predictors of early mortality among patients with acute-on-chronic liver failure.

JGH Open 2021 Jun 19;5(6):686-694. Epub 2021 May 19.

Department of Gastroenterology IMS and SUM Hospital, Siksha 'O' Anusandhan, Deemed to be University Bhubaneswar India.

Background And Aim: Acute-on-chronic liver failure (ACLF) is a transpiring entity, which possesses high short-term/early mortality (28 days). Several mortality predictors have been studied, but none were proved reliable. Serum ferritin, an acute phase reactant and marker of hepatic necro-inflammation, is found to predict mortality in multiple liver diseases. Read More

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Quantitative detection of trace VBNC Cronobacter sakazakii by immunomagnetic separation in combination with PMAxx-ddPCR in dairy products.

Food Microbiol 2021 Oct 19;99:103831. Epub 2021 May 19.

Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

One immunomagnetic separation (IMS) assay based on immunomagnetic beads (IMBs) has been evaluated as a potential pretreatment tool for the separation and enrichment of target bacteria. In this study, we successfully immobilized antibodies onto magnetic bead surfaces to form IMBs through biotin and a streptavidin (SA) system to capture viable but nonculturable (VBNC) Cronobacter sakazakii (C. sakazakii) from dairy products. Read More

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October 2021

Aroma characteristics of traditional Huangjiu produced around Winter Solstice revealed by sensory evaluation, gas chromatography-mass spectrometry and gas chromatography-ion mobility spectrometry.

Food Res Int 2021 Jul 19;145:110421. Epub 2021 May 19.

Department of Food Science and Technology, Shanghai Institute of Technology, Shanghai, China. Electronic address:

Traditional Huangjiu (a kind of traditional Chinese rice wine) produced around Winter Solstice has higher quality and a more harmonious aroma than those produced during other periods. To determine the specific differences in aroma characteristics, sensory evaluation, gas chromatography-mass spectrometry (GC-MS) and gas chromatography-ion mobility spectrometry (GC-IMS) were used to analyze the volatile profiles of the traditional Huangjiu samples produced under different ambient temperature conditions. The sensory evaluation results showed that the aroma attributes of wheat, sweet, ester, alcoholic and sauce were stronger for the samples fermented near Winter Solstice than those for the other samples. Read More

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Geographical origin identification of two salmonid species via flavor compound analysis using headspace-gas chromatography-ion mobility spectrometry combined with electronic nose and tongue.

Food Res Int 2021 Jul 12;145:110385. Epub 2021 May 12.

Key Laboratory of Mariculture, Ocean University of China, Ministry of Education, Qingdao 266100, PR China; Function Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong Province 266235, PR China.

The flavor of salmonids is affected by species and origin. Sources of salmonid fish fillets are complex and difficult to identify and label fraud occasionally occurs in the market. In this study, headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS), electronic nose, electronic tongue and amino acid detection technologies were used to analyze flavor compounds in two salmonid species from different geographical origins. Read More

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Real-world evidence for carfilzomib dosing intensity on overall survival and treatment progression in multiple myeloma patients.

J Oncol Pharm Pract 2021 Jun 10:10781552211015283. Epub 2021 Jun 10.

Division of Hematology/Oncology, Mayo Clinic Florida, Jacksonville, FL, USA.

Introduction: Carfilzomib dosing as a single agent or in combination with dexamethasone (Kd) has evolved from the initial 27 mg/m twice-weekly (legacy dose), to more recently approved doses of 56 mg/m twice-weekly and 70 mg/m once-weekly (optimized doses). The objective of this study was to evaluate the overall survival (OS), and time to next treatment (TTNT) among multiple myeloma patients treated with Kd optimized vs legacy doses.

Methods: A retrospective analysis of patients receiving Kd between 01/01/2013-07/31/2017 was conducted using IQVIA's oncology electronic medical records database. Read More

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Vascularity Outcomes of Lingual Artery Ligation in Transoral Robotic Base of Tongue Resections.

Otolaryngol Head Neck Surg 2021 Jun 8:1945998211017446. Epub 2021 Jun 8.

