3,482 results match your criteria impact crc


Combination Therapy with KRAS and P38α siRNA Suppresses Colorectal Cancer Growth and Development in SW480 Cell Line.

J Gastrointest Cancer 2021 Jul 22. Epub 2021 Jul 22.

Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Science, Tabriz, Iran.

Purpose: Colorectal cancer (CRC) is one of the most prevalence malignancies in a different society with a high rate of death. The KRAS and p38α axes have critical roles in the development, migration, and growth of numerous tumors, such as colorectal malignancy. KRAS mutation acts as an oncogene in various cancers and is correlated with the poor prognosis in colorectal tumors. Read More

View Article and Full-Text PDF

Impact of Sociodemographic Disparities and Insurance Status on Survival of Patients with Early-Onset Colorectal Cancer.

Oncologist 2021 Jul 19. Epub 2021 Jul 19.

Department of Solid Tumor Oncology, Levine Cancer Institute, Charlotte, NC, USA.

Background: Low socioeconomic status (SES) has been linked to worse survival in patients with colorectal cancer (CRC); however, the impact of SES on early-onset CRC remains undescribed.

Methods: Retrospective analysis of data from the National Cancer Database (NCDB) between 2004 and 2016 was conducted. We combined income and education to form a composite measure of SES. Read More

View Article and Full-Text PDF

rs968697 T > C polymorphism is associated with the risk of colorectal cancer.

Nucleosides Nucleotides Nucleic Acids 2021 Jul 21:1-8. Epub 2021 Jul 21.

Physical Examination Centre, Xuhui District Central Hospital of Shanghai, Shanghai, China.

A genetic polymorphism (rs968697 T > C) in the gene has recently been linked to an increased risk of hepatoblastoma. However, no studies have been conducted to investigate the effect of the polymorphism on the risk of colorectal cancer (CRC). The study aimed to explore whether the rs968697 polymorphism had a significant impact on CRC risk. Read More

View Article and Full-Text PDF

Clinical impact of PET/MRI in oligometastatic colorectal cancer.

Br J Cancer 2021 Jul 19. Epub 2021 Jul 19.

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Oligometastatic colorectal cancer (CRC) is potentially curable and demands individualised strategies.

Methods: This single-centre retrospective study investigated if positron emission tomography (PET)/magnetic resonance imaging (MR) had a clinical impact on oligometastatic CRC relative to the standard of care imaging (SCI). Adult patients with oligometastatic CRC on SCI who also underwent PET/MR between 3/2016 and 3/2019 were included. Read More

View Article and Full-Text PDF

The Fruits of Inhibit Colorectal Cancer Cell Migration Induced by -Derived Extracellular Vesicles.

Molecules 2021 Jul 4;26(13). Epub 2021 Jul 4.

Department of Chinese Medicine, Taipei University Hospital, Taipei 110301, Taiwan.

Colorectal cancer (CRC) is one of the most common cancers worldwide. Gut microbiota are highly associated with CRC, and was found to be enriched in CRC lesions and correlated with CRC carcinogenesis and metastases. is a well-known herbal medicine that showed anticancer activity. Read More

View Article and Full-Text PDF

Transcranial Direct Current Stimulation (tDCS) over the Intraparietal Sulcus Does Not Influence Working Memory Performance.

Psychol Belg 2021 9;61(1):200-211. Epub 2021 Jul 9.

Psychology & Neuroscience of Cognition Research Unit, University of Liège, Belgium.

Mixed results of the impact of transcranial direct current stimulation (tDCS) on working memory have been reported. Contrarily to previous studies who focused mainly on stimulating the dorsolateral prefrontal cortex, we modulated the left intraparietal sulcus (IPS) area which is considered to support attentional control aspects of working memory. Using a within-participant experimental design, participants completed three different conditions: anodal stimulation of the IPS, cathodal stimulation of the IPS, and sham stimulation of the IPS. Read More

View Article and Full-Text PDF

Obesity and telomere status in the prognosis of patients with colorectal cancer submitted to curative intention surgical treatment.

