215,111 results match your criteria imaging contrast

Pulsed field ablation selectively spares the oesophagus during pulmonary vein isolation for atrial fibrillation.

Europace 2021 May 7. Epub 2021 May 7.

IHU LIRYC-CHU Bordeaux, Univ. Bordeaux, Inserm U1045, Avenue du Haut Lévêque, 33604 Pessac, France.

Aims: Extra-atrial injury can cause complications after catheter ablation for atrial fibrillation (AF). Pulsed field ablation (PFA) has generated preclinical data suggesting that it selectively targets the myocardium. We sought to characterize extra-atrial injuries after pulmonary vein isolation (PVI) between PFA and thermal ablation methods. Read More

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Very Late-onset Neuromyelitis Optica Spectrum Disorders.

Eur J Neurol 2021 May 7. Epub 2021 May 7.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Background: Neuromyelitis optica spectrum disorder (NMOSD) often presents in the elderly with an insidious onset of symptoms and aggressive progression. There have been anecdotal cases of very late-onset (VLO)-NMOSD, but case series reports are rare. The aim of this retrospective study was to clarify the clinical features of VLO-NMOSD. Read More

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Cross-Scanner Harmonization of Neuromelanin-Sensitive MRI for Multisite Studies.

J Magn Reson Imaging 2021 May 6. Epub 2021 May 6.

Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, USA.

Background: Neuromelanin-sensitive magnetic resonance imaging (NM-MRI) is a validated measure of neuromelanin concentration in the substantia nigra-ventral tegmental area (SN-VTA) complex and is a proxy measure of dopaminergic function with potential as a noninvasive biomarker. The development of generalizable biomarkers requires large-scale samples necessitating harmonization approaches to combine data collected across sites.

Purpose: To develop a method to harmonize NM-MRI across scanners and sites. Read More

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Bioinspired Dual-Mode Temporal Communication via Digitally Programmable Phase-Change Materials.

Adv Mater 2021 May 7:e2008119. Epub 2021 May 7.

State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.

Switchable optical properties are essential for numerous technologies including communication, anticounterfeiting, camouflage, and imaging/sensing. Typically, the switching is enabled by applying external stimulation such as UV light for fluorescence detection. In contrast, ground squirrels utilize spontaneous live infrared emission for fencing off predators as a unique way of communication. Read More

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Changes in brown adipose tissue lipid mediator signatures with aging, obesity, and DHA supplementation in female mice.

FASEB J 2021 Jun;35(6):e21592

Center for Nutrition Research, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.

Brown adipose tissue (BAT) dysfunction in aging and obesity has been related to chronic unresolved inflammation, which could be mediated by an impaired production of specialized proresolving lipid mediators (SPMs), such as Lipoxins-LXs, Resolvins-Rvs, Protectins-PDs, and Maresins-MaRs. Our aim was to characterize the changes in BAT SPMs signatures and their association with BAT dysfunction during aging, especially under obesogenic conditions, and their modulation by a docosahexaenoic acid (DHA)-rich diet. Lipidomic, functional, and molecular studies were performed in BAT of 2- and 18-month-old lean (CT) female mice and in 18-month-old diet-induced obese (DIO) mice fed with a high-fat diet (HFD), or a DHA-enriched HFD. Read More

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Haemodialysis and peritoneal dialysis patients have severely impaired post-occlusive skin forearm vasodilatory response assessed with laser speckle contrast imaging.

Clin Kidney J 2021 May 21;14(5):1419-1427. Epub 2020 Oct 21.

Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: Endothelial dysfunction is associated with cardiovascular events and mortality in various disease states, including end-stage renal disease (ESRD). Novel technological approaches have emerged for real-time assessment of endothelial reactivity. This study examined skin microcirculation using laser speckle contrast imaging (LSCI) before and after arterial occlusion in ESRD patients undergoing haemodialysis (HD) or peritoneal dialysis (PD). Read More

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Implications of extreme serum neurofilament light chain levels for the management of patients with relapsing multiple sclerosis.

Ther Adv Neurol Disord 2021 20;14:17562864211001977. Epub 2021 Apr 20.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.

Background: Serum neurofilament light chain (sNfL) is a promising biomarker to complement the decision-making process in multiple sclerosis (MS) patients. However, although sNfL levels are able to detect disease activity and to predict future disability, the growing evidence has not yet been translated into practicable recommendations for an implementation into clinical routine.

