22,713 results match your criteria impact visual


The Efficacy of Platelet-Rich Plasma on Improving Pain and Function for Lateral Epicondylitis: A Systematic Review and Meta-analysis with Risk-of-Bias Assessment.

Arthroscopy 2021 May 5. Epub 2021 May 5.

Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California. Electronic address:

Purpose: To assess the efficacy of PRP for lateral epicondylitis and evaluate its impact on pain and functional outcomes.

Methods: This study followed Preferred Reporting Items and Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search was conducted in September 2019 and repeated in April 2020 using electronic databases PubMed, MEDLINE, and the Cochrane Library. Read More

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Use of low dose vaginal misoprostol in office hysteroscopy: a pre-post interventional study.

J Obstet Gynaecol 2020 Dec 2:1-5. Epub 2020 Dec 2.

Department of Obstetrics and Gynecology, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

A pre-post interventional study of patients undergoing office hysteroscopy alone and in combination with endometrial biopsy was performed during October 2015-March 2018 to evaluate the effect of low dose vaginal misoprostol on patient's pain. Pain scores were assessed using the visual analog scale at the completion of the procedure. There were 646 patients included in the study. Read More

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December 2020

Incidence of concussion and recovery of neurocognitive dysfunction on ImPACT assessment among youth athletes with premorbid depression or anxiety taking antidepressants.

J Neurosurg Pediatr 2021 May 7:1-7. Epub 2021 May 7.

1Neurosurgery Department, Icahn School of Medicine at Mount Sinai, New York.

Objective: Concussions in youth sports comprise an estimated 1.6-3.8 million annual injuries in the US. Read More

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Appearance of special colors in deuteranomalous trichromacy.

Vision Res 2021 May 4;185:77-87. Epub 2021 May 4.

College of Optometry, Ohio State University, USA.

Deuteranomalous color matching behavior is different from normal because the middle-wavelength sensitive cones contain an abnormal L' pigment instead of the M pigment of the normal observer. However, there is growing evidence that deuteranomalous color experience is not very different from that of normal trichromats. Here, normal and deuteranomalous observers chose monochromatic unique yellow lights. Read More

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Arts activity and well-being for visually impaired military veterans: a narrative discussion of current knowledge.

Public Health 2021 May 4;194:232-237. Epub 2021 May 4.

Veterans and Families Institute for Military Social Research, Anglia Ruskin University, Chelmsford, Essex, UK.

Objectives: The objective of this study was to offer an overview of literature relating to the topic of arts as activity within the context of military and veteran health and to consider the implications of current knowledge on future research with visually impaired veterans.

Study Design: A search for literature addressing the topic of visual art activities with visually impaired veterans was undertaken. No research addressing this topic was identified. Read More

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The limited effect of neural stimulation on visual attention and social cognition in individuals with schizophrenia.

Neuropsychologia 2021 May 4:107880. Epub 2021 May 4.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX; Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX.

Background: Research demonstrates a relationship between faulty visual attention and poorer social cognition in schizophrenia. One potential explanatory model suggests abnormal neuromodulation in specific neural networks may result in reduced attention to socially important cues, leading to poorer understanding of another's emotional state or intentions.

Objective: The current study experimentally manipulated neural networks using tDCS to examine this potential causal mechanism. Read More

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Beyond the skin: disease parameters in pemphigus.

Ital J Dermatol Venerol 2021 Apr;156(2):147-150

Department of Dermatology, St George Hospital, University of NSW, Sydney, Australia.

Pemphigus represents a group of rare autoimmune bullous diseases that affect the skin and mucous membranes. This group has a chronic course leading to high morbidity and mortality. Because of the painful chronic-recurring blisters and/or erosions on skin and mucosa, pemphigus can impair quality of life (QOL). Read More

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Health-related quality of life and lifestyle changes in patients with chronic kidney disease and hyperkalemia: Real-world data from the US, five European countries and China.

Int J Clin Pract 2021 May 6:e14326. Epub 2021 May 6.

Global Payer Evidence, AstraZeneca, Cambridge, UK.

Background: Chronic kidney disease patients have impaired health-related quality of life and an increased risk of hyperkalemia.

Aims: The objective was to evaluate the impact of hyperkalemia on health-related quality of life, and investigate lifestyle change recommendations, in these patients.

