793,099 results match your criteria immune thrombocytopenia


A Phytophthora capsici RXLR effector targets and inhibits the central immune kinases to suppress plant immunity.

New Phytol 2021 Jun 22. Epub 2021 Jun 22.

MOA Key Lab of Pest Monitoring and Green Management, Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing, 100193, China.

Receptor-like cytoplasmic kinase subfamily VII (RLCK-VII) proteins are the central immune kinases in plant pattern-recognition receptor (PRR) complexes, and they orchestrate a complex array of defense responses against bacterial and fungal pathogens. However, the role of RLCK-VII in plant-oomycete pathogen interactions has not been determined. Phytophthora capsici is a notorious oomycete pathogen that infects many agriculturally important vegetables. Read More

View Article and Full-Text PDF

Challenges Facing Pathologists Evaluating PD-L1 in Head & Neck Squamous Cell Carcinoma.

J Oral Pathol Med 2021 Jun 22. Epub 2021 Jun 22.

Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.

Programmed death-ligand 1 (PD-L1) expression with combined positive score (CPS) ≥1 is required for administration of checkpoint inhibitor therapy in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). The 22C3 pharmDx Dako immunohistochemical assay is the one approved as companion diagnostic for pembrolizumab, but many laboratories work on other platforms and/or with other clones, and studies exploring the potential interchangeability of assays have appeared. After review of the literature, it emerges that the concordance among assays ranges from fair to moderate, with a tendence of assay SP263 to yield a higher quota of positivity and of assay SP142 to stain better immune cells. Read More

View Article and Full-Text PDF

Lasting response after discontinuation of Cemiplimab in a patient with locally advanced basal cell carcinoma.

Clin Exp Dermatol 2021 Jun 22. Epub 2021 Jun 22.

Section of Dermatology, Department of Health Sciences, University of Florence, Florence, Italy.

Basal cell carcinoma (BCC) is the most common skin malignancy in humans. Most of the cases can be cured through complete surgical excision as recommended by international guidelines. However, a minority of BCCs progress to a locally advanced (laBCC) or metastatic form and in these late stages, surgery is not indicated as it is not effective. Read More

View Article and Full-Text PDF

Immunomodulatory effects of lenvatinib plus anti-PD1 in mice and rationale for patient enrichment in hepatocellular carcinoma.

Hepatology 2021 Jun 22. Epub 2021 Jun 22.

Mount Sinai Liver Cancer Program, Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

Background & Aims: Lenvatinib is an effective drug in advanced hepatocellular carcinoma (HCC). Its combination with the anti-PD1 immune checkpoint inhibitor pembrolizumab has generated encouraging results in phase Ib and is currently being tested in phase III trials. Here, we aimed to explore the molecular and immunomodulatory effects of lenvatinib alone or in combination with anti-PD1. Read More

View Article and Full-Text PDF

Immunologic and Virologic Factors Associated with Hospitalization in HIV-Exposed, Uninfected Infants in the United States.

Clin Infect Dis 2021 Jun 22. Epub 2021 Jun 22.

Departments of Pediatrics, Medicine, and Pathology, University of Colorado, Aurora, CO, USA.

Background: HIV-exposed, uninfected (HEU) infants experience higher rates of morbidity and mortality than HIV-unexposed uninfected (HUU) infants. Few studies have examined whether particular infections and/or immune responses are associated with hospitalization among HEU infants born in the United States.

Methods: We evaluated a subset of HEU infants enrolled in the International Maternal Pediatric Adolescent AIDS Clinical Trials Group P1025 and/or Pediatric HIV/AIDS Cohort Study Surveillance Monitoring for ART Toxicities studies. Read More

View Article and Full-Text PDF

Immune Reconstitution Following Allogeneic Stem Cell Transplantation in HIV infected Individuals: Years of Living Danger-ously.

Clin Infect Dis 2021 Jun 22. Epub 2021 Jun 22.

Clinical Retrovirology Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland.

