200 results match your criteria ilm flap


Two years outcomes of treating full-thickness macula hole associated with idiopathic macular telangiectasia type 2 by internal limiting membrane inverted flap technique: Case reports.

Medicine (Baltimore) 2021 Sep;100(36):e27078

Department of Ophthalmology, Akita University Graduate School of Medicine, Akita, Japan.

Rational: Macular telangiectasia (MacTel) is an uncommon ocular disorder that can lead to legal blindness. MacTel type 2 is characterized by a bilateral loss of macular transparency, the presence of white crystals on the retina, aberrant blood vessel growth, and neurodegeneration of the macula. Full-thickness macular holes (FTMHs) are a prominent cause of vision reduction in MacTel type 2, and the standard care for an FTMH is pars plana vitrectomy (PPV) to restore the FTMH and best-corrected visual acuity (BCVA). Read More

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September 2021

Single-layer Inverted Internal Limiting Membrane Flap Versus Conventional Peel for Small- or Medium-sized Full-thickness Macular Holes.

Am J Ophthalmol 2021 Sep 9. Epub 2021 Sep 9.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address:

Purpose: To compare the outcomes of using an internal limiting membrane (ILM) flap and the conventional ILM peel technique for small- or medium-sized full-thickness macular hole (FTMH) repair.

Design: Retrospective, interventional case series.

Methods: Eyes with an FTMH ≤ 400 µm that underwent vitrectomy with either a single-layer inverted ILM flap (flap group, 55 eyes) or an ILM peel (peel group, 62 eyes) were enrolled. Read More

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September 2021

Surgical Management of Recurrent and Persistent Macular Holes: A Practical Approach.

Ophthalmol Ther 2021 Sep 7. Epub 2021 Sep 7.

Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, i-32, Cleveland, OH, 44195, USA.

Primary surgery for macular hole (MH) closure has a high success rate with current methods of pars plana vitrectomy and internal limiting membrane (ILM) peeling. When primary surgery fails, there are several options available for secondary repair, including extension of the ILM peel, creation of an ILM flap, pedunculated ILM flap, lens capsule flap transplantation, autologous retinal transplantation, use of a human amniotic membrane plug, adjuvant autologous platelet concentrate, induction of macular detachments with subretinal blebs, and creation of retinal incisions. In this review, we discuss the practical approach to each of these surgical techniques for the management of recurrent or persistent MHs. Read More

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September 2021

Flap technique-assisted surgeries for advanced retinitis pigmentosa complicated with macular hole: a case report and literature review.

BMC Ophthalmol 2021 Sep 6;21(1):322. Epub 2021 Sep 6.

Department of Ophthalmology, National Taiwan University Hospital, Medical College, National Taiwan University, 7 Chung-Shan S. Road, Taipei, Taiwan.

Background: Full-thickness macular hole (FTMH) is a rare complication in retinitis pigmentosa (RP) patients and may increase intraoperative challenges. Furthermore, lens capsular flap transplantation and inverted internal limiting membrane (ILM) flap were reported to close complicated FTMH successfully. Here, we present a case of bilateral advanced RP complicated by a FTMH treated with a novel lens capsular flap transplantation and inverted internal limiting membrane flap. Read More

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September 2021

Inverted Internal Limiting Membrane Flap Technique: Is It the Best Option for Macular Holes?

Clin Ophthalmol 2021 8;15:3295-3303. Epub 2021 Aug 8.

Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, 4099-001, Portugal.

Surgical treatment is generally necessary to repair full-thickness macular holes (FTMH). Although vitrectomy with or without internal limiting membrane (ILM) peeling remains the standard surgical technique, the inverted ILM flap procedure has increasingly assumed a role in the primary surgical repair of FTMHs. Some vitreoretinal surgeons reserve this technique to treat large or myopic holes, whereas others use it routinely in all cases. Read More

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Combination of Inverted ILM Flap Technique and Subretinal Fluid Application Technique for Treatment of Chronic, Persistent and Large Macular Holes.

Ophthalmol Ther 2021 Sep 6;10(3):643-658. Epub 2021 Jul 6.

Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20251, Hamburg, Germany.

Introduction: The choice of surgical treatment for chronic, persistent and large full-thickness macular holes (FTMH) continues to be undefined and challenging, as some of these cases remain refractory to the treatment. We report the efficacy of combination of inverted internal limiting membrane flap technique (IILMFT) and subretinal application of the fluid (SR fluid application) technique for treatment of refractory FTMHs.

