1,077,655 results match your criteria impact


Enhancing the cardiovascular protective effects of a healthy dietary pattern with wolfberry (Lycium barbarum): A randomized controlled trial.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore, Singapore.

Background: The consumption of wolfberry (Lycium barbarum), a rich source of carotenoids and bioactive polysaccharides, may serve as a potential dietary strategy for cardiovascular disease (CVD) risk management although limited studies examined its effects as whole fruits.

Objectives: To investigate the impact of wolfberry consumption as part of a healthy dietary pattern on vascular health-related outcomes and classical CVD risk factors in middle-aged and older adults in Singapore.

Methods: This is a 16-week, parallel design, randomized controlled trial. Read More

View Article and Full-Text PDF

Metabolic risk factors, genetic predisposition, and risk of severe liver disease in Chinese: a prospective study of 0.5 million people.

Am J Clin Nutr 2021 May 8. Epub 2021 May 8.

Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: Metabolic risk factors have been shown to be associated with severe liver disease (SLD) in Chinese populations. However, there is limited evidence on the combined impact of these factors, or the genetic variants associated with SLD.

Objectives: We examined the associations of combined metabolic risk factors with risks of SLD, both overall and by genetic predisposition to SLD. Read More

View Article and Full-Text PDF

UKRAINE'S INTERNATIONAL LIABILITIES ON INITIATION OF MEASURES FOR PUBLIC HEALTH PROTECTION AND THE ROLE OF LOCAL AUTHORITIES IN IMPLEMENTATION OF HEALTH CARE POLICY.

Georgian Med News 2021 Mar(312):163-168

4Lviv University of Trade and Economics, Ukraine.

The article examines the international obligations of Ukraine to implement measures to protect public health and the role of local governments in implementation of health policy. Emphasis is placed on Ukraine's implementation of the Sustainable Development Goals being a member of the UN, the Association Agreement between Ukraine and the EU, and the commitment to develop cooperation in the field of health care undertaken by Ukraine, radical health care reform and decentralization reform in Ukraine. The purpose of the article is to determine the role of local governments in implementation of health policy in the context of decentralization reform and the second stage of health care reform in Ukraine, to identify shortcomings in Ukrainian legislation and the practice that lead to violations of regional communities residents' rights for health care and medical aid, as well as violations of the rights of medical personnel for labor. Read More

View Article and Full-Text PDF

NORMALIZING EFFECT OF ELECTROMAGNETIC STIMULATION ON BLOOD QUANTITATIVE INDICES IN DEPRESSED RATS ON THE BACKGROUND OF OXYTOCIN.

Georgian Med News 2021 Mar(312):100-104

3European University, Tbilisi, Georgia.

Depression is linked to systemic inflammation. There is an association between blood cell count and/or hematological inflammatory markers with depression symptoms. Oxytocin reduces the activity of brain regions that produce anxiety and might involve in the rehabilitation of depressive-like behavior. Read More

View Article and Full-Text PDF

[MODERN ISSUES OF KALCIPHEROL INFLUENCE ON CHILDREN AND ADULTS' HEALTH (REVIEW)].

Georgian Med News 2021 Mar(312):82-87

Tbilisi State Medical University, Department of Peadiatric Neurology; Iashvili Children's Central Hospital, Tbilisi, Georgia.

The purpose of this review is study of literature for the development of biological effect of Kalcipherol (D vitamin group) on children population. Different factors seem, that D- vitamin deficiency disbalance elevated, children specifically negative effect, which have a major impact on health, growth and development of infants, children and adolescents. Vitamin D and calcium deficiencies are preventable global public health problems in pediatric medicine. Read More

View Article and Full-Text PDF

COMORBIDITY OF TYPE 1 DIABETES MELLITUS WITH OTHER CHRONIC PATHOLOGY IN CHILDREN.

Georgian Med News 2021 Mar(312):78-82

1V. Karazin Kharkiv National University, School of Medicine; 2SI "Institute of Health of Children and Adolescents of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.

In this study was to investigate the сoexistence of diabetes mellitus type 1 with other chronic pathology in children and adolescents and their impact on the course of diabetes mellitus type 1 (DM1). The 88 children from 3 to 17 years who had DM1 were observed. The study was conducted by survey with the aim of finding risk factors and associated comorbidties with a questionnaire-based, objective-subjective study. Read More

View Article and Full-Text PDF

Follow-up of functional exercise capacity in patients with COVID-19: It is improved by telerehabilitation.

