1,900 results match your criteria improved 1980s

Australian Lentil Breeding Between 1988 and 2019 Has Delivered Greater Yield Gain Under Stress Than Under High-Yield Conditions.

Front Plant Sci 2021 2;12:674327. Epub 2021 Jun 2.

South Australian Research and Development Institute, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA, Australia.

The contemporary lentil ( ssp. ) industry in Australia started in the late 1980s. Yield in farmers' fields averages 1. Read More

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Levelling up: Global examples of reducing health inequalities.

Clare Bambra

Scand J Public Health 2021 Jun 19:14034948211022428. Epub 2021 Jun 19.

Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, UK.

There are significant inequalities in health by socio-economic status, race/ethnicity, gender, neighbourhood deprivation and other axes of social inequality. Reducing these health inequalities and improving health equity is arguably the 'holy grail' of public health. This article engages with this quest by presenting and analysing historical examples of when sizeable population-level reductions in health inequalities have been achieved. Read More

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Use of molecular docking computational tools in drug discovery.

Prog Med Chem 2021 27;60:273-343. Epub 2021 May 27.

Cambridge Crystallographic Data Centre, Cambridge, United Kingdom.

Molecular docking has become an important component of the drug discovery process. Since first being developed in the 1980s, advancements in the power of computer hardware and the increasing number of and ease of access to small molecule and protein structures have contributed to the development of improved methods, making docking more popular in both industrial and academic settings. Over the years, the modalities by which docking is used to assist the different tasks of drug discovery have changed. Read More

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Food-grade carrageenans and their implications in health and disease.

Compr Rev Food Sci Food Saf 2021 Jun 19. Epub 2021 Jun 19.

USDA-ARS Animal Genomics and Improvement Laboratory, Beltsville, Maryland, USA.

Food additives, often used to guarantee the texture, shelf-life, taste, and appearance of processed foods, have gained widespread attention due to their increased link to the growing incidence of chronic diseases. As one of the most common additives, carrageenans have been used in human diets for hundreds of years. While classified as generally recognized as safe (GRAS) for human consumption, numerous studies since the 1980s have suggested that carrageenans, particularly those with random coil conformations, may have adverse effects on gastrointestinal health, including aggravating intestinal inflammation. Read More

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The Sorghum Grain Mold Disease Complex: Pathogens, Host Responses, and the Bioactive Metabolites at Play.

Front Plant Sci 2021 28;12:660171. Epub 2021 May 28.

Cereal Grains Breeding and Genetics, Pee Dee Research and Education Center, Department of Plant & Environmental Sciences, Clemson University, Florence, SC, United States.

Grain mold is a major concern in sorghum [ (L.) Moench] production systems, threatening grain quality, safety, and nutritional value as both human food and livestock feed. The crop's nutritional value, environmental resilience, and economic promise poise sorghum for increased acreage, especially in light of the growing pressures of climate change on global food systems. Read More

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Systemic Treatment of Gastroenteropancreatic Neuroendocrine Carcinoma.

Curr Treat Options Oncol 2021 Jun 10;22(8):68. Epub 2021 Jun 10.

Department of Medical Sciences, Uppsala University, Akademiska Sjukhuset ing 100, 75185, Uppsala, Sweden.

Opinion Statement: Treatment recommendations for advanced gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are based on uncontrolled, mainly retrospective data. Chemotherapy can offer palliative relief, but long-lasting complete responses or cures are rare. The European Neuroendocrine Tumour Society (ENETS) and European Society for Medical Oncology (ESMO) recommend platinum-based chemotherapy as first-line treatment. Read More

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Effect of Additives during Interfacial Polymerization Reaction for Fabrication of Organic Solvent Nanofiltration (OSN) Membranes.

Polymers (Basel) 2021 May 24;13(11). Epub 2021 May 24.

Department of Energy and Chemical Engineering, Incheon National University, Incheon 22012, Korea.