Mol Clin Oncol 2021 Sep 3;15(3):184. Epub 2021 Jul 3.

Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University, Madrid 28040, Spain.

The risk of colorectal cancer (CRC) development has been associated with telomere dysfunction and obesity. However, clinical relevance of these parameters in CRC prognosis is not clear. Therefore, the aim of the present study was to evaluate the impact of obesity and telomere status in the prognosis of patients affected by CRC and submitted to curative surgical treatment. Read More

View Article and Full-Text PDF
September 2021

Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells.

Front Pharmacol 2021 2;12:699842. Epub 2021 Jul 2.

Musculoskeletal Research Group and Tumor Biology, Chair of Vegetative Anatomy, Faculty of Medicine, Institute of Anatomy, Ludwig-Maximilian-University Munich, Munich, Germany.

Tumor microenvironment (TME) has a pivotal impact on tumor progression, and epithelial-mesenchymal transition (EMT) is an extremely crucial initial event in the metastatic process in colorectal cancer (CRC) that is not yet fully understood. Calebin A (an ingredient in ) has been shown to repress CRC tumor growth. However, whether Calebin A is able to abrogate TME-induced EMT in CRC was investigated based on the underlying pathways. Read More

View Article and Full-Text PDF

Incidence of Colorectal Adenomas After Bariatric Surgery: Pre-operative Super Morbid Obesity Is Independently Associated with Increased Risk.

Obes Surg 2021 Jul 18. Epub 2021 Jul 18.

The Division of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.

Purpose: The impact of pre-bariatric surgery BMI on the incidence of colorectal adenomas in the post-operative period is unknown. Here we aim to evaluate the incidence of colorectal adenomas after bariatric surgery and to assess super morbid obesity (SMO) as a risk factor for post-operative colorectal adenomas.

Materials And Methods: An inception cohort of 1639 patients that underwent bariatric surgery between 2011 and 2019 in a referral center was retrospectively analyzed. Read More

View Article and Full-Text PDF

Obeticholic Acid Impact on Quality of Life in Patients With Nonalcoholic Steatohepatitis: REGENERATE 18-Month Interim Analysis.

Clin Gastroenterol Hepatol 2021 Jul 15. Epub 2021 Jul 15.

Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.

BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) affects patients' health-related quality of life (HRQoL). Patient-reported outcomes (PROs) evaluating HRQoL were assessed in the REGENERATE study, which demonstrated that obeticholic acid (OCA) significantly improved fibrosis in patients with NASH.

Methods: Noncirrhotic NASH patients in a phase 3, double-blind, randomized, placebo-controlled, multicenter, international study of OCA. Read More

View Article and Full-Text PDF

The impact of acute pneumococcal disease on health state utility values: a systematic review.

Qual Life Res 2021 Jul 17. Epub 2021 Jul 17.

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

Purpose: Streptococcus pneumoniae infections remain a significant source of morbidity and mortality worldwide. The purpose of this review was to summarize the impact of pneumococcal disease on health state utilities (HSU) in the acute phase of illness.

Methods: We searched MEDLINE, EMBASE, EconLit, the Health Technology Assessment Database, the National Health Economic Evaluation Database, and Tufts Cost-Effectiveness Registry (up to January 2020) for primary studies. Read More

View Article and Full-Text PDF

Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and colorectal cancer survival.

Cancer Epidemiol Biomarkers Prev 2021 Jul 16. Epub 2021 Jul 16.

Department of Nutrition, Harvard T.H. Chan School of Public Health

Background: Cancer patients are recommended to follow cancer prevention guidelines due to inadequate evidence for specific recommendations for cancer survivors.

