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Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers.

J Complement Integr Med 2021 May 6. Epub 2021 May 6.

Department of Yoga, Government Yoga and Naturopathy Medical College and Hospital, Chennai, India.

Objectives: Steam bath is extensively used around the world. However, its physiological influence is not understood in detail. Objective of the current study is to examine the effects of 12 sessions of steam bath on spirometric parameters among healthy participants. Read More

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Liver Transplantation Selection and Allocation Criteria for Hepatocellular Carcinoma: A European Perspective.

Semin Liver Dis 2021 May 6. Epub 2021 May 6.

Department of Visceral and Transplantation Surgery, University of Geneva Hospitals, Geneva, Switzerland.

For patients with early-stage hepatocellular carcinoma (HCC), liver transplantation offers the best chance of cure. Over the past two decades, selection criteria to determine eligibility for liver transplantation have been constantly refined but a fair allocation strategy of liver grafts to HCC patients remains challenging. In Europe, over a dozen transplantation networks apply different liver transplantation criteria for HCC patients. Read More

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Results of a tri-national online survey on the current status of sports injury prevention among members of the German-Speaking Orthopaedic Sports Medicine Society (GOTS).

Sportverletz Sportschaden 2021 May 6. Epub 2021 May 6.

Department of Orthopedics, University Medical Center, Rostock, Germany.

Objectives:  To assess the current opinions and state of knowledge in primary sports injury prevention among members of the (.

Methods:  On 21 August 2019, a web-based questionnaire was sent to the members of the tri-national society Austria, Germany and Switzerland). The survey was online until 21 November 2019 and included twenty-two questions, which were divided into five sections: 1) general importance of prevention (n = 4), 2) specifications of the study population (n = 3), 3) implementation of prevention (n = 8), 4) improvement opportunities in prevention (n = 4) and 5) future research areas (n = 3). Read More

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Time-Out and Its Role in Neurosurgery.

Neurosurgery 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.

Background: Safety checklists have improved surgical outcomes; however, much of the literature comes from general surgery.

Objective: To identify the role of time-outs in neurosurgery, understand neurosurgeons' attitudes toward time-out, and highlight areas for improvement.

Methods: A cross-sectional study using a 15-item survey to evaluate how time-outs were performed across 5 hospitals affiliated with a single neurosurgery training program. Read More

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Fractionated Carbon Dioxide Laser for the Treatment of Vulvar Lichen Sclerosus: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Mercer University Physician Assistant Program, Atlanta, Georgia; the Centers for Vulvovaginal Disorders the Department of Obstetrics and Gynecology, George Washington University School of Medicine and Health Sciences, Washington, DC; the Department of Pathology and Laboratory Medicine and the Department Obstetrics, Gynecology, and Women's Health, Rutgers New Jersey Medical School, Newark, and Women's Healthcare of Princeton, Princeton, New Jersey; and Strategic Research, Laerdal Medical, Stavanger, Norway.

Objective: To estimate the efficacy of fractionated carbon dioxide (CO2) laser therapy for vulvar lichen sclerosus.

Methods: We conducted a prospective, double-blind, randomized, sham-controlled, trial conducted in a clinic specializing in vulvar disorders. The study participants were 40 women with active vulvar lichen sclerosus confirmed with biopsy who were abstaining from topical and systemic treatments for at least 4 weeks before enrollment. Read More

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Clobetasol Compared With Fractionated Carbon Dioxide Laser for Lichen Sclerosus: A Randomized Controlled Trial.

Obstet Gynecol 2021 May 6. Epub 2021 May 6.

Department of Obstetrics and Gynecology, Section of Female Pelvic Medicine and Reconstructive Surgery, MedStar Washington Hospital Center and Georgetown University School of Medicine, Washington, DC; the Department of Biostatistics, Medstar Health Research Institute, Hyattsville, Maryland; the Department of Obstetrics and Gynecology, Magee-Womens Hospital, University of Pittsburgh Health System, Pittsburgh, Pennsylvania; the Department of Urogynecology, Brown Women & Infants Hospital of Rhode Island, Providence, Rhode Island; and the Department of Subspecialty Care for Women's Health, Cleveland Clinic, Cleveland, Ohio.

Objective: To compare 6-month safety and efficacy outcomes of fractionated CO2 laser (laser) with topical clobetasol propionate (steroid) for treatment of symptomatic vulvar lichen sclerosus.

