264,682 results match your criteria improvement function

Establishing Clinically Significant Outcomes of the PROMIS Upper Extremity Questionnaire after Primary Reverse Total Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Apr 17. Epub 2021 Apr 17.

Midwest Orthopaedics at Rush, Chicago, IL, USA. Electronic address:

Background: and Hypothesis: Since its introduction, the Patient Reported Outcome Measurement Information System Upper Extremity (PROMIS UE) assessment has been increasingly used in shoulder arthroplasty outcome measurement. However, determination of clinically significant outcomes using PROMIS UE has yet to be investigated following reverse total shoulder arthroplasty (RTSA). We hypothesized that we could establish clinically significant outcomes of the PROMIS UE outcome assessment in patients undergoing primary RTSA and identify significant baseline patient factors associated with achievement of these measures. Read More

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A moderate intensity exercise program improves physical function and oxidative damage in older women with and without sarcopenic obesity.

Exp Gerontol 2021 Apr 17:111360. Epub 2021 Apr 17.

Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional, Ciudad de México, Mexico. Electronic address:

Background And Objectives: The excess of body fat and muscle mass loss in adulthood results in sarcopenic obesity, which is associated with disability and poor physical condition. A relationship among obesity, sarcopenia and oxidative stress also has been established. These aspects limit a good muscle function which is crucial in the independence of older women with and without sarcopenic obesity. Read More

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A Mobile Health Intervention to Increase Physical Activity in Pulmonary Arterial Hypertension.

Chest 2021 Apr 17. Epub 2021 Apr 17.

Division of Cardiovascular Medicine and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN. Electronic address:

Background: Supervised exercise training improves outcomes in patients with pulmonary arterial hypertension (PAH). The effect of an unsupervised activity intervention has not been tested.

Research Question: Can a text-based mobile health intervention increase step counts in patients with PAH?

Study Design And Methods: We performed a randomized, parallel arm, single-blind clinical trial. Read More

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Long-term cognitive outcome after radiosurgery in epileptic hypothalamic hamartomas and review of the literature.

Epilepsia 2021 Apr 20. Epub 2021 Apr 20.

Department of Functional and Stereotactic Neurosurgery and Gamma Knife Radiosurgery, Timone University Hospital, Aix-Marseille University, Marseille, France.

Objective: Epileptic patients with hypothalamic hamartoma (HH) frequently present cognitive impairments. Surgical techniques aiming at HH can be very efficient for epilepsy relief and cognitive improvement but are also demonstrated to carry a significant risk of additional reduction in memory function in these already disabled patients. Gamma knife radiosurgery (GKS) offers an efficient minimally invasive procedure. Read More

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H∞ Codesign for Uncertain Nonlinear Control Systems Based on Policy Iteration Method.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

In this article, the problem of H∞ codesign for nonlinear control systems with unmatched uncertainties and adjustable parameters is investigated. The main purpose is to solve the adjustable parameters and H∞ controller simultaneously so that better robust control performance can be achieved. By introducing a bounded function and defining a special cost function, the problem of solving the Hamilton-Jacobi-Isaacs equation is transformed into an optimization problem with nonlinear inequality constraints. Read More

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The Effects of Laparoscopic Sleeve Gastrectomy on Cardiac Diastolic Function, Aortic Elasticity, and Atrial Electromechanics Delay.

Obes Surg 2021 Apr 20. Epub 2021 Apr 20.

Department of Cardiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Background: Obesity is a well-known risk factor for cardiovascular diseases. The aim of this study was to prospectively investigate the short-term effects of laparoscopic sleeve gastrectomy (LSG) on cardiac functions.

Methods: Forty-four morbidly obese patients who underwent LSG were included in the study. Read More

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[Low anterior resection syndrome-Causes and treatment approaches].

Chirurg 2021 Apr 20. Epub 2021 Apr 20.

Klinik für Allgemein- und Viszeralchirurgie, Städtisches Klinikum Dresden-Friedrichstadt, Friedrichstr. 41, 01067, Dresden, Deutschland.

Background: With improvement of the oncological prognosis and more sphincter-preserving procedures for rectal cancer of the lower third, the functional sequelae of anterior rectal resection become more and more predominant and are summarized under the term low anterior resection syndrome (LARS).