Thin film composite (TFC) membranes is the dominant type of desalination in the field of membrane technology. Most of the TFC membranes are fabricated via interfacial polymerization (IP) technique. The ingenious chemistry of reacting acyl chlorides with diamines at the interface between two immiscible phases was first suggested by Cadotte back in the 1980s, and is still the main chemistry employed now. Read More

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Gastrointestinal parasites in Swedish pigs: Prevalence and associated risk factors for infection in herds where animal welfare standards are improved.

Vet Parasitol 2021 Jul 18;295:109459. Epub 2021 May 18.

Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute, SVA, 751 89, Uppsala, Sweden; Swedish University of Agricultural Sciences, Department of Clinical Sciences, Box 7054, 750 07, Uppsala, Sweden.

The global pig production has undergone major changes over the past 30 years with larger farms, more intensified production as well as improved hygiene and biosecurity practices. To investigate whether these changes, along with expanded pig welfare, have had an impact on parasite occurrence, a cross-sectional study was conducted in Sweden on farms where the pigs are always loose-housed, floors are solid and bedding material is provided. A total of 1615 faecal samples were collected on 42 conventional indoor farms from a) post-weaning piglets (n = 337); b) growers (n = 345); c) fatteners (n = 308); d) dry sows (n = 277) and e) pre-partum sows (n = 348). Read More

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The Evolution of the Walch Classification for Primary Glenohumeral Arthritis.

J Am Acad Orthop Surg 2021 07;29(13):e635-e645

From New England Baptist Hospital, Boston, MA (Jawa), Boston Sports and Shoulder Center, Waltham, MA (Jawa), and Tufts Medical Center, Boston, MA (Shields).

Our understanding of the pathology of and treatment for glenohumeral arthritis (GHA) has grown dramatically in the past few decades. Original observations regarding patterns of glenoid erosion, glenoid retroversion, and posterior humeral head subluxation in patients with primary GHA were documented in the 1980s and early 1990s. In the late 1990s, Walch et al proposed what is now the most widely used classification system to describe the characteristic pathology of GHA. Read More

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LABEC, the INFN ion beam laboratory of nuclear techniques for environment and cultural heritage.

Eur Phys J Plus 2021 30;136(4):472. Epub 2021 Apr 30.

INFN Division of Florence and Department of Physics and Astronomy, University of Florence, via G. Sansone 1, 50019 Sesto Fiorentino, Italy.

The LABEC laboratory, the INFN ion beam laboratory of nuclear techniques for environment and cultural heritage, located in the Scientific and Technological Campus of the University of Florence in Sesto Fiorentino, started its operational activities in 2004, after INFN decided in 2001 to provide our applied nuclear physics group with a large laboratory dedicated to applications of accelerator-related analytical techniques, based on a new 3 MV Tandetron accelerator. The new accelerator greatly improved the performance of existing Ion Beam Analysis (IBA) applications (for which we were using since the 1980s an old single-ended Van de Graaff accelerator) and in addition allowed to start a novel activity of Accelerator Mass Spectrometry (AMS), in particular for C dating. Switching between IBA and AMS operation became very easy and fast, which allowed us high flexibility in programming the activities, mainly focused on studies of cultural heritage and atmospheric aerosol composition, but including also applications to biology, geology, material science and forensics, ion implantation, tests of radiation damage to components, detector performance tests and low-energy nuclear physics. Read More

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A 30-Year Study of Impacts, Recovery, and Development of Critical Effect Sizes for Endocrine Disruption in White Sucker () Exposed to Bleached-Kraft Pulp Mill Effluent at Jackfish Bay, Ontario, Canada.

Front Endocrinol (Lausanne) 2021 22;12:664157. Epub 2021 Apr 22.

Biological Sciences, University of Calgary, Calgary, AB, Canada.

Jackfish Bay is an isolated bay on the north shore of Lake Superior, Canada that has received effluent from a large bleached-kraft pulp mill since the 1940s. Studies conducted in the late 1980s found evidence of reductions in sex steroid hormone levels in multiple fish species living in the Bay, and increased growth, condition and relative liver weights, with a reduction in internal fat storage, reduced gonadal sizes, delayed sexual maturation, and altered levels of circulating sex steroid hormones in white sucker (). These early studies provided some of the first pieces of evidence of endocrine disruption in wild animals. Read More

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Interferon-Based Biopharmaceuticals: Overview on the Production, Purification, and Formulation.

