2,427 results match your criteria improve periodontal


Notch pathway activation promotes the differentiation of beagle dog periodontal ligament stem cells to Schwann cells.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Dentistry, The Second Affiliated Hospital, Zhejiang University School of Medicine, China.

Background: Periodontal ligament stem cells (PDLSCs) have demonstrated the potential for differentiation into many cell types, though the molecular mechanism of their neural differentiation in particular remains largely unknown.

Objectives: The Notch signaling pathway plays a key role in regulating cell differentiation and development. In this article, we explore its potential role in the differentiation of PDLSCs to Schwann cells (SCs). Read More

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Periodontal condition of mandibular incisors treated with modified Kazanjian vestibuloplasty compared to untreated sites: A prospective study.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Periodontology, Medical University of Warsaw, Poland.

Background: A shallow vestibule, insufficient keratinized tissue width and pulling of marginal gingiva may be associated with gingival recession, plaque accumulation and gingivitis. Conventional techniques for treatment of gingival recession use autogenous or allogenic grafts. However, these methods result in soreness at the donor site and pose an economic burden, which may cause patients to withdraw from treatment. Read More

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Systematic review and meta-analysis on the adjunctive use of host immune modulators in non-surgical periodontal treatment in healthy and systemically compromised patients.

Sci Rep 2021 Jun 9;11(1):12125. Epub 2021 Jun 9.

Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.

Considering the central role of inflammation in the pathogenesis of periodontitis, the combination of NSPT with different agents that can modulate the host immune-inflammatory response has been proposed to enhance the outcomes of NSPT. The aim of this paper is to systematically review the literature on the efficacy of systemic host modulators (HMs) as adjuncts to non-surgical periodontal therapy (NSPT) in improving pocket depth (PD) reduction and clinical attachment level (CAL) gain in healthy and systemically compromised patients. RCTs with ≥ 3 months follow-up were independently searched by two reviewers. Read More

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Hopeless tooth? Prognosis and comprehensive treatment. A case report.

J Med Life 2021 Mar-Apr;14(2):287-294

Department of Endodontics, University of Medicine and Pharmacy Carol Davila, Faculty of Dental Medicine, Bucharest, Romania.

A hopeless tooth from a periodontal point of view, with severe bone resorption, mobility and abnormal tooth migration, is often extracted. In advanced cases, function and esthetics are impaired, and an interdisciplinary treatment is requested. Retaining or not these teeth is based on clinician judgment. Read More

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PATHOGENETIC MECHANISMS OF COMORBIDITY OF SYSTEMIC DISEASES AND PERIODONTAL PATHOLOGY.

Wiad Lek 2021 ;74(5):1262-1267

DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY, LVIV, UKRAINE.

Objective: The aim: Of the study is to analyze the literary data regarding evaluation of the pathogenetic mechanisms of the interaction of systemic diseases and periodontal tissue damage, conducted on the basis of scientific researches of Ukrainian and foreign scientists.

Patients And Methods: Materials and methods: Bibliosematic and analytical methods were used in the research. The materials of the exploration are international experience in the study of pathogenetic mechanisms of the interplay of pathology in the cardiovascular, respiratory systems, diseases of the gastrointestinal tract and chronic generalized damage of periodontal tissues. Read More

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Gene therapy using adeno-associated virus serotype 8 encoding TNAP-D improves the skeletal and dentoalveolar phenotypes in Alpl mice.

J Bone Miner Res 2021 Jun 2. Epub 2021 Jun 2.

Sanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

Hypophosphatasia (HPP) is caused by loss-of-function mutations in the ALPL gene that encodes tissue-nonspecific alkaline phosphatase (TNAP), whose deficiency results in the accumulation of extracellular inorganic pyrophosphate (PP ), a potent mineralization inhibitor. Skeletal and dental hypomineralization characterizes HPP, with disease severity varying from life-threatening perinatal or infantile forms to milder forms that manifest in adulthood or only affect the dentition. Enzyme replacement therapy (ERT) using mineral-targeted recombinant TNAP (Strensiq/asfotase alfa), markedly improves the lifespan, skeletal phenotype, motor function, and quality of life of patients with HPP, though limitations of ERT include frequent injections due to a short elimination half-life of 2. Read More

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Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration.

Materials (Basel) 2021 May 29;14(11). Epub 2021 May 29.

Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran.

The implementation of nanomedicine not only provides enhanced drug solubility and reduced off-target adverse effects, but also offers novel theranostic approaches in clinical practice. The increasing number of studies on the application of nanomaterials in kidney therapies has provided hope in a more efficient strategy for the treatment of renal diseases. The combination of biotechnology, material science and nanotechnology has rapidly gained momentum in the realm of therapeutic medicine. Read More

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The Chairside Periodontal Diagnostic Toolkit: Past, Present, and Future.

