11,677 results match your criteria immunomodulatory activity


Barbel steed (Hemibarbus labeo) NK-lysin protects against Aeromonas hydrophila infection via immunomodulatory activity.

Dev Comp Immunol 2021 May 1:104114. Epub 2021 May 1.

College of Ecology, Lishui University, Lishui, 323000, China.

NK-lysins (NKLs) are a family of multifunctional antimicrobial peptides that have activity against various microorganisms. However, the immunomodulatory activity of NKL in fish remains unclear. In this study, the cDNA sequence of barbel steed (Hemibarbus labeo) NKL gene was cloned. Read More

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SARS-CoV-2 outbreak in immune-mediated inflammatory diseases: the Euro-COVIMID multicentre cross-sectional study.

Lancet Rheumatol 2021 Apr 28. Epub 2021 Apr 28.

Sorbonne Université, Pierre Louis Institute of Epidemiology and Public Health, Inserm UMR 1136, Paris, France.

Background: The COVID-19 pandemic has raised numerous questions among patients with immune-mediated inflammatory diseases regarding potential reciprocal effects of COVID-19 and their underlying disease, and potential effects of immunomodulatory therapy on outcomes related to COVID-19. The seroprevalence of SARS-CoV-2 and factors associated with symptomatic COVID-19 in patients with immune-mediated inflammatory diseases are still unclear. The Euro-COVIMID study aimed to determine the serological and clinical prevalence of COVID-19 among patients with immune-mediated inflammatory diseases, as well as factors associated with COVID-19 occurrence and the impact of the pandemic in its management. Read More

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Therapeutic use of Guggulsterone in COVID-19 induced obesity (COVIBESITY) and significant role in immunomodulatory effect.

Obes Med 2021 Apr 29:100346. Epub 2021 Apr 29.

SRM College of Pharmacy, SRM IST, Kattankulathur, Kancheepuram, Tamil Nadu, India.

COVID-19 has emerged as a major cause of health crisis around the world. Psychosocial, Behavioral and metabolic changes especially weigh gain, among variety of population was produced in this pandemic, through a variety of mechanisms. Hyperlipidemia is one of the major issues which results in serious cardiovascular complications. Read More

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Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants.

Chin J Nat Med 2021 May;19(5):321-338

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Cephalotaxus is the only genus of Cephalotaxaceae family, and its natural resources are declining due to habitat fragmentation, excessive exploitation and destruction. In many areas of China, folk herbal doctors traditionally use Cephalotaxus plants to treat innominate swollen poison, many of which are cancer. Not only among Han people, but also among minority ethnic groups, Cephalotaxus is used to treat various diseases, e. Read More

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Assessment of the biological activity of fish muscle protein hydrolysates using in vitro model systems.

Food Chem 2021 Apr 20;359:129852. Epub 2021 Apr 20.

School of Food and Nutritional Science, University College Cork, T12 YN60 Cork, Ireland. Electronic address:

The generation of biologically active fish protein hydrolysates (FPH) is a useful technique to produce value-added products with potential application in the functional food and nutraceutical industries. Fish muscle is an attractive substrate for the production of protein hydrolysates due to its rich protein content, containing 15-25% of total fish protein. This paper reviews the production of protein hydrolysates from fish muscle, most commonly via enzymatic hydrolysis, and their subsequent bioactivities including anti-obesity, immunomodulatory, antioxidant, angiotensin I-converting enzyme (ACE)-inhibitory, anti-microbial, and anti-cancer activities as measured by in vitro testing methods. Read More

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Recent advances in polysaccharides from Lentinus edodes (Berk.): Isolation, structures and bioactivities.

Food Chem 2021 Apr 20;358:129883. Epub 2021 Apr 20.

College of Food Science & Engineering, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, China. Electronic address:

Lentinus edodes, an important edible mushroom cultivated in East Asia for thousands of years, has been widely used as food and medicinal ingredient worldwide. Modern phytochemistry studies have demonstrated that L. edodes is very rich in bioactive polysaccharides, especially the β-glucans. Read More

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Antioxidant activity and short-chain fatty acid production of lactic acid bacteria isolated from Korean individuals and fermented foods.

