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The outcome of intra-cytoplasmic sperm injection (ICSI): do the sperm concentration and motility matter?

Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

Advanced Reproductive Centre (ARC), Hospital Canselor Tuanku Muhriz (HCTM), Kuala Lumpur, Malaysia.

Objectives: The male-factor subfertility was reported to be 30% globally; thus, the intracytoplasmic sperm injection (ICSI) procedure was implemented to improve the overall fertilization (IVF) rates. Nevertheless, at least 10% of fertilization failure still occurs. Concerning this issue, we explored the association of sperm concentration and motility with the quality of embryo development and pregnancy outcome in IVF-ICSI cycles. Read More

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Clinical benefits of precision medicine in treating solid cancers: European Society of Medical Oncology-Magnitude of Clinical Benefit Scale score-based analysis.

ESMO Open 2021 Jun 9;6(4):100187. Epub 2021 Jun 9.

Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan; Outpatient Treatment Center, National Cancer Center Hospital, Tokyo, Japan. Electronic address:

Background: Precision and matched cancer medicine has the potential to complement the existing biomarker approaches in cancer treatment. However, despite their promising potential, certain negative results have highlighted their limitations in molecular biology-driven treatment strategies. This study aimed to evaluate the clinical benefits of precision therapies. Read More

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A computational pipeline for data augmentation towards the improvement of disease classification and risk stratification models: A case study in two clinical domains.

Comput Biol Med 2021 Jun 6;134:104520. Epub 2021 Jun 6.

Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, Ioannina, GR45110, Greece; Department of Biomedical Research, FORTH-IMBB, Ioannina, GR45110, Greece. Electronic address:

Virtual population generation is an emerging field in data science with numerous applications in healthcare towards the augmentation of clinical research databases with significant lack of population size. However, the impact of data augmentation on the development of AI (artificial intelligence) models to address clinical unmet needs has not yet been investigated. In this work, we assess whether the aggregation of real with virtual patient data can improve the performance of the existing risk stratification and disease classification models in two rare clinical domains, namely the primary Sjögren's Syndrome (pSS) and the hypertrophic cardiomyopathy (HCM), for the first time in the literature. Read More

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Cognitive insight, medication adherence and methamphetamine cessation in people enrolled in a pharmacotherapy trial for methamphetamine use.

J Subst Abuse Treat 2021 May 15;130:108473. Epub 2021 May 15.

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.

Background: The current study examined correlates of cognitive insight in people enrolled in a methamphetamine pharmacotherapy trial; whether cognitive insight at the start of the trial predicted medication adherence and reductions in methamphetamine use during the trial; and, whether insight would remain stable over the trial or improve with reductions in methamphetamine use.

Methods: A subset of people enrolled in a 12-week randomised placebo-controlled pharmacotherapy trial for methamphetamine dependence completed the Beck Cognitive Insight Scale, comprising subscales for Self-Reflection and Self-Certainty, at baseline (n = 152) and at week 12 (n = 79). Medication adherence was expressed as the percentage of non-missed doses measured using eCAP™ technology. Read More

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Examining factors associated with postintervention recidivism in DUI repeat offenders after alcohol treatment: One-year follow-up study.

J Subst Abuse Treat 2021 Apr 21;130:108426. Epub 2021 Apr 21.

Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, 309 Songde Road, 110 Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, 110 Taipei, Taiwan; Psychiatric Research Center, Taipei Medical University Hospital, 250 Wu-Hsing Street, 110 Taipei, Taiwan. Electronic address:

Taiwan has deemed driving under the influence of alcohol (DUI) to be criminal, and offenders are subjected to fines and jail penalties without being offered alcohol-related treatment, although alcohol use problems are prevalent in this population. We followed the recidivism records of DUI repeat offenders for one year after they had received a newly established legal-medical joint intervention program for alcohol treatment and examined factors related to postintervention recidivism. In this study, 231 DUI repeat offenders with alcohol use problems screened out by the Alcohol Use Disorder Identification Test were referred from the prosecutors' office to one psychiatric hospital for SBIRT-based alcohol treatment. Read More

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Evaluation of an in-hospital recreation room for hospitalised children and their families.