Diagnostics (Basel) 2021 May 22;11(6). Epub 2021 May 22.

ADA Science & Research Institute, American Dental Association, Gaithersburg, MD 20879, USA.

Periodontal diseases comprise a group of globally prevalent, chronic oral inflammatory conditions caused by microbial dysbiosis and the host immune response. These diseases specifically affect the tooth-supporting tissues (i.e. Read More

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Periodontal Wound Healing and Tissue Regeneration: A Narrative Review.

Pharmaceuticals (Basel) 2021 May 12;14(5). Epub 2021 May 12.

Department of Periodontology, School of Dentistry and Dental Research Institute, Seoul National University and Seoul National University Dental Hospital, Seoul 03080, Korea.

Periodontal disease is a major public health issue, and various periodontal therapies have been performed to regenerate periodontal tissues. The periodontium is a complex structure composed of specialized tissues that support the teeth, and most periodontal surgeries are invasive procedures, including a resection of the gingiva or the alveolar bone. The periodontal wound healing process is slightly different from cutaneous wound healing and is similar to fetal healing, being almost scar-free. Read More

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Immunoglobulin G4-related periodontitis: case report and review of the literature.

BMC Oral Health 2021 May 28;21(1):279. Epub 2021 May 28.

National Clinical Research Center for Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Background: Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory systemic disease of unknown etiology that can affect one or multiple organs. The disease can mimic many infectious and inflammatory diseases, mainly causing organ enlargement or hyperplasia. Its diagnosis primarily relies on clinical, serologic, and histological features (lymphoplasmacytic infiltrates, storiform fibrosis, and obliterative phlebitis of IgG4 + plasma cells). Read More

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Periodontal health education session can improve oral hygiene in patients with gingivitis: A blinded randomized controlled clinical study.

J Periodontol 2021 May 28. Epub 2021 May 28.

Department of Periodontology, Faculty of Dentistry, Bolu Abant Izzet Baysal University, Turkey.

Background: The aim of this clinical trial was to evaluate the effect of a periodontal health education session (PHES), which included education on the pathogenesis and consequences of periodontal diseases on oral hygiene motivation in patients with gingivitis.

Methods: A randomized controlled clinical trial was conducted on 50 (26 females and 24 males) patients with gingivitis who underwent periodontal treatment. Subjects were randomly allocated into the PHES group (experimental group) and standard oral hygiene education group (control group). Read More

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Finite Element Evaluation of the Effect of Adhesive Creams on the Stress State of Dentures and Oral Mucosa.

Appl Bionics Biomech 2021 8;2021:5533770. Epub 2021 May 8.

Fraunhofer Institute for Microstructure of Materials and Systems IMWS, Department of Biological and Macromolecular Materials, Halle, Germany.

The base fit between a removable partial denture (RPD) and the underlying soft tissue plays a significant role in its performance. The application of a denture adhesive is hypothesized to result in better retention of RPDs and, as a result, contribute to lower stress on the oral mucosa. The objectives of this study were to observe and compare the distribution of simulated bite forces applied to the RPD through the abutments and soft tissue for models with and without the use of a denture adhesive. Read More

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Synergistic Effect of Omega-3 and Probiotic Supplementation on Preventing Ligature-Induced Periodontitis.

Probiotics Antimicrob Proteins 2021 May 26. Epub 2021 May 26.

Department of Biochemistry, Faculty of Arts and Sciences, Süleyman Demirel University, Isparta, Turkey.

Omega-3 and probiotics were shown to improve periodontal health by modulating the host immune response. Recently, the combination of omega-3 and probiotics has been shown to have a potential synergistic effect on host modulation. The aim of this study was to evaluate the prophylactic role of an omega-3 and probiotic combination on alveolar bone loss (ABL) via inflammatory response in an experimental periodontitis model. Read More

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Association between periodontal disease and oral cancer screening among US adults: NHANES 2011-2014.

Community Dent Oral Epidemiol 2021 May 25. Epub 2021 May 25.

Department of Biostatistics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.

Objectives: To examine oral cancer screening rates and associated factors among adults with periodontal disease (PD). We hypothesized that adults with severe PD will be less likely to report receipt of any type of oral cancer screening than adults with no PD.

Materials And Methods: We used 2011-2014 National Health and Nutrition Examination Survey (NHANES) data on adults ≥30 years. Read More

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Factors associated with the practice of periodontal management by diabetes educator nurses for outpatients with diabetes: A nationwide survey in Japan.

Prim Care Diabetes 2021 May 21. Epub 2021 May 21.

The Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba-shi, Ibaraki, 305-8575, Japan. Electronic address:

Aims: This study aimed to identify and prioritize factors contributing to the provision of periodontal care by certified diabetes nurse educators to outpatients with diabetes in medical settings in Japan.