Department of Otolaryngology-Head and Neck Surgery, Division of Head and Neck Oncology and Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

To explore the effect of lingual artery ligation on tongue vascularity, we performed an analysis of 25 patients who underwent transoral robotic surgery for base of tongue cancers (May 2011 to December 2019). Hounsfield units of the intrinsic muscles (IMs) and genioglossus muscles (GGs) were measured in postoperative imaging (mean 4 months) as a surrogate for vascularity. In ligated patients (n = 15), the values from the ligated/resected side of the tongue were compared with the contralateral side and the nonligated side of resection. Read More

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Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model.

J Orthop Translat 2021 Jul 24;29:89-99. Epub 2021 May 24.

State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu, PR China.

Background: Synovial inflammation plays a major role in the pathogenesis of osteoarthritis (OA). This study investigated the effect of andrographolide (Andro) on synovial inflammation mediated by tumor necrosis factor-alpha receptor 2 (TNFR2) trafficking and its utility in attenuating OA progression.

Methods: Knee joints were harvested from rats subjected to radial transection of the medial collateral ligament (MCLT) and medial meniscus (MMT) to examine the effect of Andro on synovial inflammation and OA progression. Read More

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Effect of Two Different Doses of Dexmedetomidine on the Hemodynamics of "Hypertensive Patients" Undergoing Laparoscopic Cholecystectomy.

Anesth Essays Res 2020 Jul-Sep;14(3):401-405. Epub 2021 Mar 22.

Department of Anesthesiology, KGMU, Lucknow, Uttar Pradesh, India.

Context: In laparoscopic cholecystectomy, pneumoperitoneum results in tachycardia, hypertension, and increased myocardial oxygen demand. These changes are more pronounced in hypertensive patients. The intravenous administration of dexmedetomidine attenuates sympathoadrenal response and provides better hemodynamic stability intraoperatively. Read More

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Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex.

Cell Chem Biol 2021 May 26. Epub 2021 May 26.

Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address:

Proteolysis-targeting chimeras (PROTACs) represent a new direction in small-molecule therapeutics whereby a heterobifunctional linker to a protein of interest (POI) induces its ubiquitination-based proteolysis by recruiting an E3 ligase. Here, we show that charge reduction, native mass spectrometry, and gas-phase activation methods combine for an in-depth analysis of a PROTAC-linked ternary complex. Electron capture dissociation (ECD) of the intact POI-PROTAC-VCB complex (a trimeric subunit of an E3 ubiquitin ligase) promotes POI dissociation. Read More

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Entropy and Multifractal-Multiscale Indices of Heart Rate Time Series to Evaluate Intricate Cognitive-Autonomic Interactions.

Entropy (Basel) 2021 May 25;23(6). Epub 2021 May 25.

Univ. Bordeaux, CNRS, Laboratoire IMS, UMR 5218 Talence, France.

Recent research has clarified the existence of a networked system involving a cortical and subcortical circuitry regulating both cognition and cardiac autonomic control, which is dynamically organized as a function of cognitive demand. The main interactions span multiple temporal and spatial scales and are extensively governed by nonlinear processes. Hence, entropy and (multi)fractality in heart period time series are suitable to capture emergent behavior of the cognitive-autonomic network coordination. Read More

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Chemical Analyses and Antimicrobial Activity of Nine Kinds of Unifloral Chinese Honeys Compared to Manuka Honey (12+ and 20+).

Molecules 2021 May 8;26(9). Epub 2021 May 8.

College of Animal Science, Zhejiang University, No. 866, Yuhangtang Road, Xihu District, Hangzhou 310058, China.

Honey has good antimicrobial properties and can be used for medical treatment. The antimicrobial properties of unifloral honey varieties are different. In this study, we evaluated the antimicrobial and antioxidant activities of nine kinds of Chinese monofloral honeys. Read More

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Quantification of Volatile Aldehydes Deriving from In Vitro Lipid Peroxidation in the Breath of Ventilated Patients.

Molecules 2021 May 21;26(11). Epub 2021 May 21.

