95,061 results match your criteria improved efficacy

Effect of cervical lesion centered access cavity restored with short glass fibre reinforced resin composites on fracture resistance in human mandibular premolars- an in vitro study.

J Mech Behav Biomed Mater 2021 Jun 26;122:104654. Epub 2021 Jun 26.

Department of Conservative Dentistry and Endodontics, Meenakshi Academy of Higher Education and Research University, Alapakkam Main Road, Maduravoyal, Chennai, 600095, India. Electronic address:

Aim: The aim of this study was to evaluate the fracture resistance of cervical lesion centered access cavity restored with short glass fibre reinforced resin materials in human mandibular premolars.

Materials And Methods: Sixty freshly extracted human mandibular premolars were collected and assigned to positive control group (G1- Intact teeth) and other experimental groups (G2, G3. G4, G5, G6), Traditional Access Cavity(TAC) and Cervical Lesion Centered Access Cavity(CLCAC). Read More

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The efficacy of incorporating mental imagery in cognitive restructuring techniques on reducing hostility: A randomized controlled trial.

J Behav Ther Exp Psychiatry 2021 Jul 19;73:101677. Epub 2021 Jul 19.

Department of Clinical Psychological Science, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, the Netherlands.

Background And Objectives: Cognitive restructuring (CR) is an effective intervention for hostility. However, the number of patients who fail to benefit suggest that the efficacy of CR can be further improved. The present study investigated whether enhancing CR with mental imagery techniques can increase its efficacy. Read More

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Impact of COVID-19 pandemic on people with epilepsy: An interventional study using early physical consultation.

Epilepsy Behav 2021 Jul 10;122:108215. Epub 2021 Jul 10.

Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: Telehealth use is limited in developing countries. Therefore, a modified approach with early physical consultation was designed and applied in our hospital. This study aimed to determine the efficacy of this early physical consultation in reducing the clinical and psychological impacts of coronavirus disease-19 (COVID-19), which enabled insight into its global feasibility. Read More

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Tendinopathy and tendon material response to load: What we can learn from small Animal studies.

Acta Biomater 2021 Jul 26. Epub 2021 Jul 26.

Musculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Department of Orthopaedic Surgery, Yerevan State Medical University, Yerevan, Armenia. Electronic address:

Tendinopathy is a debilitating disease that causes as much as 30% of all musculoskeletal consultations. Existing treatments for tendinopathy have variable efficacy, possibly due to incomplete characterization of the underlying pathophysiology. Mechanical load can have both beneficial and detrimental effects on tendon, as the overall tendon response depends on the degree, frequency, timing, and magnitude of the load. Read More

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Recent Advances in Radio-Frequency Coil Technologies: Flexible, Wireless, and Integrated Coil Arrays.

J Magn Reson Imaging 2021 Jul 29. Epub 2021 Jul 29.

Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.

Radio-frequency (RF) coils are to magnetic resonance imaging (MRI) scanners what eyes are to the human body. Because of their critical importance, there have been constant innovations driving the rapid development of RF coil technologies. Over the past four decades, the breadth and depth of the RF coil technology evolution have far exceeded the space allowed for this review article. Read More

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Safety and efficacy of intravenously administered cidofovir in adult haematopoietic cell transplant recipients: a retrospective multicentre cohort study.

J Antimicrob Chemother 2021 Jul 29. Epub 2021 Jul 29.

Division of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland.

Objectives: To evaluate the safety and efficacy of cidofovir for the treatment of double-stranded DNA (dsDNA) viral infections following allogeneic haematopoietic cell transplant (HCT).

Methods: This was a retrospective multicentre cohort study including adult HCT recipients who received ≥1 dose of IV-administered cidofovir for any dsDNA viral infection from 2006 to 2019. The objectives were to describe the rate of and risk factors for nephrotoxicity and virological response by the end of treatment (EOT). Read More

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Efficacy of past, present, and future fluid strategies in an improved large animal model of non-compressible intra-abdominal hemorrhage.