3 Biotech 2021 May 15;11(5):217. Epub 2021 Apr 15.

MEDIOGEN Co. Ltd., Biovalley 1-ro, Jecheon-si, Chungcheongbuk-do, Incheon, 27136 Korea.

Compounds of the cell walls of heat-killed lactic acid bacteria show immunomodulatory properties which boost immunological systems, and are used ad postbiotics (paraprobiotics). In this study, we used 17 different heat-killed isolates as postbiotics and evaluated their anti-inflammatory potential on the expression of proinflammatory mediators and cellular signaling pathways of murine macrophage, RAW 264.7 cells. Read More

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Combination of vegetable soup and glucan demonstrates synergistic effects on macrophage-mediated immune responses.

Food Sci Biotechnol 2021 Apr 13;30(4):583-588. Epub 2021 Mar 13.

Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju, 61186 Republic of Korea.

Vegetable soup (VS), a plant-based functional food, has been used as a traditional folk medicine and is attracting attention for its ability to enhance the immune response. β-Glucan, a well-established and effective immunomodulator, has synergistic effects when used in combination with some bioactive compounds. In the present study, we aimed to evaluate the synergistic immunomodulatory effects of the combination of VS and β-glucan on macrophage-mediated immune responses. Read More

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AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection.

Front Immunol 2021 16;12:630938. Epub 2021 Apr 16.

Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

In agreement with other fungal infections, immunoprotection in pulmonary paracoccidioidomycosis (PCM) is mediated by Th1/Th17 cells whereas disease progression by prevalent Th2/Th9 immunity. Treg cells play a dual role, suppressing immunity but also controlling excessive tissue inflammation. Our recent studies have demonstrated that the enzyme indoleamine 2,3 dioxygenase (IDO) and the transcription factor aryl hydrocarbon receptor (AhR) play an important role in the immunoregulation of PCM. Read More

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Immunomodulatory activity of (oral administration of gold as electuary) in infants - A randomized controlled clinical trial.

Ayu 2019 Oct-Dec;40(4):230-236. Epub 2021 Jan 14.

Department of Kaumarabhritya, All India Institute of Ayurveda, New Delhi, India.

Background: (oral administration of gold as electuary) is a form of electuary depicted in the classics of Ayurveda under the ambit of pediatrics. A specific action on immune system has been highlighted in infants if gold is administered along with and honey for a period of 28 days.

Aim: The present trial was conducted to assess the safety and efficacy of (calcined powder), (honey) and in infants with respect to anthropometrical, hematological and immunological parameters. Read More

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January 2021

Social Distancing, Health Care Disruptions, Telemedicine Use, and Treatment Interruption During the COVID-19 Pandemic in Patients With or Without Autoimmune Rheumatic Disease.

ACR Open Rheumatol 2021 May 2. Epub 2021 May 2.

University of Alabama at Birmingham.

Background: We aimed to compare concerns, social distancing, health care disruptions, and telemedicine use in patients with autoimmune rheumatic disease (ARD) and non-ARD and to evaluate factors associated with immunomodulatory medication interruptions.

Methods: Patients in a multistate community rheumatology practice network completed surveys from April 2020 to May 2020. Adults with common ARD (rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus) or non-ARD (gout, osteoarthritis, osteoporosis) were evaluated. Read More

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Endocrine and immunomodulatory effects of social isolation and loneliness across adulthood.

Psychoneuroendocrinology 2021 Mar 8;128:105194. Epub 2021 Mar 8.

Department of Psychology, Wayne State University, USA.

Experimental and observational evidence agreed on two interconnected biological mechanisms responsible for the links between social isolation/loneliness and health: alterations in the activity of the hypothalamic-pituitary-adrenal (HPA) axis and compromised functioning of the innate immune system. However, most existing studies did not consider the simultaneous impact of social isolation and loneliness on biological outcomes. Further, they only assessed one biological outcome at a time and did not test any moderation by age, despite empirical and theoretical evidence supporting the plausibility of this hypothesis. Read More

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Time-dependent influence of infliximab on hemodynamic responses and cardiac injuries of isoproterenol-induced myocardial infarction in rats.

