388 results match your criteria improve sensibility


Bovine Serum Albumin Conjugation in Superparamagnetic/Poly(methyl methacrylate) Nanoparticles as an Alternative for Magnetic Enzyme-Linked Immunosorbent Assays.

J Nanosci Nanotechnol 2021 Nov;21(11):5493-5498

Department of Chemical Engineering and Food Engineering, Federal University of Santa Catarina, 88040-970, Santa Catarina, Brazil.

Nanomaterials, such as magnetic nanoparticles have attracted significant attention of medical area due to their capacity to improve the performance of immunoassays. Therefore the aim of this work was to study the bovine serum albumin (BSA) conjugation in superparamagnetic (MNPs)/poly(methyl methacrylate) (PMMA) nanoparticles with further characterization and application in enzyme-linked immunosorbent (ELISA) assay. The successful conjugation of BSA in MNPs- PMMA nanoparticles was confirmed by several techniques, including light scattering, zeta potential, transmission electron microscopy (TEM) and Lowry protein quantification assay. Read More

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November 2021

Intraoperative Ultrasound-Assisted Extent of Resection Assessment in Pediatric Neurosurgical Oncology.

Front Oncol 2021 21;11:660805. Epub 2021 Apr 21.

Neurosurgery Unit, Department of Neurological and Psychiatric Sciences, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Central nervous system tumors represent the most frequent solid malignancy in the pediatric population. Maximal safe surgical resection is a mainstay of treatment, with significant prognostic impact for the majority of histotypes. Intraoperative ultrasound (ioUS) is a widely available tool in neurosurgery to assist in intracerebral disease resection. Read More

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[A heart sound classification method based on joint decision of extreme gradient boosting and deep neural network].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2021 Feb;38(1):10-20

School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P.R.China.

Heart sound is one of the common medical signals for diagnosing cardiovascular diseases. This paper studies the binary classification between normal or abnormal heart sounds, and proposes a heart sound classification algorithm based on the joint decision of extreme gradient boosting (XGBoost) and deep neural network, achieving a further improvement in feature extraction and model accuracy. First, the preprocessed heart sound recordings are segmented into four status, and five categories of features are extracted from the signals based on segmentation. Read More

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February 2021

[Patients treated with palbociclib and endocrine therapy for metastatic breast cancer: Can we predict the occurrence of severe early hematological toxicity?]

Bull Cancer 2021 May 2;108(5):544-552. Epub 2021 Apr 2.

Sainte-Catherine Institute, 250, chemin des baigne-pieds, 84000 Avignon, France.

Introduction: The addition of palbociclib to endocrine therapy has been shown to improve progression free survival in hormone receptor positive metastatic breast cancer patients. This cyclin CDK4/6 inhibitor could expose patients to a grade 3-4 hematological toxicity, leading to treatment discontinuation or treatment interruption that is potentially associated with a lack of efficiency. The aim of this study was to identify predictive factors of severe early hematotoxicity (ESHT). Read More

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Recent Developments in Graphene-Based Toxic Gas Sensors: A Theoretical Overview.

Sensors (Basel) 2021 Mar 11;21(6). Epub 2021 Mar 11.

Tecnologico de Monterrey, School of Engineering and Sciences, Atizapan de Zaragoza, Estado de México 52926, Mexico.

Detecting and monitoring air-polluting gases such as carbon monoxide (CO), nitrogen oxides (NO), and sulfur oxides (SO) are critical, as these gases are toxic and harm the ecosystem and the human health. Therefore, it is necessary to design high-performance gas sensors for toxic gas detection. In this sense, graphene-based materials are promising for use as toxic gas sensors. Read More

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Application of Radiosensitizers in Cancer Radiotherapy.

Int J Nanomedicine 2021 12;16:1083-1102. Epub 2021 Feb 12.

Department of Oncology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.

Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells and shrink tumors. Although great success has been achieved on radiotherapy, there is still an intractable challenge to enhance radiation damage to tumor tissue and reduce side effects to healthy tissue. Radiosensitizers are chemicals or pharmaceutical agents that can enhance the killing effect on tumor cells by accelerating DNA damage and producing free radicals indirectly. Read More

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The emerging role of 3D-printing in ion mobility spectrometry and mass spectrometry.

Anal Methods 2021 02 12;13(7):852-861. Epub 2021 Feb 12.

CINVESTAV Unidad Irapuato, Department of Biochemistry and Biotechnology, Mexico.

