Pathology 2014 Apr;46(3):216-24
1Department of Otorhinolaryngology and Head and Neck Surgery, GROW-School for Oncology & Developmental Biology, Maastricht University Medical Centre 2Department of Otorhinolaryngology and Head and Neck Surgery, Atrium Medical Centre, Heerlen 3Departments of Molecular Cell Biology 4Pathology 5Epidemiology 6School for Mental Health and Neuroscience 7Department of Methodology and Statistics, Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Centre 8Department of Pathology, University Medical Centre Groningen, The University of Groningen, The Netherlands.
The histopathology of premalignant laryngeal lesions does not provide reliable information on the risk of malignant transformation, hence we examined new molecular markers which can easily be implemented in clinical practice. Dual-target fluorescence in situ hybridisation (FISH) for chromosome 1 and 7 centromeres was performed on tissue sections of laryngeal premalignancies in 69 patients. Chromosome instability was indicated by numerical imbalances and/or polysomy for chromosomes 1 and 7. Read More