Respir Med 2021 Apr 30;183:106438. Epub 2021 Apr 30.

Service de Pneumologie, Cliniques Universitaires Saint-Luc, Brussels, Belgium; Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie, Université Catholique de Louvain, Brussels, Belgium; Secteur de Kinésithérapie et Ergothérapie, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address:

Background: The impact of the COVID-19 pandemic on functional exercise capacity seemed quickly clinically evident. The objective of this study was to assess the functional exercise capacity of patients with severe COVID-19 and to evaluate the effect of a telerehabilitation program in the specific context of the COVID-19 pandemic.

Method: Patients hospitalized for severe or critical COVID-19 were recruited. Read More

View Article and Full-Text PDF

Monitoring the early aggregatory behaviour and size of Aβ in the absence & presence of metal ions using dynamic light scattering.

J Trace Elem Med Biol 2021 May 3;67:126766. Epub 2021 May 3.

The Birchall Centre, Lennard-Jones Laboratories, Keele University, Keele, Staffordshire, ST5 5BG, UK.

Background And Aim: Aβ is an amyloidogenic peptide found within senile plaques extracted from those who died with a diagnosis of Alzheimer's disease. The potent neurotoxicity of this peptide is related to its propensity to form aggregated conformations in vivo, a process that is influenced by the species and concentration of metal ions present within the local environment. This study examines the impact of different metals upon the early aggregatory behaviour and size of Aβ under simulated physiological conditions. Read More

View Article and Full-Text PDF

Impact of CO overpressure on yeast mitochondrial associated proteome during the "prise de mousse" of sparkling wine production.

Int J Food Microbiol 2021 May 4;348:109226. Epub 2021 May 4.

Department of Agricultural Chemistry, Edaphology and Microbiology, Severo Ochoa (C6) building, Agrifood Campus of International Excellence CeiA3, University of Cordoba, Ctra. N-IV-A mm 396, 14014 Cordoba, Spain. Electronic address:

The "prise de mousse" stage during sparkling wine elaboration by the traditional method (Champenoise) involves a second fermentation in a sealed bottle followed by a prolonged aging period, known to contribute significantly to the unique organoleptic properties of these wines. During this stage, CO overpressure, nutrient starvation and high ethanol concentrations are stress factors that affect yeast cells viability and metabolism. Since mitochondria are responsible for energy generation and are required for cell aging and response to numerous stresses, we hypothesized that these organelles may play an essential role during the prise de mousse. Read More

View Article and Full-Text PDF

Mildly toxic shrubs as indicators of goats herbivory give information for the management of natural landscapes on Mediterranean islands.

Sci Total Environ 2021 Apr 29;786:147391. Epub 2021 Apr 29.

Research Group on Plant Biology under Mediterranean Conditions, Biology Department, University of Balearic Islands, Palma, Spain.

Herbivory of insular plant communities by introduced animals has been widely studied for decades. Though their diet mainly includes palatable and highly nutritive species, goats will also eat plants that are toxic to other animals. Thus, severe affection of toxic species may indicate high herbivore pressure or a low quality of vegetative food. Read More

View Article and Full-Text PDF

LCA and economic study on the local oxygen supply in Central Europe during the COVID-19 pandemic.

Sci Total Environ 2021 Apr 29;786:147401. Epub 2021 Apr 29.

AGH University of Science and Technology, Faculty of Energy and Fuels, Department of Coal Chemistry and Environmental Sciences, Al. Mickiewicza 30, 30-059 Kraków, Poland. Electronic address:

Medical oxygen is the key to survival for COVID-19 patients. To meet the pandemic-driven oxygen demand spike, local hospitals began searching for a suitable medical oxygen delivery system. Among the studies published on the impact of COVID-19 on a range of aspects, including the global economy and the environment, no study has been conducted on the environmental impact of medical oxygen supply to hospitals under epidemic conditions. Read More

View Article and Full-Text PDF

Research on rapid cultivation of aerobic granular sludge (AGS) with different feast-famine strategies in continuous flow reactor and achieving high-level denitrification via utilization of soluble microbial product (SMP).

Sci Total Environ 2021 Apr 22;786:147237. Epub 2021 Apr 22.

Key Laboratory of Water Science and Water Environment Recovery Engineering, Beijing University of Technology, Beijing 100123, China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China.