3D-printing is revolutionizing the rapid prototyping in analytical chemistry. In the last few years, we observed the development of 3D-printed components for ion studies, such as ion sources, ion transfer and ion mobility spectrometry (IMS) devices. Often, 3D-printed gadgets add functions to existing mass spectrometry (MS) systems. Read More

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February 2021

Non-invasive monitoring of pH and oxygen using miniaturized electrochemical sensors in an animal model of acute hypoxia.

J Transl Med 2021 02 4;19(1):53. Epub 2021 Feb 4.

BCNatal | Fetal Medicine Research Center (Hospital Clínic and Hospital Sant Joan de Déu), Universitat de Barcelona, Barcelona, Spain.

Background: One of the most prevalent causes of fetal hypoxia leading to stillbirth is placental insufficiency. Hemodynamic changes evaluated with Doppler ultrasound have been used as a surrogate marker of fetal hypoxia. However, Doppler evaluation cannot be performed continuously. Read More

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February 2021

Integrating stereotactic body radiation therapy (SBRT) and systemic treatments in oligoprogressive prostate cancer: new evidence from the literature.

Clin Exp Metastasis 2021 Apr 20;38(2):227-230. Epub 2021 Jan 20.

Radiation Oncology Unit - Oncology Department, Azienda Ospedaliero Universitaria Careggi, Viale Morgagni 85, 50134, Florence, Italy.

Recent findings from literature evidenced that metastatic prostate cancer often shows heterogeneous response to therapy, with persistent sensibility to systemic treatments after biochemical, clinical, or radiographic progression. This highlights the advantage of integrated approaches in which local ablative treatments (e.g. Read More

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BIONOTE as an Innovative Biosensor for Measuring Endocannabinoid Levels.

Sensors (Basel) 2021 Jan 12;21(2). Epub 2021 Jan 12.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

In this study, a novel approach was developed to quantify endocannabinoids (eCBs), and was based on the liquid biosensor BIONOTE. This device is composed of a probe that can be immersed in a solution, and an electronic interface that can record a current related to the oxy-reductive reactions occurring in the sample. The two most representative members of eCBs have been analysed in vitro by BIONOTE: anandamide (-arachidonoylethanolamine, AEA) and 2-arachidonoylglycerol (2-AG). Read More

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January 2021

Development and validation of a novel informational booklet for pediatric long-term ventilation decision support.

Pediatr Pulmonol 2021 May 23;56(5):1198-1204. Epub 2020 Dec 23.

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Objectives: To provide accessible, uniform, comprehensive, and balanced information to families deciding whether to initiate long-term ventilation (LTV) for their child, we sought to develop and validate a novel informational resource.

Methods: The Ottawa Decision Support Framework was followed. Previous interviews with 44 lay and 15 professional stakeholders and published literature provided content for a booklet. Read More

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Metabolic syndrome in type 2 diabetic patients: a review of current evidence.

Porto Biomed J 2020 Nov-Dec;5(6):e101. Epub 2020 Dec 3.

São João University Hospital Center.

The metabolic syndrome (MS) is a set of metabolic disturbances, represented by various cardiovascular risk factors which are generally associated with the central accumulation of fat and the resistance to insulin. Inadequate changes in eating behaviours and weight loss, which are associated to taking part in regular physical activity, are considered to be primary and first choice therapies for the treatment of MS, as they assist in the reduction of the abdominal girth and visceral fat, improve the sensibility to insulin and reduce the plasmatic concentrations of glucose and triglycerides, raise the values of high density lipoproteins and, consequently decrease the risk factors which contribute to the development of type 2 diabetes. The MS is a current discussion theme in the health field as it is related to illnesses/diseases, which not only cause a worldwide high mortality rate but show increasing incidence. Read More

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December 2020

Hydroethanolic Extract from Müll. Arg. Bark Improves Haematological and Biochemical Parameters in Nicotinamide-/Streptozotocin-Induced Diabetic Rats.

Evid Based Complement Alternat Med 2020 25;2020:3160834. Epub 2020 Nov 25.

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

) is a plant used in Cameroonian traditional medicine to manage diabetes. The effects of hydroethanolic barks extract from were evaluated on diabetes disorders including hematology, inflammatory, and oxidative stress parameters. The in vitro antioxidant capacity of the hydroethanolic bark extract (70 : 30) was evaluated. Read More

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November 2020

The hidden labours of designing the Objective Structured Clinical Examination: a Practice Theory study.

Adv Health Sci Educ Theory Pract 2021 05 16;26(2):637-651. Epub 2020 Nov 16.

Centre for Research in Assessment and Digital Learning (CRADLE), Deakin University, Geelong, Australia.

