56 results match your criteria illustrates intimately

Mathematization of nature: how it is done.

J Leo van Hemmen

Biol Cybern 2021 12;115(6):655-664

Physik Department T35, Technische Universität München, 85747, Garching bei München, Germany.

Natural phenomena can be quantitatively described by means of mathematics, which is actually the only way of doing so. Physics is a convincing example of the mathematization of nature. This paper gives an answer to the question of how mathematization of nature is done and illustrates the answer. Read More

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December 2021

Familial Vulnerability: Legal Status and Mental Health within Mixed-Status Families.

Med Anthropol 2021 10 5;40(7):639-652. Epub 2021 Mar 5.

University of South Florida.

Mental and emotional well-being are intimately entangled with immigration status, personal relationships, and the broader political environment. Drawing on ethnographic fieldwork in South Texas including interviews with mixed-status families, this article illustrates the spillover impacts affecting mental and emotional health of family members with different legal statuses. Building on the notion of "structural vulnerability," we propose the concept of , a lens which highlights how racialization, legal status, and discrimination affect the family unit. Read More

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October 2021

Metabolic Regulation of Human Pluripotent Stem Cell-Derived Cardiomyocyte Maturation.

Curr Cardiol Rep 2020 06 27;22(8):73. Epub 2020 Jun 27.

QIMR Berghofer Medical Research Institute, 300 Herston Rd, Brisbane, Queensland, 4006, Australia.

Purpose Of Review: This review summarizes the important role that metabolism plays in driving maturation of human pluripotent stem cell-derived cardiomyocytes.

Recent Findings: Human pluripotent stem cell-derived cardiomyocytes provide a model system for human cardiac biology. However, these models have been unable to fully recapitulate the maturity observed in the adult heart. Read More

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Direct Correlation of Single-Particle Motion to Amorphous Microstructural Components of Semicrystalline Poly(ethylene oxide) Electrolytic Films.

J Phys Chem Lett 2020 Jun 8;11(12):4849-4858. Epub 2020 Jun 8.

Department of Chemistry, University of California Berkeley, Berkeley, California 94720, United States.

Semicrystalline polymers constitute some of the most widely used materials in the world, and their functional properties are intimately connected to their structure on a range of length scales. Many of these properties depend on the micro- and nanoscale heterogeneous distribution of crystalline and amorphous phases, but this renders the interpretation of ensemble averaged measurements challenging. We use superlocalized widefield single-particle tracking in conjunction with AFM phase imaging to correlate the crystalline morphology of lithium-triflate-doped poly(ethylene oxide) thin films to the motion of individual fluorescent probes at the nanoscale. Read More

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Roles for the Endoplasmic Reticulum in Regulation of Neuronal Calcium Homeostasis.

Cells 2019 10 10;8(10). Epub 2019 Oct 10.

Department of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX 77030, USA.

By influencing Ca homeostasis in spatially and architecturally distinct neuronal compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function are intimately related. The contribution of ER to neuronal Ca homeostasis is attributed to the organelle being the largest reservoir of intracellular Ca and having a high density of Ca channels and transporters. As such, ER Ca has incontrovertible roles in the regulation of axodendritic growth and morphology, synaptic vesicle release, and neural activity dependent gene expression, synaptic plasticity, and mitochondrial bioenergetics. Read More

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October 2019

Separation of Acute Desensitization and Long-Term Tolerance of -Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation.

Mol Pharmacol 2019 10 5;96(4):505-514. Epub 2019 Aug 5.

Vollum Institute, Oregon Health & Science University, Portland, Oregon

Phosphorylation of sites on the C terminus of the -opioid receptor (MOR) results in the induction of acute desensitization that is thought to be a precursor for the development of long-term tolerance. Alanine mutations of all 11 phosphorylation sites on the C terminus of MORs almost completely abolished desensitization and one measure of tolerance in locus coeruleus neurons when these phosphorylation-deficient MORs were virally expressed in MOR knockout rats. In the present work, we identified specific residues that underlie acute desensitization, receptor internalization, and tolerance and examined four MOR variants with different alanine or glutamate mutations in the C terminus. Read More

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October 2019

Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.

