13,394 results match your criteria immunohistochemically positive


Mesenchymal PLAG1 Tumor With PCMTD1-PLAG1 Fusion in an Infant: A New Type of "Plagoma".

Am J Dermatopathol 2021 Jul 20. Epub 2021 Jul 20.

Department of Dermatology, University Clinic of Navarra, School of Medicine, University of Navarra, Pamplona, Spain; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Department of Pediatric Hematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Roma, Italy; Department of Pathology, Ospedale Bambino Gesù, Roma, Italy; Orthopedic Division, University of Pittsburgh Medical Center, Pittsburgh, PA; and Department of Pathology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.

Abstract: In the past decade, there have been major advances in knowledge related to mesenchymal tumors, and new genetic alterations are being delineated. We report a mesenchymal spindle cell neoplasm harboring a novel gene fusion in an infant. Histopathologically, the neoplasm shared some features with sclerosing perineurioma, but immunohistochemically, EMA was negative, whereas GLUT1, NK1-C3, and BCOR were positive. Read More

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Giant Pilomatrical Tumor With Broad Epidermal Components: An Example of Histological Diversity and a Potential Diagnostic Pitfall of Tumors With Pilomatrical Differentiation.

Am J Dermatopathol 2021 Jul 20. Epub 2021 Jul 20.

Departments of Diagnostic Pathology, and Dermatology, Kyoto University Hospital, Kyoto, Japan; Department of Dermatology, Kagawa University Hospital, Kagawa, Japan; and National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Abstract: The diagnosis of pilomatricoma, the most common matrical tumor, is generally straightforward; however, it exhibits diverse histology associated with various morphological stages and several clinical variants, and matrical differentiation can occur in various neoplastic diseases. A 56-year-old man was admitted to our hospital to resect an 11.0-cm skin tumor on his right shoulder. Read More

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Hypopharyngeal Ulcers in COVID-19: Histopathological and Virological Analyses - A Case Report.

Front Immunol 2021 5;12:676828. Epub 2021 Jul 5.

Department of Neuroscience, Section of Human Anatomy, University of Padova, Padova, Italy.

In coronavirus disease 2019 (COVID-19), ulcerative lesions have been episodically reported in various segments of the gastrointestinal (GI) tract, including the oral cavity, oropharynx, esophagus, stomach and bowel. In this report, we describe an autopsy case of a COVID-19 patient who showed two undiagnosed ulcers at the level of the anterior and posterior walls of the hypopharynx. Molecular testing of viruses involved in pharyngeal ulcers demonstrated the presence of severe acute respiratory syndrome - coronavirus type 2 (SARS-CoV-2) RNA, together with herpes simplex virus 1 DNA. Read More

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Spontaneous granulocytic leukemia in a NOD/Shi- IL-2Rγ mouse.

J Toxicol Pathol 2021 Jul 18;34(3):241-244. Epub 2021 Apr 18.

CMIC Pharma Science Co., Ltd., 10221 Kobuchisawa-cho, Hokuto-shi, Yamanashi 408-0044, Japan.

Here, we report a case of spontaneous granulocytic leukemia in a 51-week-old male NOD/Shi- IL-2R (NOG) mouse. The mouse showed progressive anemia and rough respiratory movement. Macroscopically, the spleen was discolored and enlarged. Read More

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IL-36α and IL-36γ expressions in the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema: A retrospective histopathologic and immunohistochemical study.

J Cutan Pathol 2021 Jul 21. Epub 2021 Jul 21.

Department of Dermatology and Venereology, Istanbul Medeniyet University Göztepe Training and Research Hospital, Istanbul, Turkey.

Background: Diagnosing hyperkeratotic lesions on the palms and soles is often challenging for both clinicians and pathologists. Interleukin (IL)-36 cytokines play an important role in the pathogenesis of psoriasis.