J Trauma Acute Care Surg 2021 Aug;91(2S Suppl 2):S99-S106

From the Critical Innovations LLC (R.I.D., T.C.F., J.A., O.J.B., J.C.); Department of Emergency Medicine (R.I.D.), David Geffen School of Medicine at UCLA, Los Angeles; Department of Emergency Medicine (R.I.D.), Harbor-UCLA Medical Center, Torrance; Department of Epidemiology (R.I.D.), UCLA Fielding School of Public Health, Los Angeles, California; Charles T Dotter Department of Interventional Radiology (T.L.G., J.D.R.), Oregon Health and Science University, Portland, Oregon; and Military and Health Research Foundation (T.L.G., J.D.R.), Laurel, Maryland.

Background: Noncompressible hemorrhage is a leading cause of potentially survivable combat death, with the vast majority of such deaths occurring in the out-of-hospital environment. While large animal models of this process are important for device and therapeutic development, clinical practice has changed over time and past models must follow suit. Developed in conjunction with regulatory feedback, this study presents a modernized, out-of-hospital, noncompressible hemorrhage model, in conjunction with a randomized study of past, present, and future fluid options following a hypotensive resuscitation protocol consistent with current clinical practice. Read More

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Gene-editing by CRISPR-Cas9 in combination with anthracycline therapy tumor microenvironment-switchable, EGFR-targeted, and nucleus-directed nanoparticles for head and neck cancer suppression.

Nanoscale Horiz 2021 Jul 29. Epub 2021 Jul 29.

Institute of Pharmacology, National Yang-Ming University, Taipei 11221, Taiwan. and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan and Faculty of Pharmacy, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan and Center for Advanced Pharmaceutics and Drug Delivery Research, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.

Head and neck cancer (HNC) has a high incidence and a poor prognosis. Epirubicin, a topoisomerase inhibitor, is a potential anthracycline chemotherapeutic for HNC treatment. HuR (ELAVL1), an RNA-binding protein, plays a critical role in promoting tumor survival, invasion, and resistance. Read More

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Romidepsin and metformin nanomaterials delivery on streptozocin for the treatment of Alzheimer's disease in animal model.

Biomed Pharmacother 2021 Jul 14;141:111864. Epub 2021 Jul 14.

Department of Neurology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Brain insulin signal anomalies are implicated in Alzheimer's disease (AD) pathology. In this background, metformin, an insulin sensitizer's neuroprotective effectiveness, has been established in the prior findings. In the present investigation, combining an epigenetic modulator, romidepsin, and metformin will improve the gene expressions of neurotrophic factors and reduce AD-associated biochemical and cellular changes by loading them mainly into a nanocarrier surface-modified framework for improved therapeutic effectiveness and bioavailability. Read More

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Long-term Efficacy of Percutaneous Epidural Neurolysis of Adhesions in Chronic Lumbar Radicular Pain: 10 Year Follow-up of a Randomized Controlled Trial.

Pain Physician 2021 Aug;24(5):359-367

Dept. of Orthopedic Surgery and Traumatology, School of Medicine, Christian-Albrechts-University, Campus Kiel, Germany.

Background: No long-term follow-up data exist in any treatment for chronic radicular pain occurring with disc pathology and after failed back surgery. A previous randomized controlled trial (RCT) has proven efficacy in short-term follow-up as an evidence-based effective therapeutic option.

Objectives: Long term data is needed to determine the efficacy and cost- effectiveness of minimal invasive procedures. Read More

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Efficacy and safety of fremanezumab for episodic migraine prevention: Multicenter, randomized, double-blind, placebo-controlled, parallel-group trial in Japanese and Korean patients.

Headache 2021 Jul 29. Epub 2021 Jul 29.

Medical Affairs, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan.

Objective: To evaluate the efficacy and safety of two dosing regimens of fremanezumab in Japanese and Korean patients with episodic migraine.

Background: Episodic migraine, which accounts for more than 90% of migraine cases, is inadequately addressed by widely available preventive therapies. Fremanezumab, a monoclonal antibody that selectively targets the trigeminal sensory neuropeptide calcitonin gene-related peptide involved in migraine pathogenesis, has demonstrated efficacy in international Phase 3 trials of patients with both chronic and episodic migraine. Read More

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Inhibition of Janus Kinase 1 synergizes docetaxel sensitivity in prostate cancer cells.

J Cell Mol Med 2021 Jul 28. Epub 2021 Jul 28.

Center for Cancer and Stem Cell Research, Institute for Research, Development and Innovation (IRDI), International Medical University, Kuala Lumpur, Malaysia.