Methods: The observation of a patient with extensive inflammatory activity in magnetic resonance imaging (MRI) along with an extremely high sNfL level in the absence of any clinical symptoms prompted us to investigate common characteristics of our MS patients with the highest sNfL levels in a retrospective cohort study. Read More

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Released Myeloperoxidase Attenuates Neutrophil Migration and Accumulation in Inflamed Tissue.

Front Immunol 2021 20;12:654259. Epub 2021 Apr 20.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Neutrophil (PMN) recruitment to sites of insult is critical for host defense, however excessive PMN activity and tissue accumulation can lead to exacerbated inflammation and injury. Myeloperoxidase (MPO) is a PMN azurophilic granule enzyme, which together with HO, forms a powerful antimicrobial system designed to kill ingested bacteria. Intriguingly, in addition to intracellular killing of invading microorganisms and extracellular tissue damage due generation of ROS, soluble MPO has been directly implicated in modulating cellular responses and tissue homeostasis. Read More

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Case Report: A Well-Hidden Cause for Myelopathy.

Front Neurol 2021 20;12:672648. Epub 2021 Apr 20.

Department of Neurology, University Hospital Giessen and Marburg, Giessen, Germany.

Sarcoidosis is a rare, systemic inflammatory disease and can involve multiple organs, especially the lungs and lymph nodes. The nervous system is affected in <10 percent of patients, which is called neurosarcoidosis. Neurosarcoidosis can cause a multitude of symptoms and can mimic various diseases. Read More

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Prognostic Value of 2-Deoxy-2-[F]fluoro-D-glucose Positron Emission Tomography/Computed Tomography after Autologous Hematopoietic Stem Cell Transplantation in Lymphoma Using Deauville Scores.

Contrast Media Mol Imaging 2021 15;2021:5510825. Epub 2021 Apr 15.

Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.

Purpose: In the present study, we mainly aimed to evaluate the prognostic value of 2-deoxy-2-[F]fluoro-D-glucose ([F]F-FDG) positron emission tomography (PET)/computed tomography (CT) after autologous stem cell transplantation (ASCT) in lymphoma. . A total of 76 lymphoma patients who benefited from [F]F-FDG PET-CT (within 3 months and 3-6 months) after ASCT in our institution between April 2010 and December 2019 were enrolled in this retrospective study. Read More

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Comparative Effects of Repetitive Odor Identification and Odor Memory Tasks on Olfactory Engagement in Older Populations - A Pilot fMRI Study.

Neuropsychiatr Dis Treat 2021 30;17:1279-1288. Epub 2021 Apr 30.

Department of Psychiatry and Behavioral Sciences, Howard University, Washington DC, USA.

Objective: This study evaluated human Blood Oxygen Level-Dependent (BOLD) responses in primary and higher-order olfactory regions of older adults, using odor memory and odor identification tasks. The goal was to determine which olfactory and memory regions of interest are more strongly engaged in older populations comparing these two odor training tasks.

Methods: Twelve adults 55-75 years old (75% females) without intranasal or major neurological disorders performed repetitive odor memory and identification tasks using a 3-tesla magnetic resonance scanner. Read More

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Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies.

World J Gastroenterol 2021 Apr;27(15):1630-1642

Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, United States.

Background: Recurrent acute pancreatitis (RAP) may be a presenting feature of and an indication for resection of pancreatic cysts, including intra-ductal papillary mucinous neoplasm (IPMN). Few data are available regarding the prevalence of malignancy and post-operative RAP in this population.

Aim: To study the role of resection to help prevent RAP and analyze if presentation as RAP would be a predictor for malignancy. Read More

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Microvascular Dysfunction in Patients with Critical COVID-19, A Pilot Study.

Shock 2021 May 4. Epub 2021 May 4.

Karolinska Institutet, Department of Clinical Sciences, Danderyd University Hospital, Division of Internal medicine and Infectious diseases, Stockholm, Sweden.

Background: Endothelial and microvascular dysfunction may be a key pathogenic feature of severe COVID-19. The aim of this study was to investigate endothelial-dependent and endothelial-independent skin microvascular reactivity in patients with critical COVID-19.

Methods: Twelve patients with COVID-19 treated with non-invasive or invasive mechanical ventilation were included in the study. Read More

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Peptide-based 68Ga-PET radiotracer for imaging CD133 expression in colorectal cancer.

Nucl Med Commun 2021 May 6. Epub 2021 May 6.

Departments of Radiology Nuclear Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Auhui, China.