Vaccines (Basel) 2021 Apr 1;9(4). Epub 2021 Apr 1.

CICECO-Aveiro Institute of Materials, Chemistry Department, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.

The advent of biopharmaceuticals in modern medicine brought enormous benefits to the treatment of numerous human diseases and improved the well-being of many people worldwide. First introduced in the market in the early 1980s, the number of approved biopharmaceutical products has been steadily increasing, with therapeutic proteins, antibodies, and their derivatives accounting for most of the generated revenues. The success of pharmaceutical biotechnology is closely linked with remarkable developments in DNA recombinant technology, which has enabled the production of proteins with high specificity. Read More

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Survival Trends and Syndromic Esophageal Atresia.

Pediatrics 2021 May;147(5)

Departments of Paediatric Surgery,

Background And Objectives: Presence of a syndrome (or association) is predictive of poor survival in esophageal atresia (EA). However, most reports rely on historical patient outcomes, limiting their usefulness when estimating risk for neonates born today. We hypothesized improved syndromic EA survival due to advances in neonatal care. Read More

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Precision medicine in myeloid malignancies.

Semin Cancer Biol 2021 Apr 22. Epub 2021 Apr 22.

Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address:

Myeloid malignancies have always been at the forefront of an improved understanding of the molecular pathogenesis of cancer. In accordance, over the last years, basic research focusing on the aberrations underlying malignant transformation of myeloid cells has provided the basis for precision medicine approaches and subsequently has led to the development of powerful therapeutic strategies. In this review article, we will recapitulate what has happened since in the 1980s the use of all-trans retinoic acid (ATRA), as a first targeted cancer therapy, has changed one of the deadliest leukemia subtypes, acute promyelocytic leukemia (APL), into one that can be cured without classical chemotherapy today. Read More

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Update on Osteosarcoma.

Curr Oncol Rep 2021 Apr 21;23(6):71. Epub 2021 Apr 21.

Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Purpose Of Review: Osteosarcoma (OSA) is the most common primary tumor of bone, mainly affecting children and adolescents. Here we discuss recent advances in surgical and systemic therapies, and highlight potentially new modalities in preclinical evaluation and prognostication.

Recent Findings: The advent of neoadjuvant and adjuvant chemotherapy has markedly improved the disease-free recurrence and overall survival of OSA. Read More

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Direct N-butyl-2-cyanoacrylate injections to the head and neck for percutaneous embolized devascularization.

Surg Neurol Int 2021 30;12:131. Epub 2021 Mar 30.

School of Medicine, University of New Mexico, Albuquerque, New Mexico, United States.

Background: N-butyl-2-cyanoacrylate (NBCA) has been used for vascular malformations since the 1980s; however, few studies have looked at applications, procedural techniques, and outcome throughout many institutions. Herein, we review applications, procedural techniques, previous literature, and outcomes for the use of NBCA specifically through percutaneous technique in treating head and neck vascular pathology.

Methods: An extensive literature review using PubMed database with published literature containing "N-butyl-2-cyanoacrylate embolization," was performed. Read More

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MR Imaging in the 21st Century: Technical Innovation over the First Two Decades.

Magn Reson Med Sci 2021 Apr 16. Epub 2021 Apr 16.

Department of Radiological Sciences, School of Health Sciences at Narita, International University of Health and Welfare.

Clinical MRI systems have continually improved over the years since their introduction in the 1980s. In MRI technical development, the developments in each MRI system component, including data acquisition, image reconstruction, and hardware systems, have impacted the others. Progress in each component has induced new technology development opportunities in other components. Read More

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Case fatality of hospital-treated intracerebral hemorrhage in Finland - A nationwide population-based registry study.

J Neurol Sci 2021 06 14;425:117446. Epub 2021 Apr 14.