Methods: We retrospectively re-evaluated hematoxylin-eosin-stained biopsy specimens of 30 patients with clinically diagnosed palmoplantar psoriasis (PP) and 30 patients with palmoplantar eczema (PE), and then performed IL-36α and IL-36γ immunohistochemistry. Read More

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Ceruloplasmin expression in renal cell carcinoma correlates with higher-grade and shortened survival.

Biomark Med 2021 Jul 21. Epub 2021 Jul 21.

Department of Urology, University Medicine Rostock, Ernst-Heydemann-Str 8, Rostock, 18057, Germany.

We aimed to explore ceruloplasmin (CP) expression in clear cell renal cell carcinoma (ccRCC). CP was analyzed in biofluid samples of 63 ccRCC patients, divided into three grading groups, and immunohistochemically, in 308 ccRCC. Significant differences of mean plasma and urine CP levels in different grading groups were found. Read More

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Histopathological features and immunophenotyping of canine transmural gastrointestinal lymphoma using full-thickness biopsy samples.

Vet Pathol 2021 Jul 20:3009858211030523. Epub 2021 Jul 20.

The University of Tokyo, Tokyo, Japan.

To elucidate the histopathological characteristics and immunophenotypes of canine transmural "mass-forming" gastrointestinal lymphomas and plasmacytomas, 83 surgically resected biopsy samples were examined. All lymphomas and plasmacytomas were located in the small or large intestine except for 1 plasmacytoma which was in the stomach. According to the World Health Organization (WHO) classification, B-cell neoplasms (17 cases) included lymphoplasmacytic lymphoma (6/17), plasmacytoma (5/17), follicular lymphoma (3/17), and diffuse large B-cell lymphoma (3/17). Read More

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Superiority of Formalin-Fixed Paraffin-Embedded Brain Tissue for Assessment of Progressive Supranuclear Palsy Tau Pathology With [ F]PI-2620.

Front Neurol 2021 2;12:684523. Epub 2021 Jul 2.

Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Munich, Germany.

Autoradiography on brain tissue is used to validate binding targets of newly discovered radiotracers. The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission tomography (PET) radiotracer [F]PI-2620 with immunohistochemically determined tau-protein load in both formalin-fixed paraffin-embedded (FFPE) and frozen tissue samples of patients with Alzheimer's disease (AD) and Progressive Supranuclear Palsy (PSP). We applied [F]PI-2620 autoradiography to postmortem cortical brain samples of six patients with AD, five patients with PSP and five healthy controls, respectively. Read More

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Thymic Adenocarcinoma with Positivity for Thyroid Transcription Factor-1 and a BRAF V600E Mutation: A Case Report.

Intern Med 2021 Jul 17. Epub 2021 Jul 17.

Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Japan.

Thymic adenocarcinomas are rare. We herein report for the first time a case of thymic adenocarcinoma with positivity for thyroid transcription factor-1 (TTF-1) and a BRAF V600E mutation. A 50-year-old woman had persistent suffocation and chest pain. Read More

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Feline pyloric and duodenal adenoma: A histological and immunohistochemical study.

Vet Pathol 2021 Jul 16:3009858211030542. Epub 2021 Jul 16.

12143The University of Tokyo, Tokyo, Japan.

Although pyloric and duodenal adenomas occasionally occur in cats, limited information is currently available on their phenotypes and molecular features. The present study investigated the pathological features of these tumors and the mechanisms underlying their tumorigenesis. Biopsy samples from 8 cats diagnosed with pyloric or duodenal adenomas were examined by histopathology and immunohistochemistry. Read More

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Reproductive tract neoplasia in adult female Asian elephants ().

Vet Pathol 2021 Jul 16:3009858211031843. Epub 2021 Jul 16.

7114San Diego Zoo Global, San Diego, CA, USA.

Recent reports have highlighted a lower-than-expected prevalence of neoplasia in elephants and suggested mechanisms for cancer resistance. But despite infrequent reports in the literature, uterine neoplasia is common in managed Asian elephants (). This study is an archival review of reproductive tract neoplasia in 80 adult female Asian elephant mortalities in managed care facilities in the United States from 1988 to 2019. Read More

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Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats.