Material And Methods: In this narrative review the causes, associated factors, prevalence, diagnostics and treatment strategies are presented based on an evaluation of the international literature.

Results: The central role of the rectum in the physiology of defecation and continence explains the frequency of symptoms following anterior rectal resection. Read More

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Liver-targeting drugs and their effect on blood glucose and hepatic lipids.

Diabetologia 2021 Apr 20. Epub 2021 Apr 20.

Department of Internal Medicine IV, University of Tübingen, Tübingen, Germany.

The global epidemic of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) and the high prevalence among individuals with type 2 diabetes has attracted the attention of clinicians specialising in liver disorders. Many drugs are in the pipeline for the treatment of NAFLD/NASH, and several glucose-lowering drugs are now being tested specifically for the treatment of liver disease. Among these are nuclear hormone receptor agonists (e. Read More

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Effectiveness of Mobilization of the Talus and Distal Fibula in the Management of Acute Lateral Ankle Sprain.

Phys Ther 2021 Apr 20. Epub 2021 Apr 20.

Physiotherapy, Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.

Objective: Distal fibula mobilization with movement (MWM), with and without a posterior gliding fibular tape, and anteroposterior mobilization of the talus (MOB) are widely used to treat acute lateral ankle sprains. The purpose of this study was to investigate the short-term and long-term relative effectiveness of these techniques.

Methods: In this double-blind randomized controlled trial, 45 amateur soccer players with acute (<72 hours) lateral ankle sprain were randomly allocated to 6 sessions (3 per week within the first 2 weeks) of either MWM, MWM with tape (MWMtape), or MOB. Read More

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Machine Learning Algorithms Predict Functional Improvement After Hip Arthroscopy for Femoroacetabular Impingement Syndrome in Athletes.

J Bone Joint Surg Am 2021 Mar 11. Epub 2021 Mar 11.

Division of Sports Medicine, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois.

Background: Despite previous reports of improvements for athletes following hip arthroscopy for femoroacetabular impingement syndrome (FAIS), many do not achieve clinically relevant outcomes. The purpose of this study was to develop machine learning algorithms capable of providing patient-specific predictions of which athletes will derive clinically relevant improvement in sports-specific function after undergoing hip arthroscopy for FAIS.

Methods: A registry was queried for patients who had participated in a formal sports program or athletic activities before undergoing primary hip arthroscopy between January 2012 and February 2018. Read More

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Brain regional pharmacokinetics following the oral administration of curcumagalactomannosides and its relation to cognitive function.

Nutr Neurosci 2021 Apr 20:1-12. Epub 2021 Apr 20.

Akay Natural Ingredients, R&D Centre, Cochin, India.

Objective: Though a number of bioavailable formulations of curcuminoids have been reported and available commercially as nutraceuticals for brain health, systematic informations on their blood-brain-barrier permeability and brain tissue distribution have not been reported. The present study was aimed to investigate the brain regional pharmacokinetics of curcuminoids following both single dose and repeated dose oral administration of a self-emulsifying food-grade formulation of curcuminoids using fenugreek galactomannan hydrogel scaffold as 'curcumagalactomannosides' (CGM), and its influence on cognitive functions in comparison with unformulated natural curcuminoids (NC) in Wistar rats.

Methods: CGM was given to animals in single dose (100 mg curcuminoids/kg b. Read More

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Correct Sciatic Nerve Management to Apply Ultrasound-Guided Percutaneous Neuromodulation in Patients With Chronic Low Back Pain: A Pilot Study.

Neuromodulation 2021 Apr 20. Epub 2021 Apr 20.

Department of Physiotherapy, University of Seville, Seville, Spain.

Background: The objectives of this study were to evaluate the effects of an ultrasound (US)-guided percutaneous neuromodulation (PNM) intervention on the sciatic nerve, regarding pain, hip range of motion (ROM), balance, and functionality in patients with chronic low back pain (LBP); and to determine the optimal anatomical location of sciatic nerve stimulation to obtain therapeutic benefits in such patients.

