698,118 results match your criteria improve human

Emerging Technologies in Electrophysiology: From Single Chamber to Biventricular Leadless Pacemakers.

Jashan Gill

Cardiology 2022 Jan 17. Epub 2022 Jan 17.

Background: Transvenous pacemakers have been shown to improve quality of life and mortality in patients with bradycardia and cardiac conduction blocks. However, they possess inevitable drawbacks as they have a relatively high incidence of lead and device pocket-related complications. Therefore, leadless pacemakers have emerged as a solution to reduce the complications seen with conventional pacemakers. Read More

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January 2022

Evaluation of the impacts of human activities on propagation from meteorological drought to hydrological drought in the Weihe River Basin, China.

Sci Total Environ 2022 Jan 13:153030. Epub 2022 Jan 13.

College of Water Resources and Architectural Engineering, Northwest A & F University, Yangling 712100, China; Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas, Ministry of Education, Northwest A & F University, Yangling 712100, China.

Understanding the relationship among different types of drought is crucial for drought mitigation and early warnings. Much attention has been recently focused on the propagation from meteorological drought (MD) to hydrological drought (HD); however, the influences of human activities on drought propagation have rarely been explored. The novelty of the study was to propose an effective framework to quantify the impacts of human activities on MD-HD propagation. Read More

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January 2022

Calcium Intake and Metabolism in Infants and Young Children: A Systematic Review of Balance Studies for Supporting the Development of Calcium Requirements.

Adv Nutr 2022 Jan 17. Epub 2022 Jan 17.

Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA.

Determining calcium requirements for infants and children is vital due to high calcium needs for growth. Balance studies enable comprehensive measurement of calcium metabolism and can support nutrient requirements development. This systematic review summarized evidence from mass balance and isotopic studies in children aged 0-4 years to address key questions on calcium loss and absorption/retention identified by an expert group developing calcium requirements. Read More

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January 2022

Fertilization failure after human ICSI and the clinical potential of PLCZ1.

Reproduction 2022 Jan 1. Epub 2022 Jan 1.

B Heindryckx, Department for Reproductive Medicine, Ghent University Hospital, Ghent, 9000, Belgium.

Two decades have passed since the discovery of phospholipase C zeta (PLCZ1) as the sperm oocyte activating factor. At present, there is a general consensus that PLCZ1 is responsible for triggering the calcium (Ca2+) oscillations necessary to start the oocyte activation process in mammals. One proof is that abnormal, reduced, or absent PLCZ1 in human spermatozoa leads to fertilization failure (FF) after intracytoplasmic sperm injection (ICSI). Read More

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January 2022

A New Class of Electronic Devices Based on Flexible Porous Substrates.

Adv Sci (Weinh) 2022 Jan 17:e2105084. Epub 2022 Jan 17.

Department of Mechanical and Materials Engineering, University of Western Ontario, London, ON, N6A 5B9, Canada.

With the advent of the Internet of Things era, the connection between electronic devices and humans is getting closer and closer. New-concept electronic devices including e-skins, nanogenerators, brain-machine interfaces, and implantable medical devices, can work on or inside human bodies, calling for wearing comfort, super flexibility, biodegradability, and stability under complex deformations. However, conventional electronics based on metal and plastic substrates cannot effectively meet these new application requirements. Read More

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January 2022

Readout-Segmented Echo-Planar Diffusion-Weighted MR Imaging Improves the Differentiation of Breast Cancer Receptor Statuses Compared With Conventional Diffusion-Weighted Imaging.

J Magn Reson Imaging 2022 Jan 17. Epub 2022 Jan 17.

Department of Radiology, Meizhou People's Hospital, Meizhou, 514031, China.

Background: Readout-segmented echo-planar diffusion-weighted imaging (RS-EPI) can improve image quality and signal-to-noise ratio, the resulting apparent diffusion coefficient (ADC) value acts as a more sensitive biomarker to characterize tumors. However, data regarding the differentiation of breast cancer (BC) receptor statuses using RS-EPI are limited.