Methods: Nine patients (nine eyes) were enrolled into this retrospective non-randomized exploratory consecutive case series study. Read More

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September 2021

Diffuse retinal pigment epithelium atrophy following pars plana vitrectomy for high myopic macular hole assisted by Brilliant Blue G: A case report.

Am J Ophthalmol Case Rep 2021 Sep 18;23:101148. Epub 2021 Jun 18.

Instituto de Microcirugia Ocular, Barcelona, Spain.

Purpose: To describe a case of diffuse retinal pigment epithelium (RPE) disturbance following 23-gauge pars plana vitrectomy (PPV) with the inverted internal limiting membrane (ILM) technique and Brilliant Blue staining for a high myopic macular hole (MH).

Observations: A 53-year-old pseudophakic high myopic female was referred to the Vitreoretinal Department with a diagnosis of a full thickness myopic MH of her right eye. Her initial visual acuity was 20/40 of her right eye and 20/20 in the left eye. Read More

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September 2021

Early Vascular and Functional Changes after Vitreoretinal Surgery: A Comparison between the Macular Hole and Epiretinal Membrane.

Diagnostics (Basel) 2021 Jun 3;11(6). Epub 2021 Jun 3.

Institute of Ophthalmology, University of Modena and Reggio Emilia, 41121 Modena, Italy.

(1) Background: The aim of this observational comparative study was to investigate early retinal vascular and functional changes in patients undergoing vitreoretinal surgery for idiopathic epiretinal membrane (iERM) or macular hole (MH) using a widefield swept-source optical coherence tomography angiography (WSS-OCTA). (2) Methods: Forty one diseased eyes were enrolled in the study. Twenty three eyes with iERM diagnosis (ERM group) underwent 25-gauge vitrectomy with inner limiting membrane (ILM) and MER peeling, while eighteen eyes with MH (MH group) underwent 25-gauge vitrectomy with inverted flap technique. Read More

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Comparing clinical outcomes of macular hole surgeries performed by trainee surgeons using a 3D heads-up display viewing system versus a standard operating microscope.

Int Ophthalmol 2021 Aug 28;41(8):2649-2655. Epub 2021 Jun 28.

Srimati Kanuri Santhamma Centre for Vitreo Retinal Diseases, LV Prasad Eye Institute, L V Prasad Marg, Banjara Hills, Hyderabad, Telangana, 500034, India.

Purpose: To compare the surgical outcomes of macular hole (MH) surgery performed by trainee surgeons using a three-dimensional heads-up display (3D HUD) versus a standard operating microscope (SOM).

Materials And Methods: A retrospective review of all consecutive medical records patients operated on for MHs by a trainee surgeon between 2017 and 2020 using either 3D HUD or SOM was performed. Minimum hole diameter, maximum hole diameter, total surgical time, and MH closure rates were compared between the two groups. Read More

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Foveal Displacement following Temporal Inverted Internal Limiting Membrane Technique for Full Thickness Macular Holes: 12 Months Results.

Curr Eye Res 2021 Jul 12:1-8. Epub 2021 Jul 12.

Retina Department, Bursa Retina Eye Hospital, Bursa, Turkey.

To compare conventional 360° internal limiting membrane (ILM) peeling and temporal inverted ILM flap technique with regard to postoperative foveal displacement. Patients who underwent 23 G vitrectomy with either 360° ILM peeling (Group 1) or temporal inverted ILM technique (Group 2) for idiopathic macular hole with a minimum follow up of 12 months were included. The metamorphopsia rates and distances between fovea and 3 retinal landmarks: the first retinal vascular bifurcation or crossover located superonasal and inferonasal to the fovea and ciliary vessel at the temporal margin of the disc, were compared on MultiColor SLO and near-infrared reflectance images. Read More

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Comparative study of vitrectomy combined with internal limiting membrane peeling and vitrectomy combined with internal limiting membrane flap covering in idiopathic macular hole treatment: a meta-analysis and systematic review.

Ann Palliat Med 2021 May;10(5):5474-5482

The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, China; Department of Ophthalmology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: To compare the therapeutic effects of vitrectomy (PPV) combined with the internal limiting membrane (ILM) flap coverage and PPV in combination with ILM peeling on the idiopathic large macular hole (MH), in order to better guide the treatment of large MH.