The mixture of partial AGS and flocculent sludge in continuous flow reactors were operated with periodic famine (PF) strategy and continuous feast (CF) strategy to reveal the impact of the feast-famine strategies on cultivation of AGS and the dynamics of microbial communities. The experimental results showed that the mature AGS were cultivated with PF and CF strategy on the 31st and the 71st days respectively, which was the result of good extracellular polymeric substance (EPS) secretion with PF strategy. It could accelerate the formation of microbial aggregates due to the conditions of periodic famine. Read More

View Article and Full-Text PDF

Leaching prediction for vertical test panels coated with plaster and mortars exposed under real conditions by a PHREEQC leaching model.

Chemosphere 2021 Apr 28;280:130657. Epub 2021 Apr 28.

Chair of Urban Water Systems Engineering, Technical University of Munich, Am Coulombwall 3, 85748, Garching, Germany. Electronic address:

A requirement of the Construction Products Regulation (CPR) in the European Union states that construction works must be designed in such a way that throughout their entire life cycle, they have no exceedingly high environmental impact. The objective of the current work was to simulate the leaching of selected metals and sulfate in vertical test panels (VTPs) covered by plaster and mortar. The investigation is based on 18-month leaching outdoor tests (LOT) under real weather conditions. Read More

View Article and Full-Text PDF

Psychological distress and burden among family caregivers of children with and without developmental disabilities six months into the COVID-19 pandemic.

Res Dev Disabil 2021 May 5;114:103983. Epub 2021 May 5.

Department of Educational Psychology, University of Connecticut, United States.

The COVID-19 pandemic has created unique challenges for family caregivers of children with developmental disabilities (DD). The purpose of this study was to conduct a 6-month follow-up on the experiences of caregiver burden and psychological distress among caregivers of children with autism (ASD) and/or attention deficit hyperactivity disorder (ADHD) during COVID-19 pandemic, compare their experiences to caregivers of children without DD, and test the interaction between opportunities for self-care and caregiver burden and psychological distress. Results indicated caregivers of children with ASD/ADHD continued to report significantly higher levels of psychological distress and caregiver burden compared to caregivers of children without DD. Read More

View Article and Full-Text PDF

The impact on health outcomes of implementing electronic health records to support the care of older people in residential aged care: A scoping review.

Int J Med Inform 2021 Apr 24;151:104471. Epub 2021 Apr 24.

Center for Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Aim: The implementation of electronic health records (EHRs) in the aged care sector has been shown to improve efficiency and quality of care, administrative and funding processes. The aim of this study was to examine whether implementing EHRs and/or interventions leveraging EHRs in residential aged care facilities has any impact on health outcomes for residents and to review and summarise any published evidence.

Methods: Using the Joanna Briggs Institute guidelines for conducting scoping reviews, we searched PubMed, CINAHL, Embase, Cochrane and Scopus databases for articles describing the impact of EHRs and/or EHR-based interventions on health outcomes for residents in residential aged care. Read More

View Article and Full-Text PDF

Conductive hearing loss in large vestibular aqueduct syndrome -clinical observations and proof-of-concept predictive modeling by a biomechanical approach.

Int J Pediatr Otorhinolaryngol 2021 Apr 29;146:110752. Epub 2021 Apr 29.

ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, 200031, China. Electronic address:

Objective: The purpose of this study was to investigate the effect of a dilated vestibular aqueduct on conductive hearing loss (CHL). A biomechanical method was proposed for modeling the patterns of CHL in patients with large vestibular aqueduct syndrome (LVAS).

Study Design: High resolution computed tomography (CT) scans and pure tone audiometry (PTA) were retrospectively collected from 16 patients who were diagnosed with LVAS. Read More

View Article and Full-Text PDF

UV filters and UV stabilisers adsorbed in microplastic debris from beach sand.

Mar Pollut Bull 2021 May 5;168:112434. Epub 2021 May 5.

Instituto Universitario de Estudios Ambientales y Recursos Naturales (i-UNAT), Universidad de Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain.

Microplastics (MPs) in oceans adsorb different types of pollutants, which can negatively impact the food chain. The extensive use of personal care products (PCPs) has led to their ubiquitous environmental presence, and their partition between plastic matrices and surroundings is determined by their physico-chemical characteristics and environmental conditions. This work develops and applies a methodology to determine 12 UV filters (UVFs) and UV stabilisers (UVSs) in MPs collected in beach sand. Read More

View Article and Full-Text PDF

Impact of condensed tannin interactions with grain proteins and non-starch polysaccharides on batter system properties.

Food Chem 2021 Apr 27;359:129969. Epub 2021 Apr 27.