CBR-Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, Homburg, 66421 Saarland, Germany.

Exhaled aliphatic aldehydes were proposed as non-invasive biomarkers to detect increased lipid peroxidation in various diseases. As a prelude to clinical application of the multicapillary column-ion mobility spectrometry for the evaluation of aldehyde exhalation, we, therefore: (1) identified the most abundant volatile aliphatic aldehydes originating from in vitro oxidation of various polyunsaturated fatty acids; (2) evaluated emittance of aldehydes from plastic parts of the breathing circuit; (3) conducted a pilot study for in vivo quantification of exhaled aldehydes in mechanically ventilated patients. Pentanal, hexanal, heptanal, and nonanal were quantifiable in the headspace of oxidizing polyunsaturated fatty acids, with pentanal and hexanal predominating. Read More

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AST-120 Treatment Alters the Gut Microbiota Composition and Suppresses Hepatic Triglyceride Levels in Obese Mice.

Endocr Res 2021 Jun 1:1-8. Epub 2021 Jun 1.

Department of Cardiovascular Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.

The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide. The existence of a relationship between the microbiota and the pathology of hepatic steatosis is also becoming increasingly clear. AST-120, an oral spherical carbon adsorbent, has been shown to be useful for delaying dialysis initiation and improving uremic symptoms in patients with chronic kidney disease. Read More

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Drones for litter mapping: An inter-operator concordance test in marking beached items on aerial images.

Mar Pollut Bull 2021 May 27;169:112542. Epub 2021 May 27.

CNR-National Research Council, Institute of Marine Science ISMAR-CNR, 19032 Lerici, SP, Italy. Electronic address:

Unmanned aerial systems (UAS, aka drones) are being used to map macro-litter on the environment. Sixteen qualified researchers (operators), with different expertise and nationalities, were invited to identify, mark and categorize the litter items (manual image screening, MS) on three UAS images collected at two beaches. The coefficient of concordance (W) among operators varied between 0. Read More

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Socioeconomic gaps over time in colorectal cancer survival in England: flexible parametric survival analysis.

J Epidemiol Community Health 2021 May 28. Epub 2021 May 28.

Inequalities in Cancer Outcomes Network, Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.

Background: Despite persistent reports of socioeconomic inequalities in colorectal cancer survival in England, the magnitude of survival differences has not been fully evaluated.

Methods: Patients diagnosed with colon cancer (n=68 169) and rectal cancer (n=38 267) in England (diagnosed between January 2010 and March 2013) were analysed as a retrospective cohort study using the National Cancer Registry data linked with other population-based healthcare records. The flexible parametric model incorporating time-varying covariates was used to assess the difference in excess hazard of death and in net survival between the most affluent and the most deprived groups over time. Read More

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Antiplatelet Medications Are Associated With Bleeding and Decompensation Events Among Patients With Cirrhosis.

J Clin Gastroenterol 2021 May 28. Epub 2021 May 28.

Department of Medicine, Division of Digestive and Liver Diseases, University of Texas Southwestern (UTSW), Dallas, TX Department of Statistical Science, Duke University, Durham Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina (UNC) Health Care, Chapel Hill, NC.

Background: In an aging population with cardiovascular comorbidities, anticoagulant (AC), antiplatelet (AP), and nonsteroidal anti-inflammatory drug (NSAID) use are increasing. It remains unclear whether these agents pose increased bleeding risk in cirrhosis. This study aimed to assess the association between these medications and bleeding and portal hypertension complications in cirrhosis. Read More

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Anti-TNF and Immunosuppressive Combination Therapy Is Preferential to Inducing Clinical Remission in Active Patients with Inflammatory Bowel Disease: A Systemic Review and Meta-analysis.

J Dig Dis 2021 May 28. Epub 2021 May 28.

Department of Gastroenterology, The Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Objective: The current concern exists regarding the efficacy and safety of biological agent monotherapy versus combination therapy with an immunomodulator (IM) in patients with inflammatory bowel disease (IBD). We performed a meta-analysis of results from randomized controlled trials (RCTs) to compare the efficacy and safety of biological and immunosuppressive combination therapy with biological monotherapy in IBD.