Methods: We examined whether diet and lifestyle scores measuring adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention guidelines were associated with colorectal cancer-specific and overall mortality among 1,491 colorectal cancer (CRC) patients in two prospective cohorts. Cox proportional hazards regression models were used to calculate the multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Read More

View Article and Full-Text PDF

Validity and reproducibility of immunohistochemical scoring by trained non-pathologists on Tissue MicroArrays.

Cancer Epidemiol Biomarkers Prev 2021 Jul 16. Epub 2021 Jul 16.

Pathology, GROW School of Oncology and Developmental Biology, Maastricht University Medical Center

Background: Scoring of immunohistochemical (IHC) staining is often done by non-pathologists, especially in large-scale Tissue MicroArray (TMA)-based studies. Studies on the validity of scoring results from non-pathologists are very limited. Therefore, our main aim was to assess inter-observer agreement between trained non-pathologists and an experienced histopathologist for three IHC markers with different subcellular localization (nucleus/membrane/cytoplasm). Read More

View Article and Full-Text PDF

Noninvasive quantitative assessment of collagen degradation in parchments by polarization-resolved SHG microscopy.

Sci Adv 2021 Jul 16;7(29). Epub 2021 Jul 16.

Laboratoire d'Optique et Biosciences, Ecole polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, Palaiseau, France.

Nondestructive and noninvasive investigation techniques are highly sought-after to establish the degradation state of historical parchments, which is up to now assessed by thermal techniques that are invasive and destructive. We show that advanced nonlinear optical (NLO) microscopy enables quantitative in situ mapping of parchment degradation at the micrometer scale. We introduce two parameters that are sensitive to different degradation stages: the ratio of two-photon excited fluorescence to second harmonic generation (SHG) signals probes severe degradation, while the anisotropy parameter extracted from polarization-resolved SHG measurements is sensitive to early degradation. Read More

View Article and Full-Text PDF

Smoking induces the occurrence of colorectal cancer via changing the intestinal permeability.

J BUON 2021 May-Jun;26(3):1009-1015

Department of Hepatobiliary Surgery, Baogang Hospital, Baogang, China.

Purpose: Colorectal cancer (CRC) is the third most frequent cancer. Its occurrence is closely linked to lifestyle and diet habits, such as excessive intake of high-fat food, but their impact on CRC, however, remain unclear.

Methods: Eligible CRC patients were retrospectively analyzed. Read More

View Article and Full-Text PDF

Longitudinal Analysis of Circulating Tumor Cells in Colorectal Cancer Patients by a Cytological and Molecular Approach: Feasibility and Clinical Application.

Front Oncol 2021 28;11:646885. Epub 2021 Jun 28.

Institute for Experimental Cancer Research, Kiel University and University Hospital Schleswig-Holstein Campus, Kiel, Kiel, Germany.

Introduction: Liquid biopsies allowing for individualized risk stratification of cancer patients have become of high significance in individualized cancer diagnostics and treatment. The detection of circulating tumor cells (CTC) has proven to be highly relevant in risk prediction, e.g. Read More

View Article and Full-Text PDF

Prognostic Impact and Clinicopathological Features of Multiple Colorectal Cancers and Extracolorectal Malignancies: A Nationwide Retrospective Study.

Digestion 2021 Jul 14:1-10. Epub 2021 Jul 14.

Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: Multiple primary malignancies (MPMs) are likely to develop in patients with colorectal cancer (CRC); however, their prognoses are unclear. This study aims to investigate the prognostic impacts and clinicopathological features of multiple CRCs and extracolorectal malignancies (EMs) with CRC.

Methods: We retrospectively evaluated a total of 22,628 patients with stage I-III CRC who underwent curative resection at 24 referral institutes in Japan between January 2004 and December 2012. Read More

View Article and Full-Text PDF

Evaluation of Protein Purification Techniques and Effects of Storage Duration on LC-MS/MS Analysis of Archived FFPE Human CRC Tissues.

Pathol Oncol Res 2021 3;27:622855. Epub 2021 May 3.