J Pediatr Nurs 2021 Jun 9;61:191-198. Epub 2021 Jun 9.

School of Women's and Children's Health, UNSW Sydney, Kensington, New South Wales 2031, Australia; Kids Cancer Centre, Sydney Children's Hospital, High Street, Randwick, New South Wales 2031, Australia.

Objective: Many children's hospitals have established 'recreation rooms' to help reduce distress among hospitalised children and families. We investigated recreation rooms in two Australian children's hospitals to determine: 1) families' first use of the room (including discovery and delays); 2) characteristics of families accessing the room; 3) parents' positive and negative associations with the room; and 4) parents' most and least valued aspects of the room.

Method: Using a concurrent mixed methods design, parents completed questionnaires (Restorative Experiences Tool, Parenting Stress Index-Short Form, Paediatric Quality of Life Inventory) and an optional interview. Read More

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Digital health, big data and smart technologies for the care of patients with systemic autoimmune diseases: Where do we stand?

Autoimmun Rev 2021 Jun 9:102864. Epub 2021 Jun 9.

Department of neuroradiology, A. Rothshield Foundation Hospital, Paris, France. Electronic address:

The past decade has seen tremendous development in digital health, including in innovative new technologies such as Electronic Health Records, telemedicine, virtual visits, wearable technology and sophisticated analytical tools such as artificial intelligence (AI) and machine learning for the deep-integration of big data. In the field of rare connective tissue diseases (rCTDs), these opportunities include increased access to scarce and remote expertise, improved patient monitoring, increased participation and therapeutic adherence, better patient outcomes and patient empowerment. In this review, we discuss opportunities and key-barriers to improve application of digital health technologies in the field of autoimmune diseases. Read More

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Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro.

Eur J Pharmacol 2021 Jun 9;906:174201. Epub 2021 Jun 9.

National Centre of Excellence in Molecular Biology, University of Punjab, 87-West Canal Bank Road, Lahore, Pakistan; Jinnah Burn & Reconstructive Surgery Centre, Lahore, Pakistan. Electronic address:

Mesenchymal stem cells are known to support hepatic defense against liver fibrosis. However, the fibrosis induced oxidative microenvironment affects the proliferative, regenerative, and angiogenic properties of mesenchymal stem cells. Alpha lipoic acid (ALA) is a strong anti-oxidant which has been shown to ameliorate the adverse effects of fibrosis that otherwise can lead to severe liver problems like cirrhosis and liver failure. Read More

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Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States.

J Int AIDS Soc 2021 Jun;24(6):e25747

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction: Vaginal rings are a promising approach to provide a woman-centred, long-acting HIV prevention strategy. Prior trials of a 25 mg dapivirine (DPV) ring have shown a favourable safety profile and approximately 30% risk reduction of HIV-1 infection. Extended duration rings replaced every three months may encourage user adherence, improve health service efficiency and reduce cost overall. Read More

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Can the human development level in middle-income regions meet the challenges of natural capital change from the perspective of decoupling? Evidence from Shaanxi Province.

Authors:
Yi Yang Ke Zhang

Environ Sci Pollut Res Int 2021 Jun 12. Epub 2021 Jun 12.

School of Economics and Management, Xi'an University of Technology, Xi'an, 710054, China.

Human activities in middle-income regions (MIRs) accelerate the appropriation of natural capital (NC) through production and living activities. The environmental changes caused by these activities in turn have an impact on human development and challenge the human adaptability of MIRs. Therefore, it is very important to realize the decoupling of NC and human development. Read More

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Enhanced Eradication of Mucin-Embedded Bacterial Biofilm by Locally Delivered Antibiotics in Functionalized Microcontainers.