Methods: We conducted a single-center randomized controlled trial that compared fractionated CO2 laser with steroid treatment for patients with biopsy-proven lichen sclerosus. Randomization was stratified by prior clobetasol propionate use. Read More

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Gonadal Failure and Infertility in Cancer Survivors: Clinical Management and Strategies for Prevention.

Front Horm Res 2021 May 6;54:1-11. Epub 2021 May 6.

Division of Obstetrics and Gynaecology, Physiopathology of Reproduction and IVF Unit, Sant'Anna Hospital, University of Turin, Turin, Italy.

Modern advances in oncological treatments determined a significant improvement in survival rates for several malignancies. Nevertheless, survivorship and quality of life of cancer survivors may be negatively impaired by metabolic and endocrine side effects related to anticancer treatments, including alterations of pituitary-gonadal axis function. In fact, both medical (chemo- and radiotherapy) and surgical approaches may negatively impact on gonadal function, leading to transient or permanent hypogonadism and infertility. Read More

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Subthalamic Nucleus Deep Brain Stimulation Lessens Acquired Dystonia: Report of Two Patients and Systematic Review of Published Cases.

Stereotact Funct Neurosurg 2021 May 6:1-13. Epub 2021 May 6.

Neurology and Functional Neurosurgery Department, Hospital Santa Marcelina, São Paulo, Brazil.

Introduction: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an efficient treatment of primary dystonia. Few studies have reported the effect of STN-DBS on secondary or acquired dystonia.

Methods: We reported 2 patients with acquired dystonia treated by subthalamic DBS and followed up for 24 months, besides providing a systematic review and meta-analysis of published series. Read More

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Gold nanorods doping induced performance improvement of room temperature OTFT NOsensors.

Nanotechnology 2021 May 6. Epub 2021 May 6.

School of Optoelectronic Information, University of Electronic Science and Technology of China, Chengdu 610054, chengdu, CHINA.

Solution-processed organic thin-film transistors (OTFTs) are regarded as the promising candidates for low-cost gas sensors due to their advantages of high throughput, large-area and sensitive to various gas analytes. Microstructure control of organic active layers in OTFTs is an effective route to improve the sensing performance. In this work, we report a simple method to modify the morphology of 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene) thin films via doping gold nanorods (Au NRs) for enhancing the performance of the corresponding OTFT sensors for nitrogen dioxide (NO) detection. Read More

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Performance improvements in all-solution processed inverted QLEDs realized by inserting an electron blocking layer.

Nanotechnology 2021 May 6. Epub 2021 May 6.

ShineOn (Beijing) Technology Co., Ltd, Beijing, CHINA.

Highly efficient, all-solution processed inverted quantum dot light-emitting diodes (QLEDs) are demonstrated by employing 1,3,5-tri(m-pyrid-3-yl-phenyl)benzene (TmPyPB) layer as electron blocking layer (EBL). Electron injection from ZnO electron transport layer to quantum dots (QDs) emission layer (EML) can be adjusted by thickness of TmPyPB layer, enabling the balanced charge carriers in QDs EML. With optimal thickness of this TmPyPB adjuster, 59. Read More

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Global trends and characteristics of nano- and micro-bubbles research in environmental engineering over the past two decades: A scientometric analysis.

Sci Total Environ 2021 Apr 27;785:147362. Epub 2021 Apr 27.

Department of Civil and Environmental Engineering, The Faculty of Engineering, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

The present study has two primary goals, the first goal is to investigate a bibliometric analysis and assess the trends to evaluate the global scientific production of microbubbles and nanobubbles from 2000 to 2020. The aim is to elucidate the cornucopia of benefits the two technologies (micro and nanobubbles) can offer in environmental sciences and environmental amelioration such as wastewater treatment, seed germination, separation processes, etc. The second goal is to explicate the reason behind every chart and trend through environmental engineering perspectives, which can confer value to each analysis. Read More

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Metanalysis of alloplastic materials versus autologous fat for injection augmentation pharyngoplasty treatment of velopharyngeal insufficiency.

Int J Pediatr Otorhinolaryngol 2021 Apr 28;146:110738. Epub 2021 Apr 28.

Tufts Medical Center, Boston, MA, USA.