Texas A&M University, Soil & Crop Sciences Department, 2474 TAMU, College Station, TX 77843, United States; Texas A&M University, Food Science & Technology Department, College Station, TX 77843, United States.

Proanthocyanidins (PA) cross-link wheat gluten proteins and dramatically enhance batter viscosity; PA could similarly affect related grains. This study aimed to determine PA effect on viscosity and pasting properties of barley, rye, and oat flours, and the relative contributions of PA interactions with proteins and non-starch polysaccharides (NSP). PA significantly increased batter viscosity, stability, and RVA peak viscosity in rye and barley flours (2. Read More

View Article and Full-Text PDF

Challenges in Predicting Discharge Disposition for Trauma and Emergency General Surgery Patients.

J Surg Res 2021 May 5;265:278-288. Epub 2021 May 5.

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Background: Changes in discharge disposition and delays in discharge negatively impact the patient and hospital system. Our objectives were to determine the accuracy with which trauma and emergency general surgery (TEGS) providers could predict the discharge disposition for patients and determine the factors associated with incorrect predictions.

Methods: Discharge dispositions and barriers to discharge for 200 TEGS patients were predicted individually by members of the multidisciplinary TEGS team within 24 h of patient admission. Read More

View Article and Full-Text PDF

The Impact of Surgeon Experience on Script Concordance Test Scoring.

J Surg Res 2021 May 5;265:265-271. Epub 2021 May 5.

Division of General Surgery, Department of Surgery, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Department of Innovation in Medical Education (DIME), University of Ottawa, Ottawa, Ontario, Canada.

Objective: The Script Concordance Test (SCT) is a test of clinical decision-making that relies on an expert panel to create its scoring key. Existing literature demonstrates the value of specialty-specific experts, but the effect of experience among the expert panel is unknown. The purpose of this study was to explore the role of surgeon experience in SCT scoring. Read More

View Article and Full-Text PDF

Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function.

Neurobiol Aging 2021 Mar 12;104:32-41. Epub 2021 Mar 12.

Department of Neurology, Neuromuscular Division, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Physical Medicine and Rehabilitation, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Sarcopenia, or age-related loss of muscle mass and strength, is an important contributor to loss of physical function in older adults. The pathogenesis of sarcopenia is likely multifactorial, but recently the role of neurological degeneration, such as motor unit loss, has received increased attention. Here, we investigated the longitudinal effects of muscle hypertrophy (via overexpression of human follistatin, a myostatin antagonist) on neuromuscular integrity in C57BL/6J mice between the ages of 24 and 27 months. Read More

View Article and Full-Text PDF

Changes in Sexual Fantasy and Solitary Sexual Practice During Social Lockdown Among Young Adults in the UK.

Sex Med 2021 May 5;9(3):100342. Epub 2021 May 5.

Bournemouth University, Poole, England, UK. Electronic address:

Introduction: Pandemic-related social lockdown limited many sexual behaviors, but to date, no study has examined the perceived impact of social lockdown due to COVID-19 on sexual fantasy and solitary sexual behavior.

Aims: The present study sought to examine the perceived impact of social lockdown on sexual fantasy and solitary sexual behavior among UK young adults in various living situations.

Methods: A convenience sample of 565 adults aged 18-32 and living in the UK completed anonymous, web-based, study-specific questionnaires between May 14 and 18, 2020, 7 weeks after social lockdown was initiated. Read More

View Article and Full-Text PDF

COVID-19 Related Symptoms of Anxiety, Depression, and PTSD among US Adults.

Psychiatry Res 2021 Apr 24;301:113959. Epub 2021 Apr 24.

Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY, USA. Electronic address:

During the COVID-19 pandemic, social distancing measures often result in individual isolation, which can lead to adverse mental outcomes. We collected online questionnaires from 3,952 US adults to examine the impact of "shelter-in-place" guidelines on mental health, and to explore potential disparities and modifiable factors. Self-reported anxiety, depression, and PTSD symptoms were associated with more restrictive quarantine. Read More

View Article and Full-Text PDF

Adult child socio-economic status disadvantage and cognitive decline among older parents in Mexico.

Soc Sci Med 2021 Apr 24;279:113910. Epub 2021 Apr 24.

Leonard Davis School of Gerontology, University of Southern California, USA.