Prostate cancer (PCa) is the second most common malignancy and is the fifth leading cause of cancer mortality among men globally. Docetaxel-based therapy remains the first-line treatment for metastatic castration-resistant prostate cancer. However, dose-limiting toxicity including neutropenia, myelosuppression and neurotoxicity is the major reason for docetaxel dose reductions and fewer cycles administered, despite a recent study showing a clear survival benefit with increased total number of docetaxel cycles in PCa patients. Read More

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Happy Talk: A pilot effectiveness study of a targeted-selective speech-language and communication intervention for children from areas of social disadvantage.

Int J Lang Commun Disord 2021 Jul 28. Epub 2021 Jul 28.

Newcastle University, Newcastle upon Tyne, Newcastle, UK.

Background: Despite the public health implications of language difficulties associated with social disadvantage, there is a dearth of effectiveness studies investigating the effects of targeted speech and language programmes in this area.

Aims: To determine the effects of a targeted selective community-based child language intervention programme (Happy Talk), which simultaneously engaged with parents and early childhood educators, in the Republic of Ireland.

Methods & Procedures: A mixed methods methodology was applied with quantitative outcome and qualitative process data collected. Read More

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Current Evidence for the Effectiveness of Psychosocial Interventions for Children Undergoing Medical Procedures.

Child Care Health Dev 2021 Jul 28. Epub 2021 Jul 28.

Stanford Children's Health, Lucile Packard Children's Hospital Stanford, Palo Alto, CA.

Background: Because more than three million children are hospitalized every year in the United States, psychosocial and emotional impacts of hospitalization on children cannot be overlooked. As such, a variety of psychosocial support services are offered in pediatric facilities to reduce the negative effects often associated with hospitalization. This review examines current evidence for the effectiveness of common psychosocial interventions for children and youth undergoing medical procedures. Read More

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Safety, Patient-Reported Well-Being, and Physician-Reported Assessment of Walking Ability in Patients with Multiple Sclerosis for Prolonged-Release Fampridine Treatment in Routine Clinical Practice: Results of the LIBERATE Study.

CNS Drugs 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurology, MS Center Amsterdam, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands.

Background: Prolonged-release fampridine (PR-FAM) 10-mg tablet twice daily is the only approved pharmacological treatment for improvement of walking ability in adults with multiple sclerosis (MS). LIBERATE assessed the safety/effectiveness of PR-FAM in the real-world.

Objectives: The aim of this study was to collect additional safety data, including the incidence rate of seizures and other adverse events (AEs) of interest, from patients with MS taking PR-FAM in routine clinical practice (including patients aged ≥ 65 years and those with pre-existing cardiovascular risk factors). Read More

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Drug resistance and combating drug resistance in cancer.

Cancer Drug Resist 2019 19;2:141-160. Epub 2019 Jun 19.

Department of Biological Sciences, Ohio University, Athens, OH 45701, USA.

Cancer is the second leading cause of death in the US. Current major treatments for cancer management include surgery, cytotoxic chemotherapy, targeted therapy, radiation therapy, endocrine therapy and immunotherapy. Despite the endeavors and achievements made in treating cancers during the past decades, resistance to classical chemotherapeutic agents and/or novel targeted drugs continues to be a major problem in cancer therapies. Read More

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Health education intervention to improve vaccination knowledge and attitudes in a cohort of obstetrics students.

J Prev Med Hyg 2021 Mar 29;62(1):E110-E116. Epub 2021 Apr 29.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.

Introduction: To improve the vaccination coverage in pregnant women it is important to increase their knowledge of vaccines and related preventable diseases. Midwifes can play an important role because they are often the first contact for woman during her pregnancy. This study aimed to explore the vaccination knowledge and attitudes in a cohort of Obstetrics students in Italy and improve their knowledge through an informative health education intervention. Read More

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Functionalized non-viral cationic vectors for effective siRNA induced cancer therapy.

DNA RNA Nanotechnol 2017 May 27;4(1):1-20. Epub 2017 May 27.

RNA Structure and Design Section, RNA Biology Laboratory, National Cancer Institute, National Institutes of Health, Frederick 21702, MD, USA.