Materials And Methods: Thirty patients with chronic LBP were recruited and divided randomly into three groups. All patients received a single percutaneous electrical stimulation intervention on the sciatic nerve, with a different anatomical application location for each group (proximal, middle, and distal). Read More

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Polymorphisms in SLC44A1 are associated with cognitive improvement in children diagnosed with fetal alcohol spectrum disorder: an exploratory study of oral choline supplementation.

Am J Clin Nutr 2021 Apr 19. Epub 2021 Apr 19.

Department of Psychiatry and Behavioral Sciences, University of Minnesota Twin Cities, Minneapolis, MN, USA.

Background: The essential nutrient choline provides one-carbon units for metabolite synthesis and epigenetic regulation in tissues including brain. Dietary choline intake is often inadequate, and higher intakes are associated with improved cognitive function.

Objective: Choline supplements confer cognitive improvement for those diagnosed with fetal alcohol spectrum disorder (FASD), a common set of neurodevelopmental impairments; however, the effect sizes have been modest. Read More

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Antifreeze protein from Ammopiptanthus nanus functions in temperature-stress through domain A.

Sci Rep 2021 Apr 19;11(1):8458. Epub 2021 Apr 19.

Key Laboratory of Biology and Genetic Improvement of Maize in Southwest Region, Ministry of Agriculture; Maize Research Institute, Sichuan Agricultural University, Chengdu, 611130, China.

Temperature stress restricts plant growth and development. Antifreeze protein (AFP) can improve plants antifreeze ability. In our previous study, the AnAFP gene cloned from Ammopiptanthus nanus was confirmed to be an excellent candidate enhancing plant cold resistance. Read More

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Selenomethionine protects hematopoietic stem/progenitor cells against cobalt nanoparticles by stimulating antioxidant actions and DNA repair functions.

Aging (Albany NY) 2021 Apr 19;13. Epub 2021 Apr 19.

Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) can differentiate into all blood lineages to maintain hematopoiesis, wound healing, and immune functions. Recently, cobalt-chromium alloy casting implants have been used extensively in total hip replacements; however, cobalt nanoparticles (CoNPs) released from the alloy were toxic to HSCs and HPCs. We aimed to investigate the mechanism underlying the toxic effect of CoNPs on HSCs/HPCs and to determine the protective effect of selenomethionine (SeMet) against CoNPs and . Read More

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Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model.

Mol Brain 2021 Apr 19;14(1):70. Epub 2021 Apr 19.

Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA.

Aim: We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation. The enzyme nSMase2 is involved in the production of exosomes carrying proteopathic seeds and could contribute to cell-to-cell transmission of pathological protein aggregates implicated in neurodegenerative diseases such as Parkinson's disease (PD). Here, we performed in vivo studies to determine if DDL-112 can reduce brain EV/exosome production and proteopathic alpha synuclein (αSyn) spread in a PD mouse model. Read More

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[Effects of hand continuous passive motion system combined with functional training and pressure gloves in treating early scar contracture after burn on the back of the hand].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-8. Epub 2021 Mar 24.

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

To observe the effects of continuous passive motion (CPM) system combined with functional training and pressure gloves in treating early scar contracture after burn on the back of the hand. A retrospective cohort study was conducted in 43 patients who met the inclusion criteria and were admitted to the First Affiliated Hospital of Air Force Medical University from June 2017 to December 2019 with scar contracture after partial-thickness to full-thickness burn on the back of the hand. According to the treatment methods applied, 13 patients were enrolled into pressure glove alone group (9 males and 4 females, aged (31±6) years), 14 patients were enrolled into pressure glove+functional training group (11 males and 3 females, aged (30±5) years), and 16 patients were enrolled into pressure glove+functional training+CPM system group (10 males and 6 females, aged (29±5) years). Read More

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New Phytol 1987 Aug;106(4):785-790

Books reviewed in this article: Techniques in Photomorphogenesis. Ed. by H. Read More

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Co-segregation analysis of cadmium and zinc accumulation in Thlaspi caerulescens interecotypic crosses.