Objective: CD133 is a demonstrated cancer stem cell marker. A small peptide LS7, screened by a phage display technique, was identified to specifically target CD133. The purpose of this study was to develop a novel and specific peptide-based PET imaging agent for CD133 imaging in colorectal cancer. Read More

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Placental structural abnormalities in gestational diabetes and when they develop: A scoping review.

Placenta 2021 Apr 26. Epub 2021 Apr 26.

Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, MO, USA. Electronic address:

Gestational diabetes mellitus (GDM) is defined as diabetes with onset or first recognition during gestation. It is a common complication of pregnancy that has become more prevalent over the past few decades. Abnormalities in fetal growth, including increased incidence of both large and small for gestational age babies, suggest placental dysfunction. Read More

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ACR Appropriateness Criteria® Imaging of Mediastinal Masses.

J Am Coll Radiol 2021 May;18(5S):S37-S51

Specialty Chair, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Mediastinal masses can present with symptoms, signs, and syndromes or incidentally. Selecting the appropriate diagnostic imaging study for mediastinal mass evaluation requires awareness of the strengths and weaknesses of the various imaging modalities with regard to tissue characterization, soft tissue contrast, and surveillance. This publication expounds on the differences between chest radiography, CT, PET/CT, ultrasound, and MRI in terms of their ability to decipher and surveil mediastinal masses. Read More

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ACR Appropriateness Criteria® Renal Failure.

J Am Coll Radiol 2021 May;18(5S):S174-S188

Specialty Chair, University of Alabama at Birmingham, Birmingham, Alabama, Chair, ACR Appropriateness Committee.

Renal failure can be divided into acute kidney injury and chronic kidney disease. Both are common and result in increased patient morbidity and mortality. The etiology is multifactorial and differentiation of acute kidney injury from chronic kidney disease includes clinical evaluation, laboratory tests, and imaging. Read More

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ACR Appropriateness Criteria® Postmenopausal Acute Pelvic Pain.

J Am Coll Radiol 2021 May;18(5S):S119-S125

Specialty Chair, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Acute pelvic pain is a common presenting complaint in both the emergency room and outpatient settings. Pelvic pain of gynecologic origin in postmenopausal women occurs less frequently than in premenopausal women; however, it has important differences in etiology. The most common causes of postmenopausal pelvic pain from gynecologic origin are ovarian cysts, uterine fibroids, pelvic inflammatory disease, and ovarian neoplasm. Read More

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Artificial pneumothorax improves radiofrequency ablation of pulmonary metastases of hepatocellular carcinoma close to mediastinum.

BMC Cancer 2021 May 6;21(1):505. Epub 2021 May 6.

Department of Interventional Oncology, Jinan Central Hospital Affiliated to Shandong University, Jinan, 250013, Shandong, China.

Background: To investigate the feasibility, safety and efficacy of percutaneous radiofrequency ablation (RFA) of pulmonary metastases from hepatocellular carcinoma (HCC) contiguous with the mediastinum using the artificial pneumothorax technique.

Method: A total of 40 lesions in 32 patients with pulmonary metastases from HCC contiguous with the mediastinum accepted RFA treatment from August 2014 to May 2018 via the artificial pneumothorax technique. After ablation, clinical outcomes were followed up by contrast enhanced CT. Read More

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Postoperative Epidural Fibrosis Prevention: Which Is Better-Autologous Fat versus Gelfoam.

Asian Spine J 2021 May 10. Epub 2021 May 10.

Department of Orthopaedics, Guru Gobind Singh Medical College and Hospital, Faridkot, India.

Study Design: Prospective, randomized study of 100 patients with prolapsed intervertebral disc with an average of 12- to 18-month follow-up postoperatively.

Purpose: To compare the role of Gelfoam and autologous fat in the prevention of postoperative epidural fibrosis (EF) after lumbar spine surgery.

Overview Of Literature: EF is a possible sequelae of lumbar disc surgery. Read More

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Multidisciplinary management of a traumatic posterior meningeal artery pseudoaneurysm: A case report and review of the literature.

Int J Surg Case Rep 2021 Apr 29;82:105933. Epub 2021 Apr 29.

Department of Surgery, Division of Trauma and Surgical Critical Care, Kendall Regional Medical Center, Miami, FL, USA; University of South Florida, Tampa, FL, USA.

Background: Meningeal arterial injuries represent <1% of all blunt traumatic brain injuries (TBIs). Middle meningeal artery (MMA) lesions comprise the majority. However, there is little clinical data on posterior meningeal artery (PMA) injuries. Read More

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Resting-state brain metabolic fingerprinting clusters (biomarkers) and predictive models for major depression in multiple myeloma patients.