Eur J Pharmacol 2021 Apr 28:174122. Epub 2021 Apr 28.

Pharmacology and Toxicology Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Immune-induced inflammation plays an important role both in aggravating and healing of post myocardial infarction (MI) injuries. Potent anti-inflammatory and local immunomodulatory activity of infliximab has been suggested to have modulating effects on immune responses after MI. The aim of the present study was to evaluate the efficacy of infliximab on hemodynamic responses and myocardial injuries following isoproterenol-induced myocardial infarction. Read More

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Hydrogel containing (1 → 6)-β-D-glucan (lasiodiplodan) effectively promotes dermal wound healing.

Int J Biol Macromol 2021 Apr 27;183:316-330. Epub 2021 Apr 27.

Programa de Pós-Graduação em Biotecnologia, Universidade Tecnológica Federal do Paraná, Câmpus Dois Vizinhos, CEP 85660-000 Dois Vizinhos, Paraná, Brazil; Departamento de Química, Universidade Tecnológica Federal do Paraná, Campus Pato Branco, CEP 85503-390 Pato Branco, Paraná, Brazil. Electronic address:

A hydrogel containing exocellular (1 → 6)-β-D-glucan (lasiodiplodan, LAS) was developed and its wound healing potential was evaluated. β-Glucans have attracted much interest by the cosmetic industry sector because of their bioactive and functional properties and in promoting skin health. In the present work an β-glucan was studied as a healing biomaterial that has not hitherto been reported in the scientific literature. Read More

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Degraded sulfated polysaccharide relieves ovalbumin-induced food allergic response by restoring the balance of T helper cell differentiation.

Food Funct 2021 Apr 30. Epub 2021 Apr 30.

Allergy Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

We previously described that Porphyra haitanensis sulfated polysaccharide (PHSP) maintains the balance of pro-inflammation and immunosuppression. However, it is unclear whether degraded PHSP (DPHSP) still shows the immunomodulatory activity. Here, we degraded PHSP by four different methods alone or combined in pairs, and the results showed that the molecular weight and viscosity of DPHSP were significantly decreased, while the main chemical bonds and functional structure were consistent with those of PHSP. Read More

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Exploring the role of  (neem) and its active compounds in the regulation of biological pathways: an update on molecular approach.

3 Biotech 2021 Apr 20;11(4):178. Epub 2021 Mar 20.

Jagannath Gupta Institute of Medical Sciences & Hospital, KP Mondal Road, Buita, Nishchintapur, Budge Budge, Kolkata 700137 India.

In ethnomedicine, plant parts and compounds are used traditionally to treat different diseases. Neem ( A. Juss) is the most versatile and useful medicinal plant ever found. Read More

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Interplay of Opposing Effects of the WNT/β-Catenin Pathway and PPARγ and Implications for SARS-CoV2 Treatment.

Front Immunol 2021 13;12:666693. Epub 2021 Apr 13.

University Hospital Center (CHU) Amiens Picardie, University of Picardie Jules Verne (UPJV), Amiens, France.

The Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has quickly reached pandemic proportions. Cytokine profiles observed in COVID-19 patients have revealed increased levels of IL-1β, IL-2, IL-6, and TNF-α and increased NF-κB pathway activity. Recent evidence has shown that the upregulation of the WNT/β-catenin pathway is associated with inflammation, resulting in a cytokine storm in ARDS (acute respire distress syndrome) and especially in COVID-19 patients. Read More

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DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.

Cells 2021 Apr 27;10(5). Epub 2021 Apr 27.

The Guy Hilton Research Laboratories, Faculty of Medicine and Health Sciences, School of Pharmacy and Bioengineering, Keele University, Stoke on Trent ST5 5BG, UK.