There is growing interest in the contribution of offspring educational attainment to parents' health outcomes. However, less is known about the impacts of offspring socio-economic status (SES) on parents' cognitive decline or about the role of offspring SES disadvantage. We used data from the Mexican Health and Aging Study (n = 10,426) to evaluate the impact of adult child SES disadvantage on parents' verbal memory trajectories over fourteen years (2001-2015). Read More

View Article and Full-Text PDF

Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation.

Redox Biol 2021 Apr 30;43:101994. Epub 2021 Apr 30.

Laboratory of Mitochondria and Metabolism, Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China; Laboratory of Anesthesia and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration in glucose metabolism has been recognized as an important adaptive response under hypoxic conditions. However, the biological benefits underlying this metabolic phenotype remain to be elucidated. Read More

View Article and Full-Text PDF

Effects of addiction science on conceived freewill and responsibility.

Addict Behav 2021 Apr 23;120:106955. Epub 2021 Apr 23.

Department of Psychology, University of Southern California, 90089, United States; Neuroscience Graduate Program, University of Southern California, 90089, United States; Brain and Creativity Institute, University of Southern California, 90089, United States. Electronic address:

Although there is speculation that medicalization of addiction undermines conceived agency, only relatively modest effects have been reported. Research participants generally have ideas about addiction that are informed both by personal experience and by media, and their views may not be wholly updated in response to study-information. Here we examine the potential impact of addiction science theories on perceived volition and responsibility by considering the issues in the context of a hypothetical new drug, "Z. Read More

View Article and Full-Text PDF

Exploring the influence of impact severity and posture on vertebral joint mechanics in an in-vitro porcine model.

J Biomech 2021 Apr 25;122:110479. Epub 2021 Apr 25.

Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada. Electronic address:

To date, no in vitro studies have been conducted to explore lumbar soft tissue injury potential and altered mechanical properties from exposure to impact forces. After a motor vehicle collision (MVC), the cause of reported acute onset low back pain is difficult to associate with potential soft tissue strain injury sites including the facet joint and innervated facet joint capsule ligament (FJC). Thus, the purpose of this investigation was to quantify intervertebral anterior-posterior (AP) translation and facet joint capsule strain under varying postures and impact severities. Read More

View Article and Full-Text PDF

The effects of self-disclaimer Instagram captions on young women's mood and body image: The moderating effect of participants' own photo manipulation practices.

Body Image 2021 May 5;38:251-261. Epub 2021 May 5.

Department of Psychology, York University, 4700 Keele St, Toronto, ON, M3J 1P3, Canada. Electronic address:

The current experiment investigated the impact of attaching self-disclaimer captions (i.e., captions about whether photos had been edited) to thin-ideal Instagram photos on young women's body image and mood. Read More

View Article and Full-Text PDF

Contaminated soils of different natural pH and industrial origin: The role of (nano) iron- and manganese-based amendments in As, Sb, Pb, and Zn leachability.

Environ Pollut 2021 Apr 30;285:117268. Epub 2021 Apr 30.

Department of Environmental Geosciences, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00, Praha - Suchdol, Czech Republic. Electronic address:

Soils containing a large proportion of industrial waste can pose a health risk due to high environmentally available concentrations of toxic metal(loid)s. Nano zero-valent iron (nZVI) and amorphous manganese oxide (AMO) were applied as immobilising amendments (1 wt%) to soils with different industrial origin of As and Sb, and leaching of As, Sb, Pb, and Zn was investigated using a single extraction with deionised water. The different industrial impact was reflected in the mineralogy, chemical composition and pH of these soils. Read More

View Article and Full-Text PDF

Toxic effects of acute exposure to polystyrene microplastics and nanoplastics on the model insect, silkworm Bombyx mori.

Environ Pollut 2021 Apr 30;285:117255. Epub 2021 Apr 30.

Max Planck Partner Group, Institute of Sericulture and Apiculture, College of Animal Sciences, Zhejiang University, Hangzhou, China; Key Laboratory for Molecular Animal Nutrition, Ministry of Education, Zhejiang University, Hangzhou, China. Electronic address:

Microplastics and nanoplastics (MPs and NPs, respectively) are major contaminants of environmental concern due to their potentially detrimental effects on aquatic and terrestrial ecosystems. However, little is known about their potential toxicity in terrestrial organisms. Here, we used the model insect silkworm (Bombyx mori) to evaluate the potential hazardous effects of acute exposure (72 h) to polystyrene (PS) MPs and NPs at physiological, molecular, and biochemical levels as well as their impact on pathogen infection. Read More

View Article and Full-Text PDF