Background: Velopharyngeal insufficiency (VPI) can cause resonance, speech and feeding problems. While reconstructive palatoplasty and surgical pharyngoplasty techniques are the mainstay of treatment for severe VPI, injection augmentation pharyngoplasty offers a minimally invasive approach in patients with mild-to-moderate VPI.

Methods: We conducted a systematic review of the literature available on PubMed and Embase from 1990 to 2019 including studies that addressed VPI, incompetence, or dysfunction managed with injection augmentation. Read More

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Medial displacement calcaneal osteotomy versus lateral column lengthening to treat stage II tibialis posterior tendon dysfunction, a prospective randomized controlled study.

Foot (Edinb) 2021 Apr 7;47:101798. Epub 2021 Apr 7.

Orthopedic Department, Assiut University Hospital, Assiut, Egypt. Electronic address:

Purpose: Adult-acquired flatfoot deformity (AAFD) requires optimum planning that often requires several procedures for deformity correction. The objective of this study was to detect the difference between MDCO versus LCL in the management of AAFD with stage II tibialis posterior tendon dysfunction regarding functional, radiographic outcomes, efficacy in correction maintenance, and the incidence of complications.

Patient And Methods: 42 Patients (21 males and 21 females) with a mean age of 49. Read More

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Causes of delayed diagnosis of posterior ankle impingement in the pediatric and adolescent population.

Foot (Edinb) 2021 Apr 7;47:101799. Epub 2021 Apr 7.

Texas Children's Hospital, 6701 Fannin St, Houston, TX 77030, USA.

Purpose: The purpose of this study was to identify and characterize various causes of delay in the diagnosis of posterior ankle impingement syndrome (PAIS) in pediatric patients.

Methods: IRB approved prospective study of patients under 18 years who underwent arthroscopic surgery for the diagnosis of posterior ankle impingement after failed conservative treatment at a tertiary children's hospital. Radiographic findings were compared with an age-matched control group. Read More

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Acupuncture treatment for post-stroke insomnia: A systematic review and meta-analysis of randomized controlled trials.

Authors:
Jialei Yang

Complement Ther Clin Pract 2021 Apr 23;44:101396. Epub 2021 Apr 23.

Department of Traditional Chinese Medicine, Beijing Tian Tan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China. Electronic address:

Objectives: The meta-analysis aimed to assess the effectiveness and safety of acupuncture for the treatment of post-stroke insomnia.

Methods: Randomized controlled trials were identified from five databases before April 2020. The primary outcomes were the rate of improvement and the Pittsburgh sleep quality index (PSQI) scores; the secondary outcomes included the follow-up PSQI scores and safety. Read More

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Dewaterability improvement and environmental risk mitigation of waste activated sludge using peroxymonosulfate activated by zero-valent metals: Fe vs. Al.

Chemosphere 2021 Apr 27;280:130686. Epub 2021 Apr 27.

Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China; Guangdong Polytechnic of Environmental Protection Engineering, Foshan, 528216, China. Electronic address:

The stabilization and dewaterability of waste activated sludge (WAS) are essential factors for downstream disposal or reuse. Herein, two types of zero-valent metals, zero-valent iron (Fe) and zero-valent aluminum (Al), were compared for their ability to activate peroxymonosulfate (PMS) during the WAS conditioning process, with the effects of PMS activation by these two metals on WAS dewaterability and the potential environmental risks evaluated. Results showed that compared to Al/PMS treatment, Fe/PMS treatment achieved superior WAS dewaterability and reduced operational costs. Read More

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A correlation between anaesthesia-related cardiac arrest outcomes and country human development index: A narrative review.

J Clin Anesth 2021 May 3;72:110273. Epub 2021 May 3.

Anaesthesia Cardiac Arrest and Mortality Study Commission, Department of Surgical Specialties and Anaesthesiology, Botucatu Medical School, Sao Paulo State University - UNESP, Botucatu, SP, Brazil.

Studies have demonstrated gaps between developed and developing countries in the quality of surgical and anaesthesia care. The aim of this review was to provide a critical overview of documented outcomes from the 2010s of anaesthesia-related cardiac arrest events in countries with largely differing Human Development Indexes (HDIs). The HDI ranges from 0 to 1, representing the lowest and highest levels of development, respectively. Read More

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Coil assisted glue embolization to improve safety and accuracy in endovascular management of Vein of Galen patients.

Clin Neurol Neurosurg 2021 Apr 21;205:106652. Epub 2021 Apr 21.

