J Trauma Acute Care Surg 2021 Aug;91(2S Suppl 2):S99-S106
From the Critical Innovations LLC (R.I.D., T.C.F., J.A., O.J.B., J.C.); Department of Emergency Medicine (R.I.D.), David Geffen School of Medicine at UCLA, Los Angeles; Department of Emergency Medicine (R.I.D.), Harbor-UCLA Medical Center, Torrance; Department of Epidemiology (R.I.D.), UCLA Fielding School of Public Health, Los Angeles, California; Charles T Dotter Department of Interventional Radiology (T.L.G., J.D.R.), Oregon Health and Science University, Portland, Oregon; and Military and Health Research Foundation (T.L.G., J.D.R.), Laurel, Maryland.
Background: Noncompressible hemorrhage is a leading cause of potentially survivable combat death, with the vast majority of such deaths occurring in the out-of-hospital environment. While large animal models of this process are important for device and therapeutic development, clinical practice has changed over time and past models must follow suit. Developed in conjunction with regulatory feedback, this study presents a modernized, out-of-hospital, noncompressible hemorrhage model, in conjunction with a randomized study of past, present, and future fluid options following a hypotensive resuscitation protocol consistent with current clinical practice. Read More