Methods: Questionnaires were administered to 321 certified diabetes educator nurses from 1277 institutions. The practice of periodontal care was assessed, with factors contributing to periodontal care through items developed based on the capability, opportunity, and motivation-behavior model. Read More

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Periodontal therapy on the oral health-related quality of life of obese and non-obese individuals.

Odontology 2021 May 23. Epub 2021 May 23.

Department of Dentistry, Periodontics Research Division, University of Taubaté, R. dos Operários, 09, Centro, Taubaté, São Paulo, 12020-340, Brazil.

Oral diseases such as periodontitis can have a more negative influence on the quality of life of obese than in normal-weight patients. The objective of the present study was to assess the impact of one-stage full-mouth disinfection (OSFMD) therapy on the oral health-related quality of life (OHRQL) of obese and non-obese individuals with periodontitis. Fifty-five obese and thirty-nine non-obese patients were evaluated. Read More

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[Reducing sugar consumption to improve oral health-which strategies are effective?]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 May 20. Epub 2021 May 20.

Abteilung Prävention und Gesundheitsförderung, Bundeszahnärztekammer (BZÄK), Berlin, Deutschland.

Health promotion strategies can make a significant contribution to the prevention of non-communicable diseases. The most important non-communicable diseases affecting the mouth and teeth are dental caries and periodontal disease. Sugar is a causal factor in the development of dental caries, obesity and obesity-related diseases. Read More

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Impact of dental health intervention on cardiovascular metabolic risk: a pilot study of Japanese adults.

J Hum Hypertens 2021 May 18. Epub 2021 May 18.

Department of Oral Health Sciences, Nihon University School of Dentistry, Tokyo, Japan.

This study aimed to determine whether a dental health education program would reduce cardiometabolic risk (obesity, hypertension, dyslipidemia, and hyperglycemia) in people with periodontitis. We used annual check-up data provided by the Japanese company's health insurance union. Of 182 male employees with cardiometabolic risk and periodontal pockets at baseline, 21 participants of the dental health education program and 21 non-participants matched for age, the presence of obesity, and periodontal pocket at baseline were allocated to the intervention (mean age, 53. Read More

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Appraisal of Schoolchildren's Feelings and Attitudes towards Dentists and Their Potential Impact on Oral Health.

J Contemp Dent Pract 2021 Jan 1;22(1):23-26. Epub 2021 Jan 1.

Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Hadath, Lebanon.

Aim: To assess schoolchildren's feelings and attitudes towards dentists and their potential impact on oral health.

Materials And Methods: 7902 schoolchildren (12 and 15 years old) attending public and private schools completed a questionnaire that assessed their feeling and attitude toward dentists. DMFT and CPI indices were used to assess dental caries and periodontal diseases respectively according to the World Health Organization method and criteria. Read More

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January 2021

Impairment of the angiogenic process may contribute to lower success rate of endodontic treatments in diabetes mellitus.

Int Endod J 2021 May 17. Epub 2021 May 17.

University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal.

Aim: To investigate the association between root canal treatment outcome, diabetes mellitus, and alterations of the angiogenic process.

Methodology: A retrospective observational study was conducted in healthy (control group, CG) and diabetic (type II diabetes mellitus group, DG) patients after root canal treatment. The follow-up appointments were performed to clinically and radiographically observe symptoms, the healing of periapical lesions, and the quality of root filling. Read More

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A comprehensive review of the antibacterial activity of dimethylaminohexadecyl methacrylate (DMAHDM) and its influence on mechanical properties of resin-based dental materials.

Jpn Dent Sci Rev 2021 Nov 28;57:60-70. Epub 2021 Apr 28.

Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil.

The repetitive restorative cycle should be avoided, aiming at the smallest number of restorations' replacements to ensure greater tooth longevity. Antibacterial materials associated with the control of caries etiological factors can help improve restoration's durability. This review aimed to analyze the results of studies that added Dimethylaminohexadecyl methacrylate (DMAHDM), an antibacterial monomer, to restorative materials. Read More

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November 2021

Men and Oral Health: A Review of Sex and Gender Differences.

Am J Mens Health 2021 May-Jun;15(3):15579883211016361

Roseman University of Health Sciences College of Dental Medicine, South Jordan, UT, USA.

Sex and gender related health disparities in oral health remain an underappreciated and often over looked aspect of well-being. The goal of this narrative review is to identify sex and gender related oral health disparities by summarizing the current literature related to differences in oral health between men and women. The review identified that men are more likely to: ignore their oral health, have poorer oral hygiene habits, and experience higher rates of periodontal disease, oral cancer, and dental trauma. Read More

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Disparities in Preventive Oral Health Care and Periodontal Health Among Adults With Diabetes.