Purpose: To determine whether RS-EPI improves the differentiation of receptor statuses compared with conventional single-shot (SS) EPI in breast MRI. Read More

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January 2022

Indoor residual spraying for preventing malaria in communities using insecticide-treated nets.

Cochrane Database Syst Rev 2022 Jan 17;1:CD012688. Epub 2022 Jan 17.

Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.

Background: Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are used to prevent malaria transmission. Both interventions use insecticides to kill mosquitoes that bite and rest indoors. Adding IRS to ITNs may improve malaria control simply because two interventions can be better than one. Read More

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January 2022

From Patient Material to New Discoveries: a Methodological Review and Guide for Intestinal Stem Cell Researchers.

Stem Cell Rev Rep 2022 Jan 17. Epub 2022 Jan 17.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Sternwartstrasse 14, 8091, Zurich, Switzerland.

Intestinal stem cells (ISC) are characterized by their ability to continuously self-renew and differentiate into various functionally distinct intestinal epithelial cell types. Impaired stem cell proliferation and differentiation can cause severe dysfunction of the gastrointestinal tract and lead to the development of several clinical disorders. Animal mouse models provide a valuable platform to study ISC function, disease mechanisms, and the intestinal epithelium's regenerative capacity upon tissue damage. Read More

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January 2022

Marginal microleakage and modified microtensile bond strength of Activa Bioactive, in comparison with conventional restorative materials.

Clin Exp Dent Res 2022 Jan 17. Epub 2022 Jan 17.

Department of Restorative Dentistry, Dental Research Center, Dentistry Institute, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: This study aimed to assess the enamel and dentin marginal microleakage and dentin microtensile bond strength (μTBS) of ACTIVA BioACTIVE Restorative with and without a bonding agent compared with conventional restorative materials.

Material And Methods: For enamel and dentin microleakage, Class II boxes were prepared in the mesial (1 mm under the cementoenamel junction) and distal (1 mm above the cementoenamel junction) surfaces of 90 extracted human third molars. The teeth were randomly divided into five groups (n = 18): Group Z (G-Premio Bond + Filtek Z250 XT), Group X (G-Premio Bond + X-tra fil bulk-fill), Group AA (G-Premio Bond + Activa Bioactive restorative), Group A (Activa Bioactive restorative), and Group G (dentin conditioner + Fuji II LC Improve). Read More

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January 2022

The appropriateness of and barriers to glaucoma care delivery by Australian optometrists.

Clin Exp Optom 2022 Jan 16:1-9. Epub 2022 Jan 16.

School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Clinical Relevance: Establishing the level of appropriateness and barriers to glaucoma care delivery by Australian optometrists are important first steps in developing tailored interventions aimed at improving glaucoma care delivery.

Background: To determine the appropriateness of and barriers to glaucoma care by optometrists.

Methods: A mixed method study was conducted. Read More

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January 2022

Adaptation and validation of the Interprofessional Socialization and Valuing Scale (ISVS) in Spanish university health sciences students.

J Interprof Care 2022 Jan 16:1-7. Epub 2022 Jan 16.

Department of Nursing, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Madrid, Spain.

Many interprofessional education programs are being designed to help students improve their collaborative practice. Traditionally, the evaluation of these programs is focused on attitudes, knowledge and skills, but according to some authors, the evaluation of these activities should be expanded to include the evaluation of the development of an interprofessional identity. The Interprofessional Socialization and Valuing Scale (ISVS) is a self-report tool used to measure interprofessional socialization, but it has not been validated with Spanish students. Read More

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January 2022

Regulation of gingival fibroblast phenotype by periodontal ligament cells in vitro.

J Periodontal Res 2022 Jan 17. Epub 2022 Jan 17.

Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.

