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Periocular Presentation of Solitary Plasmacytomas and Multiple Myeloma.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Orbital Service, Moorfields Eye Hospital, London, United Kingdon.

Aims: To describe patients with periocular solitary extramedullary plasmacytoma (SEMP) and multiple myeloma (MM), together with an estimate of the risk of progression from SEMP to MM.

Patients And Methods: A retrospective case-note review for patients seen between 1978 and 2020, examining demographics, presentation, imaging, pathology, management, and outcome.

Results: Twenty patients (10 male; 50%) presented at a mean age of 60. Read More

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Blood Perfusion of Human Upper Eyelid Skin Flaps Is Better in Myocutaneous than in Cutaneous Flaps.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Clinical Sciences Lund, Ophthalmology, Skåne University Hospital, Lund University, Lund, Sweden Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.

Background: The aim of this study was to monitor blood perfusion in human upper eyelid skin flaps and examine how the perfusion is affected by the thickness of the flap.

Methods: Twenty upper eyelids were dissected as part of a blepharoplasty procedure in patients. The medial end of the blepharoplasty flap remained attached to mimic a flap design often used in reconstruction in the periocular area, a myocutaneous flap in which the blood supply follows the fibers of the orbicularis muscle and is thus parallel to the long axis of the flap. Read More

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Combined Central Retinal Arterial and Venous Occlusions due to Leukemic Infiltration.

Retin Cases Brief Rep 2021 Sep 19. Epub 2021 Sep 19.

Department of Ophthalmology, Antwerp University Hospital, Edegem, Belgium Department of Pathology, Antwerp University Hospital, Edegem, Belgium Department of Radiology, Antwerp University Hospital, Edegem, Belgium Faculty of Health Sciences, University of Antwerp, Edegem, Belgium Name and address for correspondence: Vincent M. De La Porte, M.D. E-mail: Telephone: +32 3 821 4428, Address: Department of Ophthalmology, Antwerp University Hospital, 2650 Edegem, Belgium.

Purpose: To report combined central arterial and venous occlusions secondary to bilateral leukemic interfascicular optic nerve infiltration in a 56-year-old man. This was the sole presentation of a relapse in T/Myeloid mixed-phenotype acute leukemia after 5 months of remission.

Methods: Case report with clinical photography. Read More

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September 2021

Retinal Toxicity Following Presumed Inadvertent Intraocular Injection of Mitomycin C during Trabeculectomy.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Northwestern Lake Forest Hospital, Lake Forest, Illinois, United States of America Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

Purpose: To describe a case of post-operative retinal toxicity following the use of mitomycin C during a routine trabeculectomy.

Methods: Case report of a single patient who underwent complete ophthalmic examination and multimodal imaging, including color fundus photos, optical coherence tomography (OCT), fundus autofluorescence (FAF), and fluorescein angiography (FA). The study was declared exempt by the Institutional Review Board of Northwestern University. Read More

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Novel MFRP Mutation with Nanophthalmos, Optic Disc Drusen, and Peripheral Retinoschisis Imaged with Ultra-Widefield OCT.

Retin Cases Brief Rep 2021 Jul 16. Epub 2021 Jul 16.

Department of Ophthalmology, Weill Cornell Medical College, New York, United States.

Purpose: To describe with multimodal imaging including the use of ultra-widefield optical coherence tomography (OCT) imaging a distinct phenotype of autosomal recessive nanophthalmos associated with a novel mutation of the MFRP gene (membrane-type frizzled-related protein).

Methods: Case report and review of the relevant literature.

Patients: Single patient followed by the Weill Cornell Medicine Department of Ophthalmology Retina and Glaucoma Services. Read More

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Anatomic Distribution of Cherry Angiomas in the General Population.

Dermatology 2021 Jul 22:1-9. Epub 2021 Jul 22.

The University of Queensland Diamantina Institute, The University of Queensland, Dermatology Research Centre, Brisbane, Queensland, Australia.