Objective Structured Clinical Examinations (OSCEs) have become ubiquitous as a form of assessment in medical education but involve substantial resource demands and considerable local variation. A detailed understanding of the processes by which OSCEs are designed and administered could improve feasibility and sustainability. This exploration of OSCE design is informed by Practice Theory, which suggests assessment design processes are dynamic, social and situated activities. Read More

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Two Measures of Interoceptive Sensibility and the Relationship With Introversion and Neuroticism in an Adult Population.

Psychol Rep 2020 Oct 28:33294120965461. Epub 2020 Oct 28.

Leeds School of Social Sciences, Leeds Beckett University, Leeds, UK.

Interoception, the ability to detect internal bodily signals, is vital for an individual's well-being and is increasingly connected to mental health disorders. Research investigating relationships between individual differences in interoception and personality types is limited, and mixed results are reported across a variety of interoceptive tasks, measures, and conceptualisations. Guided by biological theories, this study contributed further to the understanding of the relationship between interoception and personality by utilising two interoceptive measures. Read More

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October 2020

At the Heart of Neurological Dimensionality: Cross-Nosological and Multimodal Cardiac Interoceptive Deficits.

Psychosom Med 2020 Nov/Dec;82(9):850-861

From the Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina (Abrevaya, Yoris, De la Fuente, Martorell-Caro); National Scientific and Technical Research Council (CONICET), Argentina (Abrevaya, Fittipaldi, García, Birba, Yoris, Salamone, De la Fuente, García-Cordero, Martorell-Caro, Sedeño, Ibáñez); Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina (Abrevaya, Fittipaldi, Salamone, Pautassi); Universidad de San Andrés, Buenos Aires, Argentina (Fittipaldi, García, Dottori, Birba, García-Cordero, Martorell-Caro, Ibáñez); Faculty of Education, National University of Cuyo, Mendoza, Argentina (García); Departamento de Lingu[Combining Diaeresis]ística y Literatura, Facultad de Humanidades, Universidad de Santiago de Chile, Santiago, Chile (García); Global Brain Health Institute, University of California, San Francisco, USA (García, Ibáñez); Radiology Hospital Universitario San Ignacio (HUSI), Bogotá, Colombia (Santamaria-Garcia); Chair for Addiction Research, Institute for Clinical Psychology and Psychotherapy, Dresden, Germany (Hildebrandt); Buenos Aires Physics Institute (IFIBA) and Physics Department, University of Buenos Aires, Buenos Aires, Argentina (De la Fuente); Faculty of Human Sciences and Behavior, Favaloro University, Buenos Aires, Argentina (Alarco-Martí); Instituto de Investigación Médica M. y M. Ferreyra, INIMEC-CONICET-UNC, Córdoba, Argentina (Pautassi); Memory and Balance Clinic, Buenos Aires, Argentina (Serrano); Universidad Autónoma del Caribe, Barranquilla, Colombia (Ibáñez); and Department of Psychology, Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile (Ibáñez).

Objective: Neurological nosology, based on categorical systems, has largely ignored dimensional aspects of neurocognitive impairments. Transdiagnostic dimensional approaches of interoception (the sensing of visceral signals) may improve the descriptions of cross-pathological symptoms at behavioral, electrophysiological, and anatomical levels. Alterations of cardiac interoception (encompassing multidimensional variables such as accuracy, learning, sensibility, and awareness) and its neural correlates (electrophysiological markers, imaging-based anatomical and functional connectivity) have been proposed as critical across disparate neurological disorders. Read More

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October 2020

[Expert consensus of Oncology Committee of Chinese Medical Association in early diagnosis and treatment of pancreatic cancer].

Authors:

Zhonghua Zhong Liu Za Zhi 2020 Sep;42(9):706-712

Pancreatic cancer(PC) remains one of the most challenging malignant tumor in gastrointestinal cancer, and the incidence and mortality rates are significantly increased in the past decades. The 5-years survival rate of PC is less than 8% since its dormant clinical symptoms and lacking of sensibility and specificity markers in early diagnosis. The early diagnosis of pancreatic cancer is a worldwide problem, and the early diagnosis rate is only 5%. Read More

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September 2020

The Role of 2D/3D Ultrasound to Assess the Response to Neoadjuvant Chemotherapy in Locally Advanced Cervical Cancer.

Oncology 2020 4;98(11):807-813. Epub 2020 Sep 4.

Dipartimento Universitario Materno-infantile e Scienze Urologiche, Università di Roma "Sapienza'', Rome, Italy.

Introduction: Different imaging techniques were introduced to improve preoperative clinical staging of locally advanced cervical cancer (LACC) with transvaginal ultrasound (TV-US) or transrectal ultrasound (TR-US) representing a promising staging technique in the evaluation of the local extension of the disease for invasive tumors. The aim of this study was to evaluate the response to neoadjuvant chemotherapy (NACT) in LACC by 2D/3D ultrasound examination.