Methods: The Adelphi Real World Chronic Kidney Disease Disease Specific Programme™ was used. Read More

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Assessment of Commercial Off-the-Shelf Tissue Adhesives for Sealing Military-Relevant Corneal Perforation Injuries.

Mil Med 2021 May 7. Epub 2021 May 7.

Department of Sensory Trauma, United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA.

Introduction: Open-globe ocular injuries have increased in frequency in recent combat operations due to increased use of explosive weaponry. Unfortunately, open-globe injuries have one of the worst visual outcomes for the injured warfighter, often resulting in permanent loss of vision. To improve visual recovery, injuries need to be stabilized quickly following trauma, in order to restore intraocular pressure and create a watertight seal. Read More

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Predictors of clinical outcomes after non-operative management of symptomatic full-thickness rotator cuff tears.

World J Orthop 2021 Apr 18;12(4):223-233. Epub 2021 Apr 18.

Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48106, United States.

Background: Previous studies have shown that non-surgical management can be an effective treatment strategy for many patients with rotator cuff tears. Despite the prevalence of rotator cuff disease, few studies have examined the patient and tear related factors that predict outcomes of nonsurgical management in this cohort of patients.

Aim: To identify factors that are associated with changes in patient reported outcomes over time in individuals with full-thickness rotator cuff tears treated without surgery. Read More

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Functional 3-Dimensional Retinal Organoids: and Existing Challenges.

Front Neurosci 2021 20;15:668857. Epub 2021 Apr 20.

Physiology and Pathophysiology of the Retina Group, Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany.

Stem cell scientists have developed methods for the self-formation of artificial organs, often referred to as organoids. Organoids can be used as model systems for research in multiple biological disciplines. Yoshiki Sasai's innovation for deriving mammalian retinal tissue from stem cells has had a large impact on the study of the biology of vision. Read More

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Improving health-related quality of life in glaucoma during 11 years and its association with vision loss and treatment of the disease.

Acta Ophthalmol 2021 May 6. Epub 2021 May 6.

Department of Ophthalmology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Purpose: To evaluate the impact of glaucoma on health-related quality of life (HRQoL) and mental health in the ageing population of Finland.

Methods: Altogether 7380 and 5774 Finnish individuals aged 30 years and older with known eye disease status were studied in 2000 and 2011, respectively, in two population-based surveys, including an 11-year follow-up of 4683 participants. Data on HRQoL (EQ-5D-3L, 15D), depression (BDI), psychological distress (GHQ-12) and eye disease diagnoses were obtained from self-reported assessments. Read More

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Prevalence and predictors of colour vision defects among Egyptian university students.

East Mediterr Health J 2021 Apr 27;27(4):399-406. Epub 2021 Apr 27.

Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Nowadays, widespread usage of colours increases the need for accurate estimation of colour vision defects and their effect on performing daily activities and study/work tasks.

Aims: To determine the prevalence and predictors of colour vision defects among Assiut university students and to identify their relationship with self-reported visual function and perceived difficulties in performing daily activities.

Methods: A cross-sectional study was conducted among 1426 students at Assiut University, Egypt. Read More

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Relationships influencing caring in first-line nursing leadership: A visual hermeneutic study.

Scand J Caring Sci 2021 May 6. Epub 2021 May 6.

Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.

Aim: To explore and interpret relationships that influence caring in nursing leadership, in the context of Nordic municipal health care, from first-line nurse managers' perspectives.

Design And Method: We chose a visual hermeneutic design. A three-stage interpretation process outlined by Drew and Guillemin, based on Rose, was used to analyse drawings and the following reflective dialogue from three focus groups, with a purposive sample of 11 first-line nurse managers. Read More

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Identification of mutant K-RAS in pituitary macroadenoma.

Pituitary 2021 May 5. Epub 2021 May 5.

Laboratório de Biomedicina do Cérebro, Instituto Estadual do Cérebro Paulo Niemeyer, Rua do Rezende156-Centro, Rio de Janeiro, 20231-092, Brazil.

Purpose: RAS genes are among the most frequently mutated genes in cancer, where their mutation frequency varies according to the distinct RAS isoforms and tumour types. Despite occurring more prevalent in malignant tumours, RAS mutations were also observed in few benign tumours. Pituitary adenomas are examples of benign tumours which vary in size and aggressiveness. Read More

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Visual Impact of Large and Giant Congenital Naevi: Comparison of Surgical Scars with Naevi Before Surgery.