New Phytol 2004 Aug;163(2):299-312

Agriculture and Environment Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

•  Cadmium (Cd) hyperaccumulation in Thlaspi caerulescens varies among ecotypes. Here we investigated segregation of Cd and zinc (Zn) accumulation in F crosses between high (Ganges) and low (Prayon) Cd-accumulating ecotypes. •  Accumulation was measured in plants grown in compost treated with 5 and 100 mg kg Cd and Zn, respectively, and in hydroponics with 50 m Zn and 10 or 50 m Cd. Read More

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Nonstomatal limitations are responsible for drought-induced photosynthetic inhibition in four C grasses.

New Phytol 2003 Sep;159(3):599-608

Crop Performance and Improvement, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK.

•   Here, the contribution of stomatal and nonstomatal factors to photosynthetic inhibition under water stress in four tropical C grasses was investigated (Panicum coloratum, Bothriochloa bladhii, Cenchrus ciliaris and Astrebla lappacea). •   Plants were grown in well watered soil, and then the effects of soil drying were measured on leaf gas exchange, chlorophyll a fluorescence and water relations. •   During the drying cycle, leaf water potential (Ψ ) and relative water content (RWC) decreased from c. Read More

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September 2003

Phosphorus acquisition and use: critical adaptations by plants for securing a nonrenewable resource.

New Phytol 2003 Mar;157(3):423-447

Soil, Water and Climate, University of Minnesota 1991 Upper Buford Circle, St Paul, MN 55108, USA.

Phosphorus (P) is limiting for crop yield on > 30% of the world's arable land and, by some estimates, world resources of inexpensive P may be depleted by 2050. Improvement of P acquisition and use by plants is critical for economic, humanitarian and environmental reasons. Plants have evolved a diverse array of strategies to obtain adequate P under limiting conditions, including modifications to root architecture, carbon metabolism and membrane structure, exudation of low molecular weight organic acids, protons and enzymes, and enhanced expression of the numerous genes involved in low-P adaptation. Read More

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The role of phytochelatins in arsenic tolerance in the hyperaccumulator Pteris vittata.

New Phytol 2003 Aug;159(2):403-410

Agriculture and Environment Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

•  Pteris vittata was the first identified arsenic (As) hyperaccumulator. Here we investigated whether phytochelatins (PCs) are involved in the hypertolerance of arsenic by P. vittata. Read More

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Placing covered self-expanding metal stents by suspension laryngoscope in benign tracheal stenosis.

Am J Otolaryngol 2021 Apr 13;42(5):103040. Epub 2021 Apr 13.

Department of Thoracic Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Tracheobronchial stent placement for malignant airway strictures has been proved to improve respiratory function, but experience for benign tracheobronchial stenoses is limited. The purpose of our study is to investigate the efficacy of covered expandable metallic stents, inserted through a suspension laryngoscope, treating tracheal stenosis following intubation or tracheostomy.

Methods: From 2010 to 2018, 67 adult patients with the benign tracheal stenosis, underwent stent placement, using a suspension laryngoscope. Read More

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Feedback mechanisms of periphytic biofilms to ZnO nanoparticles toxicity at different phosphorus levels.

J Hazard Mater 2021 Apr 8;416:125834. Epub 2021 Apr 8.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Sciences, Chinese Academy of Sciences, Nanjing 210008, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.

The increasing use of nanoparticles (NPs) has raised concerns about their potential environmental risks. Many researches on NPs focused on the toxicity mechanism to microorganisms, but neglect the toxicity effects in relation to nutritional conditions. Here, we evaluated the interactive effects of zinc oxide (ZnO) NPs and phosphorus (P) levels on the bacterial community and functioning of periphytic biofilms. Read More

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Current progress and challenges in crop genetic transformation.

J Plant Physiol 2021 Apr 5;261:153411. Epub 2021 Apr 5.