Objectives: Stem cell transplantation has shown modest effects on periodontal tissue regeneration, and it is still unclear how regenerative effects utilizing this modality are mediated. A greater understanding of the basic interactions between implanted and host cells is needed to improve future strategies. The aims of this study were to investigate the effects of periodontal ligament (PDL) cells on expression of periodontal markers and alkaline phosphatase (ALP) activity of gingival fibroblasts (GF). Read More

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January 2022

Discernible effects of tDCS over the primary motor and posterior parietal cortex on different stages of motor learning.

Brain Struct Funct 2022 Jan 17. Epub 2022 Jan 17.

Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany.

Implicit motor learning and memory involve complex cortical and subcortical networks. The induction of plasticity in these network components via non-invasive brain stimulation, including transcranial direct current stimulation (tDCS), has shown to improve motor learning. However, studies showing these effects are mostly restricted to stimulation of the primary motor cortex (M1) during the early stage of learning. Read More

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January 2022

Glucose Sensing in Human Whole Blood Based on Near-Infrared Phosphors and Outlier Treatment with the Programming Language "R".

ACS Omega 2022 Jan 20;7(1):198-206. Epub 2021 Dec 20.

Department of Chemistry, Soochow University, 70 Linhsi Road, Shihlin, Taipei 111, Taiwan.

A near-infrared paper-based analytical device () for glucose detection in whole blood was based on iridium(III) metal complexes embedded in a three-dimensional (3D) enzyme gel. These complexes emit NIR luminescence, can avoid interference from the color of blood, and increase the sensitivity of sensing glucose. The glucose reaction behaviors of another two different iridium(III) and platinum(II) complexes were also tested. Read More

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January 2022

Automatic emotion recognition in healthcare data using supervised machine learning.

PeerJ Comput Sci 2021 15;7:e751. Epub 2021 Dec 15.

School of Electrical Engineering and Computer Science, National University of Sciences and Technology, Islamabad, Pakistan.

Human feelings are fundamental to perceive the conduct and state of mind of an individual. A healthy emotional state is one significant highlight to improve personal satisfaction. On the other hand, bad emotional health can prompt social or psychological well-being issues. Read More

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December 2021

Gene knock-out chain reaction enables high disruption efficiency of HPV18 / genes in cervical cancer cells.

Mol Ther Oncolytics 2022 Mar 18;24:171-179. Epub 2021 Dec 18.

Department of Obstetrics and Gynecology, Academician Expert Workstation, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, Hubei, China.

A genome editing tool targeting the high-risk human papillomavirus (HPV) oncogene is a promising therapeutic strategy to treat HPV-related cervical cancer. To improve gene knockout efficiency, we developed a gene knockout chain reaction (GKCR) method for continually generating mutagenic disruptions and used this method to disrupt the HPV18 and genes. We verified that the GKCR Cas9/guide RNA (gRNA) cassettes could integrated into the targeted loci via homology-independent targeted insertion (HITI). Read More

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Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank.

Front Oncol 2021 30;11:762184. Epub 2021 Dec 30.

Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, China.

Organoids are self-assembling, organ-like, three-dimensional cellular structures that stably retain key characteristics of the respective organs. Organoids can be generated from healthy or pathological tissues derived from patients. Cancer organoid culture platforms have several advantages, including conservation of the cellular composition that captures the heterogeneity and pharmacotypic signatures of the parental tumor. Read More

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December 2021

Discriminative Localized Sparse Approximations for Mass Characterization in Mammograms.

Front Oncol 2021 30;11:725320. Epub 2021 Dec 30.

Math Imaging and Visual Computing Lab, Division of Physics, Engineering, Mathematics and Computer Science, Delaware State University, Dover, DE, United States.

The most common form of cancer among women in both developed and developing countries is breast cancer. The early detection and diagnosis of this disease is significant because it may reduce the number of deaths caused by breast cancer and improve the quality of life of those effected. Computer-aided detection (CADe) and computer-aided diagnosis (CADx) methods have shown promise in recent years for aiding in the human expert reading analysis and improving the accuracy and reproducibility of pathology results. Read More

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December 2021

Cardiac CT and Transesophageal Echocardiogram Evaluation of a Sinus Venosus-Type Atrial Septal Defect With Partial Anomalous Pulmonary Venous Return and a Persistent Left Superior Vena Cava.