Methods: We comprehensively and systematically identified eligible studies from Embase, PubMed, and Cochrane library and compared the biological and immunomodulator treatment with biological monotherapy. Read More

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Identification of changes in volatile organic compounds in Ophiopogonis Radix containing spoiled products in different proportions by headspace-gas chromatography-ion mobility spectrometry.

J Food Biochem 2021 May 26:e13802. Epub 2021 May 26.

Zhejiang Institute for Food and Drug Control, Hangzhou, China.

Ophiopogonis Radix is a kind of traditional Chinese medicine as well as a type of functional food. Because Ophiopogonis Radix grows in the ground, it is often damaged by worms during planting or broken when people try to dig them out, which leads to the containments of spoiled products of different proportion in Ophiopogonis Radix. Volatile organic compounds (VOCs) in Ophiopogonis Radix, which involves spoiled products in different proportions, were analyzed by headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS). Read More

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Correlation of exhaled propofol with Narcotrend index and calculated propofol plasma levels in children undergoing surgery under total intravenous anesthesia - an observational study.

BMC Anesthesiol 2021 May 26;21(1):161. Epub 2021 May 26.

Clinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background: Exhaled propofol concentrations correlate with propofol concentrations in adult human blood and the brain tissue of rats, as well as with electroencephalography (EEG) based indices of anesthetic depth. The pharmacokinetics of propofol are however different in children compared to adults. The value of exhaled propofol measurements in pediatric anesthesia has not yet been investigated. Read More

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The characterization and pollution status of the surface sediment in the Boka Kotorska Bay, Montenegro.

Environ Sci Pollut Res Int 2021 May 25. Epub 2021 May 25.

Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, 11120, Serbia.

Surface sediments collected from twelve stations in the Boka Kotorska Bay were analyzed for the level and distribution of twenty-six elements and ten oxides, grain sizes, organic matter, and carbonate content. Potentially toxic elements (Al, Fe, Mn, Cr, Zn, Ni, Cu, Pb, As, Co, U) were determined to assess the contamination status and potential environmental risk according to the single-element indices (enrichment factor (EF), geoaccumulation index (Igeo), contamination factor (CF)), and combined index (pollution load index (PLI)). The single-element indices EF and CF revealed that the surface marine sediment was moderately polluted with Pb, Cu, and Cr, while Igeo indicated moderate pollution with Ni > Cr > Zn > Cu > As and moderate to heavy pollution with Pb, as a result of the anthropogenic factors. Read More

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Acoustic Feedback in Gait Rehabilitation-Pre-Post Effects in Patients With Unilateral Hip Arthroplasty.

Front Sports Act Living 2021 7;3:654546. Epub 2021 May 7.

Institute of Sports Science, Leibniz University Hannover, Hannover, Germany.

It is known that patients after unilateral hip arthroplasty still suffer from a deficient gait pattern compared to healthy individuals one year after surgery. Through the method of gait sonification, it may be possible to achieve a more efficient training and a more physiological gait pattern. Increased loads on the musculoskeletal system could thus be reduced and rehabilitation times shortened. Read More

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Determination of volatile organic compounds by HS-GC-IMS to detect different stages of infection in Xiang Ling walnut.

Food Sci Nutr 2021 May 11;9(5):2703-2712. Epub 2021 Mar 11.

School of Food and Biological Engineering Shaanxi University of Science and Technology Xi'an China.

The aim of this study was to evaluate the performance of volatile organic compounds (VOCs) for evolution monitoring and early detection of () contamination in walnuts. We successfully applied headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) to evaluate walnut VOC changes caused by contamination. A total of 48 VOCs were identified in walnuts contaminated with . Read More

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Glycan Imaging Mass Spectrometry: Progress in Developing Clinical Diagnostic Assays for Tissues, Biofluids, and Cells.

Clin Lab Med 2021 Jun 24;41(2):247-266. Epub 2021 Apr 24.