Background: Cherry angiomas are common benign vascular skin lesions of unknown aetiology, found largely on the trunk. However, their exact anatomic distribution besides their truncal predisposition, and how they manifest in the general population, has not been characterised.

Methods: Three-dimensional (3D) total body imaging was obtained from 163 adult participants of a general population cohort study in Brisbane, Australia. Read More

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Tetrad of Split Cord Malformation I with Neuroenteric Cyst, Dermoid Cyst, and Thickened Filum Terminale in a 2-Year-Old Child: A Case Report.

Pediatr Neurosurg 2021 Jul 22:1-7. Epub 2021 Jul 22.

Department of Neurosurgery, National Institute of Mental health and Neurosciences, Bengaluru, India.

Introduction: Split cord malformations (SCMs) are developmental anomalies that are associated with a number of congenital defects. However, a combination of SCM I with a neuroenteric cyst (NEC) is extremely rare, and only 11 cases have been described in the literature. To the best of authors' knowledge, the combination of the above two with dermoid cyst and thickened filum terminale has never been reported in the literature. Read More

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HEDOS - a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Division of Radiation Biophysics, Department of Radiation Oncology, , Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, UNITED STATES.

We have developed a time-dependent computational framework, HEDOS (HEmatological DOSe), to estimate dose to circulating blood cells from radiation therapy treatment fields for any treatment site. Two independent dynamic models were implemented in HEDOS: one describing the spatiotemporal distribution of blood particles (BPs) in organs and the second describing the time-dependent radiation field delivery. A whole-body blood flow network based on blood volumes and flow rates from ICRP Publication 89 was simulated to produce the spatiotemporal distribution of BPs in organs across the entire body using a discrete-time Markov process. Read More

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Synthetic pulmonary perfusion images from 4DCT for functional avoidance using deep learning.

Phys Med Biol 2021 Jul 22. Epub 2021 Jul 22.

Radiation Oncology, Beaumont Health System, Royal Oak, Michigan, UNITED STATES.

Purpose: To develop and evaluate the performance of a deep learning model to generate synthetic pulmonary perfusion images from clinical 4DCT images for patients undergoing radiotherapy for lung cancer.

Methods: A clinical data set of 58 pre- and post-radiotherapy 99mTc-labelled MAA-SPECT perfusion studies (32 patients) each with contemporaneous 4DCT studies was collected. Using the inhale and exhale phases of the 4DCT, a 3D-Residual Network was trained to create synthetic perfusion images utilizing the MAA-SPECT as ground truth. Read More

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Characteristics and predictors for silent hypoxemia in a cohort of hospitalized COVID-19 patients.

Auton Neurosci 2021 Jul 17;235:102855. Epub 2021 Jul 17.

Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Electronic address:

Background: An intriguing feature recently unveiled in some COVID-19 patients is the "silent hypoxemia" phenomenon, which refers to the discrepancy of subjective well-being sensation while suffering hypoxia, manifested as the absence of dyspnea.

Objective: To describe the clinical characteristics and predictors of silent hypoxemia in hospitalized COVID-19 patients.

Methods: We conducted a prospective cohort study including consecutive hospitalized adult (≥ 18 years) patients with confirmed COVID-19 presenting to the emergency department with oxygen saturation (SpO2) ≤ 80% on room air from March 15 to June 30, 2020. Read More

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A patient with concurrent multiple sclerosis and moyamoya disease.

Mult Scler Relat Disord 2021 Jul 16;54:103151. Epub 2021 Jul 16.

Division of Neuro-Immunology, Department of Neurology, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY. Electronic address:

Background: Moyamoya disease (MMD) is a rare vasculopathy and Multiple Sclerosis (MS) is an autoimmune disease which causes CNS demyelination. While most literature has focused on misdiagnosis of MMD as an "MS-mimic", we present a patient in which both co-existed.