Cureus 2021 Dec 12;13(12):e20367. Epub 2021 Dec 12.

Radiology, Northside Hospital, Saint Petersburg, USA.

The sinus venosus (SV) plays a significant role in the embryological heart as the initial structure where the cardinal, umbilical, and vitelline veins drain before remodeling into the caval veins. As the human heart develops, the SV incorporates into the posterior wall of the right atrium. Sinus venosus atrial septal defects (SVASDs) result from a defect in the wall present among the right pulmonary veins, the superior vena cava (SVC), and the right atrium. Read More

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December 2021

A review of starch biosynthesis in cereal crops and its potential breeding applications in rice ( L.).

PeerJ 2021 22;9:e12678. Epub 2021 Dec 22.

State Key Laboratory of Rice Biology and Chinese National Center for Rice Improvement, China National Rice Research Institute, Hangzhou, China.

Starch provides primary storage of carbohydrates, accounting for approximately 85% of the dry weight of cereal endosperm. Cereal seeds contribute to maximum annual starch production and provide the primary food for humans and livestock worldwide. However, the growing demand for starch in food and industry and the increasing loss of arable land with urbanization emphasizes the urgency to understand starch biosynthesis and its regulation. Read More

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December 2021

Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells.

Mol Ther Nucleic Acids 2022 Mar 21;27:611-620. Epub 2021 Dec 21.

Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

Tropism of neural stem cells (NSCs) to hypoxic tumor areas provides an opportunity for the drug delivery. Here, we demonstrate that NSCs effectively transport antisense oligonucleotides (ASOs) targeting oncogenic and tolerogenic signal transducer and activator of transcription 3 (STAT3) protein into glioma microenvironment. To enable spontaneous, scavenger receptor-mediated endocytosis by NSCs, we used previously described CpG-STAT3ASO conjugates. Read More

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Slinker: Visualising novel splicing events in RNA-Seq data.

F1000Res 2021 7;10:1255. Epub 2021 Dec 7.

Peter MacCallum Cancer Centre, Melbourne, Victoria, 3000, Australia.

Visualisation of the transcriptome relative to a reference genome is fraught with sparsity. This is due to RNA sequencing (RNA-Seq) reads being predominantly mapped to exons that account for just under 3% of the human genome. Recently, we have used exon-only references, superTranscripts, to improve visualisation of aligned RNA-Seq data through the omission of supposedly unexpressed regions such as introns. Read More

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December 2021

Value-rich exposures in medical education: phenomenology of practice according to the lived experiences of medical students in Iran.

J Med Ethics Hist Med 2021 13;14. Epub 2021 Jul 13.

Associate Professor, Department of Medical Ethics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Values ​​predispose people to make the right and especially ethical decisions, and are important for good performance in medical sciences. Students' lived experiences and the value-rich exposures during their education are some effective means of achieving professional values that help them build their own value frameworks. In this phenomenology of practice study, we aimed to explore and describe the lived experiences of a sample of medical students in regarding their value-rich exposures. Read More

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Exploring the universal healthy human gut microbiota around the World.

Comput Struct Biotechnol J 2022 30;20:421-433. Epub 2021 Dec 30.

Institute of Integrative Systems Biology (I2Sysbio), University of València and Consejo Superior de Investigaciones Científicas (CSIC), 46980 València, Spain.

The human gut holds a special place in the study of different microbial environments due to growing evidence that the gut microbiota is related to host health. However, despite extensive research, there is still a lack of knowledge about the core taxa forming the gut microbiota and, moreover, available information is biased towards western microbiomes in both genome databases and most core taxa studies. To tackle these limitations, we tested a database enrichment strategy and analyzed public datasets of whole-genome shotgun data, generated from 545 fecal samples, comprising three gradients of westernization. Read More

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December 2021

Effects of cerebral artery thrombectomy on efficacy, safety, cognitive function and peripheral blood Aβ, IL-6 and TNF-α levels in patients with acute cerebral infarction.

