J Vis Exp 2021 Jul 1(173). Epub 2021 Jul 1.
Department of Anatomy and Structural Biology, Einstein College of Medicine / Montefiore Medical Center; Gruss-Lipper Biophotonics Center, Einstein College of Medicine / Montefiore Medical Center; Integrated Imaging Program, Einstein College of Medicine / Montefiore Medical Cente;
Metastasis, accounting for ~90% of cancer-related mortality, involves the systemic spread of cancer cells from primary tumors to secondary sites such as the bone, brain, and lung. Although extensively studied, the mechanistic details of this process remain poorly understood. While common imaging modalities, including computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI), offer varying degrees of gross visualization, each lacks the temporal and spatial resolution necessary to detect the dynamics of individual tumor cells. Read More