View Article and Full-Text PDF

Type I Hypersensitivity in Ferrets Following Exposure to SARS-CoV-2 Inoculum: Lessons Learned.

ILAR J 2021 Jun 23. Epub 2021 Jun 23.

Commonwealth Scientific and Industrial Research Organisation, Australian Centre for Disease Preparedness, Geelong, Victoria, Australia.

This case report discusses Type I hypersensitivity in ferrets following exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculum, observed during a study investigating the efficacy of candidate COVID-19 vaccines. Following a comprehensive internal root-cause investigation, it was hypothesized that prior prime-boost immunization of ferrets with a commercial canine C3 vaccine to protect against the canine distemper virus had resulted in primary immune response to fetal bovine serum (FBS) in the C3 preparation. Upon intranasal exposure to SARS-CoV-2 virus cultured in medium containing FBS, an allergic airway response occurred in 6 out of 56 of the ferrets. Read More

View Article and Full-Text PDF

Human immune response against salivary antigens of Simulium damnosum s.l.: A new epidemiological marker for exposure to blackfly bites in onchocerciasis endemic areas.

PLoS Negl Trop Dis 2021 Jun 22;15(6):e0009512. Epub 2021 Jun 22.

Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic.

Background: Simulium damnosum sensu lato (s.l.) blackflies transmit Onchocerca volvulus, a filarial nematode that causes human onchocerciasis. Read More

View Article and Full-Text PDF

Mediated Electrochemical Probing: A Systems-Level Tool for Redox Biology.

ACS Chem Biol 2021 Jun 22. Epub 2021 Jun 22.

Institute for Bioscience & Biotechnology Research, University of Maryland, College Park, Maryland 20742, United States.

Biology uses well-known redox mechanisms for energy harvesting (e.g., respiration), biosynthesis, and immune defense (e. Read More

View Article and Full-Text PDF

[Evaluation of aqueous cytokine levels in eyes with Fuchs endothelial corneal dystrophy and bullous keratopathy].

Vestn Oftalmol 2021 ;137(3):13-18

Research Institute of Eye Diseases, Moscow, Russia.

Purpose: To evaluate cytokine levels in the aqueous humor (AH) of patients with Fuchs endothelial corneal dystrophy (FECD) and bullous keratopathy (BK).

Material And Methods: The study included 74 patients (74 eyes). The first group consisted of 31 patients (72. Read More

View Article and Full-Text PDF
January 2021

Immune-related adverse events as clinical biomarkers in metastatic renal cell carcinoma patients treated with immune checkpoint inhibitors.

Oncologist 2021 Jun 22. Epub 2021 Jun 22.

Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Background: Immune checkpoint inhibitors (ICI) are an important treatment for metastatic renal cell carcinoma (mRCC). These agents may cause immune-related adverse events (irAEs) and the relationship between irAEs and outcomes is poorly understood. We investigated the association between irAEs and clinical outcomes in ICI-treated mRCC patients. Read More

View Article and Full-Text PDF

PD-L1 expression and immune stromal features in HPV-independent cervical adenocarcinoma.

Histopathology 2021 Jun 22. Epub 2021 Jun 22.

Department of Pathology, The Second Hospital of Jilin University, Changchun, Jilin, 130041, China.

Aims: Human papilloma virus (HPV)-independent cervical adenocarcinoma (CA) is usually diagnosed at an advanced stage, while the therapeutic options are limited. Therefore, effective treatment options are required. The programmed cell death 1 inhibitor pembrolizumab has been approved for the treatment of patients with recurrent or metastatic cervical squamous cell carcinoma expressing PD-L1. Read More

View Article and Full-Text PDF

Immunomodulatory agents as potential therapeutic or preventive strategies for COVID-19.

Eur Rev Med Pharmacol Sci 2021 Jun;25(11):4174-4184

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.

