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Fairness analysis and compensation strategy in the Triangle of Central China driven by water-carbon-ecological footprints.

Environ Sci Pollut Res Int 2021 Jun 11. Epub 2021 Jun 11.

Key Laboratory of Water Cycle and Related Land Surface Processes, Institute of Geographic Science and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.

This study proposes water-carbon-ecological footprints to form footprint family indicators for identifying the ecological compensation and regional development equilibrium in the Triangle of Central China (TOCC). The occupation of natural capital stock and flow consumption can be illustrated using a three-dimensional ecological footprint model, and Gini coefficient is integrated into the evaluation framework for fairness measurement from various aspects. Quantificational ecological compensation standards can be given with considering indicators associated with ecological resource conversion efficiency and willingness to pay. Read More

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Association of short-term fine particulate matter exposure with pulmonary function in populations at intermediate to high-risk of cardiovascular disease: A panel study in three Chinese cities.

Ecotoxicol Environ Saf 2021 Jun 8;220:112397. Epub 2021 Jun 8.

Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China. Electronic address:

Background: Decline in pulmonary function contributes to increasing cardiovascular disease (CVD) risk. Although adverse effects of short-term exposure to fine particulate matter (PM) on pulmonary function have been recognized in healthy people or patients with respiratory disease, these results were not well illustrated among people with elevated CVD risk.

Materials And Methods: A panel study was conducted in three Chinese cities with three repeated visits among populations at intermediate to high-risk of CVD, defined as treated hypertension patients or those with blood pressure ≥ 130/80 mmHg, who met any of the three conditions including abdominal obesity, dyslipidemia, and diabetes mellitus. Read More

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The Novel FAT4 Activator Jujuboside A Suppresses NSCLC Tumorigenesis by Activating HIPPO Signaling and Inhibiting YAP Nuclear Translocation.

Pharmacol Res 2021 Jun 8:105723. Epub 2021 Jun 8.

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China; State Key Laboratory of Quality Research in Chinese Medicine/ Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau (SAR), China. Electronic address:

FAT atypical cadherin 4 (FAT4) has been identified as a tumor suppressor in lung cancers. However, no agent for lung cancer treatment targeting FAT4 has been used in the clinic. Jujuboside A (JUA) is a major active compound in Semen Ziziphi Spinosae. Read More

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PKM1 Exerts Critical Roles in Cardiac Remodeling Under Pressure Overload in the Heart.

Circulation 2021 Jun 9. Epub 2021 Jun 9.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.

Metabolic remodeling precedes most alterations during cardiac hypertrophic growth under hemodynamic stress. The elevation of glucose utilization has been recognized as a hallmark of metabolic remodeling. However, its role in cardiac hypertrophic growth and heart failure in response to pressure overload remains to be fully illustrated. Read More

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Homologous recombination repair gene mutations in Chinese localized and locally advanced prostate cancer patients.

Pathol Res Pract 2021 May 29;224:153507. Epub 2021 May 29.

Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. Electronic address:

Background: Homologous recombination repair gene (HRR) mutations have been proven to be effective biomarkers for PARP inhibitor therapy for metastatic castration resistant prostate cancer. However, the frequency of HRR mutations in patients with localized and locally advanced prostate cancer is still unclear. This study investigated the profile of HRR gene mutations in Chinese localized and locally advanced prostate cancer patients. Read More

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The role of STIM1/ORAI1 channel in the analgesic effect of grain-sized moxibustion on inflammatory pain mice model.

Life Sci 2021 Jun 5:119699. Epub 2021 Jun 5.

Department of Traditional Chinese Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan Province, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, Sichuan Province, China. Electronic address:

The therapeutic effect of grain-sized moxibustion (GS-Moxi) on inflammatory pain has been well recognized clinically, but the mechanism remains unclear. STIM1/ORAI1 is a sensible temperature channel, therefore; this study aimed to investigate the analgesic effect of GS-Moxi and the association with STIM1/ORAI1 expression. CFA-induced inflammatory pain model was established and was treated with GS-Moxi after 3 days of CFA injection. Read More

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An Azobenzene-Modified Photoresponsive Thorium-Organic Framework: Monitoring and Quantitative Analysis of Reversible Photoisomerization.