PLoS One 2021 6;16(5):e0251026. Epub 2021 May 6.

Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America.

Background: Major depression is a common comorbidity in cancer patients. Oncology clinics lack practical, objective tools for simultaneous evaluation of cancer and major depression. Fludeoxyglucose F-18 positron emission tomography-computed tomography (FDG PET/CT) is universally applied in modern medicine. Read More

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Concave Array Ultrasonic Transducer from Multilayer Piezoelectric Ceramic for Photoacoustic Imaging.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 May 6;PP. Epub 2021 May 6.

Implementation of piezoelectric multilayer ceramic (MLC) is an effective way to reduce impedance and improve performance of linear array transducer for ultrasonic system applications. However, the ultrasonic image derived from a planar linear array transducer generally suffers from degradation of lateral resolution and contrast. Here we designed and fabricated a focused 5-MHz 128-element linear array ultrasonic transducer with concave structure using 5-layered PNN-PZN-PMN-PZ-PT piezoelectric ceramic. Read More

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Contralaterally Enhanced Networks for Thoracic Disease Detection.

IEEE Trans Med Imaging 2021 May 6;PP. Epub 2021 May 6.

Identifying and locating diseases in chest X-rays are very challenging, due to the low visual contrast between normal and abnormal regions, and distortions caused by other overlapping tissues. An interesting phenomenon is that there exist many similar structures in the left and right parts of the chest, such as ribs, lung fields and bronchial tubes. This kind of similarities can be used to identify diseases in chest X-rays, according to the experience of broad-certificated radiologists. Read More

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Optimized scan delay for late hepatic arterial or pancreatic parenchymal phase in dynamic contrast-enhanced computed tomography with bolus-tracking method.

Br J Radiol 2021 May 6:20210315. Epub 2021 May 6.

Department of Radiology, Gifu University, Gifu, Japan.

Objectives: To determine the optimal scan delay corresponding to individual hemodynamic status for pancreatic parenchymal phase in dynamic contrast-enhanced CT of the abdomen.

Methods: One hundred and fourteen patients were included in this retrospective study (69 males and 45 females; mean age, 67.9 ± 12. Read More

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Combined computed tomography and magnetic resonance imaging improves diagnosis of hepatocellular carcinoma ≤ 3.0 cm.

Hepatol Int 2021 May 6. Epub 2021 May 6.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Republic of Korea.

Background/purpose: Imaging diagnosis of hepatocellular carcinoma (HCC) is important, but the diagnostic performance of combined computed tomography (CT) and magnetic resonance imaging (MRI) using the Liver Imaging Reporting and Data System (LI-RADS) v2018 is not fully understood. We evaluated the clinical usefulness of combined CT and MRI for diagnosing HCC ≤ 3.0 cm using LI-RADS. Read More

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Contrast-enhanced ultrasound for screening hepatocellular carcinoma: an implemented program at a semi-rural academic center.

Abdom Radiol (NY) 2021 May 6. Epub 2021 May 6.

Penn State College of Medicine, Hershey, PA, USA.

Purpose: To describe our early experience using a contrast-enhanced ultrasound (CEUS) protocol for surveillance of hepatocellular carcinoma (HCC) at a semi-rural academic medical center.

Methods: Retrospective, longitudinal study of the first 100 patients who underwent CEUS liver screening imaging over 2 years. Each patient underwent a standard of care abdominal ultrasound, which was checked with the radiologist, who searched for a focal lesion on the cine clips to target specifically with contrast. Read More

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Rational design of a HA-AuNPs@AIED nanoassembly for activatable fluorescence detection of HAase and imaging in tumor cells.

Anal Methods 2021 May 14;13(17):2030-2036. Epub 2021 Apr 14.

Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, Hunan Provincial Key Lab of Advanced Materials for New Energy Storage and Conversion, Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China.

Aggregation induced emission (AIE) dots have gained broad attention in fluorescence bioimaging and biosensors in virtue of their distinctive optical properties of splendid biocompatibility, high brightness and good photostability. However, the application of AIE dots in sensing and imaging of enzymes in cells remains at an early stage and needs to be further explored. In this report, we proposed a novel AIE-dot-based nanoprobe for hyaluronidase (HAase) detection using a simple electrostatic self-assembly of AIE dots with gold nanoparticles functionalized using hyaluronic acid (HA-AuNPs), named HA-AuNPs@AIEDs. Read More

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