Methods: Searching was conducted within PubMed, Web of Science, Embase, CNKI, and Wanfang databases, and relevant pieces of literature between 2010 and 2020 published in English or Chinese were included.

Results: A total of 11 studies including 667 patients and 667 affected eyes were included; the effective rate of hole closure between the 2 groups were compared in 11 studies. Read More

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Outer retina reconstruction following inverted internal limiting membrane flap technique for large macular holes.

Saudi J Ophthalmol 2020 Jul-Sep;34(3):160-166. Epub 2021 Feb 27.

Department of Ophthalmology, Eye Foundation Retina Institute, Ikeja, Lagos, Nigeria.

Purpose: The aim of this study is to investigate the outer retina reconstruction using postoperative spectral domain optical coherence tomography (SD OCT) in large diameter macular holes (MHs) treated with the inverted internal limiting membrane (ILM) flap technique.

Methods: A retrospective study of 14 consecutive eyes that had vitrectomy and inverted ILM flap technique for MHs with a base diameter of 400 μ or greater. Preoperative and postoperative SD OCT images were assessed for MH closure and for outer retina presence; represented by the external limiting membrane (ELM) and ellipsoid zone (EZ), in the subfoveal and parafoveal areas. Read More

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February 2021

Case of Macular Hole Secondary to Ocular Toxoplasmosis Treated Successfully by Vitrectomy with Inverted Internal Limiting Membrane Flap.

Case Rep Ophthalmol 2021 May-Aug;12(2):363-368. Epub 2021 May 10.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

We report a case of ocular toxoplasmosis that developed a full-thickness macular hole (FTMH) which was successfully treated by pars plana vitrectomy combined with an inverted internal limiting membrane (ILM) flap. A 49-years-old Japanese man was aware of blurred vision in his right eye. Slit-lamp biomicroscopy, ophthalmoscopy, and optical coherence tomography (OCT) of the right eye showed that there was a grayish-white subretinal lesion at the macula accompanied by retinal exudation and mild vitreous flare and iritis. Read More

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Viscoelastic-assisted inverted cover and free ILM flap techniques.

Eur J Ophthalmol 2021 May 14:11206721211016976. Epub 2021 May 14.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Surgical technique: an innovative way of using cohesive viscoelastic to stabilize the ILM flap during the cover inverted-flap and free-flap procedures. Surgical technique: an innovative way of using cohesive viscoelastic to stabilize the ILM flap during the covering step in the inverted-flap and free-flap procedures. Read More

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Autologous retina transplantation for treatment of refractory double full-thickness macular hole in Alport syndrome.

Retin Cases Brief Rep 2021 Jan 13. Epub 2021 Jan 13.

1Department of Ophthalmology, Centro de Oftalmología Barraquer, Barcelona, Spain; 2Instituto Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain.

Purpose: To report the structural and functional outcomes of autologous neurosensory retinal transplantation for closure of refractory double full-thickness macular hole in a patient diagnosed with Alport syndrome.

Methods: Patient with previous pars plana vitrectomy (PPV) and a failed macular hole surgery (ILM removal) underwent PPV and autologous neurosensory retinal flap transplantation with silicone oil tamponade. Follow-up was performed after one year. Read More

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January 2021

Partial detachment of internal limiting membrane flap and spontaneous re-covering of macular hole by flap.

Am J Ophthalmol Case Rep 2021 Jun 14;22:101089. Epub 2021 Apr 14.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Japan.

Purpose: To report a case in which an internal limiting membrane (ILM) flap that was used to cover an idiopathic macular hole (MH) during pars plana vitrectomy (PPV) with the inverted internal limiting membrane flap technique partially detached from the retina. Most interestingly, the flap fell back spontaneously to re-cover the MH.

Observations: A 70-year-old woman presented with a full-thickness MH, and her vision was 20/400. Read More

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A simple new technique for the induction of residual posterior vitreous cortex removal and membrane peeling.

Int J Ophthalmol 2021 18;14(4):622-625. Epub 2021 Apr 18.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.

Aim: To describe a quick, cost-effective alternative to using a scraper to remove the residual posterior vitreous cortex and create an inner limiting membrane (ILM) flap during vitrectomy.