Army Hospital (Referral & Research), Delhi Cantt, New Delhi 110010, India. Electronic address:

Background: Vein of Galen malformation (VOGM) patients present in neonatal age with cardiac failure or significant neurologic consequences. The most established method of treatment has been transarterial embolization with high concentration glue (N-Butyl Cyano Acrylate) which may be difficult to control due to very high flow rates and may migrate to the venous side with undesirable consequences. We describe our experience in four patients in whom initial coil placement in prominent feeding arteries helped inflow reduction thereby facilitating controlled glue injection with a good result and no incidence of non-target embolization. Read More

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Post-surgery cholesteatoma complicated by facial nerve paralysis: A case report from Afghanistan.

Int J Surg Case Rep 2021 Apr 28;82:105916. Epub 2021 Apr 28.

Medical Research Center, Kateb University, Kabul, Afghanistan. Electronic address:

Introduction: Cholesteatoma is a benign tumoral lesion of squamous epithelial cells in middle ear that can exist as congenital or acquired forms.

Presentation Of Cases: A 35-year-old housewife presented to ENT clinic of a private hospital in Kabul, Afghanistan, with a complete facial nerve paralysis in the right side. In her antecedents, there is a tympanomastoidectomy due to chronic middle ear infection. Read More

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Pedicle screw system reconstruction in shoulder resection type IV-total scapulectomy: A case report and short term follow up.

Int J Surg Case Rep 2021 Apr 27;82:105899. Epub 2021 Apr 27.

Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia. Electronic address:

Introduction: Shoulder resection remains a challenging procedure after scapulectomy for tumour resection. The results have various functional outcome, wound coverage, and cosmetic aspect. In this case report, we reported the outcome of pedicle screw application after scapulectomy procedure within 1 month follow up after surgical tumour excision. Read More

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Learning emotions latent representation with CVAE for text-driven expressive audiovisual speech synthesis.

Neural Netw 2021 Apr 21;141:315-329. Epub 2021 Apr 21.

Université de Lorraine, CNRS, Inria, LORIA, F-54000 Nancy, France. Electronic address:

Great improvement has been made in the field of expressive audiovisual Text-to-Speech synthesis (EAVTTS) thanks to deep learning techniques. However, generating realistic speech is still an open issue and researchers in this area have been focusing lately on controlling the speech variability. In this paper, we use different neural architectures to synthesize emotional speech. Read More

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Examining Ultrasound Diagnostic Performance Improvement with Utilization of Maternal-Fetal Medicine Tele-Interpretation.

Am J Obstet Gynecol MFM 2021 May 3:100389. Epub 2021 May 3.

Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Background: Telemedicine can extend essential health services to under-resourced settings and improve level and quality of obstetric care. Specifically, evaluation and management of fetal anomalies often requires perinatal subspecialists, rendering prenatal diagnosis essential, and may benefit from telemedicine platforms to improve access to care.

Objective: This study examines the impact of a maternal-fetal medicine (MFM) tele-ultrasound program on diagnostic accuracy of fetal anomalies when deployed within practices where ultrasounds are otherwise interpreted by general obstetricians or family medicine physicians. Read More

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Tandem mass tag-based proteomics for studying the effects of a biotechnologically produced oyster mushroom against hepatic steatosis in obese Zucker rats.

J Proteomics 2021 May 3:104255. Epub 2021 May 3.

Protein Analytics, Institute of Biochemistry, Faculty of Medicine, Justus-Liebig-University Giessen, Friedrichstrasse 24, 35392 Giessen, Germany.

Hepatic steatosis is a very common response to liver injury and often attributed to metabolic disorders. Prior studies have demonstrated the efficacy of a biotechnologically produced oyster mushroom (Pleurotus sajor-caju, PSC) in alleviating hepatic steatosis in obese Zucker rats. This study aims to elucidate molecular events underlying the anti-steatotic effects of PSC. Read More

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The effectiveness of memory remediation strategies after traumatic brain injury: systematic review and meta-analysis.

Ann Phys Rehabil Med 2021 May 3:101530. Epub 2021 May 3.

Department of Psychology and Leslie and Susan Gonda (Goldschmied), Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel. Electronic address:

Background: Traumatic brain injury (TBI) is a steadily rising health concern associated with significant risk of emotional, behavioral and cognitive impairments. Cognitive memory impairment is one of the most concerning outcomes after TBI, affecting a wide range of everyday activities, social interactions and employment. Several comparative and comprehensive reviews on the effects of cognitive interventions in individuals with TBI have been conducted but usually with a qualitative rather than quantitative approach. Read More

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Neuroprotective effect of stroke pretreated MSCs against cerebral ischemia/reperfusion injury in rats.