Macromol Biosci 2021 Jun 12:e2100150. Epub 2021 Jun 12.

The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Ørsteds Plads 345C, Lyngby, 2800 Kgs., Denmark.

Bacterial biofilm-related infections are difficult to eradicate and require repeated treatments with high doses of antibiotics. Thus, there is an urgent need for new treatment strategies that minimize the use of antibiotics while enhancing biofilm eradication. Functionalized reservoir-based microdevices, such as, microcontainers (MCs), offer, high drug loading capacity, mucus embedment, and tuneable drug release. Read More

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Nanoparticle-Mediated STING Agonist Delivery for Enhanced Cancer Immunotherapy.

Macromol Biosci 2021 Jun 12:e2100133. Epub 2021 Jun 12.

CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Stimulator of interferon genes (STING) are located in the endoplasmic reticulum of cells, which have been demonstrated to show considerable potentials to achieve efficient antitumor immunity by inducing various pro-inflammatory cytokines and chemokines, such as type I interferons. A variety of STING agonists have been prepared for STING activation, and many of them have been promoted to preclinical trials or clinical applications for the immunotherapy of cancers. However, the intrinsic disadvantages of the small molecule STING agonists can limit the in vivo application and final therapeutic efficacy due to low bioavailability of targeting tissues. Read More

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Poly(amino ester)-Based Polymers for Gene and Drug Delivery Systems and Further Application toward Cell Culture System.

Macromol Biosci 2021 Jun 12:e2100106. Epub 2021 Jun 12.

School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Various synthetic polymers based on poly(amino ester) (PAE) are suggested as candidates for gene and drug delivery owing to their pH-responsiveness, which contributes to efficient delivery performance. PAE-based pH-responsive polymers are more biodegradable and hydrophilic than other types of pH-responsive polymers. The functionality of PAE-based polymers can be reinforced by using different chemical modifications to improve the efficiency of gene and drug delivery. Read More

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Patient-centred e-health supports value cocreation and quality of medical care in Taiwan.

Health Info Libr J 2021 Jun 11. Epub 2021 Jun 11.

Department of Business Administration, National Cheng Kung University, Tainan City, Taiwan.

Background: Patient-centred e-health (PCEH) focusses on the interaction between patients and physicians. However, only a limited number of studies have focussed on the design of physician-patient value cocreation mechanisms in the PCEH context. Thus, we extend Grönroos' concept of value cocreation to understand how PCEH might improve the quality of care. Read More

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Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury.

J Biomed Mater Res B Appl Biomater 2021 Jun 11. Epub 2021 Jun 11.

School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona, USA.

Coagulopathy may occur following traumatic brain injury (TBI), thereby negatively affecting patient outcomes. Here, we investigate the use of platelet-like particles (PLPs), poly(N-isopropylacrylamide-co-acrylic-acid) microgels conjugated with a fibrin-specific antibody, to improve hemostasis post-TBI. The objective of this study was to diminish coagulopathy in a mouse TBI model (controlled cortical impact) via PLP treatment, and subsequently decrease blood-brain barrier (BBB) permeability and neuroinflammation. Read More

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Nanographene-Osmapentalyne Complexes as a Cathode Interlayer in Organic Solar Cells Enhance Efficiency over 18.

Adv Mater 2021 Jun 12:e2101279. Epub 2021 Jun 12.

Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen, 518055, China.

Interface engineering is a critical method by which to efficiently enhance the photovoltaic performance of nonfullerene solar cells (NFSC). Herein, a series of metal-nanographene-containing large transition metal involving d -p conjugated systems by way of the addition reactions of osmapentalynes and p-diethynyl-hexabenzocoronenes is reported. Conjugated extensions are engineered to optimize the π-conjugation of these metal-nanographene molecules, which serve as alcohol-soluble cathode interlayer (CIL) materials. Read More

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Animal models of chronic and recurrent Pseudomonas aeruginosa lung infection - significance of macrolide treatment.