Inorg Chem 2021 Jun 7. Epub 2021 Jun 7.

Laboratory of Nuclear Energy Chemistry, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Monitoring and quantification of the photoresponsive behavior of metal-organic frameworks that respond to a light stimulus are crucial to establish a clear structure-activity relationship related to light regulation. Herein, we report the first azobenzene-modified photoresponsive thorium-organic framework ( with the formula [ThO(OH)(HO)] (H = ()-2'--tolyldiazenyl-1,1':4',4'-terphenyl-4,4″-dicarboxylic acid), in which the utilization of a thorium cluster as a metal node leads to one of the largest pore sizes among all the azobenzene-containing metal-organic frameworks (MOFs). The phototriggered transformation of the isomer to the isomer is monitored and characterized quantitatively by comprehensive analyses of NMR and UV spectroscopy, which reveals that the maximum isomerization ratio of in the solid state is 19. Read More

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Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance.

Chem Sci 2020 Aug 19;11(35):9554-9562. Epub 2020 Aug 19.

Department of Chemical and Biomolecular Engineering, University of California Los Angeles CA 90095 USA

Overcoming resistance to bioactive small molecules is a significant challenge for health care and agriculture. As a result, efforts to uncover the mechanisms of resistance are essential to the development of new antibiotics, anticancer drugs and pesticides. To study how nature evolves resistance to highly potent natural products, we examined the biosynthesis and mechanism of self-resistance of the fungal glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor heptelidic acid (HA). Read More

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Development and Validation of an Immune-Related Long Non-coding RNA Prognostic Model in Glioma.

J Cancer 2021 19;12(14):4264-4276. Epub 2021 May 19.

Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.

Long non-coding RNAs (lncRNAs) play an important role in the immune processes of glioma. Immune related lncRNAs (IRlncRs) may be a critical prognosis in patients with glioma. The current study aimed to construct a glioma immune-related prognosis model by IRlncRs. Read More

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Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases.

Org Lett 2021 Jun 4. Epub 2021 Jun 4.

State Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Genome-based discovery of two previously unreported fungal bifunctional terpene synthases (BFTSs) from phytopathogenic fungi are reported: FoFS catalyzing the formation of fusoxypenes A-C (-) and (-)-astellatene () and AtAS capable of synthesizing preaspterpenacid I (). Interestingly, FoFS and AtAS catalyzed the formation of enantiomeric sesterterpenes with a 5-6-7-3-5 ring system. C22-oxidative modification of preaspterpenacid I by AtP450 was characterized as well. Read More

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Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten.

Biochem Genet 2021 Jun 3. Epub 2021 Jun 3.

Department of Clinical Laboratory, The People's Hospital of Longhua District, Shenzhen, 518109, Guangdong Province, China.

Diabetes mellitus (DM), a familiar disease, is characterized by high blood glucose levels owing to insulin deficiency. Researches have suggested that the incidence rate of diabetes is increasing and it has become an important global epidemic. The type 2 diabetes mellitus (T2DM) is featured with pancreatic β-cell loss and lack of insulin release. Read More

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A novel linear active disturbance rejection controller for main steam temperature control based on the simultaneous heat transfer search.

ISA Trans 2021 May 17. Epub 2021 May 17.

CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, China. Electronic address:

The main steam temperature of boiler outlet has been deemed as a significant parameter of the safety and economic performances in the thermal power plant operation. The complex working status of the thermal generation endures highly uncertain factors and remarkable disturbance, which call for effective controlling approaches in the corresponding temperature management. The linear active disturbance rejection controller (LADRC) is a conducive and powerful controlling method, whereas strong correlation between LADRC parameters leads to difficulties in optimally determining the controller parameters. Read More

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Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy.

Redox Biol 2021 May 25;44:102010. Epub 2021 May 25.