Materials And Methods: We prospectively enrolled patients affected by histologically and clinically confirmed LACC. Read More

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November 2020

Necrosis and Brain Invasion Predict Radio-Resistance and Tumor Recurrence in Atypical Meningioma: A Retrospective Cohort Study.

Neurosurgery 2020 12;88(1):E42-E48

Division of Neurosurgery, University of Toronto, Toronto, Canada.

Background: Meningiomas are the most common tumors occurring in the central nervous system, with variable recurrence rates depending on World Health Organization grading. Atypical (Grade II) meningioma has a higher rate of recurrence than benign (Grade I) meningioma. The efficacy of adjuvant radiotherapy (RT) to improve tumor control has been questioned. Read More

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December 2020

Tetrahedral Framework Nucleic Acids Loading Ampicillin Improve the Drug Susceptibility against Methicillin-Resistant .

ACS Appl Mater Interfaces 2020 Aug 11;12(33):36957-36966. Epub 2020 Aug 11.

State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

The overuse of antibiotics has led to the emergence of multidrug-resistant pathogens. There is an urgent need to develop alternative therapeutic strategies to reduce mortality and morbidity related to drug-resistant bacterial infections. Self-synthesized tetrahedral framework nucleic acids (tFNAs) are used as the drug loading platform to deliver ampicillin to combat methicillin-resistant (MRSA) infection. Read More

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Description of Normative Spine TBS Data for Men and Women in Mexican Population.

J Clin Densitom 2021 Jan-Mar;24(1):129-134. Epub 2020 Jul 2.

Clinical Epidemiology Unit, Hospital Infantil de México Federico Gómez-Facultad de Medicina UNAM, Mexico City, Mexico; Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico. Electronic address:

Trabecular Bone Score (TBS) has proven its usefulness to improve areal Bone Mineral Density in diagnosing fracture risk and bone status evaluation. For it to be better interpreted, local reference values are recommended to account for population differences and, if possible, both in women and men, the former being scarcer. Using TBS, we reanalyzed data obtained from the Mexican population included in the Latin American Vertebral Osteoporosis Study and the Mexican Vertebral Study in men that included a random probability sample of 408 women and 414 men aged 50 and older without fractures. Read More

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The comprehensive evaluation of patients' condition in recovery and residual periods of aneurysmal subarachnoid hemorrhage.

Wiad Lek 2020 ;73(4):777-781

I. Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine.

Objective: The aim: is to evaluate peculiarities of clinical and neurological characteristics, quality of life, brain morphometry changes and metabolic deviations of patients, who suffered from aneurysmal subarachnoid hemorrhage.

Patients And Methods: Materials and methods: In the period of 2016-2019 we examined 114 patients, who signed the informed consent, taking into account their age, clinical and anatomical form of hemorrhage, disease duration, Hunt-Hess severity grade, complications of acute period. Such parameters were evaluated, as clinical and neurological characteristics, the degree of the Barthel index and the modified Rankin scale, cognitive functioning (MoCA), psycho-emotional sphere and quality of life (HADS, SF-36), morphometric parameters based on brain computed tomography measurements, explored the indicators of apoptosis, mitochondrial dysfunction, intracellular oxidative stress. Read More

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The polysemy of psychotropic drugs: continuity and overlap between neuroenhancement, treatment, prevention, pain relief, and pleasure-seeking in a clinical setting.

BMC Med Ethics 2020 07 6;21(1):54. Epub 2020 Jul 6.

Department of Neuropsychiatry, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Background: Enhancement involves the use of biomedical technologies to improve human capacities beyond therapeutic purposes. It has been well documented that enhancement is sometimes difficult to distinguish from treatment. As a subtype of enhancement, neuroenhancement aims to improve one's cognitive or emotional capacities. Read More

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Ultrasound-Augmented Phase Transition Nanobubbles for Targeted Treatment of Paclitaxel-Resistant Cancer.

Bioconjug Chem 2020 08 16;31(8):2008-2020. Epub 2020 Jul 16.

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China.