Methods: Case Report RESULTS: A 57-year-old woman presented with gait dysfunction and paresthesias in both feet. Read More

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Prediction of chemotherapy response in breast cancer patients at pre-treatment using second derivative texture of CT images and machine learning.

Transl Oncol 2021 Jul 19;14(10):101183. Epub 2021 Jul 19.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Physical Sciences Platform, Sunnybrook Research Institute, Sunnybrook Health Sciences Center, Toronto, ON, Canada; Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address:

Although neoadjuvant chemotherapy (NAC) is a crucial component of treatment for locally advanced breast cancer (LABC), only about 70% of patients respond to it. Effective adjustment of NAC for individual patients can significantly improve survival rates of those resistant to standard regimens. Thus, the early prediction of NAC outcome is of great importance in facilitating a personalized paradigm for breast cancer therapeutics. Read More

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Prognostic value of tumour-infiltrating lymphocytes based on the evaluation of frequency in patients with oestrogen receptor-positive breast cancer.

Eur J Cancer 2021 Jul 19;154:217-226. Epub 2021 Jul 19.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350007, China. Electronic address:

Purpose: We investigate the prognostic value of tumour-infiltrating lymphocytes (TILs) based on the evaluation of the present frequency in patients with breast cancer rather than that of the density proposed in previous research.

Methods: Multiphoton microscopy (MPM) was introduced to label-freely obtain TIL images from a total of 564 patients, and then TILs were redefined as TILs-1 to TILs-3 from MPM images according to the relative positions between TILs, tumour cells and collagen fibres. More seminally, a new method, which was based on the present frequency of TILs-1 to TILs-3, was presented for assessing the predictive ability of TILs, and then a tumour-infiltrating lymphocytes score (TILs-score) for each patient was obtained by ridge regression analysis. Read More

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Monitoring Intramural Hematoma on Vessel Wall Imaging to Evaluate the Healing of Intracranial Vertebral Artery Dissection.

J Stroke Cerebrovasc Dis 2021 Jul 19;30(9):105992. Epub 2021 Jul 19.

Department of Neurosurgery Graduate School of Biomedical and Health Sciences Hiroshima University, Hiroshima, Japan.

Objective: Unruptured intracranial vertebral artery dissection (VAD) generally heals spontaneously. A chronological evaluation of intramural hematoma (IMH) using T1-weighted vessel wall imaging (VWI) may provide a more detailed understanding of the pathophysiology of VAD. We herein investigated the relationship between chronological signal changes in IMH on VWI and the spontaneous healing of VAD. Read More

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Threatening Blindness in a Child With Typical Hemolytic Uremic Syndrome.

Pediatr Neurol 2021 Jun 25;122:35-37. Epub 2021 Jun 25.

Department of Paediatric Neurology, APHM La Timone, Marseille, France. Electronic address:

Background: Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children younger than five years. Central nervous system involvement occurs in 15% of patients, with clinical manifestations including confusion, coma, seizures, stroke, and cortical blindness. Ocular involvement in children with HUS is rare, but retinal and choroidal hemorrhages as well as ischemic retinopathy due to thrombotic microangiopathic lesions have been documented. Read More

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Role of deep learning in brain tumor detection and classification (2015 to 2020): A review.

Comput Med Imaging Graph 2021 May 15;91:101940. Epub 2021 May 15.

iVision Lab, Electrical Engineering Department, Institute of Space Technology, Islamabad, Pakistan.

During the last decade, computer vision and machine learning have revolutionized the world in every way possible. Deep Learning is a sub field of machine learning that has shown remarkable results in every field especially biomedical field due to its ability of handling huge amount of data. Its potential and ability have also been applied and tested in the detection of brain tumor using MRI images for effective prognosis and has shown remarkable performance. Read More

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Flow inside a bone scaffold: Visualization using 3D phase contrast MRI and comparison with numerical simulations.

J Biomech 2021 Jul 12;126:110625. Epub 2021 Jul 12.