Neurosci Lett 2021 Jul 12:136113. Epub 2021 Jul 12.

Department of Physiology, The Nippon Dental University, School of Life Dentistry at Tokyo, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan.

The activation of imidazoline 1 (I) receptors is suggested to stimulate the respiratory drive in newborn rats. Here, we immunohistochemically examined whether nischarin, an I receptor candidate protein, is expressed in the ventrolateral medulla, where cardiorespiratory centers are located. Newborn rats (age, 3 to 5 days) were deeply anesthetized with isoflurane; the brainstem was dissected, sectioned sagittally, and labeled with nischarin. Read More

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Expression of SOX2 and OCT4 in odontogenic cysts and tumors.

Head Face Med 2021 Jul 14;17(1):29. Epub 2021 Jul 14.

Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Road, Pathumwan, 10330, Bangkok, Thailand.

Background: Aberrant expression of stem cell markers has been observed in several types of neoplasms. This trait attributes to the acquired stem-like property of tumor cells and can impact patient prognosis. The objective of this study was to comparatively analyze the expression and significance of SOX2 and OCT4 in various types of odontogenic cysts and tumors. Read More

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A case of intracranial myxoid mesenchymal tumor with EWSR1:CREM fusion in an adult female: Extensive immunohistochemical evaluation.

Neuropathology 2021 Jul 13. Epub 2021 Jul 13.

Division of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Tottori, Japan.

Intracranial myxoid mesenchymal tumor (IMMT) is a recently described, extremely rare group of neoplasms characterized by fusions between the female-expressed transcript (FET) family genes and the cAMP response element-binding protein (CREB) family genes. Controversy persists regarding whether the tumor is a myxoid variant of angiomatoid fibrous histiocytoma or a completely distinct clinicopathological entity. Here, we report a case of IMMT arising in the posterior fossa in a 65-year-old woman with a history of breast cancer. Read More

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Primary central nervous system lymphomas with massive intratumoral hemorrhage: Clinical, radiological, pathological, and molecular features of six cases.

Neuropathology 2021 Jul 13. Epub 2021 Jul 13.

Department of Pathology, School of Health Sciences, Fujita Health University, Toyoake, Japan.

Primary central nervous system lymphomas (PCNSLs) rarely exhibit intratumoral hemorrhage. The differential diagnosis of hemorrhagic neoplasms of the central nervous system (CNS) currently includes metastatic carcinomas, melanomas, choriocarcinomas, oligodendrogliomas, and glioblastomas. Here we present the clinical, radiological, pathological, and molecular genetic features of six cases of PCNSL associated with intratumoral hemorrhage. Read More

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Topical onion juice mitigates the morphological alterations of the cornea in the aged male rats.

Anat Cell Biol 2021 Jul 13. Epub 2021 Jul 13.

Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Aging is associated with structural and functional changes of the cornea. Fresh onion juice contains phenolic compounds and flavonoids that may provide an anti-aging effect. The aim of this study was to assess the ability of the onion juice to ameliorate these aging changes. Read More

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Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature.

Front Endocrinol (Lausanne) 2021 23;12:692553. Epub 2021 Jun 23.

Department of Pathology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Adenomatoid tumor (AT) is an uncommon benign neoplasm of mesothelial origin, usually occurring in the female and male genital tracts. Extragenital localization such as the adrenal gland is extremely rare. Until now, only 39 cases of adrenal AT have been reported in the English literature. Read More

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Overexpression of claspin promotes docetaxel resistance and is associated with prostate-specific antigen recurrence in prostate cancer.

Cancer Med 2021 Jul 9. Epub 2021 Jul 9.

Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Although docetaxel (DTX) confers significant survival benefits in patients with castration-resistant prostate cancer (CRPC), resistance to DTX inevitably occurs. Therefore, clarifying the mechanisms of DTX resistance may improve survival in patients with CRPC. Claspin plays a pivotal role in DNA replication stress and damage responses and is an essential regulator for the S-phase checkpoint. Read More

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Primary adenocarcinoma of the esophagogastric junction, combined with an obscure hepatoid adenocarcinoma component, as discovered after the development of a metachronous liver metastasis.

Hippokratia 2020 Jul-Sep;24(3):138-142

1st Department of Surgery, National and Kapodistrian University of Athens, Athens, Greece.

Background: Esophageal hepatoid adenocarcinomas (HACs) belong to alpha fetoprotein (AFP)-producing adenocarcinomas and are relatively sparse.

Case Presentation: A 35-year-old man suffering from adenocarcinoma of the esophagogastric junction (EGJ), with negative preoperative studies for metastatic disease, underwent Ivor Lewis esophagectomy. The histologic examination demonstrated a poorly differentiated, IIA (TNM) staged EGJ adenocarcinoma. Read More

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Evaluation of E-Cadherin and β-Catenin Immunoreactivity for Determining Undifferentiated Cells in Anaplastic Thyroid Carcinoma.

Pathobiology 2021 Jul 8:1-8. Epub 2021 Jul 8.

Department of Surgery, Kuma Hospital, Kobe, Japan.

Introduction: An immunohistochemical study has occasionally been performed to diagnose anaplastic thyroid carcinoma (ATC). However, antibodies to confirm the undifferentiated nature of ATC have not yet been evaluated. The aim of this study was to evaluate E-cadherin and β-catenin expressions in immunoreactivity to determine undifferentiated carcinoma cells in the diagnosis of ATC. Read More

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Effect of low-intensity pulsed ultrasound on orofacial sensory disturbance following inferior alveolar nerve injury: Role of neurotrophin-3 signaling.

Eur J Oral Sci 2021 Jul 8:e12810. Epub 2021 Jul 8.

Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan.

Percutaneous treatment of low-intensity pulsed ultrasound (LIPUS) to the site of inferior alveolar nerve (IAN) transection promotes functional regeneration, but the detailed mechanism is unknown. We examined the involvement of neurotrophin-3 (NT-3), which primarily binds with tropomyosin receptor kinase C (TrkC), in functional transected IAN regeneration following LIPUS treatment in rats. Daily LIPUS treatment to the transected IAN was performed, and the mechanical sensitivity of the facial skin was measured for 14 d. Read More

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Novel detection of the CAMTA1-WWTR1 fusion gene in extra-adrenal myelolipoma-like lesion: a case report.

Virchows Arch 2021 Jul 6. Epub 2021 Jul 6.

Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.

A mediastinal mass was incidentally detected by chest X-ray in a 44-year-old man. Computed tomography findings revealed that the mass was a possible malignancy in the right and middle mediastinum and was removed by surgical resection. Macroscopically, the resected specimen was a well-demarcated yellowish, brownish, and whitish mass. Read More

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SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma.

Head Neck Pathol 2021 Jul 5. Epub 2021 Jul 5.

Department of Diagnostic Sciences, University of Tennessee Health Science Center, College of Dentistry, 875 Union Avenue, Memphis, TN, 38163, USA.

Peripheral ossifying fibromas (POFs) and peripheral odontogenic fibromas (POdFs) appear clinically similar but of different histogenesis. The novel marker SATB2 is involved in regulation of osteoblastic differentiation and phenotype. However, SATB2 expression has not been previously explored in POFs and POdFs. Read More

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An ectopic adrenocortical oncocytic adenoma in the liver highly mimicking hepatocellular carcinoma: case report and literature review.

Diagn Pathol 2021 Jul 4;16(1):58. Epub 2021 Jul 4.

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730, Beijing, China.