The application of physiological oxygen (physoxia) concentrations is becoming increasingly commonplace within a mammalian stem cell culture. Human mesenchymal stem cells (hMSCs) attract widespread interest for clinical application due to their unique immunomodulatory, multi-lineage potential, and regenerative capacities. Descriptions of the impact of physoxia on global DNA methylation patterns in hMSCs and the activity of enzymatic machinery responsible for its regulation remain limited. Read More

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Antimicrobial and Immunomodulating Activities of Two Endemic Species and Their Major Iridoids Isolated from Natural Sources.

Pharmaceuticals (Basel) 2021 Apr 28;14(5). Epub 2021 Apr 28.

Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.

Two Balkan Peninsula endemics, and subsp. , both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two species and their major iridoids isolated from natural sources--NL, -NL, and 1,5,9-epideoxyloganic acid (1,5,9-DLA), as well as of phenolic acid rosmarinic acid (RA). Read More

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Synthetic Hexanucleotides as a Tool to Overcome Excessive Neutrophil Activation Caused by CpG-Containing Oligonucleotides.

Pathogens 2021 Apr 28;10(5). Epub 2021 Apr 28.

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.

Mimicking bacterial DNA, synthetic CpG-containing oligodeoxyribonucleotides (CpG-ODNs) have a powerful immunomodulatory potential. Their practical application is mainly associated with the production of vaccines, where they are used as adjuvants, as well as in local antimicrobial therapy. CpG-ODNs act on a wide variety of immune cells, including neutrophilic granulocytes. Read More

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Probiotic Properties and Immunomodulatory Activity of Strains Isolated from Dairy Products.

Microorganisms 2021 Apr 13;9(4). Epub 2021 Apr 13.

Unidad Periférica de Investigación Básica y Clínica en Enfermedades Infecciosas, Laboratorio de Patogenicidad Bacteriana, Departamento de Salud Pública/División de Investigación, Facultad de Medicina Universidad Nacional Autónoma de México, Unidad de Hemato-Oncología e Investigación, Hospital Infantil de México Federico Gómez/Facultad de Medicina, Universidad Nacional Autónoma de México, Dr. Márquez 162, Col. Doctores, Delegación Cuauhtémoc, Ciudad de México 06720, Mexico.

species are an effective biotherapeutic alternative against bacterial infections and intestinal inflammatory disorders. However, it is important to evaluate their beneficial properties, before considering them as probiotics for medical use. In this study we evaluated some probiotic properties of GG, KLSD, IMAU70129, and IMAU60214 previously isolated from dairy products and as control Shirota. Read More

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Non-Tumorigenic Pluripotent Reparative Muse Cells Provide a New Therapeutic Approach for Neurologic Diseases.

Cells 2021 Apr 20;10(4). Epub 2021 Apr 20.

Department of Stem Cell Biology and Histology, School of Medicine, Tohoku University, Sendai 980-8575, Japan.

Muse cells are non-tumorigenic endogenous reparative pluripotent cells with high therapeutic potential. They are identified as cells positive for the pluripotent surface marker SSEA-3 in the bone marrow, peripheral blood, and connective tissue. Muse cells also express other pluripotent stem cell markers, are able to differentiate into cells representative of all three germ layers, self-renew from a single cell, and are stress tolerant. Read More

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Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus.

Medicina (Kaunas) 2021 Apr 20;57(4). Epub 2021 Apr 20.

Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USA.

Alpha-1 antitrypsin (AAT) has established anti-inflammatory and immunomodulatory effects in chronic obstructive pulmonary disease but there is increasing evidence of its role in other inflammatory and immune-mediated conditions, like diabetes mellitus (DM). AAT activity is altered in both developing and established type 1 diabetes mellitus (T1DM) as well in established type 2 DM (T2DM). Augmentation therapy with AAT appears to favorably impact T1DM development in mice models and to affect β-cell function and inflammation in humans with T1DM. Read More

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Molecular, Immunomodulatory, and Histopathological Role of Mesenchymal Stem Cells and Beetroot Extract on Cisplatin Induced Testicular Damage in Albino Rats.