Am J Transl Res 2021 15;13(12):14005-14014. Epub 2021 Dec 15.

Department of Neurology, Xuzhou Medical University Affiliated Hospital of Huai'an Huai'an 223002, Jiangsu Province, China.

Objective: Acute cerebral infarction (ACI) can lead to death or disability, posing a serious threat to human health. This study aimed to investigate the effects of cerebral artery thrombectomy on the efficacy, safety, cognitive function and peripheral blood amyloid-β (Aβ), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in patients with ACI.

Methods: The clinical data of 169 patients with ACI admitted to our hospital from April 2019 to September 2020 were analyzed retrospectively. Read More

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December 2021

Antibacterial and Antioxidant Effects of Magnesium Alloy on Titanium Dental Implants.

Comput Math Methods Med 2022 6;2022:6537676. Epub 2022 Jan 6.

Department of Stomatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

Objectives: In this study, a new type of dental implant by covering the surface of the titanium (Ti) implant with zinc-magnesium (Zn-Mg) alloy was designed, to study the antibacterial and antioxidant effects of Mg alloy on titanium (Ti) implants in oral implant restoration.

Methods: Human gingival fibroblasts (HGFs), S. sanguinis, and F. Read More

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January 2022

Microorganisms in Whole Botanical Fermented Foods Survive Processing and Simulated Digestion to Affect Gut Microbiota Composition.

Front Microbiol 2021 7;12:759708. Epub 2021 Dec 7.

School of Agriculture and Food, The University of Melbourne, Parkville, VIC, Australia.

Botanical fermented foods have been shown to improve human health, based on the activity of potentially beneficial lactic acid bacteria (LAB) and yeasts and their metabolic outputs. However, few studies have explored the effects of prolonged storage and functional spices on microbial viability of whole fermented foods from fermentation to digestion. Even fewer have assessed their impact on the gut microbiota. Read More

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December 2021

Effect of dentin biomodification techniques on the stability of the bonded interface.

J Conserv Dent 2021 May-Jun;24(3):265-270. Epub 2021 Nov 22.

Department of Conservative Dentistry and Endodontics, Kothiwal Dental College and Research Centre, Moradabad, Uttar Pradesh, India.

Aim: The aim of this study is to evaluate the effect of different bonding techniques ethanol wet bonding and dimethyl sulfoxide (DMSO) wet bonding and a novel collagen cross-linker Quercetin application on the durability of resin-dentin bond and observe the bonded interface under the scanning electron microscope (SEM).

Materials And Methods: For shear bond strength testing, flat coronal dentin surfaces were prepared on 110 extracted human molars. Teeth were randomly divided into five experimental groups according to different surface pretreatments techniques. Read More

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November 2021

Strategies to improve the quality of midwifery care and developing midwife-centered care in Iran: analyzing the attitudes of midwifery experts.

BMC Pregnancy Childbirth 2022 Jan 16;22(1):40. Epub 2022 Jan 16.

School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.

Background: In recent years, extensive studies have been designed and performed in the context of providing midwifery care in developed countries, which has been unfortunately neglected in some low resources and upper middle-income countries such as Iran. This study was conducted to identify the best strategies for improving the quality of midwifery care and developing midwife-centered care in Iran.

Methods: This was a qualitative study using focus group discussion and content analysis method. Read More

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January 2022

Influence of load knowledge on lifting biomechanics.

Int J Occup Saf Ergon 2022 Jan 15:1-18. Epub 2022 Jan 15.

Institute of Human Factors and Ergonomics, Shenzhen University, Shenzhen, China.

. Findings from previous studies implied that appropriately controlling load knowledge might help improve the biomechanical performance during lifting tasks. However, only load weight knowledge was often discussed in previous studies. Read More

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January 2022