11,727 results match your criteria illness psychotic

Long range temporal correlations (LRTCs) in MEG-data during emerging psychosis: Relationship to symptoms, medication-status and clinical trajectory.

Neuroimage Clin 2021 Jun 8;31:102722. Epub 2021 Jun 8.

Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.

Long-Range Temporal Correlations (LRTCs) index the capacity of the brain to optimally process information. Previous research has shown that patients with chronic schizophrenia present altered LRTCs at alpha and beta oscillations. However, it is currently unclear at which stage of schizophrenia aberrant LRTCs emerge. Read More

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Reduced TMS-evoked fast oscillations in the motor cortex predict the severity of positive symptoms in first-episode psychosis.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Jun 12;111:110387. Epub 2021 Jun 12.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States of America. Electronic address:

Accumulating evidence points to neurophysiological abnormalities of the motor cortex in Schizophrenia (SCZ). However, whether these abnormalities represent a core biological feature of psychosis rather than a superimposed neurodegenerative process is yet to be defined, as it is their putative relationship with clinical symptoms. in this study, we used Transcranial Magnetic Stimulation coupled with electroencephalography (TMS-EEG) to probe the intrinsic oscillatory properties of motor (Brodmann Area 4, BA4) and non-motor (posterior parietal, BA7) cortical areas in twenty-three first-episode psychosis (FEP) patients and thirteen age and gender-matched healthy comparison (HC) subjects. Read More

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Reduced willingness to expend effort for rewards is associated with risk for conversion and negative symptom severity in youth at clinical high-risk for psychosis.

Psychol Med 2021 Jun 14:1-8. Epub 2021 Jun 14.

Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.

Background: Schizophrenia (SZ) is typically preceded by a prodromal (i.e. pre-illness) period characterized by attenuated positive symptoms and declining functional outcome. Read More

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Warwick-India-Canada (WIC) global mental health group: rationale, design and protocol.

BMJ Open 2021 06 11;11(6):e046362. Epub 2021 Jun 11.

Division of Mental Health & Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK.

Introduction: The primary aim of the National Institute of Health Research-funded global health research group, Warwick-India-Canada (WIC), is to reduce the burden of psychotic disorders in India. India has a large pool of undetected and untreated patients with psychosis and a treatment gap exceeding 75%. Evidence-based packages of care have been piloted, but delivery of treatments still remains a challenge. Read More

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Chinese mental health workers' family-focused practices: a cross-sectional survey.

BMC Health Serv Res 2021 Jun 9;21(1):569. Epub 2021 Jun 9.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.

Background: Mental disorders impose heavy burdens on patients' families and children. It is imperative to provide family-focused services to avoid adverse effects from mental disorders on patients' families and children. However, implementing such services requires a great deal of involvement of mental health workers. Read More

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Demographic, clinical and forensic characteristics of alleged offenders referred to West End Specialised Hospital, Kimberley, South Africa.

Psychiatr Psychol Law 2020 May 5;27(6):925-938. Epub 2020 May 5.

Department of Psychiatry, University of the Free State, Bloemfontein, South Africa.

The study investigated demographic, clinical and forensic characteristics of alleged offenders referred for forensic assessment. A data collection form was used to gather information from 155 offenders' clinical records. The subjects were mainly young males, aged between 18 and 35 years, with low educational levels and high unemployment rate. Read More

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Colorectal cancer Outcomes in people with Severe Mental Illness Cohort (COSMIC): a protocol for an Australian retrospective cohort using linked administrative data.

BMJ Open 2021 06 8;11(6):e044737. Epub 2021 Jun 8.

School of Clinical Medicine, The University of Queensland, Brisbane, Queensland, Australia

Introduction: Colorectal cancer (CRC) mortality is significantly higher in those with severe mental illness (SMI) compared with the general population, despite similar incidence rates, suggesting that barriers to optimal screening and cancer care may contribute to disparities in CRC mortality in those with SMI. This study aims to compare participation in Australia's National Bowel Cancer Screening Programme (NBCSP) in those with SMI and those in the general population. We will also investigate treatment pathways after diagnosis to determine whether treatment variations could explain differences in CRC mortality. Read More

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Challenging diagnosis of leprosy in a psychotic homeless patient with atypical clinical manifestations: an interesting case report.

BMC Infect Dis 2021 Jun 7;21(1):540. Epub 2021 Jun 7.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Jl. Pasteur No. 38, Bandung, 40161, Indonesia.

Background: A decision to diagnose certain skin diseases in patient undergoing psychotic break is challenging; this includes establishing the diagnosis of leprosy. Diagnosis of leprosy is established if there is at least one of the three cardinal signs of leprosy. Histopathological examination is not a gold standard, but remains useful in atypical or clinically suspicious cases. Read More

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[Disease burden of borderline personality disorder: cost of illness, somatic comorbidity and mortality].