Department of Rheumatology and Immunology, Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China. Electronic address:

Activated microglia are an important type of innate immune cell in the brain, and they secrete inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding neurons and are involved in the pathogenesis of many brain disorders. Quercetin (Qu), a natural flavonoid, is known to have anti-inflammatory and antioxidant properties. Previous studies have shown that both increased reactive oxygen species (ROS) stress and decreased autophagy participate in the activation of microglial. Read More

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A smart spectral analysis strategy-based UV and FT-IR spectroscopy fingerprint: Application to quality evaluation of compound liquorice tablets.

J Pharm Biomed Anal 2021 Aug 25;202:114172. Epub 2021 May 25.

Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, College of Pharmacy, Jinan University, Guangzhou, Guangdong, 510632, China.

This study focuses on development of a smart spectral analysis strategy for rapid quality evaluation of complex sample. Firstly, the ultraviolet (UV) and Fourier Transform Infrared (FT-IR) spectroscopy were established. Secondly, the second derivative UV spectral was obtained and showed 7 major absorption peaks, which was the projection of the 3D-spectrum profile. Read More

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Antibiotic Prescriptions among China Ambulatory Care Visits of Pregnant Women: A Nationwide Cross-Sectional Study.

Antibiotics (Basel) 2021 May 19;10(5). Epub 2021 May 19.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Background: Antibiotic use in pregnant women at the national level has rarely been reported in China.

Objectives: We aimed to investigate antibiotic prescriptions during pregnancy in ambulatory care settings in China.

Methods: Data of 4,574,961 ambulatory care visits of pregnant women from October 2014 to April 2018 were analyzed. Read More

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Research Development on Anti-Microbial and Antioxidant Properties of Camel Milk and Its Role as an Anti-Cancer and Anti-Hepatitis Agent.

Antioxidants (Basel) 2021 May 17;10(5). Epub 2021 May 17.

State Key Laboratory of Animal Nutrition, Beijing Engineering Technology Research Center of Raw Milk Quality and Safety Control, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.

Camel milk is a rich source of vitamin C, lactic acid bacteria (LAB), beta-caseins and milk whey proteins, including lactoferrin, lysozyme, lactoperoxidase, alpha-lactalbumin and immunoglobulin. The lactoferrin plays a key role in several physiological functions, such as conferring antioxidant, anti-microbial and anti-inflammatory functions in cells. Similarly, the camel milk alpha-lactalbumin has shown greater antioxidative activity because of its higher antioxidant amino acid residues. Read More

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Age and Sex-Related Differences in the Tongue Pressure Generated during Maximum Isometric and Swallowing Tasks by Healthy Chinese Adults.

Int J Environ Res Public Health 2021 May 20;18(10). Epub 2021 May 20.

College of Nursing, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan.

The aims of this prospective observational study were to investigate age, sex, and factors related to the tongue pressure generated. A correlational research design was used. A total of 150 Chinese people who had a normal swallowing condition were enrolled by convenience sampling. Read More

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Age Differences in State Curiosity: Examining the Role of Personal Relevance.

Gerontology 2021 Jun 1:1-9. Epub 2021 Jun 1.

Department of Psychology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Objectives: Curiosity, or the desire for novel information and/or experience, is associated with improved well-being and more informed decisions, which has implications on older adults' (OAs') adoption of novel technologies. There have been suggestions that curiosity tends to decline with age. However, it was rarely studied under specific contexts, and there were relatively limited attempts to enhance OAs' curiosity. Read More

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ER stress and its PERK branch enhance TCR-induced activation in regulatory T cells.

Biochem Biophys Res Commun 2021 Jul 28;563:8-14. Epub 2021 May 28.