Paclitaxel (PTX) resistance in most epithelial ovarian cancers (EOCs) with increasing membrane expression of mucin 16 (MUC16) is mediated by the Toll-like receptor-myeloid differentiation factor 2/myeloid differentiation factor 88 (TLR4-MD2/MyD88) signaling pathway. 6-Shogaol (6S), an α,β-unsaturated carbonyl compound with lipophilic property, can block PTX-induced formation of the TLR4-MD2 complex that activates the MyD88/NF-κB signaling pathway. Herein, to improve the effectiveness of 6S, augment the sensibility of PTX, and enhance the targeting ability of PTX-resistant cancer therapies, we report a class of 6S-loaded phase transition nanobubbles conjugated with the MUC16 antibody ([email protected]), which can enhance the sensitivity of PTX to EOC cells through ultrasound-controlled targeted-delivery of 6S. Read More

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Multilayer myocardial strain improves the diagnosis of heart failure with preserved ejection fraction.

ESC Heart Fail 2020 10 21;7(5):3240-3245. Epub 2020 Jun 21.

Department of Internal Medicine/Cardiology, German Heart Center Berlin, Berlin, 13353, Germany.

Aims: The diagnostic and treatment of patients with heart failure with preserved ejection fraction (HFpEF) are both hampered by an incomplete understanding of the pathophysiology of the disease. Novel imaging tools to adequately identify these patients from individuals with a normal cardiac function and respectively patients with HF with reduced EF are warranted. Computing multilayer myocardial strain with feature tracking is a fast and accurate method to assess cardiac deformation. Read More

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October 2020

Virtual Management of Patients With Cancer During the COVID-19 Pandemic: Web-Based Questionnaire Study.

J Med Internet Res 2020 06 24;22(6):e19691. Epub 2020 Jun 24.

Department of Oncology, Alzahra Hospital, Dubai, United Arab Emirates.

Background: During the coronavirus disease (COVID-19) pandemic, patients with cancer in rural settings and distant geographical areas will be affected the most by curfews. Virtual management (telemedicine) has been shown to reduce health costs and improve access to care.

Objective: The aim of this survey is to understand oncologists' awareness of and views on virtual management, challenges, and preferences, as well as their priorities regarding the prescribing of anticancer treatments during the COVID-19 pandemic. Read More

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Gender awareness among medical students in a Swiss University.

BMC Med Educ 2020 Jun 3;20(1):156. Epub 2020 Jun 3.

Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Background: Gender is an important social determinant, that influences healthcare. The lack of awareness on how gender influences health might lead to gender bias and can contribute to substandard patient care. Our objectives were to assess gender sensitivity and the presence of gender stereotypes among swiss medical students. Read More

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Ensemble Models Based on QuBiLS-MAS Features and Shallow Learning for the Prediction of Drug-Induced Liver Toxicity: Improving Deep Learning and Traditional Approaches.

Chem Res Toxicol 2020 07 14;33(7):1855-1873. Epub 2020 May 14.

Grupo de Investigación Prometeus & Biomedicina Aplicada a las Ciencias Clínicas, Área de Bioquímica, Campus de Zaragocilla, Facultad de Medicina, Universidad de Cartagena, Cartagena de Indias 130001, Colombia.

Drug-induced liver injury (DILI) is a key safety issue in the drug discovery pipeline and a regulatory concern. Thus, many tools have been proposed to improve the hepatotoxicity prediction of organic-type chemicals. Here, classifiers for the prediction of DILI were developed by using QuBiLS-MAS 0-2. Read More

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MiR-153-5p promotes sensibility of colorectal cancer cells to oxaliplatin via targeting Bcl-2-mediated autophagy pathway.

Biosci Biotechnol Biochem 2020 Aug 7;84(8):1645-1651. Epub 2020 May 7.

Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College Huazhong University of Science and Technology , Wuhan, Hubei Province, China.

Oxaliplatin (L-OHP) is one of the effective chemotherapeutic drugs for colorectal cancer (CRC). Further investigation into the molecular mechanism of chemoresistance could improve outcomes for patients with colorectal cancer. Recently, microRNAs have been reported as a key in drug resistance of tumors. Read More

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Development of a Sample-Preparation Workflow for Sulfopeptide Enrichment: From Target Analysis to Challenges in Shotgun Sulfoproteomics.

Anal Chem 2020 06 20;92(11):7964-7971. Epub 2020 May 20.

Department of Chemistry, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy.

Protein tyrosine O-sulfation is an important post-translational modification, as it has been correlated to inflammation, virus infection, and signal pathways. Nevertheless, methods for the characterization of protein sulfation by sulfopeptide enrichment are currently limited. In this Article, two standard compounds, representative of mono- and disulfated peptides, were used to compare the enrichment capabilities of five sorbent materials: two commercial weak anion-exchange mixed-mode sorbents (Strata X-AW and Oasis WAX) and three phosphopeptide enrichment materials based on affinity chromatography to either immobilized metals (IMAC) or metal oxides, i. Read More

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