Prev Chronic Dis 2021 May 13;18:E47. Epub 2021 May 13.

College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, Massachusetts.

Introduction: People with diabetes are more vulnerable to periodontal disease than those without; thus, practicing preventive oral health care is an important part of diabetes self-care. Our objective was to examine disparities in preventive oral health care among US adults with diabetes.

Methods: We performed a secondary analysis of data from the National Health and Nutrition Examination Survey (NHANES) 2011-2016. Read More

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Effect of photobiomodulation in secondary intention gingival wound healing-a systematic review and meta-analysis.

BMC Oral Health 2021 05 13;21(1):258. Epub 2021 May 13.

Department of Periodontics, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Shahid Fahmideh Blvd, 654178-38741, Hamadan, Iran.

Background: Photobiomodulation is widely being used to improve the wound healing process in dentistry and a vast majority of studies have proven its benefits. But there are plenty of knowledge gaps according to the optimal laser characteristics which should be used to maximize the healing effects of lasers. The goal of this systematic review and meta-analysis was to determine the effect of photobiomodulation (PBM) as an adjunctive treatment to periodontal therapies to evaluate secondary intention gingival wound healing and post-operative pain. Read More

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Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial.

BMC Oral Health 2021 05 12;21(1):253. Epub 2021 May 12.

Department of Research & Biostatistics, School of Public Health, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan.

Background: Treating periodontitis through non-surgical periodontal therapy (NSPT) may improve glycemic control in type-2 Diabetes Mellitus (T2DM) patients. However, the evidence to maintain this improvement beyond four months is insufficient. Hence, this trial was conducted to assess clinical efficacy of NSPT on glycemic control in T2DM patients. Read More

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Effect of peri-implant disease on oral health-related quality of life in geriatric patients.

Gerodontology 2021 May 11. Epub 2021 May 11.

Department of Prosthodontics, Gaziantep University, Gaziantep, Turkey.

Objective: This study aimed to evaluate the effect of peri-implant disease on the quality of life in geriatric patients using implant-supported overdentures.

Background: Peri-implant disease and bone loss are two main complications of dental implant treatment that can impact the quality of life in the geriatric population.

Materials And Methods: This cross-sectional study included 109 geriatric individuals treated in the prosthodontics and periodontology departments. Read More

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Evaluating True Barriers to Dental Care for Patients with Periodontal Disease.

Int J Dent Oral Health 2021 Mar 18;7(2). Epub 2020 Dec 18.

Research Division of Periodontology, Center for Oral Health Research, University of Kentucky College of Dentistry, Lexington KY, USA.

Background: The cost of care is often reported as a primary reason why patients fail to seek dental treatment; however, this may not the only component.

Aims/objectives: To examine an underserved population's perspective on the importance of dental care and barriers they face to seek treatment. The effectiveness of compliance incentives, such as gift cards, was also examined. Read More

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Recent update on craniofacial tissue engineering.

J Tissue Eng 2021 Jan-Dec;12:20417314211003735. Epub 2021 Apr 20.

Division of Craniofacial and Surgical Care, University of North Carolina (UNC) School of Dentistry, Chapel Hill, NC, USA.

The craniofacial region consists of several different tissue types. These tissues are quite commonly affected by traumatic/pathologic tissue loss which has so far been traditionally treated by grafting procedures. With the complications and drawbacks of grafting procedures, the emerging field of regenerative medicine has proved potential. Read More

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The effects of topical erythropoietin on non-surgical treatment of periodontitis: a preliminary study.

BMC Oral Health 2021 05 6;21(1):240. Epub 2021 May 6.

Department of Periodontics, School of Dentistry, Faculty of Dentistry, Tehran University of Medical Sciences, North Kargar Street, Tehran, Iran.

Background: The purpose of periodontal treatments is to reduce inflammation, restore gingival health and clinical attachment level gain by controlling microbial plaque formation and other etiological factors. One of the drugs that has been tested in many areas and shown good anti-inflammatory properties is erythropoietin (EPO). We evaluated the effect of this drug on the improvement of periodontitis after the phase I treatment. Read More

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Reduction of hsCRP levels following an Oral Health Education Program combined with routine dental treatment.

J Dent 2021 May 4;110:103686. Epub 2021 May 4.

The University of Sydney, The Charles Perkins Centre and the School of Dentistry, Faculty of Medicine and Health, Camperdown, Sydney, New South Wales, Australia. Electronic address:

Objectives: The present study aimed to determine the effect of a personalised oral health education program, in combination with routine dental treatment, on serum biomarkers of systemic disease compared to dental treatment alone in a population from a low-socioeconomic community with poor oral health.

Methods: This secondary analysis of a randomised clinical trial involved 295 participants (mean age, 45.4 ± 11 years) assigned to two groups. Read More

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