Heart Center, Turku University Hospital, Turku, Finland; Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Center for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland; Administrative Center, Hospital District of Southwest Finland, Turku, Finland. Electronic address:

Background: Case-fatality of Intracerebral hemorrhage (ICH) has been reported to have improved in some areas recently. Previous reports have shown that in Finland ICH survival has improved already from the 1980s. We aimed to investigate if this trend has continued and to assess possible predictors for death. Read More

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Lung and heart-lung transplantation for children with PAH: Dramatic benefits from the implementation of a high-priority allocation program in France.

J Heart Lung Transplant 2021 03 26. Epub 2021 Mar 26.

Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardio-pulmonaire, Groupe hospitalier Marie-Lannelongue -Saint Joseph, Le Plessis-Robinson, France; Université Paris-Saclay, Le Kremlin Bicêtre, France; UMR_S 999, Université Paris-Sud, INSERM, Groupe hospitalier Marie-Lannelongue -Saint Joseph, Le Plessis-Robinson, France.

Purpose: Pulmonary arterial hypertension (PAH) is rare but remains fatal in infants and children despite the advance of targeted therapies. Lung transplantation (LTx), first performed in pediatric patients in the 1980s, is, with the Potts shunt, the only potentially life-extending option in patients with end-stage PAH but is possible only in tightly selected patients. Size-matching challenges severely restrict the donor organ pool, resulting-together with peculiarities of PAH in infants-in high waitlist mortality. Read More

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Current Challenges for Education and Training in Transanal Surgery.

Meagan Costedio

Clin Colon Rectal Surg 2021 May 29;34(3):151-154. Epub 2021 Mar 29.

Department of Colorectal Surgery, University Hospitals Ahuja Medical Center, Beachwood, Ohio.

Transanal endoscopic microsurgery (TEM) is a technique that was introduced in the 1980s for improved exposure to upper rectal polyps. This technique, though initially difficult to master due to new skill acquisition for surgeons, has spared many patients proctectomy. There are many benign indications for transanal endoscopic surgery which has led to in vivo operating room training with fewer undesirable effects to the patient. Read More

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Application of Remote Sensing Data for Locust Research and Management-A Review.

Insects 2021 Mar 9;12(3). Epub 2021 Mar 9.

German Remote Sensing Data Center (DFD), German Aerospace Center (DLR), 82234 Wessling, Germany.

Recently, locust outbreaks around the world have destroyed agricultural and natural vegetation and caused massive damage endangering food security. Unusual heavy rainfalls in habitats of the desert locust () and lack of monitoring due to political conflicts or inaccessibility of those habitats lead to massive desert locust outbreaks and swarms migrating over the Arabian Peninsula, East Africa, India and Pakistan. At the same time, swarms of the Moroccan locust () in some Central Asian countries and swarms of the Italian locust () in Russia and China destroyed crops despite developed and ongoing monitoring and control measurements. Read More

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Late massive radial artery pseudoaneurysm following cardiac catheterization: A case report.

Int J Surg Case Rep 2021 Apr 16;81:105774. Epub 2021 Mar 16.

Division of Cardiology, Department of Internal Medicine, University of Florida, 655 W 8th St., 5th Floor, Ambulatory Care Center, Jacksonville, FL, 32209, United States. Electronic address:

Introduction: Transradial artery approach for cardiac catheterization was first introduced in the late 1980s and has now become the approach of choice due to its anatomical advantage, reduction in complications, and overall improved patient experience.

Case Presentation: We present a case of a 77 year-old female who presented with an extremely rare and late complication of radial artery pseudoaneurysm after transradial coronary intervention. The patient presented at a post-procedural follow-up with severe pain at the radial access site and was found to have a partially thrombosed pseudoaneurysm. Read More

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Cowden syndrome: new clinical features in a large family; joint hyperextensibility, dental abnormalities and gingival enlargement.

BMJ Case Rep 2021 Mar 10;14(3). Epub 2021 Mar 10.

Clinical Genetics Department, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

A 4-year-old boy presented with his mother to genetics in the 1980s, with a family history (FH) of macrocephaly and intellectual disability (ID). He remained undiagnosed until his mother developed multiple cancers and was diagnosed with Cowden syndrome (CS) in 2017, a rare, multisystem cancer predisposition syndrome. CS was then confirmed in multiple family members. Read More

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Roadmap towards solar fuel synthesis at the water interface of liposome membranes.

