22,899 results match your criteria improve stroke


Pre-sewn Multi-branched Aortic Graft and 3D-Printing Guidance for Crawford Extent II or III Thoracoabdominal Aortic Aneurysm Repair.

Semin Thorac Cardiovasc Surg 2021 May 7. Epub 2021 May 7.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Reconstruction of the visceral and segmental arteries is a challenging part of open surgical repair of extensive thoracoabdominal aortic aneurysm (TAAA). For more efficient reconstruction of these branching vessels, a technique of using pre-hand-sewn multi-branched aortic graft (octopod technique) has been adopted with the aid of 3D-printing-guidance in latest cases. The octopod graft has been employed for the extent II or III TAAA repair, in which the commercially available two 4-branched aortic grafts were interconnected before surgery. Read More

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Inhibition of mTOR by rapamycin does not improve hypoxic pulmonary hypertension-induced right heart failure in old mice.

Exp Gerontol 2021 May 7:111395. Epub 2021 May 7.

Division of Kinesiology & Health, University of Wyoming, Laramie, WY, United States of America. Electronic address:

Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin attenuates heart failure (HF) and age-associated changes in left ventricular (LV) function. Rapamycin has also been suggested as a therapy for pulmonary hypertension (PH) and concomitant right heart failure (PH-RHF) based on reports of elevated mTOR signaling in young models with PH. However, rapamycin has yet to be tested in the setting of aging, PH, and right heart disease despite the fact that RV function predicts survival in both age-related HF as well as several pulmonary disease states including PH. Read More

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Role of Telemedicine in Prehospital Stroke Care.

Curr Cardiol Rep 2021 May 10;23(6):71. Epub 2021 May 10.

Department of Neurology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, 79905, USA.

Purpose Of Review: To summarize evidence for the feasibility and the efficacy of mobile stroke units (MSUs) and telemedicine in the field to reduce time delays in offering acute stroke interventions.

Recent Findings: A mobile stroke unit is a modified ambulance and includes sophisticated equipment, either trained personnel on board, or connection with skilled physicians via telemedicine. Stroke assessment and treatment agreeability between the on board and remote neurologist is high in MSUs. Read More

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Immersive Virtual Reality to Improve Outcomes in Veterans With Stroke: Protocol for a Single-Arm Pilot Study.

JMIR Res Protoc 2021 May 10;10(5):e26133. Epub 2021 May 10.

Research and Development Service, James A Haley Veterans' Hospital, Tampa, FL, United States.

Background: Over the last decade, virtual reality (VR) has emerged as a cutting-edge technology in stroke rehabilitation. VR is defined as a type of computer-user interface that implements real-time simulation of an activity or environment allowing user interaction via multiple sensory modalities. In a stroke population, VR interventions have been shown to enhance motor, cognitive, and psychological recovery when utilized as a rehabilitation adjunct. Read More

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Contemporary therapeutics and new drug developments for treatment of Fabry disease: a narrative review.

Cardiovasc Diagn Ther 2021 Apr;11(2):683-695

Department of Internal Medicine I, Fabry Center for Interdisciplinary Therapy (FAZIT) and Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.

Fabry disease (OMIM 301500) is an X-linked (Xq22.1) lysosomal storage disorder leading to a progressive multisystem disease with high variability in both genotype and phenotype expression. The pathophysiological origin is found in an enzyme deficiency of the α-galactosidase A (enzyme commission no. Read More

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Roles of Fibroblast Growth Factors and Their Therapeutic Potential in Treatment of Ischemic Stroke.

Front Pharmacol 2021 22;12:671131. Epub 2021 Apr 22.

School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.

Stroke is the leading cause of death worldwide, and its treatment remains a challenge. Complex pathological processes are involved in stroke, which causes a reduction in the supply of oxygen and energy to the brain that triggers subsequent cascade events, such as oxidative stress, inflammatory responses and apoptosis, resulting in brain injury. Stroke is a devastating disease for which there are few treatments, but physical rehabilitation can help improve stroke recovery. Read More

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Highlighting gaps in spinal cord injury research in activity-based interventions for the upper extremity: A scoping review.

NeuroRehabilitation 2021 May 6. Epub 2021 May 6.

Jefferson College of Rehabilitation Sciences, Thomas Jefferson University, Philadelphia, PA, USA.

Background: Upper extremity activity-based therapy for neurologic disorders employs high-intensity, high repetition functional training to exploit neuroplasticity and improve function. Research focused on high-intensity upper extremity activity-based therapy for persons with spinal cord injury (SCI) is limited.

Objective: To summarize high-intensity activity-based interventions used in neurological disorders for their current or potential application to SCI. Read More

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Post-stroke gait training practices in a low resource setting: A cross-sectional survey among Indian physiotherapists.