RNA interference (RNAi) has been regarded as a vital asset in the field of therapeutics as it has the capability to silence various disease causing genes including those that cause cancer. Small non-coding RNA molecules such as short interfering RNAs (siRNAs) are one of the extensively studied RNAi inducers for gene modulations. However, the delivery of RNAi inducers including siRNAs is compromised due to the barriers imposed by the biological system such as degradation by nucleases, rapid clearance, high anionic charge, immunogenicity and off-target effects. Read More

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First Do No Harm: Moving Beyond Universal Preprocedural Testing for COVID-19.

Open Forum Infect Dis 2021 Jul 24;8(7):ofab342. Epub 2021 Jun 24.

Division of Geographic Medicine and Infectious Disease, Tufts Medical Center, Boston, Massachusetts, USA.

Preprocedural testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was introduced early in the pandemic in an effort to protect health care workers, direct appropriate use of personal protective equipment (PPE), and improve patient outcomes. In light of our appreciation for the efficacy of PPE and the nuances associated with interpretation of polymerase chain reaction testing for SARS-CoV-2, particularly as community transmission decreases, we call for a re-evaluation of universal preprocedural testing. We propose a transition to a patient-centered approach, focusing on testing patients whose outcomes would be improved by a delayed procedure in the event of a positive test and a greater reliance on appropriate PPE rather than preprocedural test results. Read More

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Ablative fractional CO laser surgery improving sleep quality, pain and pruritus in adult hypertrophic scar patients: a prospective cohort study.

Burns Trauma 2021 27;9:tkab023. Epub 2021 Jul 27.

Department of Burn Surgery, the First affiliated Hospital to Naval Medical University, Shanghai 200433, People's Republic of China.

Background: Poor sleep quality is associated with a decrease in quality of life in patients with major burn scars, combined with pruritus and pain. Few interventions have been reported to improve the sleep quality of patients with scars. In the current prospective cohort study, we investigated the efficacy of CO-ablative fractional laser (AFL) surgery conventional surgery in post-burn patients with hypertrophic scars with sleep quality as the primary study outcome. Read More

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Adjuvanticity of β -Glucan for Vaccine Against .

Front Cell Dev Biol 2021 12;9:701708. Epub 2021 Jul 12.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Institute of Zoonosis, Jilin University, Changchun, China.

In the past 30 years, few researches focus on the efficacy of adjuvant against infection. Identifying new, improved vaccine adjuvants for infection are required. β-glucan are effective and safe as adjuvant for infectious diseases. Read More

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Empowering adolescents as peer-educators for early prevention of non-communicable diseases: Through existing 'POSBINDU' program in Indonesia.

J Family Med Prim Care 2021 Jun 2;10(6):2202-2208. Epub 2021 Jul 2.

Department of Medical, Health Professions Education, and Bioethics, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Background: Human lifestyles, including sedentary activities, obesity, and smoking, are associated with a high risk of non-communicable diseases that are a leading cause of death globally. Accordingly, health promotion should be done as early as possible in the adolescent period.

Aims: This study explores the efficacy of a peer-educator program in promoting the healthy habits of adolescents, via an existing Indonesian community initiative program called 'POSBINDU' (Integrated Counseling Post), led by the general practitioners. Read More

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Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor.

Front Oncol 2021 12;11:672500. Epub 2021 Jul 12.

Department of Medicine, Portland VA Health Care System and OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR, United States.

The majority of gastrointestinal stromal tumors (GIST) harbor an activating mutation in either the KIT or PDGFRA receptor tyrosine kinases. Approval of imatinib, a KIT/PDGFRA tyrosine kinase inhibitor (TKI), meaningfully improved the treatment of advanced GIST. Other TKIs subsequently gained approval: sunitinib as a second-line therapy and regorafenib as a third-line therapy. Read More

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A Novel Mechanism of Carvedilol Efficacy for Rosacea Treatment: Toll-Like Receptor 2 Inhibition in Macrophages.

Front Immunol 2021 12;12:609615. Epub 2021 Jul 12.

Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, China.

Background: Rosacea, a chronic inflammatory skin disorder etiologically associated with immune cells and the antibacterial peptide cathelicidin LL-37, can be effectively treated by oral carvedilol administration.

Objective: To investigate the molecular mechanisms underlying carvedilol efficacy in rosacea treatment.