Vitam Horm 2018 12;107:473-513. Epub 2018 Feb 12.

University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

Human thymidylate synthase (hTS) has an important role in DNA biosynthesis, thus it is essential for cell survival. TS is involved in the folate pathways, specifically in the de novo pyrimidine biosynthesis. Structure and functions are intimately correlated, account for cellular activity and, in a broader view, with in vivo mechanisms. Read More

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November 2018

Creamed Dishes for the Convalescent.


Am J Nurs 2018 Mar;118(3):44-45

Editor's note: From its first issue in 1900 through to the present day, AJN has unparalleled archives detailing nurses' work and lives over more than a century. These articles not only chronicle nursing's growth as a profession within the context of the events of the day, but also reveal prevailing societal attitudes about women, health care, and human rights. Today's nursing school curricula rarely include nursing's history, but it's a history worth knowing. Read More

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Circuit-Host Coupling Induces Multifaceted Behavioral Modulations of a Gene Switch.

Biophys J 2018 02;114(3):737-746

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois; Carl Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois; National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, Illinois. Electronic address:

Quantitative modeling of gene circuits is fundamentally important to synthetic biology, as it offers the potential to transform circuit engineering from trial-and-error construction to rational design and, hence, facilitates the advance of the field. Currently, typical models regard gene circuits as isolated entities and focus only on the biochemical processes within the circuits. However, such a standard paradigm is getting challenged by increasing experimental evidence suggesting that circuits and their host are intimately connected, and their interactions can potentially impact circuit behaviors. Read More

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February 2018

Vibronic Boson Sampling: Generalized Gaussian Boson Sampling for Molecular Vibronic Spectra at Finite Temperature.

Sci Rep 2017 08 7;7(1):7462. Epub 2017 Aug 7.

Department of Physics, South University of Science and Technology of China, Shenzhen, 518055, China.

Molecular vibroic spectroscopy, where the transitions involve non-trivial Bosonic correlation due to the Duschinsky Rotation, is strongly believed to be in a similar complexity class as Boson Sampling. At finite temperature, the problem is represented as a Boson Sampling experiment with correlated Gaussian input states. This molecular problem with temperature effect is intimately related to the various versions of Boson Sampling sharing the similar computational complexity. Read More

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Using computational theory to constrain statistical models of neural data.

Curr Opin Neurobiol 2017 10 18;46:14-24. Epub 2017 Jul 18.

Department of Psychology and Center for Brain Science, Harvard University, United States. Electronic address:

Computational neuroscience is, to first order, dominated by two approaches: the 'bottom-up' approach, which searches for statistical patterns in large-scale neural recordings, and the 'top-down' approach, which begins with a theory of computation and considers plausible neural implementations. While this division is not clear-cut, we argue that these approaches should be much more intimately linked. From a Bayesian perspective, computational theories provide constrained prior distributions on neural data-albeit highly sophisticated ones. Read More

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October 2017

"Triple negative breast cancer": Translational research and the (re)assembling of diseases in post-genomic medicine.

Stud Hist Philos Biol Biomed Sci 2016 Oct 26;59:20-34. Epub 2016 May 26.

Department of the History of Science, University of Wisconsin-Madison, United States.

The paper examines the debate about the nature and status of "Triple-negative breast cancer", a controversial biomedical entity whose existence illustrates a number of features of post-genomic translational research. The emergence of TNBC is intimately linked to the rise of molecular oncology, and, more generally, to the changing configuration of the life sciences at the turn of the new century. An unprecedented degree of integration of biological and clinical practices has led to the proliferation of bio-clinical entities emerging from translational research. Read More

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October 2016

Update on PCSK9 therapies for the treatment of dyslipidemia.