South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville, South Africa.

To elucidate cancer pathogenesis and its mechanisms at the molecular level, the collecting and characterization of large individual patient tissue cohorts are required. Since most pathology institutes routinely preserve biopsy tissues by standardized methods of formalin fixation and paraffin embedment, these archived FFPE tissues are important collections of pathology material that include patient metadata, such as medical history and treatments. FFPE blocks can be stored under ambient conditions for decades, while retaining cellular morphology, due to modifications induced by formalin. Read More

View Article and Full-Text PDF

Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages.

Cancer Lett 2021 Jul 10;520:184-200. Epub 2021 Jul 10.

Institute of Medical Genetics, Medical University of Vienna, Währinger Straße 10, A-1090 Vienna, Austria. Electronic address:

Colorectal cancer (CRC) accounts for about 10% of cancer deaths worldwide. Colon carcinogenesis is critically influenced by the tumor microenvironment. Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) represent the major components of the tumor microenvironment. Read More

View Article and Full-Text PDF

Impact of assumptions on future costs, disutility and mortality in cost-effectiveness analysis; a model exploration.

PLoS One 2021 12;16(7):e0253893. Epub 2021 Jul 12.

Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Introduction: In cost-effectiveness analyses, the future costs, disutility and mortality from alternative causes of morbidity are often not completely taken into account. We explored the impact of different assumed values for each of these factors on the cost-effectiveness of screening for colorectal cancer (CRC) and esophageal adenocarcinoma (EAC).

Methods: Twenty different CRC screening strategies and two EAC screening strategies were evaluated using microsimulation. Read More

View Article and Full-Text PDF

The newly identified MEK1 tyrosine phosphorylation target MACC1 is druggable by approved MEK1 inhibitors to restrict colorectal cancer metastasis.

Oncogene 2021 Jul 10. Epub 2021 Jul 10.

Translational Oncology of Solid Tumors, Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Cancer metastasis causes >90% of cancer deaths and remains a major treatment challenge. Here we deciphered the impact of tyrosine phosphorylation of MACC1, a causative driver for cancer metastasis, for cancer cell signaling and novel interventions to restrict cancer metastasis. We identified MACC1 as new MEK1 substrate. Read More

View Article and Full-Text PDF

Extracellular Flux Analysis to Investigate the Impact of NF-κB on Mitochondrial Respiration in Colorectal Carcinoma (CRC).

Methods Mol Biol 2021 ;2366:293-303

Centre for Molecular Immunology and Inflammation, Department of Immunology and Inflammation, Imperial College London, London, UK.

The reprogramming of cell metabolism is a hallmark of cancer. NF-κB transcription factors coordinate the host defense responses to stress, injury, and infection. They also play a central role in oncogenesis, at least in part by regulating cell metabolism and the adaptation to energy stress conditions in various types of cancer, such as colorectal carcinoma (CRC). Read More

View Article and Full-Text PDF
January 2021

The Prognostic Impact of KRAS G12C Mutation in Patients with Metastatic Colorectal Cancer: A Multicenter Retrospective Observational Study.

Oncologist 2021 Jul 7. Epub 2021 Jul 7.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Background: KRAS is one of the most frequently mutated oncogenes in colorectal cancer (CRC). Recently, a novel therapy targeting KRAS G12C mutation has demonstrated promising activities for corresponding advanced solid tumors, including metastatic CRC (mCRC). However, the prognostic impact of the KRAS G12C mutation remains unclear in patients with mCRC. Read More

View Article and Full-Text PDF

The Pediatric Emergency Research Network (PERN): A decade of global research cooperation in paediatric emergency care.

Emerg Med Australas 2021 Jul 3. Epub 2021 Jul 3.

Pediatric Emergency Care Applied Research Network (PECARN).

Objectives: The Pediatric Emergency Research Network (PERN) was launched in 2009 with the intent for existing national and regional research networks in paediatric emergency care to organise globally for the conduct of collaborative research across networks.