Department of Cell and Molecular Pharmacology, Medical University of South Carolina, 173 Ashley Avenue, BSB 358, Charleston, SC 29425, USA. Electronic address:

N-glycan imaging mass spectrometry (IMS) can rapidly and reproducibly identify changes in disease-associated N-linked glycosylation that are linked with histopathology features in standard formalin-fixed paraffin-embedded tissue samples. It can detect multiple N-glycans simultaneously and has been used to identify specific N-glycans and carbohydrate structural motifs as possible cancer biomarkers. Recent advancements in instrumentation and sample preparation are also discussed. Read More

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TLR7 Agonist Suppresses ILC2-mediated Inflammation via IL-27-producing Interstitial Macrophages.

Am J Respir Cell Mol Biol 2021 May 18. Epub 2021 May 18.

Keio University School of Medicine, Pulmonary Medicine, Shinjuku-ku, Japan.

Group 2 innate lymphoid cells (ILC2s) play an important role in the pathophysiology of asthma via the robust production of type 2 cytokines. Recent studies have demonstrated that Toll-like receptor 7 (TLR7) signaling skews toward a type 1 inflammatory response in asthma, which may lead to the development of novel treatment strategies. However, the effect of TLR7 signaling on ILC2-dependent non-allergic eosinophilic inflammation remains unclear. Read More

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SPINK1 Mutation in Idiopathic Chronic Pancreatitis: How Pertinent Is It in Coastal Eastern India?

Cureus 2021 Apr 12;13(4):e14427. Epub 2021 Apr 12.

Molecular Diagnostic and Research Center, Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, IND.

Background and aim Idiopathic chronic pancreatitis (ICP) is said to be present when no identifiable etiology can be identified. Robust evidence suggested that the serine protease inhibitor nucleus Kazol type 1 (SPINK1) N34S mutation was frequently associated with ICP. As there is a paucity of data on genetic studies in ICP cases from the coastal eastern region of India, we performed this study with an aim to evaluate the SPINK1 genetic mutations and other associated clinical correlates in ICP cases. Read More

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On the Relation Between Over-Indebtedness and Well-Being: An Analysis of the Mechanisms Influencing Health, Sleep, Life Satisfaction, and Emotional Well-Being.

Front Psychol 2021 29;12:591875. Epub 2021 Apr 29.

CICPSI, Faculdade de Psicologia, Universidade de Lisboa, Lisbon, Portugal.

This paper aims to explore the association between over-indebtedness and two facets of well-being - life satisfaction and emotional well-being. Although prior research has associated over-indebtedness with lower life satisfaction, this study contributes to the extant literature by revealing its effects on emotional well-being, which is a crucial component of well-being that has received less attention. Besides subjective well-being (SWB), reported health, and sleep quality were also assessed. Read More

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Pretransplantation Red Blood Cell and Platelet Transfusion Burden in De Novo Myelodysplastic Syndrome Undergoing Allogeneic Transplantation.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan; Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Most patients of myelodysplastic syndrome (MDS) require red blood cell (RBC) or platelet transfusion during their disease courses, which could cause an increased risk of iron overload and alloimmunization. However, it remains less clear whether pretransplantation RBC or platelet transfusion burden affects transplant outcomes in patients with MDS. The objective was to examine the significance of pretransplantation RBC and platelet transfusion burden on transplant outcomes after allogeneic HCT for adults with de novo MDS. Read More

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Analysis of environmental radioxenon detections in the UK.

J Environ Radioact 2021 Aug 11;234:106629. Epub 2021 May 11.

CTBTO, Vienna, Austria.

Radioxenon activity concentrations are monitored globally using the International Monitoring System (IMS) of the Comprehensive Nuclear-Test-Ban Treaty Organisation, improving the monitoring community's ability to detect radionuclide signatures from an underground nuclear test (UNT). An IMS-like noble gas system is in operation at AWE (Aldermaston, UK) and can collect and measure radioxenon isotopes in environmental air samples. When operated in this mode, data produced is analysed at the UK National Data Centre (NDC) and significant detection events are flagged for further investigation. Read More

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