Chem Soc Rev 2021 Apr;50(8):4833-4855

Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Artificial photosynthesis has experienced rapid developments aimed at producing photocatalytic systems for the synthesis of chemical energy carriers. Conceptual advances of solar fuel systems have been inspired by improved understanding of natural photosynthesis and its key operational principles: (a) light harvesting, (b) charge separation, (c) directional proton and electron transport between reaction centres and across membranes, (d) water oxidation and (e) proton or CO2 reduction catalysis. Recently, there has been a surge of bio-inspired photosynthetic assemblies that use liposomes as nanocompartments to confine reaction spaces and enable vectorial charge transport across membranes. Read More

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Modern classification and molecular-genetic aspects of osteogenesis imperfecta.

Vavilovskii Zhurnal Genet Selektsii 2020 Mar;24(2):219-227

Institute of Biochemistry and Genetics - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russia Republican Medical-Genetic Center, Ufa, Russia.

Osteogenesis imperfecta (imperfect osteogenesis in the Russian literature) is the most common hereditary form of bone fragility, it is a genetically and clinically heterogeneous disease with a wide range of clinical severity, often leading to disability from early childhood. It is based on genetic disorders leading to a violation of the structure of bone tissue, which leads to frequent fractures, impaired growth and posture, with the development of characteristic disabling bone deformities and associated problems, including respiratory, neurological, cardiac, renal impairment, hearing loss. Osteogenesis imperfecta occurs in both men and women, the disease is inherited in both autosomal dominant and autosomal recessive types, there are sporadic cases of the disease due to de novo mutations, as well as X-linked forms. Read More

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The changing accuracy of traffic forecasts.

Transportation (Amst) 2021 Feb 26:1-22. Epub 2021 Feb 26.

Department of Civil Engineering, University of Kentucky, Lexington, KY USA.

Researchers have improved travel demand forecasting methods in recent decades but invested relatively little to understand their accuracy. A major barrier has been the lack of necessary data. We compiled the largest known database of traffic forecast accuracy, composed of forecast traffic, post-opening counts and project attributes for 1291 road projects in the United States and Europe. Read More

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February 2021

New Advancements in Inflatable Penile Prosthesis.

Sex Med Rev 2021 Feb 17. Epub 2021 Feb 17.

Department of Urology, Lenox Hill Hospital, Zucker School of Medicine at Hofstra/Northwell, New York, NY; Advanced Urological Care, PC, New York, NY. Electronic address:

Introduction: Inflatable penile prosthesis (IPP) technology is a mainstay in the treatment of erectile dysfunction refractory to medical management. Technological advancements in the design of 3-piece IPPs have been improved to optimize concealability and surgical placement since the 1980s. Recent advancements over the past 10 years include pump, reservoir, tubing, and cylinder updates. Read More

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February 2021

Improved Incidence of Cardiovascular Disease in Patients with Incident Rheumatoid Arthritis in the 2000s: a Population-Based Cohort Study.

J Rheumatol 2021 Feb 15. Epub 2021 Feb 15.

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Department of Cardiovascular Disease, Division of Circulatory Failure, Mayo Clinic, Rochester, Minnesota Division of Medical statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Funding: This work was supported by a grant from the National Institutes of Health, NIAMS (R01 AR46849) and NHLBI (HL120859). Research reported in this publication was supported by the National Institute of Aging of the National Institutes of Health under Award Number R01AG034676. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Address correspondence to Elena Myasoedova, MD, PhD. Mayo Clinic College of Medicine and Science, Division of Rheumatology, 200 1st St. SW, Rochester, MN 55905. Email:

Objective: To assess trends in incidence of cardiovascular disease (CVD) and mortality following incident CVD events in patients with rheumatoid arthritis (RA) onset in 1980- 2009 versus non-RA subjects.

Methods: We studied Olmsted County, Minnesota residents with incident RA (age ≥ 18 years, 1987 ACR criteria met in 1980-2009) and non-RA subjects from the same source population with similar age, sex and calendar year of index. All subjects were followed until death, migration, or 12/31/2016. Read More

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February 2021