Methods: PERN has grown from five to eight member networks over the past decade. With an executive committee comprising representatives from all member networks, PERN plays a supportive and collaborative rather than governing role. Read More

View Article and Full-Text PDF

The national FIT-based colorectal cancer screening program in the Netherlands during the COVID-19 pandemic.

Prev Med 2021 10 30;151:106643. Epub 2021 Jun 30.

Department of Public Health, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

The COVID-19 pandemic has affected many healthcare services worldwide. Like many other nations, the Netherlands experienced large numbers of individuals affected by COVID-19 in 2020, leading to increased demands on hospitals and intensive care units. The Dutch Ministry of Health decided to suspend the Dutch biennial fecal immunochemical test (FIT) based colorectal cancer (CRC) screening program from March 16, 2020. Read More

View Article and Full-Text PDF
October 2021

Modelling the impacts of COVID-19 pandemic on the quality of population-based colorectal cancer screening.

Prev Med 2021 10 30;151:106597. Epub 2021 Jun 30.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address:

COVID-19 pandemic has severely affected regular public health interventions including population-based cancer screening. Impacts of such screening delays on the changes in structure and screening process and the resultant long-term outcomes are unknown. It is therefore necessary to develop a systematic framework to assess theses impacts related to these components of quality. Read More

View Article and Full-Text PDF
October 2021

Path Analysis of the Impact of Obesity on Postoperative Outcomes in Colorectal Cancer Patients: A Population-Based Study.

J Clin Med 2021 Jun 29;10(13). Epub 2021 Jun 29.

Division of Colon & Rectal Surgery, Department of Surgery, E-DA Hospital, Kaohsiung 82445, Taiwan.

Background: Obesity is adversely affecting perioperative outcomes; however, long-term outcomes do not appear to be affected by excess body weight (the obesity paradox). The purpose of this study is to examine the association between obesity and surgical outcomes in patients with colorectal cancer (CRC) using data from the United States National Inpatient Sample (NIS).

Methods: Patients ≥20 years old diagnosed with CRC who received surgery were identified in the 2004-2014 NIS database. Read More

View Article and Full-Text PDF

Insulin-Like Growth Factor 2 mRNA-Binding Protein 1 (IGF2BP1) Is a Prognostic Biomarker and Associated with Chemotherapy Responsiveness in Colorectal Cancer.

Int J Mol Sci 2021 Jun 28;22(13). Epub 2021 Jun 28.

Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an RNA-binding protein and serves as a post-transcriptional fine-tuner regulating the expression of mRNA targets. However, the clinicopathological roles of IGF2BP1 in colorectal cancer (CRC) remains limited. Thus, we aimed to elucidate the clinical significance and biomarker potentials of IGF2BP1 in CRC. Read More

View Article and Full-Text PDF

Analyzing the Opportunities to Target DNA Double-Strand Breaks Repair and Replicative Stress Responses to Improve Therapeutic Index of Colorectal Cancer.

Cancers (Basel) 2021 Jun 23;13(13). Epub 2021 Jun 23.

Laboratory of Genetic Toxicology, Federal University of Health Sciences of Porto Alegre, Avenida Sarmento Leite, 245, Porto Alegre 90050-170, Brazil.

Despite the ample improvements of CRC molecular landscape, the therapeutic options still rely on conventional chemotherapy-based regimens for early disease, and few targeted agents are recommended for clinical use in the metastatic setting. Moreover, the impact of cytotoxic, targeted agents, and immunotherapy combinations in the metastatic scenario is not fully satisfactory, especially the outcomes for patients who develop resistance to these treatments need to be improved. Here, we examine the opportunity to consider therapeutic agents targeting DNA repair and DNA replication stress response as strategies to exploit genetic or functional defects in the DNA damage response (DDR) pathways through synthetic lethal mechanisms, still not explored in CRC. Read More

View Article and Full-Text PDF