Nervenarzt 2021 Jun 7. Epub 2021 Jun 7.

Klinik für Allgemeine Psychiatrie, Universitätsklinikum Heidelberg, Zentrum für Psychosoziale Medizin, Heidelberg, Deutschland.

Background: Severe mental illnesses (SMI) are characterized by high psychosocial impairment as well as by increased somatic morbidity and mortality. The term SMI commonly includes psychotic, bipolar and severe unipolar depressive disorders but borderline personality disorder (BPD) also shows severe sequelae of the disease.

Material And Methods: Published reviews and studies since 2010 examining disease burden of BPD, in terms of direct and indirect costs of illness, somatic comorbidity, and mortality were included. Read More

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Intramuscular clozapine in the acute medical hospital: Experiences from a liaison psychiatry team.

SAGE Open Med Case Rep 2021 20;9:2050313X211004796. Epub 2021 May 20.

Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UK.

We present two cases demonstrating safe and effective use of intramuscular clozapine for patients who are physically unwell in acute medical care settings. Both patients described were admitted to inpatient medical care units and required treatment with clozapine to control their psychotic symptoms, but were unable or unwilling to take oral clozapine. We describe the use of intramuscular clozapine in these patients, including dosing decisions, administration routes and frequency of dosing. Read More

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Safety and efficacy of Ayurvedic interventions and Yoga on long term effects of COVID-19: A structured summary of a study protocol for a randomized controlled trial.

Trials 2021 Jun 3;22(1):378. Epub 2021 Jun 3.

Central Council for Research in Ayurvedic Sciences Headquarters, 61-65, Institutional Area, Opp. 'D' Block, Janakpuri, New Delhi, 110058, India.

Objectives: Primary Objective • To assess the efficacy of Ayurveda interventions and Yoga in rehabilitation of COVID-19 cases suffering with long term effects of COVID 19 as compared to WHO Rehabilitation Self-Management after COVID-19- Related Illness. Secondary Objective • To assess the safety of Ayurvedic interventions in cases suffering with long term effects of COVID 19 TRIAL DESIGN: Multi-centric, randomized, controlled, parallel group, open-label, exploratory study. The study duration is 9 months and the intervention period is 90 days from the day of enrolment of the participant. Read More

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Obesity as a Risk Factor for Accelerated Brain Ageing in First-Episode Psychosis-A Longitudinal Study.

Schizophr Bull 2021 Jun 3. Epub 2021 Jun 3.

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Background: Obesity is highly prevalent in schizophrenia, with implications for psychiatric prognosis, possibly through links between obesity and brain structure. In this longitudinal study in first episode of psychosis (FEP), we used machine learning and structural magnetic resonance imaging (MRI) to study the impact of psychotic illness and obesity on brain ageing/neuroprogression shortly after illness onset.

Methods: We acquired 2 prospective MRI scans on average 1. Read More

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Pregnancy outcomes, early separation, and psychiatric relapse experienced by South African women with peripartum psychosis: a descriptive exploration.

Afr J Reprod Health 2020 Dec;24(4):58-68

Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa.

The peripartum is associated with increased incidence of severe mental illness (SMI), a greater occurrence of psychotic symptoms and psychiatric admissions. This study aimed to describe the psychiatric, medical and psycho-social risk factors affecting South African mothers who experienced peripartum psychosis. Using a prospective, descriptive design, we conducted a detailed interview and supplementary information was collected by review of clinical records. Read More

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December 2020

Relatives' Experiences of Mental Health Care, Family Burden and Family Stigma: Does Participation in Patient-Appointed Resource Group Assertive Community Treatment (RACT) Make a Difference?

Issues Ment Health Nurs 2021 Jun 1:1-10. Epub 2021 Jun 1.

Department of Health Care Sciences, Ersta Sköndal Bräcke University College, Stockholm, Sweden.

The aim of this exploratory cross-sectional study was to investigate the experiences of relatives of individuals with severe mental illness with and without participation in patient-appointed Resource Group Assertive Community Treatment (RACT). A total of 139 relatives (79 with and 60 without RACT) completed the Family Involvement and Alienation Questionnaire, the Burden Inventory for Relatives of Persons with Psychotic Disturbances, and the family version of the Inventory of Stigmatizing Experiences. We found that relatives participating in RACT experienced a more positive approach from the healthcare professionals, as well as a lower degree of alienation from the provision of care. Read More

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Cannabis use and clinical outcome in people with first-episode schizophrenia spectrum disorders over 24 months of treatment.

Psychiatry Res 2021 May 19;302:114022. Epub 2021 May 19.

Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Cannabis use is associated with an unfavourable course of illness in schizophrenia, although several factors may confound this association. In this longitudinal study, we explored the influence of cannabis use on baseline symptom severity and treatment outcomes in 98 patients with first-episode schizophrenia spectrum disorders treated with a long acting injectable antipsychotic over 24 months. Using mixed models for repeated measures, we compared visit-wise changes in psychopathology, social and occupational functioning and quality of life between recent/current cannabis users (n=45) and non-users (n=53). Read More

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Identification of psychiatric inpatient recovery trajectories using routine outcome monitoring with emerging adults.

Psychiatry Res 2021 May 13;302:114000. Epub 2021 May 13.

Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada; Alberta Health Services, Addiction and Mental Health, Edmonton, Alberta, Canada.

Early intervention for emerging adults with addiction and mental health disorders is beneficial for long-term recovery. The present study investigated the utility of routine outcome monitoring during acute inpatient hospitalization for identifying emerging adults at risk of poor outcomes. This is a retrospective study using latent class growth analysis (LCGA) to identify patient groups with different recovery trajectories, with additional analyses to clarify the characteristics of these trajectory groups. Read More

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Long-term quality of life in treatment-resistant depression after electroconvulsive therapy.

J Affect Disord 2021 May 18;291:135-139. Epub 2021 May 18.

Department of Psychiatry, University of Utah, Salt Lake City, USA; Department of Psychiatry, University of Michigan, Ann Arbor, USA.

Background: Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression (TRD), and previous studies have demonstrated short-term improvements in quality of life (QoL) after ECT.  However, long-term QoL after ECT has not been studied, and the baseline patient characteristics that predict long-term QoL remain unknown.

Methods: Seventy-nine subjects with unipolar or bipolar TRD were enrolled in this prospective longitudinal observational study. Read More

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Examination of the impact of COVID-19 public health quarantine measures on acute mental health care services: A retrospective observational study.

Psychiatry Res 2021 May 13;302:113999. Epub 2021 May 13.

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Mental Health and Addictions, Nova Scotia Health, Nova Scotia, Canada.

This study assesses for the impact of Covid-19 public health quarantine measures on acute care psychiatric admissions, by comparing admission data from the quarantine period to a comparator period. A chart review was conducted for all admissions to an urban acute care psychiatric centre from Mar 22 - June 5 2020 (quarantine) and January 5 - Mar 21 2020 (comparator). Data was collected on the number of admissions, demographics, patients' psychiatric history, characteristics of admissions, discharge information, patients' substance use and social factors. Read More

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Efficacy and tolerability of aripiprazole versus D antagonists in the early course of schizophrenia: a systematic review and meta-analysis.

NPJ Schizophr 2021 May 25;7(1):29. Epub 2021 May 25.

British Columbia Mental Health & Substance Use Services Research Institute, Vancouver, Canada.

Early intervention is essential for favorable long-term outcomes in schizophrenia. However, there is limited guidance in the scientific literature on how best to choose between dopamine D receptor (DR) partial agonists and DR antagonists in early stages of schizophrenia. The aim of this meta-analysis was to directly compare DR partial agonists with DR antagonists for efficacy and tolerability, using randomized controlled trials (RCTs) that involved participants diagnosed with first-episode psychosis, schizophrenia, or related psychotic disorders with a duration of illness ≤5 years. Read More

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Social work training to reduce duration of untreated psychosis: Methodology and considerations of a web-based training for community providers.

Early Interv Psychiatry 2021 May 24. Epub 2021 May 24.

Department of Psychological Science, University of California, Irvine, California, USA.

Aim: Outcomes for individuals with psychotic disorders can be improved through early intervention services; however, identification continues to be a major problem in connecting individuals with these services. Social workers form a vast majority of the human service and mental health workforce in the United States and therefore have the potential to play a unique role in identifying and referring those who may benefit from specialty early intervention services.

Methods: The current article describes the methodological design, implementation, and participant recruitment procedures of a large-scale, web-based training program for social workers promoting identification and referral of individuals with emerging symptoms of a mental illness with psychosis in the context of a randomized clinical trial. Read More

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Do outcomes of psychiatric hospital treatment differ for migrants and non-migrants?

Soc Psychiatry Psychiatr Epidemiol 2021 May 24. Epub 2021 May 24.

Unit for Social & Community Psychiatry, WHO Collaborating Centre for Mental Health Services Development, East London NHS Foundation Trust, Newham Centre for Mental Health, Queen Mary University of London, London, E13 8SP, UK.

Purpose: Providing effective treatment for immigrants is an increasing challenge for mental health services across Europe. Yet, little is known as to whether current practice is associated with different outcomes in migrant and non-migrant patients. We compared outcomes of inpatient psychiatric treatment for migrants and non-migrants in a sample from five European countries. Read More

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Mental illness among 500 people living homeless and referred for psychiatric evaluation in Lisbon, Portugal.

CNS Spectr 2021 May 25:1-10. Epub 2021 May 25.

Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Background: Our goal was to identify the demographic profile of the people living homeless with mental illness in Lisboa, Portugal, and their relationship with the national healthcare system. We also tried to understand which factors contribute to the number and duration of psychiatric admissions among these homeless people.

Methods: We used a cross-sectional design, collecting data for 4 years among homeless people, in Lisboa, Portugal, that were referred as possible psychiatric patients to Centro Hospitalar Psiquiátrico de Lisboa (CHPL). Read More

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Psychotic-like experiences among 9,564 Kenyan adolescents and young adults.

Psychiatry Res 2021 May 14;302:113994. Epub 2021 May 14.

Africa Mental Health Research and Training Foundation, Nairobi, Kenya; Department of Psychiatry, University of Nairobi, Kenya.

Objective: To investigate the prevalence and characteristics of psychotic-like experiences (PLE) in a large cohort of Kenyan adolescents and young adults.

Method: The Washington Early Recognition Center Affectivity and Psychosis (WERCAP) Screen was used to the study the 12-month prevalence of PLE's among 9,564 Kenyan youths (aged 15-25 yrs), and the rates of psychosis high-risk (HR) and medium-risk (MR) cases, based on cut-off scores. Relationships with clinical, demographic and economic profiles were investigated. Read More

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Acceptability and Usability of Mobile Apps for Smoking Cessation Among Young Adults With Psychotic Disorders and Other Serious Mental Illness.

Front Psychiatry 2021 7;12:656538. Epub 2021 May 7.

Geisel School of Medicine at Dartmouth, Hanover, NH, United States.

Young adults with serious mental illness (SMI) are over twice as likely to smoke cigarettes than those in the general population, but little research has evaluated the efficacy of interventions for this group. While smartphone apps are a promising tool to address this need, their usability should be evaluated among young adults with psychotic disorders, whose symptoms and cognitive impairments may be a barrier to app use. We compared usability and acceptability of National Cancer Institute apps (QuitGuide and quitSTART) between young adult smokers with SMI psychotic disorders and other SMI diagnoses. Read More

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Is psychodynamic psychotherapy a useful approach in treatment of bipolar disorder? A review of research, actualization of technique and clinical illustrations.

Lech Kalita

Psychiatr Pol 2021 Feb 28;55(1):145-170. Epub 2021 Feb 28.

praktyka prywatna.

The author attempts to describe a role of psychodynamic psychotherapy in treatment of bipolar disorder. A general role of psychological interventions in treating this illness is sketched, highlighting the approach of combining psychotherapy and pharmacological treatment as the most common perspective. Recent research data on effectiveness of various psychotherapies in treating BD is presented. Read More

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February 2021

Investigating the impact of HIV on patients with first episode psychosis: a study protocol for a longitudinal cohort study.

BMJ Open 2021 05 21;11(5):e046593. Epub 2021 May 21.

Department of Psychiatry, School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Introduction: South Africa (SA) has a high HIV prevalence and limited mental healthcare resources. Neuropsychiatric complications such as psychosis onset in people living with HIV (PLWHIV) remains poorly understood. The study aims to compare the socio-demographic, clinical, substance use, cognitive and trauma profile of PLWHIV presenting with first episode psychosis (FEP) to those with the condition but without HIV. Read More

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Physical-mental multimorbidity in children and youth: a scoping review.

BMJ Open 2021 05 20;11(5):e043124. Epub 2021 May 20.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada

Objective: Efforts to describe the current state of research are needed to advance the field of physical-mental multimorbidity (ie, the co-occurrence of at least one physical illness and at least one mental disorder) among children and youth. Our objective was to systematically explore the breadth of physical-mental multimorbidity research in children and youth and to provide an overview of existing literature topics.

Design: Scoping review. Read More

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Effectiveness and cost effectiveness of interpersonal community psychiatric treatment (ICPT) for people with long-term severe non-psychotic mental disorders: a multi-Centre randomized controlled trial.

BMC Psychiatry 2021 May 19;21(1):261. Epub 2021 May 19.

Department of Psychiatry, Epidemiological and Social Psychiatric Research Institute, Erasmus MC, Rotterdam, the Netherlands.

Background: Long-term community mental health treatment for non-psychotic disorder patients with severe mental illness (SMI) who are perceived as difficult by clinicians, is poorly developed and lacks a structured, goal-centred approach. This study compares (cost-)effectiveness of Interpersonal Community Psychiatric Treatment (ICPT) with Care As Usual (CAU) on quality of life and clinician perceived difficulty in the care for non-psychotic disorder SMI-patients. A multi-centre cluster-randomized clinical tria was conducted in which Community Mental Health Nurses (Clinicians) in three large community mental health services in the Netherlands were randomly allocated to providing either ICPT or CAU to included patients. Read More

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