Department of Mechanical and Industrial Engineering, University of Massachusetts, Amherst, MA, USA. Electronic address:

We report on results of experimental flow measurements inside a bone scaffold model, subjected to a uniform incoming flow (applied perfusion). Understanding the flow behavior inside a tissue engineered scaffold is essential for mechanistic studies of mechanobiology, particularly flow-sensitive bone cells. Nearly all existing studies that quantify interstitial flow inside engineered bone scaffolds have been based on numerical results, in part due to the difficulties associated with quantitative measurements and visualization of flow inside large, opaque bone or bone mimics. Read More

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Engineering glutathione-responsive near-infrared polymeric prodrug system for fluorescence imaging in tumor therapy.

Colloids Surf B Biointerfaces 2021 Jul 3;206:111966. Epub 2021 Jul 3.

Pediatric Research Institute, Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, PR China. Electronic address:

The release and biodistribution of drugs in the body have an important impact on tumor diagnosis and treatment. Near-infrared (NIR) fluorescent active fluorophores with good photostability are used to detect drug release and perform in vivo imaging. Here, we developed a glutathione-responsive NIR prodrug POEGMA-b-P(CPT-CyOH) (PCC) for effective cancer diagnosis and treatment, whereby the camptothecin (CPT) and NIR fluorophore CyOH in PCC are connected by disulfide bonds. Read More

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The predictive value of segmentation metrics on dosimetry in organs at risk of the brain.

Med Image Anal 2021 Jul 13;73:102161. Epub 2021 Jul 13.

ARTORG Center for Biomedical Research, University of Bern, Bern, Switzerland. Electronic address:

Background: Fully automatic medical image segmentation has been a long pursuit in radiotherapy (RT). Recent developments involving deep learning show promising results yielding consistent and time efficient contours. In order to train and validate these systems, several geometric based metrics, such as Dice Similarity Coefficient (DSC), Hausdorff, and other related metrics are currently the standard in automated medical image segmentation challenges. Read More

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Leveraging unsupervised image registration for discovery of landmark shape descriptor.

Med Image Anal 2021 Jul 9;73:102157. Epub 2021 Jul 9.

Scientific Computing and Imaging Institute, 72 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA; School of Computing, 50 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA.

In current biological and medical research, statistical shape modeling (SSM) provides an essential framework for the characterization of anatomy/morphology. Such analysis is often driven by the identification of a relatively small number of geometrically consistent features found across the samples of a population. These features can subsequently provide information about the population shape variation. Read More

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Choriocapillaris: Fundamentals and advancements.

Prog Retin Eye Res 2021 Jul 19:100997. Epub 2021 Jul 19.

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

The choriocapillaris is the innermost structure of the choroid that directly nourishes the retinal pigment epithelium and photoreceptors. This article provides an overview of its hemovasculogenesis development to achieve its final architecture as a lobular vasculature, and also summarizes the current histological and molecular knowledge about choriocapillaris and its dysfunction. After describing the existing state-of-the-art tools to image the choriocapillaris, we report the findings in the choriocapillaris encountered in the most frequent retinochoroidal diseases including vascular diseases, inflammatory diseases, myopia, pachychoroid disease spectrum disorders, and glaucoma. Read More

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Int J Pharm 2021 Jul 19:120905. Epub 2021 Jul 19.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal; Institute of Interdisciplinary Research (III), University of Coimbra, Casa Costa Alemão - Pólo II, Rua Dom Francisco de Lemos, 3030-789 Coimbra, Portugal. Electronic address:

Cancer is one of the most prevalent and deadly diseases in the world, to which conventional treatment options, such as chemotherapy and radiotherapy, have been applied to overcome the disease or used in a palliative manner to enhance the quality of life of the patient. However, there is an urgent need to develop new preventive and treatment strategies to overcome the limitations of the commonly used approaches. The field of cancer nanomedicine, and more recently the field of nanotheranostics, where imaging and therapeutic agents are combined in a single platform, provide new opportunities for the treatment and the diagnosis of cancer. Read More

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Combined transarterial embolization, and percutaneous sclerotherapy as treatment for refractory and non resectable aneurysmal bone cysts.