Methods: The surgical technique and a retrospective interventional single-center series of cases were described. A hook was made on the tip of a conventional syringe needle (outer diameter, 0. Read More

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Optic Disc Pit Maculopathy: One-Year Outcomes of Pars Plana Vitrectomy with Foveal Sparing Inverted Internal Limiting Membrane Flap.

Cureus 2021 Mar 23;13(3):e14057. Epub 2021 Mar 23.

Department of Retina and Vitreous, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Coimbatore, IND.

Purpose To evaluate the anatomical and visual outcomes in optic disc pit maculopathy following pars plana vitrectomy (PPV) with inverted internal limiting membrane (ILM) flap Methods Retrospective interventional case series of 10 patients diagnosed with serous macular detachment secondary to optic disc pit who underwent PPV with inverted ILM flap and were followed up for a year. Results A p-value of less than 0.05 was defined as statistically significant. Read More

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Simultaneous presentation of idiopathic macular and posterior full-thickness retinal holes successfully treated with inverted internal limiting membrane flap technique.

Am J Ophthalmol Case Rep 2021 Jun 10;22:101070. Epub 2021 Mar 10.

Eye Clinic, Department of Surgical Science, University of Cagliari, Cagliari, Italy.

Purpose: To report an unusual non-iatrogenic case of central macular and posterior full-thickness retinal holes (FTRHs).

Observations: A 60-year-old man presented with a progressive visual loss in the right eye. A complete ophthalmological evaluation including best corrected visual acuity (BCVA) measurement, fundus examination and spectral - domain optical coherence tomography (SD-OCT) was performed. Read More

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Vitrectomy for full thickness macular hole developed during the course of anti-VEGF treatment of type 1 neovascular AMD.

Eur J Ophthalmol 2021 Mar 19:11206721211002123. Epub 2021 Mar 19.

Ophthalmic Clinic "Jasne Blonia," Lodz, Poland.

Purpose: To report a case of treatment of a full-thickness macular hole, which appeared after 10 months of anti-VEGF treatment in neovascular age related macular degeneration (nAMD).

Methods: The patient was diagnosed as type 1 nAMD. The coexisting vitreomacular traction caused a full thickness macular hole after 10 months of treatment. Read More

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Anatomical and Functional Outcomes in Eyes with Idiopathic Macular Holes that Underwent Surgery Using the Inverted Internal Limiting Membrane (ILM) Flap Technique Versus the Conventional ILM Peeling Technique.

Adv Ther 2021 04 10;38(4):1931-1945. Epub 2021 Mar 10.

Ophthalmology Department, China-Japan Friendship Hospital, Beijing, China.

Introduction: To evaluate the anatomical and functional outcomes of the inverted internal limiting membrane (ILM) flap technique (IFT) in macular holes (MHs), especially in MHs with a macular hole index (MHI) < 0.5.

Methods: This was a retrospective comparative study. Read More

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Inverted internal limiting membrane flap technique for myopic macular hole: A meta-analysis.

Surv Ophthalmol 2021 Sep-Oct;66(5):771-780. Epub 2021 Feb 27.

2nd Department of Ophthalmology, National and Kapodistian University of Athens, Athens, Greece.

A macular hole (MH) may be a significant complication in patients with high myopia. The recently reported inverted internal limiting membrane (ILM) flap technique is a promising alternative to treat myopic MHs. We performed a meta-analysis of the published anatomical and functional results of the "inverted ILM flap" technique for the treatment of myopic MH with or without retinal detachment (RD). Read More

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February 2021

[Biomarkers in full-thickness and lamellar defects of the macula].

Ophthalmologe 2021 Apr 1;118(4):321-336. Epub 2021 Mar 1.

Augenklinik Herzog Carl Theodor, Nymphenburger Str. 43, 80335, München, Deutschland.

Background: Biomarkers are characteristic biological measurable signs and objective parameters to detect the state of health. Besides functional and temporal factors, imaging biomarkers play an increasingly important role. In full-thickness and lamellar defects of the macula numerous imaging parameters have been described. Read More

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Inverted ILM Flap Technique in Idiopathic Full-Thickness Macular Hole Surgery: Functional Outcomes and Their Correlation with Morphologic Findings.

J Ophthalmol 2021 11;2021:6624904. Epub 2021 Feb 11.

Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.