APMIS 2021 Jun 12. Epub 2021 Jun 12.

Department of Clinical Microbiology, Rigshospitalet, Copenhagen University Hospital. Copenhagen, Copenhagen, Denmark.

Animal models of human diseases are invaluable and inevitable elements in identifying and testing novel treatments of serious diseases, including severe infections. Planning and conducting investigator initiated human trials are generally accepted as being enormously challenging. In contrast, it is often underestimated how much planning, including background and modifying experiments, there is needed to establish a relevant infectious disease animal model. Read More

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Treatment Patterns, Effectiveness, and Satisfaction Among Patients with Type 2 Diabetes Treated with Insulin in Saudi Arabia: Results of the RIMODIS Study.

Diabetes Ther 2021 Jun 11. Epub 2021 Jun 11.

Sanofi Medical Department, Jeddah, Saudi Arabia.

Introduction: The alarming increase in type 2 diabetes mellitus (T2DM) in Saudi Arabia is aggravated by increasing obesity, sedentary lifestyle, and population aging. The RIMODIS study aimed at describing the practices in the therapeutic management of patients with T2DM treated with different insulin regimens.

Methods: This national, multicenter, non-interventional, cross-sectional disease registry on the real-life therapeutic management of insulin-treated patients with T2DM in Saudi Arabia enrolled 3010 patients. Read More

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Mandatory HPV Vaccination; Opportunity to Save Lives, Improve Readiness and Cut Costs.

Mil Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Obstetrics and Gynecology, Brooke Army Medical Center, Joint Base San Antonio, TX 78234, USA.

Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the U.S. military and accounts for more healthcare visits than the next two most common STIs combined. Read More

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Malicious traffic detection combined deep neural network with hierarchical attention mechanism.

Sci Rep 2021 Jun 11;11(1):12363. Epub 2021 Jun 11.

School of Computer Science and Engineering, Chongqing University of Technology, Chongqing, 400054, China.

Given the gradual intensification of the current network security situation, malicious attack traffic is flooding the entire network environment, and the current malicious traffic detection model is insufficient in detection efficiency and detection performance. This paper proposes a data processing method that divides the flow data into data flow segments so that the model can improve the throughput per unit time to meet its detection efficiency. For this kind of data, a malicious traffic detection model with a hierarchical attention mechanism is also proposed and named HAGRU (Hierarchical Attention Gated Recurrent Unit). Read More

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Melatonin influences the early growth stage in Zoysia japonica Steud. by regulating plant oxidation and genes of hormones.

Sci Rep 2021 Jun 11;11(1):12381. Epub 2021 Jun 11.

College of Grassland Science, Beijing Forestry University, Beijing, 100083, China.

Zoysia japonica is a commonly used turfgrass species around the world. Seed germination is a crucial stage in the plant life cycle and is particularly important for turf establishment and management. Experiments have confirmed that melatonin can be a potential regulator signal in seeds. Read More

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Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice.

NPJ Regen Med 2021 Jun 11;6(1):34. Epub 2021 Jun 11.

UConn Center on Aging, Farmington, CT, USA.

The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. Read More

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Mortalin/glucose-regulated protein 75 promotes the cisplatin-resistance of gastric cancer via regulating anti-oxidation/apoptosis and metabolic reprogramming.

Cell Death Discov 2021 Jun 11;7(1):140. Epub 2021 Jun 11.

Department of General Surgery, The Affiliated Changzhou No. 2 Hospital of Nanjing Medical University, Changzhou, China.

Platinum drug treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). However, the therapeutic effect is less than satisfactory, largely due to the acquired resistance to platinum drugs. Therefore, a better understanding of the underlying mechanisms can greatly improve the therapeutic efficacy of GC. Read More

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Electronic Family History Screening Tool for Detection of Inherited Cancer Risk: A Prospective Pilot Study.