Department of Microbiology and Immunology, Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, PR China. Electronic address:

Although accumulating evidence indicates participation of endoplasmic reticulum (ER) stress pathway or the unfolded protein response (UPR) in immunity, there still exists little information linking ER stress to regulatory T cells (Tregs). To evaluate the potential contribution of the UPR, we tested the effects of thapsigargin (TG), an ER stress inducer, on the function of Tregs. Here we reported that TG stimulation induced the up-regulation of the endoplasmic reticulum (ER)-stress chaperon Glucose-Regulated Protein 78 (GRP78), which is a master regulator of the UPR, the phosphorylation of eukaryotic initiation factor 2 alpha (elF2α) and the induction of activating transcription factor 4 (ATF4), which are both protein kinase R (PKR)-like ER kinase (PERK) downstream targets in Tregs. Read More

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Quantifying Frustrations for Molecular Complexes with Noncovalent Interactions.

J Phys Chem A 2021 Jun 30;125(22):4910-4917. Epub 2021 May 30.

Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), and College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan 410081, P. R. China.

Molecular systems bound together through noncovalent interactions are involved in a lot of life-essential processes such as molecular recognition, signal transduction, and allosteric regulation. While cooperation as an important effect discovered in these systems focuses on the behavior of system's entirety, we need also examine the behavior of individual parts. In this work, using the distortion energy as the descriptor, we quantify frustration as the energetic loss of individual parts due to the formation of nonadditive molecular complexes. Read More

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Berberine Reverses Breast Cancer Multidrug Resistance Based on Fluorescence Pharmacokinetics and .

ACS Omega 2021 Apr 13;6(16):10645-10654. Epub 2021 Apr 13.

Department of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.

Exploring the mechanism through which berberine (Ber) reverses the multidrug resistance (MDR) of breast cancer is of great importance. Herein, we used the methyl thiazolyl tetrazolium assay to determine the drug resistance and cytotoxicity of Ber and doxorubicin (DOX) alone or in combination on the breast cancer cell line MCF-7/DOX. The results showed that Ber could synergistically enhance the inhibitory effect of DOX on tumor cell proliferation , and the optimal combination ratio was Ber/DOX = 2:1. Read More

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/ Are Essential for the Formation of Anther Cuticle and Pollen Exine in Cotton ( L.).

Front Plant Sci 2021 13;12:667739. Epub 2021 May 13.

State Key Laboratory of Cotton Biology, Institute of Cotton Research, Chinese Academy of Agricultural Sciences, Anyang, China.

Glycerol-3-phosphate acyltransferases (GPATs), critical for multiple biological processes like male fertility, have been extensively characterized. However, their precise functions and underlying regulatory mechanism in cotton anther development are unclear. This research demonstrated the importance of / (a paralogs pair on A12/D12 sub-chromosome of cotton) to regulate the degradation of tapetum, anther cuticle formation, and pollen exine development. Read More

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Taxonomic study of the Oriental genus Bierman, 1910 (Hemiptera, Fulgoromorpha, Tropiduchidae), with description of a new species from China.

Zookeys 2021 17;1037:119-136. Epub 2021 May 17.

Institute of Insect Resources and Biodiversity, School of Life Sciences, Chemistry & Chemical Engineering, Jiangsu Second Normal University, Nanjing, China Jiangsu Second Normal University Nanjing China.

The tropiduchid genus Bierman, 1910 is redescribed and illustrated. includes two species, Bierman, 1910 (the type species) and Zhu, Wang & Song, A key to the species of the genus is provided. Read More

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The association between frequency of eating out with overweight and obesity among children aged 6-17 in China: a National Cross-sectional Study.

BMC Public Health 2021 05 28;21(1):1005. Epub 2021 May 28.

Department of Nutrition and Health Education, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No. 27 Nanwei Road, Xicheng District, Beijing, 100050, China.

Background: In parallel with the increased prevalence of childhood overweight and obesity, the proportion of eating out in China has increased dramatically in recent years. The purpose of the study was to explore the association between frequency of eating out with overweight and obesity among Chinese children.

Methods: The representative sample was recruited from Chinese National Nutrition and Health Survey (CNNHS) in 2010-2012, which included Chinese children aged 6-17 years (7685 boys and 7576 girls). Read More

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Integrated Strategy of Network Pharmacological Prediction and Experimental Validation Elucidate Possible Mechanism of Bu-Yang Herbs in Treating Postmenopausal Osteoporosis via ESR1.