World Neurosurg 2021 May 3. Epub 2021 May 3.

Department of General Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. Electronic address:

Background: Mesenchymal stem cells (MSCs) have been shown to enhance neurological recovery after stroke. In this study, a middle cerebral artery occlusion (MCAO) rat model was designed to assess the neuroprotective effects of stroke pretreated MSCs on cerebral ischemia/reperfusion (I/R) injury.

Method: The MSCs were isolated and cultured in medium with 10% FBS, normal control serum (NS), or stroke serum (SS). Read More

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Outcomes of endovenous laser ablation with additional iliac vein stenting of non-thrombotic lesions in patients presenting with active venous ulcers.

J Vasc Surg Venous Lymphat Disord 2021 May 3. Epub 2021 May 3.

Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine; Vascular Center of Shanghai JiaoTong University, Shanghai 200011, China. Electronic address:

Objective: To evaluate the clinical outcomes of superficial and perforator ablation and the impact on wound healing by adding iliac vein stenting of non-thrombotic iliac vein lesions (NIVLs) in patients presenting with active venous ulcers.

Methods And Materials: A retrospective analysis was performed from January 2017 to December 2019, examining patients presenting with venous ulcers who were diagnosed with NIVLs. Patients with> 50% diameter reduction in the iliac vein based on computed tomography venogram underwent transfemoral venography for further confirmation. Read More

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Cellular pathways of recombinant adeno-associated virus production for gene therapy.

Biotechnol Adv 2021 May 3:107764. Epub 2021 May 3.

Center for Biomedical Innovation, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

Recombinant adeno-associated viruses (rAAVs) are among the most important vectors for in vivo gene therapies. With the rapid development of gene therapy, current rAAV manufacturing capacity faces a challenge to meet the emerging demand for these therapies in the future. To examine the bottlenecks in rAAV production during cell culture, we focus here on an analysis of cellular pathways of rAAV production, based on an overview of assembly mechanisms first in the wild-type (wt) AAV replication and then in the common methods of rAAV production. Read More

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Does Advanced Trauma Life Support Training work? 10-Year Follow Up of Advanced Trauma Life Support India Program.

J Am Coll Surg 2021 Apr 28. Epub 2021 Apr 28.

- Sharda Hospital, Greater Noida, Uttar Pradesh, India, & Advanced Trauma Life Support, India.

Background: Studies evaluating the efficacy of ATLS in Low & Middle-income countries (LMICs) are limited. We followed up ATLS providers certified by ATLS India program over a decade (2008-2018), aiming at measuring the benefits, if any, in knowledge, skills & attitude (KSA) from ATLS, and attrition over time.

Methods: Survey instrument was developed taking a cue from published literature on ATLS and improvised using the Delphi method. Read More

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Predicting In-Hospital Mortality in Patients Undergoing Percutaneous Coronary Intervention.

J Am Coll Cardiol 2021 Apr 28. Epub 2021 Apr 28.

Department of Medicine (Cardiology), University of North Carolina, Chapel Hill, NC. Electronic address:

Background: Standardization of risk is critical in benchmarking and quality improvement efforts for percutaneous coronary interventions (PCI). In 2018, the CathPCI Registry was updated to include additional variables to better classify higher-risk patients.

Objectives: We sought to develop a model for predicting in-hospital mortality risk following PCI incorporating these additional variables. Read More

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Superior capsular reconstruction with autologous fascia lata using single lateral row technique is an effective option in massive irreparable rotator cuff tears. Minimum two-year follow-up.

Arthroscopy 2021 May 3. Epub 2021 May 3.

Hospital Puerto Montt, Los Aromos 65, Puerto Montt, Chile.

Purpose: The purpose of this study is to evaluate clinical and radiological outcomes of arthroscopic superior capsular reconstruction (ASCR) with fascia lata autograft in patients with irreparable rotator cuff tears (IRCT) performed with a single lateral row fixation technique.

Methods: Retrospective case series of patients with large or massive IRCTs for ASCR with fascia lata autograft. Clinical outcomes were evaluated with visual analog scale (VAS) and Constant Score. Read More

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