Am J Med Qual 2021 Jun 10. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, Kaiser Permanente San Francisco Medical Center, San Francisco, CA Division of Research, Kaiser Permanente Northern California, Oakland, CA Department of Genetics, Kaiser Permanente San Francisco Medical Center, San Francisco, CA National Quality, Kaiser Permanente, Oakland, CA Kaiser Permanente Northern California Gynecologic Cancer Program, San Francisco, CA.

Family history screening to identify individuals at increased risk for hereditary cancers could be a powerful strategy to prevent cancer but is used inconsistently in primary care. The objective was to improve identification of women with at-risk family histories using a point-of-care family history screening tool administered on an electronic tablet device during well-woman appointments. A total of 288 women were invited to participate and 136 women (47. Read More

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Applications of machine learning in the chemical pathology laboratory.

J Clin Pathol 2021 Jun 11. Epub 2021 Jun 11.

Computer Science, University of Pretoria Faculty of Engineering Built Environment and IT, Pretoria, Gauteng, South Africa.

Machine learning (ML) is an area of artificial intelligence that provides computer programmes with the capacity to autodidact and learn new skills from experience, without continued human programming. ML algorithms can analyse large data sets quickly and accurately, by supervised and unsupervised learning techniques, to provide classification and prediction value outputs. The application of ML to chemical pathology can potentially enhance efficiency at all phases of the laboratory's total testing process. Read More

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Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):916-925. Epub 2021 Jun 11.

Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan

Background And Objectives: Patients with kidney failure have a high risk of cardiovascular disease due to cardiac remodeling, left ventricular fibrosis, and hyperaldosteronism, all of which can be potentially mitigated by mineralocorticoid receptor antagonists. However, because of the fear of hyperkalemia, the use of mineralocorticoid receptor antagonists in patients with kidney failure is limited in current clinical practice, and few studies have investigated the efficacy and safety. Thus, we aimed to determine the benefits and side effects of mineralocorticoid receptor antagonists in patients with kidney failure treated with dialysis. Read More

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Warwick-India-Canada (WIC) global mental health group: rationale, design and protocol.

BMJ Open 2021 Jun 11;11(6):e046362. Epub 2021 Jun 11.

Division of Mental Health & Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK.

Introduction: The primary aim of the National Institute of Health Research-funded global health research group, Warwick-India-Canada (WIC), is to reduce the burden of psychotic disorders in India. India has a large pool of undetected and untreated patients with psychosis and a treatment gap exceeding 75%. Evidence-based packages of care have been piloted, but delivery of treatments still remains a challenge. Read More

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Promoting social emotional development during the paediatric well-child visit: a demonstration project.

BMJ Open Qual 2021 Jun;10(2)

Programs, National Institute for Children's Health Quality (NICHQ), Boston, Massachusetts, USA.

Supporting social emotional development, beginning at birth, can improve lifelong health. The American Academy of Paediatrics recommends 12 well-child visits between birth and age 3 years. Each well-child visit provides a unique opportunity to interact with and support families to promote social emotional development of children. Read More

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Low Relative Valve Load is Associated With Paradoxical Low-Flow Aortic Stenosis Despite Preserved Left Ventricular Ejection Fraction and Adverse Clinical Outcomes.

Heart Lung Circ 2021 Jun 8. Epub 2021 Jun 8.

Department of Cardiology, National University Heart Centre Singapore, National University Health System, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Background: Paradoxical low-flow (LF) severe aortic stenosis (AS) despite preserved left ventricular (LV) ejection fraction (LVEF) has been shown to be distinct from normal-flow (NF) AS, with a poorer prognosis. Relative valve load (RVL) is a novel echocardiographic haemodynamic index based on the ratio of transaortic mean pressure gradient to the global valvulo-arterial impedance (Zva) in order to estimate the contribution of the valvular afterload to the global LV load. We aimed to determine the usefulness of RVL in LF AS versus NF AS. Read More

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