Front Pharmacol 2021 11;12:654714. Epub 2021 May 11.

Graduated School, Jiangxi University of Chinese Medicine, Nanchang, China.

Postmenopausal osteoporosis (PMOP) is a type of bone metabolism disease-related to estrogen deficiency with an increasing incidence. Traditional Chinese (TCM) has always been used and showed effectiveness in treating PMOP. In the current study, Bu-Yang herbs were considered to be the most frequently used and efficient TCM herbs in PMOP treatment. Read More

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Clinical performance of intraoral digital impression for fixed prosthodontics: a Meta-analysis.

Hua Xi Kou Qiang Yi Xue Za Zhi 2021 Jun;39(3):306-312

The Affiliated Stomatology Hospital, Zhejiang University School of Medicine, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China.

Objectives: To analyze the clinical performance of the intraoral digital impression (IDI) in the fixed prosthodontics.

Methods: Databases of Medline (Ovid), EMBASE, Cochrane Central Register of Controlled Trials, and CNKI were searched for randomized controlled trial (RCT) on the use of IDI in fixed prosthodontics until May 2020. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Read More

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The relationship between PLOD1 expression level and glioma prognosis investigated using public databases.

PeerJ 2021 14;9:e11422. Epub 2021 May 14.

Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

Background: Glioma is the most common type of intracranial tumor with high malignancy and poor prognosis despite the use of various aggressive treatments. Targeted therapy and immunotherapy are not effective and new biomarkers need to be explored. Some Procollagen-lysine 2-oxyglutarate 5-dioxygenase () family members have been found to be involved in the metastasis and progression of tumors. Read More

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Symptomatic aseptic necrosis of benign thyroid lesions after microwave ablation: risk factors and clinical significance.

Int J Hyperthermia 2021 ;38(1):815-822

Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China.

Background: Symptomatic aseptic necrosis (SAN) followed by nodule rupture is a kind of severe complications after thermal ablation for benign thyroid nodules (BTN). No studies are available to evaluate its pathologic process, clinical manifestations, risk factors and effectiveness of therapies after microwave ablation (MWA).

Methods: From 2012 to 2019, 398 patients who received MWA for BTN were retrospectively reviewed. Read More

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January 2021

[Economic Benefit of Air Quality Improvement During Implementation of the Air Pollution Prevention and Control Action Plan in Beijing].

Huan Jing Ke Xue 2021 Jun;42(6):2730-2739

Environmental Research Center of Beijing-Tianjin-Hebei Region, Chinese Academy of Environmental Planning, Beijing 100012, China.

Air quality in Beijing has been improved significantly since the implementation of the Air Pollution Prevention and Control Action Plan ('Action Plan'). To evaluate the effect of the Action Plan, the cost-of-illness, human capital, and market value approaches were used to estimate air quality improvement benefits including human health, agriculture, building materials, and cleanliness. The policy benefit through monetization was also evaluated, which can affirm the positive effect of air pollution prevention and control by local government. Read More

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Facile Synthesis of Unimodal Polymethacrylates with Narrow Dispersity via NIR LED Light-Controlled Bromine-Iodine Transformation Reversible-Deactivation Radical Polymerization.

Macromol Rapid Commun 2021 May 24:e2100211. Epub 2021 May 24.

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China.

A facile and clean strategy for synthesizing unimodal polymethacrylates with narrow dispersity (Đ < 1.10) is successfully developed by a near-infrared (NIR) light-emitting diode (LED) light (λ = 740 nm)-controlled in situ bromine-iodine transformation reversible-deactivation radical polymerization system without the use of NIR dyes and expensive catalysts. In this system, alkyl iodide ethyl α-iodophenylacetate (EIPA) initiator is generated in situ by the nucleophilic substitution reaction between an alkyl bromide compound ethyl α-bromophenylacetate and sodium iodide (NaI). Read More

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