Expert Rev Endocrinol Metab 2016 Jan;11(1):87-95

a Section of Cardiology, The University of Chicago , Chicago , IL , USA.

The mechanistic role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in cholesterol metabolism has been well elucidated, and serves as an example of how genetics has informed modern drug development with the advent of PCSK9 inhibitors. PCSK9 is intimately involved in the hepatic regulation of the Low-density lipoprotein (LDL) receptor, which in turn plays a key role in the circulation of serum LDL. Monoclonal antibodies targeting PCSK9, which act by inhibiting PCSK9 thereby allowing for constitutively active LDL receptors, are now well established as an effective method for significant LDL lowering. Read More

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January 2016

Epigenetic and Posttranslational Modifications in Light Signal Transduction and the Circadian Clock in Neurospora crassa.

Int J Mol Sci 2015 Jul 7;16(7):15347-83. Epub 2015 Jul 7.

Department of Biology and Biotechnologies "Charles Darwin", Sapienza-University of Rome, Piazzale Aldo Moro 5, Rome 00185, Italy.

Blue light, a key abiotic signal, regulates a wide variety of physiological processes in many organisms. One of these phenomena is the circadian rhythm presents in organisms sensitive to the phase-setting effects of blue light and under control of the daily alternation of light and dark. Circadian clocks consist of autoregulatory alternating negative and positive feedback loops intimately connected with the cellular metabolism and biochemical processes. Read More

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Hepatitis C virus life cycle and lipid metabolism.

Biology (Basel) 2014 Dec 15;3(4):892-921. Epub 2014 Dec 15.

Center for Infection & Immunity of Lille (CIIL), Inserm U1019, CNRS UMR8204, Institut Pasteur de Lille and Université de Lille, F-59000 Lille, France.

Hepatitis C Virus (HCV) infects over 150 million people worldwide. In most cases HCV infection becomes chronic, causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. HCV affects the cholesterol homeostasis and at the molecular level, every step of the virus life cycle is intimately connected to lipid metabolism. Read More

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December 2014

NMR studies of DNA support the role of pre-existing minor groove variations in nucleosome indirect readout.

Biochemistry 2014 Sep 26;53(35):5601-12. Epub 2014 Aug 26.

LBPA, UMR 8113, ENS de Cachan CNRS , 61 avenue du Président Wilson, 94235 Cachan cedex, France.

We investigated how the intrinsic sequence-dependent properties probed via the phosphate linkages (BI ↔ BII equilibrium) influence the preferred shape of free DNA, and how this affects the nucleosome formation. First, this exploits NMR solution studies of four B-DNA dodecamers that together cover 39 base pairs of the 5' half of the sequence 601, of special interest for nucleosome formation. The results validate our previous prediction of a systematic, general sequence effect on the intrinsic backbone BII propensities. Read More

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September 2014

Fluorescence methods in the investigation of the DEAD-box helicase mechanism.

Exp Suppl 2014;105:161-92

Institute for Physical Chemistry, University of Muenster, Corrensstrasse 30, 48149, Muenster, Germany,

DEAD-box proteins catalyze the ATP-dependent unwinding of RNA duplexes and accompany RNA molecules throughout their cellular life. Conformational changes in the helicase core of DEAD-box proteins are intimately linked to duplex unwinding. In the absence of ligands, the two RecA domains of the helicase core are separated. Read More

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October 2014

Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked.

Cancers (Basel) 2014 Jul 17;6(3):1500-21. Epub 2014 Jul 17.

Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

Cancer and inflammation are intimately linked due to specific oxidative processes in the tumor microenvironment. Lipoxygenases are a versatile class of oxidative enzymes involved in arachidonic acid metabolism. An increasing number of arachidonic acid metabolites is being discovered and apart from their classically recognized pro-inflammatory effects, anti-inflammatory effects are also being described in recent years. Read More

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Platelets effects on tumor growth.

Semin Oncol 2014 Jun 23;41(3):359-69. Epub 2014 Apr 23.