NeuroRehabilitation 2021 May 3. Epub 2021 May 3.

Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, India.

Background: Independent mobility is the most important determinant of quality of life after stroke and it is vital that training aimed at restoration of gait is based on contemporary evidence. Despite several practice guidelines for gait rehabilitation after stroke existing globally, their feasibility of application in low-resource settings is often questionable.

Objective: To investigate the current practices in gait training among Indian physiotherapists involved in the rehabilitation of stroke survivors. Read More

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Evaluation of quality of life in individuals with chronic stroke who underwent aquatic exercises: A case series.

NeuroRehabilitation 2021 Apr 30. Epub 2021 Apr 30.

Laboratory of Biomechanics and Clinical Epidemiology, PAIFIT Research Group, Universidade Estadual de Londrina, Londrina, PR, Brazil.

Background: Aquatic exercises are among the treatments available to improve the quality of life after stroke.

Objectives: To investigate changes in the quality of life after 8-week of aquatic exercises in post-stroke individuals.

Methods: A case series study was designed, including four male participants. Read More

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Stroke and Neurointervention in the COVID-19 pandemic: A narrative review.

Expert Rev Med Devices 2021 May 8. Epub 2021 May 8.

Cooper Neurological Institute, Cooper University Hospital, Camden NJ 08103.

Introduction: In this review, we will summarize the impact of the COVID-19 pandemic on neurointerventional care for patients with cerebrovascular disease, with a particular emphasis on epidemiology, neurointerventional processes, and lessons learned from paradigm shifts in endovascular care.

Areas Covered: Peer-reviewed research is summarized regarding the complications of COVID-19 as related to the pandemic's impact on hospital admissions, imaging capabilities, treatment times, and outcomes of neurointerventional cases.

Expert Opinion: In the first wave of the COVID-19 pandemic, there was a global decline in neuroimaging, use of intravenous thrombolysis, thrombectomy, and coil embolization for ruptured intracranial aneurysms. Read More

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Application effect of the hospital-community integrated service model in home rehabilitation of stroke in disabled elderly: a randomised trial.

Ann Palliat Med 2021 Apr;10(4):4670-4677

Department of Neurology, Affiliated Hospital of Jiangnan University, Wuxi, China.

Background: Disabled elderly with stroke usually have difficulty in obtaining professional rehabilitation intervention after being discharged from the hospital, and their self-health management ability is low, so their illness is prone to relapse. The hospital community-integrated service model (HCISM) is a scientific model designed to meet the needs of home care after discharge from the hospital, improve the quality of life of patients after discharge from the hospital, ease the burden on the family, and improve the service capabilities of community medical staff. The purpose of this study is to explore the effect of HCISM in home rehabilitation of stroke disabled elderly. Read More

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Endovascular treatment of hemodialysis-induced lower limb artery ischemia: retrospective analysis from a single center.

Ann Palliat Med 2021 Apr;10(4):4661-4669

Department of Nephrology, Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Wuxi, China.

Background: Critical limb artery ischemia is one of common complications after hemodialysis, with endovascular therapy (EVT) having become its first-line treatment. There is no relevant study investigating the relationship between EVT and the prognosis of hemodialysis patients with critical lower limb ischemia, the most common site of vascular dysfunction.

Methods: This was a retrospective, nonrandomized, single-center study. Read More

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β1-blocker in sepsis.

J Intensive Care 2021 May 8;9(1):39. Epub 2021 May 8.

Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Background: The use of ultrashort-acting β1-blockers recently has attracted attention in septic patients with non-compensatory tachycardia. We summarized the metabolic and hemodynamic effects and the clinical evidence of ultrashort-acting β1-blockers.

Main Body: A recent meta-analysis showed that ultrashort-acting β1-blockers reduced the mortality in septic patients with persistent tachycardia. Read More

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The cost of community research-recruiting community-dwelling participants to a feasibility primary care cluster randomised controlled trial.

Trials 2021 May 8;22(1):332. Epub 2021 May 8.

Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.

Background: To support a robust evidence base for the organisation and provision of community-delivered health services for older people, clinical trials need to be designed to account for community-based participant recruitment. There is currently little reported information available on the time and cost of recruiting community-dwelling older people, which makes the completion of cost attribution documentation problematic when applying for research funding.

Main Body: We aimed to establish the amount of researcher time it takes to recruit community-dwelling older people to a feasibility primary care cluster randomised controlled trial, including collecting baseline data. Read More

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Platelet Function Monitoring Performed after Carotid Stenting during Endovascular Stroke Treatment Predicts Outcome.

J Stroke Cerebrovasc Dis 2021 May 4;30(7):105800. Epub 2021 May 4.