Acta Derm Venereol 2021 May 6. Epub 2021 May 6.

Dermatology Department, Melanoma Group IDIBAPS, Hospital Clinic Barcelona - University of Barcelona, Villarroel 170, ES-08036 Barcelona, Spain.

Surgical attempts to remove large/giant congenital melanocytic naevi (LGCMN) are supported mainly by the theoretical improvement in patients' self-image; however such surgery can result in unaesthetic scarring. We hypothesize that difference in appearance itself has an impact, and hence surgery cannot negate this impact. The aim of this cross-sectional study was to explore how LGCMN and scarring are perceived by non-affected people. Read More

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Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice.

Genetics 2020 Jan;214(1):121-134

Department of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.

One major aspect of the aging process is the onset of chronic, low-grade inflammation that is highly associated with age-related diseases. The molecular mechanisms that regulate these processes have not been fully elucidated. We have identified a spontaneous mutant mouse line, small with kinky tail (skt), that exhibits accelerated aging and age-related disease phenotypes including increased inflammation in the brain and retina, enhanced age-dependent retinal abnormalities including photoreceptor cell degeneration, neurodegeneration in the hippocampus, and reduced lifespan. Read More

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January 2020

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice.

Genetics 2020 Jan;214(1):121-134

Department of Medical Genetics, University of Wisconsin-Madison, Wisconsin 53706.

One major aspect of the aging process is the onset of chronic, low-grade inflammation that is highly associated with age-related diseases. The molecular mechanisms that regulate these processes have not been fully elucidated. We have identified a spontaneous mutant mouse line, small with kinky tail (skt), that exhibits accelerated aging and age-related disease phenotypes including increased inflammation in the brain and retina, enhanced age-dependent retinal abnormalities including photoreceptor cell degeneration, neurodegeneration in the hippocampus, and reduced lifespan. Read More

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January 2020

Exposure-Response Modeling to Support Dosing Selection for Phase IIb Development of Kukoamine B in Sepsis Patients.

Front Pharmacol 2021 19;12:645130. Epub 2021 Apr 19.

Clinical Pharmacology Research Center and State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Kukoamine B, a small molecule compound, is being developed for the treatment of sepsis in a Phase II clinical trial. The objective of this study was to optimize dosing selection for a Phase IIb clinical trial using an exposure-response model. Data of 34 sepsis patients from a Phase IIa clinical trial were used in the model: 10 sepsis patients from the placebo group and a total of 24 sepsis patients from the 0. Read More

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Evaluating the Effectiveness of a One-Week Multimodal Prevention Program for Slowing down and Stress Reduction Performed in a German Health Resort: Results of a Randomized Controlled Trial.

Complement Med Res 2021 May 5:1-11. Epub 2021 May 5.

Chair of Public Health and Health Services Research, Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Pettenkofer School of Public Health, Ludwig-Maximilians-Universität München, Munich, Germany.

Background: Effective concepts are required to overcome the negative impact of daily stressful overwhelming. We investigated the effectiveness of a 1-week multimodal program for stress reduction.

Methods: We performed a randomized controlled trial including adults with above-average stress level. Read More

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Analytical approach for lubricant characterization of excipients using the surface replication method.

Drug Dev Ind Pharm 2021 May 5:1-20. Epub 2021 May 5.

Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku 422-8526, Japan.

Lubricants are indispensable pharmaceutical ingredients for preventing tableting failure due to powder adhesion to the die wall. The impact of lubricants was evaluated with use of the Binding Identification for Net Detriment (BIND) surface replication method. Raloxifene hydrochloride (RH) was selected as a model chemical with high adhesion, and four commercially available tablet lubricants - stearic acid, sodium stearyl fumarate, calcium stearate and magnesium stearate - were used for RH formulation. Read More

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Effects of preoperative serum vitamin D levels on early clinical function outcomes and the moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty.

Menopause 2021 May 3. Epub 2021 May 3.

Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Objective: To investigate the impact of vitamin D levels on early clinical function outcomes and the potential risk factors of moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty (TKA).