Institute of Biomedical Materials and Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

Unlike other blood cells, platelets are small anucleate structures derived from marrow megakaryocytes. Thought for almost a century to possess solely hemostatic potentials, platelets, however, play a much wider role in tissue regeneration and repair and interact intimately with tumor cells. On one hand, tumor cells induce platelet aggregation (TCIPA), known to act as the trigger of cancer-associated thrombosis. Read More

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Long-range correlation energy calculated from coupled atomic response functions.

J Chem Phys 2014 May;140(18):18A508

Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, 14195 Berlin, Germany.

An accurate determination of the electron correlation energy is an essential prerequisite for describing the structure, stability, and function in a wide variety of systems. Therefore, the development of efficient approaches for the calculation of the correlation energy (and hence the dispersion energy as well) is essential and such methods can be coupled with many density-functional approximations, local methods for the electron correlation energy, and even interatomic force fields. In this work, we build upon the previously developed many-body dispersion (MBD) framework, which is intimately linked to the random-phase approximation for the correlation energy. Read More

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Identification of avian malaria (Plasmodium sp.) and canine heartworm (Dirofilaria immitis) in the mosquitoes of Tennessee.

J Parasitol 2014 Aug 3;100(4):455-62. Epub 2014 Mar 3.

Department of Entomology and Plant Pathology, University of Tennessee Institute of Agriculture, 370 Plant Biotechnology Building, 2505 E. J. Chapman Drive, Knoxville Tennessee 37996-4560.

Plasmodium reticulum, the causative agent for avian malaria (a protozoan), and Dirofilaria immitis, the causative agent for canine heartworm (a filarial nematode), are 2 obligate parasites transmitted by mosquitoes. The objective of this project was to identify whether either parasite was present in Tennessee mosquitoes and to illustrate the need for collecting spatial and temporal vector-parasite data. During 2012, mosquitoes were collected from the East Tennessee Research and Education Center (ETREC) in eastern Tennessee and the Ames Plantation Research and Education Center (AMES) in western Tennessee using CO(2) traps and gravid traps. Read More

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Passing through: queer lesbian film and Fremde Haut.

Michele Aaron

J Lesbian Stud 2012 ;16(3):323-39

American and Canadian Studies, University of Birmingham, Edgbaston, Birmingham, UK.

Expanding the horizons of lesbian film, Fremde Haut is located within three broad frames: the cross-dressing genre, the New Queer Cinema (NQC) movement, and an Accented or diasporic film aesthetic. While strong connections exist between the cross-dressing film and NQC, less addressed are the links between the New Queer and the Accented yet these are of more radical, that is queerer, potential. Through Fremde Haut, this article illustrates how intimately tied to race and nation, gender and sexuality are, to reveal the accented as queer and the queer as accented. Read More

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November 2012

Timing is everything: the demarcation of 'later' abortions in Scotland.

Soc Stud Sci 2012 Feb;42(1):53-74

Science and Technology Studies Unit (SATSU), Department of Sociology, University of York, York YO10 5DD, UK.

Feminist STS analyses of contemporary reproductive medicine have illustrated the proliferation of practices that position fetuses as individual subjects, and have highlighted the major implications of such practices for pregnant women. In an attempt to challenge medicine's claims to 'know' the fetus, this body of literature has also demonstrated the renegotiable basis of pregnant/fetal subjectivity, using detailed empirical analyses of the practices through which particular pregnant and fetal subjects emerge in particular contexts. In this paper I contribute to this endeavour utilizing an empirical case study of an important, but neglected aspect of reproductive healthcare: the demarcation of temporal thresholds on abortion provision in the absence of diagnosed fetal abnormality. Read More

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February 2012

Integrative food grade expression system for lactic acid bacteria.

Methods Mol Biol 2011 ;765:373-87

Department of Food, Bioprocessing & Nutrition Sciences, North Carolina State University, Raleigh, NC, USA.