Stroke Unit, Neurology Unit, Department of Neuroscience, Ospedale Civile, Azienda Ospedaliera Universitaria di Modena, Via Giardini 1355, Modena, Emilia Romagna 41126, Italy. Electronic address:

Objectives: Many studies showed that platelet reactivity testing can predict ischemic events after carotid stenting or ischemic stroke. The aim of our study was to assess the role of early platelet function monitoring in predicting 90-days functional outcome, stent thrombosis and hemorrhagic transformation in patients with ischemic stroke treated with endovascular procedures requiring emergent extracranial stenting.

Materials And Methods: We performed a retrospective study on consecutive patients with acute anterior circulation stroke admitted to our hospital between January 2015 and March 2020, in whom platelet reactivity testing was performed within 10 days from stenting. Read More

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Prognostic value of lower bone mineral density in predicting adverse cardiovascular disease in Asian women.

Heart 2021 May 7. Epub 2021 May 7.

Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Republic of Korea.

Objective: We investigated whether the evaluation of bone mineral density (BMD) provides independent and incremental prognostic value for predicting atherosclerotic cardiovascular disease (ASCVD) in women.

Methods: A total of 12 681 women aged 50-80 years (mean, 63.0±7. Read More

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Potential of dual-layer spectral CT for the differentiation between hemorrhage and iodinated contrast medium in the brain after endovascular treatment of ischemic stroke patients.

Clin Imaging 2021 Apr 29;79:158-164. Epub 2021 Apr 29.

Department of Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany.

Background: One possible complication after mechanical thrombectomy is hemorrhage. In conventional CT it is often difficult to differ between extravasation of iodinated contrast medium and blood. This differentiation, however, is essential for treatments with anticoagulants and antiplatelets. Read More

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Smart glasses evaluation during the COVID-19 pandemic: First-use on Neurointerventional procedures.

Clin Neurol Neurosurg 2021 Apr 19;205:106655. Epub 2021 Apr 19.

Interventional Neuroradiology, Clinical Hospital Center "Sisters of Mercy", Zagreb, Croatia.

The COVID-19 pandemic is rapidly transforming the healthcare system, with telemedicine, or virtual health, being one of the key drivers of the change. Smart glasses have recently been introduced to the public and have generated interest with healthcare professionals as demonstrated by their early adoption in clinics and hospitals. Observing procedures is essential for young interventionalist-in-training, but sometimes it is difficult for them to be able to get the volume of exposure to procedures that they need. Read More

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Central and Peripheral Arterial Diseases in Chronic Kidney Disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2021 May 4. Epub 2021 May 4.

Department of Cardiology I: Coronary and Peripheral Vascular Disease, Heart Failure, Münster University Hospital, Münster, Germany. Electronic address:

Chronic kidney disease (CKD) affects about 10% of all populations worldwide, with about 2 million people requiring dialysis. Although patients with CKD are at high risk of cardiovascular disease (CVD) and events, they are often underrepresented or excluded in clinical trials, leading to important knowledge gaps about how to treat these patients. KDIGO (Kidney Disease: Improving Global Outcomes) convened the fourth Clinical Controversies Conference on the Heart, Kidney and Vasculature in Dublin, Ireland, in February 2020, entitled "Central and Peripheral Arterial Diseases in Chronic Kidney Disease. Read More

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An exploration of goal-setting practices in Queensland rehabilitation services.

Disabil Rehabil 2021 May 7:1-11. Epub 2021 May 7.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia.

Background: Goals are vital in rehabilitation; however, how goal-setting occurs varies widely in clinical practice. This study aims to review goal-setting practices across the rehabilitation continuum within varied case mix services in Queensland, Australia.

Method: A descriptive multisite qualitative case study with medical record audits and interviews of adult rehabilitation clients was used to evaluate four propositions across three inpatient and two community rehabilitation services. Read More

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Healthcare Quality Assessments: No Guarantees of Same Outcomes for Different Socioeconomic Stroke Patients.

Int J Qual Health Care 2021 May 7. Epub 2021 May 7.

Health Insurance Review & Assessment Service, Wonju, Korea.

Background: Health care quality assessment is being conducted in many countries. However, although improving health equity is one of the major objectives of medical quality assessment, it is not clear whether different socioeconomic statuses shows the same health outcomes even in the same medical quality hospitals. No study has directly compared the health outcomes of different socioeconomic status in the same hospitals nationwide. Read More

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Strengthened structure-function relationships of the corticospinal tract by free water correction after stroke.

Brain Commun 2021 28;3(2):fcab034. Epub 2021 Apr 28.

Department of Neurology, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany.

The corticospinal tract is the most intensively investigated tract of the human motor system in stroke rehabilitative research. Diffusion-tensor-imaging gives insights into its microstructure, and transcranial magnetic stimulation assesses its excitability. Previous data on the interrelationship between both measures are contradictory. Read More

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Improved Functional Outcome After Peripheral Nerve Stimulation of the Impaired Forelimb Post-stroke.