Currently, the COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus, represents the greatest global health threat. Most people infected by the virus present mild to moderate respiratory symptoms and recover with supportive treatments. However, certain susceptible hosts develop an acute respiratory distress syndrome (ARDS), associated with an inflammatory "cytokine storm", leading to lung damage. Read More

View Article and Full-Text PDF

Histone Deacetylase Inhibitor SAHA Induces Expression of Fatty Acid-Binding Protein 4 and Inhibits Replication of Human Cytomegalovirus.

Virol Sin 2021 Jun 22. Epub 2021 Jun 22.

CAS Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, 200031, China.

Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase inhibitor that shows marked efficacy against many types of cancers and is approved to treat severe metastatic cutaneous T-cell lymphomas. In addition to its anticancer activity, SAHA has significant effects on the growth of many viruses. The effect of SAHA on replication of human cytomegalovirus (HCMV) has not, however, been investigated. Read More

View Article and Full-Text PDF

Bone Health in Pediatric Patients with IBD: What Is New?

Curr Osteoporos Rep 2021 Jun 22. Epub 2021 Jun 22.

Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Purpose Of The Review: Patients with inflammatory bowel disease (IBD) have increased bone fragility, demonstrated by increased fracture risk, and often have low bone density and altered bone geometry, but the underlying pathophysiology remains poorly understood.

Recent Findings: Children and adolescents with IBD appear to have decreased bone formation, at diagnosis, which frequently improves with treatment of their underlying IBD. There is a growing body of evidence regarding how the immune system interacts with bone metabolism. Read More

View Article and Full-Text PDF

Face Mask Use Among Commercial Drivers During the COVID-19 Pandemic in Accra, Ghana.

J Community Health 2021 Jun 22. Epub 2021 Jun 22.

Department of Geography and Resource Development, University of Ghana, Accra, Ghana.

The paper contributes to unravelling the perceptions of urban commercial drivers regarding their vulnerability to catching the SARS-CoV-2 virus while at work. It further examines how the perception of vulnerability influences personal use of face masks by drivers, as well as on their insistence on appropriate masking behaviour by other persons on-board public transport. Overcrowding and unsanitary conditions in informal public transport in Africa could facilitate the spread of the corona virus. Read More

View Article and Full-Text PDF

A Decreased Response to Resistin in Mononuclear Leukocytes Contributes to Oxidative Stress in Nonalcoholic Fatty Liver Disease.

Dig Dis Sci 2021 Jun 22. Epub 2021 Jun 22.

Facultad de Farmacia Y Bioquímica, Instituto de Inmunología, Genética Y Metabolismo (INIGEM), CONICET-Universidad de Buenos Aires, Hospital de Clínicas José de San Martín, Avda. Córdoba 2351 (1120) CABA, Buenos Aires, Argentina.

Background: Deregulation of immune response and oxidative stress contribute to nonalcoholic fatty liver disease (NAFLD) pathogenesis. Resistin is a physiological modulator of inflammation and redox homeostasis of different cell types. Increased resistin serum concentration and the direct association between resistin hepatic expression and NAFLD severity suggest that resistin participates in NAFLD pathogenesis. Read More

View Article and Full-Text PDF

Influence of Crescentia cujete and Launaea taraxacifolia leaves on growth, immune indices, gut microbiota, blood chemistry, carcass, and meat quality in broiler chickens.

Trop Anim Health Prod 2021 Jun 22;53(3):365. Epub 2021 Jun 22.

Department of Animal Production, Faculty of Agriculture, University of Ilorin, Ilorin, PMB 1515, Nigeria.

The rising concerns pertaining to the safety of synthetic supplements in livestock production have encouraged the exploration of potential alternatives. This study investigated the growth, gut microbiota, blood chemistry, immune indices, meat quality, and antioxidant status in broiler chickens supplemented with Crescentia cujete leaf (CCL), Launaea taraxacifolia leaf (LTL), and a combination of antibiotic (70% oxytetracycline + 30% neomycin) and tert-Butylhydroxyanisole. One-day-old Ross 308 chicks (n = 420) were randomly assigned to either T-1, basal diet (BD) only; T-2, BD + 0. Read More

View Article and Full-Text PDF

Perceptions of Infectability to Disease Moderate the Association between Daily Concerns about Contracting COVID-19 and Satisfaction with Sex.