Lactobacillus acidophilus NCFM is a probiotic microbe with the ability to survive passage to the -gastrointestinal tract, interact intimately with the host and induce immune responses. The genome of NCFM has been determined and the bacterium is genetically accessible. Therefore, L. Read More

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January 2012

Mobility in older adults: a comprehensive framework.

Gerontologist 2010 Aug 9;50(4):443-50. Epub 2010 Feb 9.

Health, Leisure and Human Performance Research Institute, Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.

Mobility is fundamental to active aging and is intimately linked to health status and quality of life. Although there is widespread acceptance regarding the importance of mobility in older adults, there have been few attempts to comprehensively portray mobility, and research has to a large extent been discipline specific. In this article, a new theoretical framework for mobility is presented with the goals of raising awareness of the complexity of factors that influence mobility and stimulating new integrative and interdisciplinary research ideas. Read More

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[Research and non-research. The values in the evaluation of epidemiological protocols].

N Lechopier

Rev Epidemiol Sante Publique 2010 Feb 29;58(1):41-8. Epub 2010 Jan 29.

Institut d'histoire et de philosophie des sciences et des techniques, 13, rue du Four, 75006 Paris, France.

Background: Evaluation and ethical review of epidemiological research projects raises the problem of the limits between research and non-research. This ambiguous boundary reflects the status of this discipline at the crossroads between research and practical action. The question then is: in the field of health research, what gives data collection and analysis its quality of scientific activity?

Methods: A conceptual and empirical study has been conducted about the practices of epidemiological research evaluation, centred on the case of the French Consultative Committee for the data processing in health research (CCTIRS), which is a consultative board that permits the National commission for the personal data protection (CNIL) to take decision about health research protocols that process personal data. Read More

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February 2010

Templating membrane assembly, structure, and dynamics using engineered interfaces.

Biochim Biophys Acta 2010 Apr 14;1798(4):839-50. Epub 2010 Jan 14.

Department of Applied Science, College of Engineering, University of California, Davis, CA 95616, USA.

The physical and chemical properties of biological membranes are intimately linked to their bounding aqueous interfaces. Supported phospholipid bilayers, obtained by surface-assisted rupture, fusion, and spreading of vesicular microphases, offer a unique opportunity, because engineering the substrate allows manipulation of one of the two bilayer interfaces as well. Here, we review a collection of recent efforts, which illustrates deliberate substrate-membrane coupling using structured surfaces exhibiting chemical and topographic patterns. Read More

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Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms.

Exp Cell Res 2010 Mar 11;316(5):813-25. Epub 2010 Jan 11.

Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA.

During angiogenesis, endothelial cells (ECs) degrade their surrounding extracellular matrix (ECM) to facilitate invasion. How interactions between ECs and other cells within their microenvironment facilitate this process is only partially understood. We have utilized a tractable 3D co-culture model to investigate the proteolytic mechanisms by which pre-committed or more highly committed mesenchymal cells stimulate capillary formation. Read More

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Somatostatin, Alzheimer's disease and cognition: an old story coming of age?

Prog Neurobiol 2009 Oct 10;89(2):153-61. Epub 2009 Jul 10.

Centre de Psychiatrie et Neuroscience, UMR 894 Inserm, Faculte de Medecine, Universite Paris Descartes, 75014 Paris, France.

In mammalian brain, the somatostatin (SRIF: somatotropin release-inhibiting factor) family is composed of two peptides: SRIF and cortistatin (CST), which interact with five different receptor subtypes, sst(1-5). This review summarizes the properties of these receptors, the involvement of somatostatinergic systems in Alzheimer's disease (SRIF/acetylcholine (Ach), SRIF/amyloid beta peptides, and SRIF/tau interactions) and their role in cognition from early studies using cysteamine as an SRIF depleting substance to the use of subtype selective analogues and knockout mice, and modulation of synaptic plasticity. The current SRIF story illustrates how cognition and emotion are intimately integrated in brain function. Read More

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October 2009