J Vasc Interv Radiol 2021 Jul 19. Epub 2021 Jul 19.

Clinic for Radiology, University Hospital Muenster, Muenster, Germany; Department of Radiology, University Hospital LMU Munich, Germany.

Purpose: To evaluate safety and effectiveness of combined transarterial embolization and percutaneous sclerotherapy in treatment for refractory and non-resectable aneurysmal bone cysts (ABCs) as assessed by imaging and clinical outcomes.

Materials And Methods: This retrospective single center study included n=16 consecutive patients (f=9, m=7; age: median 17 (6-25) years) undergoing combined transarterial embolization (using ethylene vinyl alcohol) and percutaneous sclerotherapy (ethanol-gel and polidocanol) for refractory and non-resectable ABCs. Median follow-up was 27. Read More

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Laser Ablation of the Cystic Duct Followed with Cryoablation of Gallbladder: Leave Nothing Behind.

J Vasc Interv Radiol 2021 Jul 19. Epub 2021 Jul 19.

Division of Interventional Radiology and Image-Guided Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.

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External Compression Displacement: Another Tool in the Armamentarium.

J Vasc Interv Radiol 2021 Jul 19. Epub 2021 Jul 19.

Department of Biomedical Engineering, University of Wisconsin, Madison, WI.

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Disrupted Small-world Networks are Associated with Decreased Vigilant Attention after Total Sleep Deprivation.

Neuroscience 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurology, The Second Medical Center, Sleep Medicine Research Center, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; School of Medicine, Nankai University, Tianjin, 300071, China. Electronic address:

Sleep deprivation critically affects vigilant attention. Previous neuroimaging studies have revealed altered inter-regional functional connectivity after sleep deprivation, which may disrupt topological properties of brain functional networks. However, little is known about alterations in the topology of intrinsic connectivity and its involvement in attention performance after sleep deprivation. Read More

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Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac.

Radiother Oncol 2021 Jul 19. Epub 2021 Jul 19.

University Medical Center Utrecht, Department of Radiotherapy, Utrecht 3508 GA, The Netherlands.

PurposeTo evaluate seminal vesicle (SV) intrafraction motion using cinematic magnetic resonance imaging (cine-MR) during the delivery of online adaptive MR-Linac radiotherapy fractions, in preparation of MR-guided extremely hypofractionated radiotherapy for intermediate to high-risk prostate cancer patients.Material and MethodsFifty prostate cancer patients were treated with 5 x 7.25 Gy on a 1. Read More

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Single molecule RNA localization and translation in the mammalian oocyte and embryo.

J Mol Biol 2021 Jul 19:167166. Epub 2021 Jul 19.

Institute of Animal Physiology and Genetics, ASC, Libechov 27721, Czech Republic. Electronic address:

During oocyte growth the cell accumulates RNAs to contribute to oocyte and embryo development which progresses with ceased transcription. To investigate the subcellular distribution of specific RNAs and their translation we developed a technique revealing several instances of localized translation with distinctive regulatory implications. We analyzed the localization and expression of candidate non-coding and mRNAs in the mouse oocyte and embryo. Read More

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Innovations in ex vivo Light Sheet Fluorescence Microscopy.

Prog Biophys Mol Biol 2021 Jul 19. Epub 2021 Jul 19.

Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. Electronic address:

Light Sheet Fluorescence Microscopy (LSFM) has revolutionized how optical imaging of biological specimens can be performed as this technique allows to produce 3D fluorescence images of entire samples with a high spatiotemporal resolution. In this manuscript, we aim to provide readers with an overview of the field of LSFM on ex vivo samples. Recent advances in LSFM architectures have made the technique widely accessible and have improved its acquisition speed and resolution, among other features. Read More

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