Methods: From April 2017 to December 2019, 226 women were retrospectively recruited. The women were divided into two groups based on their preoperative serum 25-hydroxyvitamin D levels: (1) vitamin D-sufficient group (≥30 ng/mL); (2) vitamin D-deficient group (<30 ng/mL). Read More

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Optic disc morphology and peripapillary atrophic changes in diabetic children and adults without diabetic retinopathy or visual impairment.

Acta Ophthalmol 2021 May 5. Epub 2021 May 5.

Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, National Clinical Research Center for Eye Diseases, Shanghai Key laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: To investigate the changes in optic disc morphology and peripapillary atrophy (PPA) in diabetic children and adults without diabetic retinopathy (DR) or visual impairment (VI).

Methods: This cross-sectional study included two groups of subjects. One group included 91 children with type 1 diabetes mellitus (T1DM) and 86 healthy children, and the other group included 444 adults with T2DM and 442 healthy controls. Read More

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A population-based study: how to identify high-risk T1 gastric cancer patients?

Am J Cancer Res 2021 15;11(4):1463-1479. Epub 2021 Apr 15.

Department of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou, Zhejiang, P. R. China.

In T1 gastric cancer (GC), lymph nodes metastasis (LNM) is considered as a significant prognostic predictor and closely associated with following therapeutic approaches as well as distant metastasis (DM). This study aimed to not only seek risk factors of LNM and DM but also unpack the prognosis in T1 GC patients. We performed a retrospective study enrolling 5547 patients in T1 GC from the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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The performance of an integrated model including retinal information in predicting childhood hypertension.

Pediatr Res 2021 May 4. Epub 2021 May 4.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China.

Background: The objective of this study was to examine the association of an integrated model (composed of retinal arteriolar caliber, height, and sex) with blood pressure (BP) among a group of Chinese children, and assess the predictive value of the integrated model for childhood hypertension.

Methods: This study included 1460 candidates aged 12.634 ± 0. Read More

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Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus.

NPJ Aging Mech Dis 2021 May 4;7(1):10. Epub 2021 May 4.

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Age plays a critical role in disease development and tolerance to cancer treatment, often leading to an increased risk of developing negative symptoms including sleep disturbances. Circadian rhythms and sleep become disrupted as organisms age. In this study, we explored the behavioral alterations in sleep, circadian rhythms, and masking using a novel video system and interrogate the long-term impact of age-based changes in the non-image forming visual pathway on brain anatomy. Read More

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The impact of vitrectomy on outcomes achieved with 0.19 mg fluocinolone acetonide implant in patients with diabetic macular edema.

Eur J Ophthalmol 2021 May 4:11206721211014728. Epub 2021 May 4.

Augenklinik, Dietrich-Bonhoeffer-Klinikum, Neubrandenburg, Germany.

Background: There is a lack of consensus on the use of intravitreal corticosteroid therapies in patients with diabetic macular edema (DME) and prior vitrectomized eyes in clinical practice.

Methods: Retro-IDEAL was a 3-year retrospective, multicenter study in patients with chronic DME (i.e. Read More

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Predictors of Outcomes in Patients With Mild Ischemic Stroke Symptoms: MaRISS.

Stroke 2021 May 5:STROKEAHA120032809. Epub 2021 May 5.

Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston (L.H.S.).

Background And Purpose: Although most strokes present with mild symptoms, these have been poorly represented in clinical trials. The objective of this study is to describe multidimensional outcomes, identify predictors of worse outcomes, and explore the effect of thrombolysis in this population.

Methods: This prospective observational study included patients with ischemic stroke or transient ischemic attack, a baseline National Institutes of Health Stroke Scale (NIHSS) score 0 to 5, presenting within 4. Read More

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Focal Ischemic Injury to the Early Neonatal Rat Brain Models Cognitive and Motor Deficits with Associated Histopathological Outcomes Relevant to Human Neonatal Brain Injury.

Int J Mol Sci 2021 Apr 29;22(9). Epub 2021 Apr 29.

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne 3010, Australia.

Neonatal arterial ischemic stroke is one of the more severe birth complications. The injury can result in extensive neurological damage and is robustly associated with later diagnoses of cerebral palsy (CP). An important part of efforts to develop new therapies include the on-going refinement and understanding of animal models that capture relevant clinical features of neonatal brain injury leading to CP. Read More

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