Front Neurol 2021 20;12:610434. Epub 2021 Apr 20.

Department of Neurological Surgery, Loyola University Medical Center, Maywood, IL, United States.

Lack of blood flow to the brain, i.e., ischemic stroke, results in loss of nerve cells and therefore loss of function in the effected brain regions. Read More

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Lost in Translation: Simple Steps in Experimental Design of Neurorehabilitation-Based Research Interventions to Promote Motor Recovery Post-Stroke.

Front Hum Neurosci 2021 20;15:644335. Epub 2021 Apr 20.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, United States.

Stroke continues to be a leading cause of disability. Basic neurorehabilitation research is necessary to inform the neuropathophysiology of impaired motor control, and to develop targeted interventions with potential to remediate disability post-stroke. Despite knowledge gained from basic research studies, the effectiveness of research-based interventions for reducing motor impairment has been no greater than standard of practice interventions. Read More

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Stable to improved cardiac and pulmonary function in children with high-risk sickle cell disease following haploidentical stem cell transplantation.

Bone Marrow Transplant 2021 May 6. Epub 2021 May 6.

Department of Pediatrics, New York Medical College, Valhalla, NY, USA.

Children with sickle cell disease (SCD) are at high-risk of progressive, chronic pulmonary and cardiac dysfunction. In this prospective multicenter Phase II trial of myeloimmunoablative conditioning followed by haploidentical stem cell transplantation in children with high-risk SCD, 19 patients, 2.0-21. Read More

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Stroke Complicating Infective Endocarditis After Transcatheter Aortic Valve Replacement.

J Am Coll Cardiol 2021 May;77(18):2276-2287

Emory University School of Medicine, Atlanta, Georgia, USA.

Background: Stroke is one of the most common and potentially disabling complications of infective endocarditis (IE). However, scarce data exist about stroke complicating IE after transcatheter aortic valve replacement (TAVR).

Objectives: The purpose of this study was to determine the incidence, risk factors, clinical characteristics, management, and outcomes of patients with definite IE after TAVR complicated by stroke during index IE hospitalization. Read More

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[Interdisciplinary aspects of oral anticoagulation with NOACs in atrial fibrillation].

Dtsch Med Wochenschr 2021 May 6;146(S 01):S2-S16. Epub 2021 May 6.

Kardiologie, Universitäts-Herzzentrum Freiburg.

Stroke prophylaxis with non-vitamin K-dependent oral anticoagulants (NOAKs) in patients with non-valvular atrial fibrillation (nvVHF) is now firmly established in routine clinical practice. The definition of nvVHF includes the absence of a mechanical heart valve and AF not associated with moderate- or high-grade mitral valve stenosis. The management of oral anticoagulation (OAC) requires a high degree of interdisciplinarity. Read More

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Intracranial Stenting: Angioplasty Basic Technique, Indications, and Sizing: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 May 6. Epub 2021 May 6.

Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.

Intracranial atherosclerotic disease (ICAD) is a common cause of stroke. Antiplatelet therapy is the mainstay for symptomatic ICAD treatment. Endovascular management with submaximal angioplasty and/or intracranial stenting is reserved for patients with repeated ischemic events despite optimal medical therapy. Read More

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Combined real-time fMRI and real time fNIRS brain computer interface (BCI): Training of volitional wrist extension after stroke, a case series pilot study.

PLoS One 2021 6;16(5):e0250431. Epub 2021 May 6.

Brain Rehabilitation Research Center, Malcom Randall VA Medical Center, Gainesville, Florida, United States of America.

Objective: Pilot testing of real time functional magnetic resonance imaging (rt-fMRI) and real time functional near infrared spectroscopy (rt-fNIRS) as brain computer interface (BCI) neural feedback systems combined with motor learning for motor recovery in chronic severely impaired stroke survivors.

Approach: We enrolled a four-case series and administered three sequential rt-fMRI and ten rt-fNIRS neural feedback sessions interleaved with motor learning sessions. Measures were: Arm Motor Assessment Tool, functional domain (AMAT-F; 13 complex functional tasks), Fugl-Meyer arm coordination scale (FM); active wrist extension range of motion (ROM); volume of activation (fMRI); and fNIRS HbO concentration. Read More

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Statistical shape analysis of the left atrial appendage predicts stroke in atrial fibrillation.

Int J Cardiovasc Imaging 2021 May 6. Epub 2021 May 6.

Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, USA.

The shape of the left atrium (LA) and left atrial appendage (LAA) have been shown to predict stroke in patients with atrial fibrillation (AF). Prior studies rely on qualitative assessment of shape, which limits reproducibility and clinical utility. Statistical shape analysis (SSA) allows for quantitative assessment of shape. Read More

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