Objectives: The inverted internal limiting membrane (ILM) flap technique has been shown to increase the success rate in large full-thickness macular holes (FTMHs) and in FTMHs associated with high myopia. The aim of our study was to confirm the efficacy and safety of inverted ILM flap technique in idiopathic FTMHs independent of their dimensions and to assess functional outcomes and their correlation to morphologic findings.

Methods: Sixteen consecutive patients affected by idiopathic FTMH were enrolled in this prospective study. Read More

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February 2021

Inverted internal limiting membrane flap technique versus internal limiting membrane peeling for large macular holes: A meta-analysis of randomized controlled trials.

Ophthalmic Res 2021 Feb 17. Epub 2021 Feb 17.

Background: Vitrectomy with internal limiting membrane (ILM) peeling is an effective surgical procedure for the treatment of macular holes (MHs). However, there is a possibility of poor postoperative anatomical closure with conventional ILM peeling for MHs larger than 400 μm. Therefore, a novel inverted ILM flap technique was developed for such cases. Read More

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February 2021

MANAGEMENT OF LARGE OR RECURRENT MACULAR HOLES.

Curr Ophthalmol Rep 2020 Jun 30;8(2):62-68. Epub 2020 Apr 30.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.

Purpose Of Review: To review and critically appraise the recent literature about new surgical techniques for the management of large or recurrent macular holes.

Recent Findings: A variety of surgical approaches have recently been developed ranging from autologous retinal grafts to amniotic membrane transplant with varying levels of anatomical and visual success.

Summary: More data is needed to determine if one technique is superior to others. Read More

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Inverted internal limiting membrane flap technique in eyes with large idiopathic full-thickness macular hole: long-term functional and morphological outcomes.

Graefes Arch Clin Exp Ophthalmol 2021 Jul 29;259(7):1759-1771. Epub 2021 Jan 29.

Department of Ophthalmology, Klinikum rechts der Isar, Technical University Munich (TUM), Ismaningerstr. 22, 81675, Munich, Germany.

Purpose: To investigate morphological and functional outcomes of the inverted internal limiting membrane (I-ILM) flap technique in large (≥ 400 μm) idiopathic full-thickness macular holes (FTMH) over a follow-up period of 12 months.

Methods: In this retrospective study, 55 eyes of 54 consecutive patients were enrolled. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT, Heidelberg, Spectralis) were performed preoperatively as well as 1, 3, 6, 9, and 12 months postoperatively. Read More

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Refractory full thickness macular hole: current surgical management.

Eye (Lond) 2021 Jan 21. Epub 2021 Jan 21.

Department of Ophthalmology of University of Padova, Padova, Italy.

This review aims to collect the proposed surgical techniques for treating full thickness macular hole (FTMH) refractory to pars plana vitrectomy and internal limiting membrane (ILM) peeling and to analyse and compare anatomical and functional outcomes in order to evaluate their efficacy. The articles were grouped according to the surgical techniques used. Refractory FTMH closure rate and best-corrected visual acuity (BCVA) gain were the two analysed parameters. Read More

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January 2021

Successful Treatment of Macular Hole-Evoked Retinal Detachment with Inverted ILM Flap following Complicated Cataract Surgery.

Klin Monbl Augenheilkd 2021 Aug 15;238(8):878-880. Epub 2021 Jan 15.

Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland.

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The Influence of Crescent-Shaped Selective Internal Limiting Membrane Staining on Vital Dye Toxicity in Temporal Inverted Flap Technique.

Curr Eye Res 2021 Sep 26;46(9):1363-1369. Epub 2021 Jan 26.

Ophthalmology Department, Bursa Retina Eye Hospital, Bursa, Turkey.

: To investigate the macular function and morphology after temporal inverted internal limiting membrane (ILM) flap technique with and without staining of the ILM flap in contact with the retinal pigment epithelium (RPE).: This retrospective study included 30 patients with idiopathic macular hole (MH), who underwent 27 G vitrectomy and temporal inverted ILM flap technique with brillant blue G (BBG) assisted ILM staining. In Group 1 (n = 16), a large bubble of perfluorocarbon liquid (PFCL) measuring approximately 6-disc diameters was used to cover the hole and central part of the ILM flap whereas in Group 2 (n = 14), only a small drop of PFCL to merely cover the MH was used. Read More

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September 2021