Animals (Basel) 2021 Apr 16;11(4). Epub 2021 Apr 16.

Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo 11757, Egypt.

Cisplatin (Cis) a drug commonly used as a chemotherapeutic agent to treat various types of cancer, inducing testicular damage. The present study aimed to investigate the inhibitory potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) and beetroot extract (BRE) in albino rats after testicular toxicity induced by cisplatin. Thirty adult male albino rats were grouped into: the control group, Cis group receiving a single dose of 7 mg/kg i. Read More

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Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets.

Int J Mol Sci 2021 Apr 25;22(9). Epub 2021 Apr 25.

Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USA.

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. Read More

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Immunomodulatory Factors in Primary Endometrial Cell Cultures Isolated from Cancer and Noncancerous Human Tissue-Focus on RAGE and IDO1.

Cells 2021 Apr 25;10(5). Epub 2021 Apr 25.

Laboratory of Separation and Spectroscopic Method Applications, Centre for Interdisciplinary Research, The John Paul II Catholic University of Lublin, Konstantynow 1J, 20-708 Lublin, Poland.

Background: Immune modulatory factors like indoleamine 2,3-dioxygenase 1 (IDO1) generating kynurenine (Kyn) and receptor for advanced glycation end-products (RAGE) contribute to endometrial and cancer microenvironment. Using adequate experimental models is needed to learn about the significance of these molecular factors in endometrial biology. In this paper we study IDO1 activity and RAGE expression in the in vitro cultured primary human endometrial cells derived from cancerous and noncancerous tissue. Read More

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Decitabine Promotes Modulation in Phenotype and Function of Monocytes and Macrophages That Drive Immune Response Regulation.

Cells 2021 Apr 12;10(4). Epub 2021 Apr 12.

Faculdade de Ciências Farmacêuticas de Ribeirão Preto-FCFRP-USP, Ribeirão Preto, São Paulo 14041-903, Brazil.

Decitabine is an approved hypomethylating agent used for treating hematological malignancies. Although decitabine targets altered cells, epidrugs can trigger immunomodulatory effects, reinforcing the hypothesis of immunoregulation in treated patients. We therefore aimed to evaluate the impact of decitabine treatment on the phenotype and functions of monocytes and macrophages, which are pivotal cells of the innate immunity system. Read More

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Microparticles and Nanoparticles from Plants-The Benefits of Bioencapsulation.

Vaccines (Basel) 2021 Apr 11;9(4). Epub 2021 Apr 11.

Institute of Plant Biotechnology and Cell Biology, Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria.

The efficacy of drugs and vaccines depends on their stability and ability to interact with their targets in vivo. Many drugs benefit from encapsulation, which protects them from harsh conditions and allows targeted delivery and controlled release. Although many encapsulation methods are inexpensive, such as the formulation of tablets for oral delivery, others require complex procedures that add significantly to production costs and require low-temperature transport and storage, making them inaccessible in developing countries. Read More

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Probiogenomics of subsp. CIDCA 133: In Silico, In Vitro, and In Vivo Approaches.

Microorganisms 2021 Apr 14;9(4). Epub 2021 Apr 14.

Laboratório de Genética Celular e Molecular (LGCM), Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.

subsp. CIDCA 133 (CIDCA 133) has been reported as a potential probiotic strain, presenting immunomodulatory properties. This study investigated the possible genes and molecular mechanism involved with a probiotic profile of CIDCA 133 through a genomic approach associated with in vitro and in vivo analysis. Read More

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Transcriptome Analysis Reveals Possible Immunomodulatory Activity Mechanism of sp. Exopolysaccharides on RAW264.7 Macrophages.

Mar Drugs 2021 Apr 14;19(4). Epub 2021 Apr 14.

Guangxi Key Laboratory for Polysaccharide Materials and Modifications, School of Marine and Biotechnology, GuangXi University for Nationalities, Nanning 530006, China.

In this study, the exopolysaccharides of sp. (CEP) were isolated to obtain the purified fraction CEP4. Characterization results showed that CEP4 was a sulfated heteropolysaccharide. Read More

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