Arch Sex Behav 2021 Jun 22. Epub 2021 Jun 22.

Department of Psychology, Florida State University, 1107 West Call Street, Tallahassee, FL, 32306, USA.

The behavioral immune system is an evolved adaptation comprised of automatic behavioral, cognitive, and affective reactions that has allowed humans throughout evolutionary history to avoid situations that risk infection by pathogens (e.g., physical proximity to sick people). Read More

View Article and Full-Text PDF

Immunotherapy era in the treatment of small cell lung cancer.

Med Oncol 2021 Jun 22;38(7):86. Epub 2021 Jun 22.

Department of Medical Oncology, Meram Faculty of Medicine, Necmettin Erbakan University, Yunus Emre Mah. Beyşehir Cad. No:281, Konya, Turkey.

Small cell lung cancer (SCLC) is differentiated from non-small cell lung cancers with its histological and morphological features, rapid response to chemotherapy, and recurrence in a short time after treatment is discontinued. Platinum plus etoposide chemotherapy combination has been used as a standard treatment, and no new drug has been found for more than 30 years in this disease. In research, the targeted pathways that may affect survival have not been identified yet. Read More

View Article and Full-Text PDF

Alternative uses of ustekinumab for non-indicated dermatological conditions: a systematic review.

Arch Dermatol Res 2021 Jun 22. Epub 2021 Jun 22.

Department of Dermatology, Stony Brook University Hospital, Stony Brook, NY, USA.

Ustekinumab is approved for the treatment of psoriasis and Crohn's disease. Because many dermatological conditions are due to immune-mediated development, ustekinumab may be effective in other conditions. A systematic review of the off-label uses of ustekinumab, as well as on-label adverse effect, was performed, reporting on clinical improvement. Read More

View Article and Full-Text PDF

Multiomic analysis of the function of across cancers: an integrated bioinformatics approach.

J Int Med Res 2021 Jun;49(6):300060520962659

Infection Disease Center of Peking University International Hospital, Beijing, China.

Objective: To investigate SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 () gene expression across The Cancer Genome Atlas (TCGA) cancers, both in cancer versus normal tissues and in different stages across the cancer types.

Methods: This integrated bioinformatics study used data from several bioinformatics databases (Cancer Cell Line Encyclopedia, Genotype-Tissue Expression, TCGA, Tumor Immune Estimation Resource [TIMER]) to define the expression pattern of the gene. A survival analysis was undertaken across the cancers. Read More

View Article and Full-Text PDF

The Salivary Microbiota, Cytokines, and Metabolome in Patients with Ankylosing Spondylitis Are Altered and More Proinflammatory than Those in Healthy Controls.

mSystems 2021 Jun 22:e0117320. Epub 2021 Jun 22.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang Universitygrid.13402.34, Hangzhou, China.

The pathogenesis of ankylosing spondylitis (AS) remains unclear but appears to be associated with heredity and the environment. The mouth links the external environment to the gut and lungs. In the present study, compared to that observed in healthy controls (HCs), AS saliva was depleted of Bacilli such as Streptococcus, enriched with Clostridia such as , and enriched with opportunistic pathogens from such as Brucella spp. Read More

View Article and Full-Text PDF

Molecular Evolution and Adaptation of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) Sequence Type 9.

mSystems 2021 Jun 22:e0049221. Epub 2021 Jun 22.

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) sequence type 9 (ST9) has emerged and disseminated in Asia. It is associated with colonization or infection in both humans and animal hosts; however, the genetic factors underpinning its adaptation to animal and human population remain to be determined. Here, we conducted a genomic analysis of 191 ST9 S. Read More

View Article and Full-Text PDF

The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle.

mSystems 2021 Jun 22:e0039721. Epub 2021 Jun 22.

