Mediators Inflamm 2014 28;2014:494956. Epub 2014 Dec 28.
Laboratorio de Imunologia Tumoral, Instituto de Bioquímica Médica Leopoldo de Meis, Centro de Ciencias da Saude, Bloco H02, Sala 003, Universidade Federal do Rio de Janeiro, 21 941-902 Rio de Janeiro, RJ, Brazil.
Although known as a Na,K-ATPase inhibitor, several other cellular and systemic actions have been ascribed to the steroid Ouabain (Oua). Particularly in the immune system, our group showed that Ouabain acts on decreasing lymphocyte proliferation, synergizing with glucocorticoids in spontaneous thymocyte apoptosis, and also lessening CD14 expression and blocking CD16 upregulation on human monocytes. However, Ouabain effects on dendritic cells (DCs) were not explored so far. Read More