Methods: Skin samples of patients with rosacea were subjected to histopathological (hematoxylin and eosin) and immunohistochemical (CD68, Toll-like receptor 2 (TLR2), kallikrein 5, cathelicidin, TNF-α, and IL-1β) evaluation. Read More

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Improving and Comparing Probiotic Plate Count Methods by Analytical Procedure Lifecycle Management.

Front Microbiol 2021 12;12:693066. Epub 2021 Jul 12.

Eurofins Microbiology Laboratory, Madison, WI, United States.

Probiotics are live microorganisms that confer a health benefit to the host when administered in adequate amounts. This definition links probiotic efficacy to microbial viability. The current gold standard assay for probiotic potency is enumeration using classical microbiology plating-based procedures, yielding results in colony-forming units (CFU). Read More

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One-Year, Efficacy and Safety Open Label Study, with a Single Injection of a New Hyaluronan for Knee OA: The SOYA Trial.

J Pain Res 2021 21;14:2229-2237. Epub 2021 Jul 21.

Meiji Pharma Spain, Alcalá de Henares, Madrid, Spain.

Purpose: To assess the efficacy and safety of a single injection of a new formulation of hyaluronic acid (MPS-HA2%) in patients with symptomatic knee osteoarthritis after 12 months' follow-up.

Patients And Methods: Prospective, single-arm, multicentre, open-label, 12-month follow-up study. Patients with Kellgren-Lawrence (KL) 2-3 and visual analogue scale (VAS) pain scores of ≥40-< 80 mm received a single injection of MPS-HA2%. Read More

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Efficacy of Acupuncture-Related Therapy in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis of Randomized Controlled Trials.

J Pain Res 2021 19;14:2209-2228. Epub 2021 Jul 19.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, People's Republic of China.

Objective: Knee osteoarthritis (KOA) is prevalent in middle-aged and elderly people. This condition negatively affects the quality of life of patients. Although non-steroidal anti-inflammatory drugs (NSAIDs) are often used to relieve symptoms associated with KOA, it is associated with many side effects. Read More

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Emerging applications of radiomics in rectal cancer: State of the art and future perspectives.

Min Hou Ji-Hong Sun

World J Gastroenterol 2021 Jul;27(25):3802-3814

Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China.

Rectal cancer (RC) is the third most commonly diagnosed cancer and has a high risk of mortality, although overall survival rates have improved. Preoperative assessments and predictions, including risk stratification, responses to therapy, long-term clinical outcomes, and gene mutation status, are crucial to guide the optimization of personalized treatment strategies. Radiomics is a novel approach that enables the evaluation of the heterogeneity and biological behavior of tumors by quantitative extraction of features from medical imaging. Read More

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Safety and Efficacy of Epithelial Island Crosslinking in Keratoconus with Thinnest Pachymetry less than 400µ.

Middle East Afr J Ophthalmol 2021 Jan-Mar;28(1):11-17. Epub 2021 Apr 30.

Department of Ophthalmology, Kasr Al Ainy School of Medicine, Cairo University, Giza, Egypt.

Purpose: To evaluate the efficacy and safety of epithelial-island crosslinking (EI-CXL) in keratoconus with corneas thinner than 400 µm.

Methods: Twenty-six patients (30 eyes) underwent EI-CXL (preserving the epithelium over the thinnest area), using standard protocol (3 mW/cm for 30 min). Uncorrected and best spectacle-corrected distance visual acuity (UCDVA, BCDVA), manifest refractive spherical equivalent (SEQ), mean simulated keratometry (Kmean), maximum keratometry (Kmax), and thinnest corneal thickness (TCT) were determined preoperatively and at 1, 3, 6, and 12 months following CXL. Read More

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Process intensification of the ionoSolv pretreatment: effects of biomass loading, particle size and scale-up from 10 mL to 1 L.

Sci Rep 2021 Jul 28;11(1):15383. Epub 2021 Jul 28.

Department of Chemical Engineering, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK.

The ionoSolv process is one of the most promising technologies for biomass pretreatment in a biorefinery context. In order to evaluate the transition of the ionoSolv pretreatment of biomass from bench-scale experiments to commercial scale, there is a need to get better insight in process intensification. In this work, the effects of biomass loading, particle size, pulp washing protocols and 100-fold scale up for the pretreatment of the grassy biomass Miscanthus giganteus with the IL triethylammonium hydrogen sulfate, [TEA][HSO], are presented as a necessary step in that direction. Read More

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