Department of Molecular Biology, Princeton Universitygrid.16750.35, Princeton, New Jersey, USA.

DNA sensors are critical components of innate immunity that enable cells to recognize infection by pathogens with DNA genomes. The interferon-inducible protein X (IFIX), a member of the PYHIN protein family, is a DNA sensor capable of promoting immune signaling after binding to double-stranded DNA (dsDNA) within either the nucleus or cytoplasm. Here, we investigate the impact of IFIX on the cellular proteome upon introduction of foreign DNA to the nucleus or the cytoplasm as well as regulatory hubs that control IFIX subcellular localization. Read More

View Article and Full-Text PDF

First-line pembrolizumab with or without platinum doublet chemotherapy in non-small-cell lung cancer patients with PD-L1 expression ≥50.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Pneumology & Thoracic Oncology, CH Annecy-Genevois, 74370, Metz-Tessy, France.

Pembrolizumab plus chemotherapy is currently used in the first-line treatment of advanced non-small-cell lung cancer without mutations or rearrangements, regardless of PD-L1 expression status. A study comparing chemotherapy plus pembrolizumab versus pembrolizumab alone has never been performed in patients with PD-L1 ≥50%. The aim of this trial is to perform such a comparison as first-line treatment in patients not eligible for locally advanced treatment who have expression of PD-L1 on ≥50% of tumor cells. Read More

View Article and Full-Text PDF

Immune-related genes and correlate with tumor sites and predict poor survival in pancreatic adenocarcinoma.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

The aim of this study was to identify the immune- and locus-associated genes in pancreatic ductal adenocarcinoma and evaluate their value in prognosis. The pancreatic ductal adenocarcinoma stromal and immune scores were calculated with the estimation of stromal and immune cells in malignant tumor tissues using expression data algorithm. The authors screened the differentially expressed genes to generate immune- and stromal-related differentially expressed genes. Read More

View Article and Full-Text PDF

Chimeric antigen receptor T-cell therapy for breast cancer.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 14177-55469, Iran.

One of the main reasons that researchers pay enormous attention to immunotherapy is that, despite significant advances in conventional therapy approaches, breast cancer remains the leading cause of death from malignant tumors among women. Genetically modifying T cells with chimeric antigen receptors (CAR) is one of the novel methods that has exhibited encouraging activity with relative safety, further urging investigators to develop several CAR T cells to target overexpressed antigens in breast tumors. This article is aimed not only to present such CAR T cells and discuss their remarkable results but also indicates their shortcomings with the hope of achieving possible strategies for improving therapeutic response. Read More

View Article and Full-Text PDF

Cell-based immunotherapy approaches for colorectal cancer: main achievements and challenges.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Shahid fahmideh boulevard, 6517838687, Hamadan, Iran.

Immunotherapy is becoming as a major treatment modality for multiple types of solid tumors, including subsets of colorectal cancers (CRCs). The successes with immunotherapy alone has largely been achieved in patients with advanced-stage mismatch-repair-deficient and microsatellite instability-high (dMMR-MSI-H) CRCs. However, the benefits of immunotherapy have not been demonstrated to be effective in patients with proficient mismatch repair (pMMR) CRC, who are microsatellite-stable (MSS) or have low levels of microsatellite instability (MSI-L). Read More

View Article and Full-Text PDF

Mechanistic underpinning of an inside-out concept for autoimmunity in multiple sclerosis.

Ann Clin Transl Neurol 2021 Jun 22. Epub 2021 Jun 22.

Department Anatomy and Neuroscience, University Medical Center Amsterdam, Amsterdam, The Netherlands.

The neuroinflammatory disease multiple sclerosis is driven by autoimmune pathology in the central nervous system. However, the trigger of the autoimmune pathogenic process is unknown. MS models in immunologically naïve, specific-pathogen-free bred rodents support an exogenous trigger, such as an infection. Read More

View Article and Full-Text PDF