Background: Ectopic adrenocortical tissue is a lesion usually found incidentally during autopsy or inguinal surgery. Here, we demonstrate an extremely unusual case of intrahepatic adrenocortical adenoma which highly mimicks hepatocellular carcinoma (HCC) and brings challenges for clinicians and pathologists. The diagnostic pitfalls have been discussed in detail to provide clues for guiding differential diagnosis and future treatment. Read More

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Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice.

Sci Rep 2021 Jul 1;11(1):13640. Epub 2021 Jul 1.

Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.

Euglena gracilis is widely utilized as food or supplement to promote human and animal health, as it contains rich nutrients. In this study, we administered spray-dried powder of E. gracilis and paramylon, β-glucan stored in E. Read More

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Characterization of Cytokines and Proliferation Marker Ki67 in Chronic Rhinosinusitis with Nasal Polyps: A Pilot Study.

Medicina (Kaunas) 2021 Jun 11;57(6). Epub 2021 Jun 11.

Institute of Anatomy and Anthropology, Riga Stradins University, Kronvalda Boulevard 9, LV-1010 Riga, Latvia.

Chronic rhinosinusitis (CRS) is a condition that affects as much as 10.9% of the population and, along with presence of nasal polyps, is associated with significant morbidity and decreased quality of life. Studies on molecular pathways that have been activated in nasal polyp tissue are mainly based on cytokine concentration detection. Read More

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Primary pulmonary epithelioid sarcoma: a case report.

J Med Case Rep 2021 Jul 1;15(1):330. Epub 2021 Jul 1.

Department of Diagnostic Pathology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Background: Epithelioid sarcoma most frequently occurs in the dermal or subcutaneous area of the distal extremities. To date, there have been three cases of primary pulmonary epithelioid sarcoma reported. We report a case of epithelioid sarcoma that is considered a primary lung tumor. Read More

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Immunohistochemical evaluation of suspected oral malignant melanoma in cats.

Vet Pathol 2021 Jun 30:3009858211025793. Epub 2021 Jun 30.

6572University of Pennsylvania, Philadelphia, PA, USA.

Oral malignant melanoma (OMM) is considered the third most common oral malignant neoplasm in cats, but its variable morphology and frequent lack of melanin pigment make it a diagnostic challenge. Twenty-two cases of cats with malignant oral neoplasms that were diagnosed as OMM or listed OMM as a suspected differential diagnosis on the biopsy report were examined using an immunohistochemistry (IHC) panel for S100, melan-A, PNL2, laminin, CD34, and pan-cytokeratin. Although OMM was suspected ( = 14) or previously diagnosed ( = 8), only 2 cases were immunohistochemically confirmed as OMM. Read More

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The expression of RIPK3 is associated with cell turnover of gastric mucosa in the mouse and human stomach.

J Mol Histol 2021 Jun 25. Epub 2021 Jun 25.

Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Necroptosis is a novel manner of programmed cell death and important for tissue development, homeostasis, damage, and repair. Activation of receptor-interacting protein kinase 3 (RIPK3), a key member of receptor-interacting protein family in contributing significantly to necroptosis, in tissues is a hallmark of cells dying by necroptosis. However, there are few studies that examine the expression of RIPK3 in the glandular cells of stomachs under physiological condition. Read More

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Association of vitamin D deficiency and insulin resistance with breast cancer in premenopausal Algerian women: A cross-sectional study.

Ann Endocrinol (Paris) 2021 Jun 21. Epub 2021 Jun 21.

USTHB, Endocrinology team, Laboratory of Biology and Physiology Faculty of Biological Sciences, DZ-16111 Algiers, Algeria. Electronic address:

Background: Low 25(OH)D levels are mainly related to breast cancer (BC) risk in postmenopausal women, while the impact of insulin resistance (IR) on BC prognosis is controversial.

Objective: Considering the high prevalence of BC in younger Algerian women, this cross-sectional study analyzed whether vitamin D status and IR are biomarkers for breast tumor status in premenopausal women.

Methods: In 96 women (mean age, 40. Read More

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