Institute of Molecular Plant Biology, Department of Biology, ETH Zurich, Universitätstrasse 2, 8092 Zurich, Switzerland; Advanced Plant Biotechnology Center, National Chung Hsing University, 145 Xingda Road, Taichung City 402, Taiwan. Electronic address:

Plant transformation remains the most sought-after technology for functional genomics and crop genetic improvement, especially for introducing specific new traits and to modify or recombine already existing traits. Along with many other agricultural technologies, the global production of genetically engineered crops has steadily grown since they were first introduced 25 years ago. Since the first transfer of DNA into plant cells using Agrobacterium tumefaciens, different transformation methods have enabled rapid advances in molecular breeding approaches to bring crop varieties with novel traits to the market that would be difficult or not possible to achieve with conventional breeding methods. Read More

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Treatment of breast cancer-related lymphedema using negative pressure massage: a pilot randomized controlled trial.

Arch Phys Med Rehabil 2021 Apr 16. Epub 2021 Apr 16.

University of California San Francisco, Department of Physical Therapy and Rehabilitation Science; University of California San Francisco, Department of Physical Therapy and Rehabilitation Science and Department of Physiological Nursing. Electronic address:

Objective: Evaluate the efficacy of negative pressure massage treatment (NPMT) compared to manual lymphatic drainage (MLD) in women with chronic breast cancer-related lymphedema (LE). We hypothesized that NPMT would result in greater improvements in LE and upper limb function.

Design: Pilot single-blinded randomized controlled trial (RCT) SETTING: Health sciences university PARTICIPANTS: Of 64 women screened, 28 met eligibility requirements (i. Read More

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Feasibility Study of Transanal Irrigation Using a Colostomy Irrigation System in Patients with Low Anterior Resection Syndrome.

Dis Colon Rectum 2021 Apr 13. Epub 2021 Apr 13.

Colorectal Surgery Division, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil. Wound, Ostomy and Continence Outpatient Care, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Background: Low anterior resection syndrome has a negative impact on quality of life. Intestinal irrigation is a method of lavage consisting of a scheduled evacuation.

Objective: To evaluate functional and quality of life outcomes in patients with low anterior resection syndrome post transanal irrigation using a colostomy irrigation system. Read More

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A New Parameter, the Smallest Oblique Sagittal Area of the Neural Foramen, as an Index to Diagnose Cervical Neural Foramen Stenosis.

Can Assoc Radiol J 2021 Apr 19:8465371211005540. Epub 2021 Apr 19.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou City, China.

Objective: The objective was to reconstruct the cervical neural foramen and accurately measure the minimum oblique sagittal area of the neural foramen. Then, a quantitative diagnostic standard for cervical neural foramen stenosis was proposed and its value as an indication for surgery was evaluated.

Methods: (1) CT data were used to reconstruct the neural foramen using Mimics software, and the minimum area was measured. Read More

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Final 5-Year Outcomes of the Multicenter Randomized Sham-Controlled Trial of Rezūm Water Vapor Thermal Therapy for Treatment of Moderate-To-Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia.

J Urol 2021 Apr 19:101097JU0000000000001778. Epub 2021 Apr 19.

University of Texas Southwestern, Dallas, Texas.

Objective: To present final 5-year outcomes of the multicenter randomized sham-controlled trial of Rezum water vapor therapy for treatment of moderate-to-severe LUTS due to BPH.

Materials And Methods: Total of 197 subjects 50 years of age, with IPSS ≥13, maximum flow rate (Qmax) ≤15 mL/s and prostate volume 30 to 80 cc were randomized and followed for 5 years. From the 61 subject control arm, a subset of 53 subjects requalified and after 3 months, received treatment as part of the crossover group and were also followed for 5 years. Read More

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Arabidopsis NF-YCs play dual roles in repressing brassinosteroid biosynthesis and signaling during light-regulated hypocotyl elongation.

Plant Cell 2021 Apr 19. Epub 2021 Apr 19.

Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement & Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Innovative Academy of Seed Design, Chinese Academy of Sciences, Guangzhou, China.

Light functions as the primary environmental stimulus and brassinosteroids (BRs) as important endogenous growth regulators throughout the plant lifecycle. Photomorphogenesis involves a series of vital developmental processes that require the suppression of BR-mediated seedling growth, but the mechanism underlying the light-controlled regulation of the BR pathway remain unclear. Here, we reveal that nuclear factor YC proteins (NF-YCs) function as essential repressors of the BR pathway during light-controlled hypocotyl growth in Arabidopsis thaliana. Read More

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