20,309 results match your criteria il-6 il-8

The Effects of Human Dermal-derived Mesenchymal Stem Cells on the Keratinocyte Proliferation and Apoptosis in Psoriasis.

Exp Dermatol 2021 Apr 10. Epub 2021 Apr 10.

Shanxi Key Laboratory of Stem Cell for Immunological Dermatosis, Institute of Dermatology, Taiyuan Central Hospital of Shanxi Medical University, No.5, east third lane, Jiefang Road, Taiyuan, 030009, Shanxi Province, China.

Psoriasis is a common chronic inflammatory skin disease, characterized by epidermal hyperproliferation. Mesenchymal stem cells (MSCs) regulate inflammation and vascular proliferation in the psoriasis lesions. Whether dermal-derived mesenchymal stem cells (DMSCs), the main MSCs in the dermis regulate keratinocyte proliferation and apoptosis remains unknown. Read More

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Inflammatory and Prothrombotic Biomarkers Associated With the Severity of COVID-19 Infection.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:1076029621999099

Laboratory of Hemostasis and Vascular Biology, Faculty of Medical and Biological Sciences "Dr Ignacio Chávez," Universidad Michoacana de San Nicolas de Hidalgo, Morelia, Michoacan, Mexico.

Among COVID-19 hospitalized patients, high incidence of alterations in inflammatory and coagulation biomarkers correlates with a poor prognosis. Comorbidities such as chronic degenerative diseases are frequently associated with complications in COVID-19 patients. The aim of this study was to evaluate inflammatory and procoagulant biomarkers in COVID-19 patients from a public hospital in Mexico. Read More

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[Sitagliptin inhibits lipopolysaccharide-induced inflammatory response in human gingival fibroblasts by blocking nuclear factor-κB signaling pathway].

Hua Xi Kou Qiang Yi Xue Za Zhi 2021 Apr;39(2):153-163

Dept. of Periodonto-logy, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan 250012, China.

Objectives: This study was performed to clarify the effects of sitagliptin on -lipopolysaccharide (LPS)-induced inflammatory response in human gingival fibroblasts (HGFs), explore the molecular mechanism of its roles, and provide a foundation for clinical therapeutics in periodontitis.

Methods: Healthy gingival samples were collected from the donors. HGFs were isolated with enzymic digestion method and identified. Read More

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Profiles of inflammation factors and inflammatory pathways around the peri-miniscrew implant.

Histol Histopathol 2021 Apr 9:18336. Epub 2021 Apr 9.

Department of Orthodontics, Stomatological Hospital, Southern Medical University, Guangzhou, China.

Background: Peri-miniscrew implant is a temporary assistant armamentarium for the treatment of severe malocclusion and complex tooth movement, the inflammation around it is the main reason for the failure of orthodontic treatment due to the implant loosening and falling out. Inflammation around the peri-miniscrew implant is associated with the release of pro-inflammatory cytokines. These pro-inflammatory cytokines, in turn, recruit immune cells (such as macrophages, dendritic cells, T cells, and B cells), which can produce and release inflammatory biomarkers, regulate the interaction between immune cells, periodontal ligament cells, osteoblasts, and so on. Read More

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NUTM2A-AS1 silencing alleviates LPS-induced apoptosis and inflammation in dental pulp cells through targeting let-7c-5p/HMGB1 axis.

Int Immunopharmacol 2021 Apr 5;96:107497. Epub 2021 Apr 5.

Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China. Electronic address:

Background: Long non-coding RNA (lncRNA) NUTM2A antisense RNA 1 (NUTM2A-AS1) has been reported to be abnormally up-regulated in pulpitis tissues. However, the function of NUTM2A-AS1 in pulpitis remains unclear. The aim of this study was to investigate the role and working mechanism of NUTM2A-AS1 in pulpitis using lipopolysaccharide (LPS)-treated human dental pulp cells (HDPCs). Read More

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Aberrant expression of cytokines in polycythemia vera correlate with the risk of thrombosis.

Blood Cells Mol Dis 2021 Mar 27;89:102565. Epub 2021 Mar 27.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Background: Thrombo-hemorrhagic complications cause significant morbidity and mortality in patients with polycythemia vera (PV).

Objectives: To assay and correlate inflammatory cytokines with the thrombotic risk in PV patients.

Methods: This prospective observational study was carried out at Postgraduate Institute of Medical Education and Research, Chandigarh, India over 18-months. Read More

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A randomized single-center controlled trial of synchronized intermittent mandatory ventilation with heliox in newborn infants with meconium aspiration syndrome.

Pediatr Pulmonol 2021 Apr 8. Epub 2021 Apr 8.

Department of Neonatology, Chongqing Key Laboratory of Pediatrics, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, National Clinical Research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objective: This study aimed to investigate the beneficial effects of synchronized intermittent mandatory ventilation (SIMV) with heliox in newborn infants with meconium aspiration syndrome (MAS).

Methods: Seventy-one newborn infants with MAS in the neonatal intensive care unit (NICU) of Daping Hospital of Army Medical University were enrolled in the trial. Infants treated with SIMV were randomized and divided into the heliox group (n = 35) and control group (n = 36). Read More

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Triclosan inhibits the activation of human periodontal ligament fibroblasts induced by lipopolysaccharide from .

J Biomed Res 2020 Aug 31:1-10. Epub 2020 Aug 31.

Department of Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China. E-mail:

Periodontitis is a highly prevalent, chronic, non-specific, and immunologically devastating disease of periodontal tissues, caused by microbial infection. This study aims to examine the efficacy and protective mechanism of triclosan (TCS), a bisphenolic, non-cationic component of oral care products, against periodontal inflammation induced by lipopolysaccharide purified from (LPS-PG). TCS markedly downregulated IL-6, IL-8, and IL-15 in human periodontal ligament fibroblasts (HPDLFs) treated with LPS-PG. Read More

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Co-infection with Pseudomonas aeruginosa impacts virulence of Staphylococcus aureus and intensifies the severity of infection.

Pak J Pharm Sci 2020 Sep;33(5):1933-1937

Department of Biotechnology, Dalian Medical University, Dalian, PR China.

Multi-specie infections display diverse interactions among pathogens that influence the severity of disease. Staphylococcus aureus and Pseudomonas aeruginosa are the two most important opportunistic, nosocomial and drug-resistant pathogens. Poly-infections due to S. Read More

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September 2020

Cytokine measurements add value to clinical variables in predicting outcomes for Staphylococcus aureus bacteremia.

BMC Infect Dis 2021 Apr 5;21(1):317. Epub 2021 Apr 5.

Department of Clinical Pharmacy, University of Southern California (USC) School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA, 90089, USA.

Background: We demonstrated that an early dysregulated cytokine response [high interleukin-10 to tissue necrosis factor (IL-10/TNF) ratio] predicted poor outcomes in patients with Staphylococcus aureus bacteremia (SAB). However, high interpatient variability in cytokine levels were observed. We grouped cytokine measurements in quartiles and assessed their additive value to clinical variables for predicting bacterial persistence and 30-day mortality in patients with SAB. Read More

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FAM134B-mediated endoplasmic reticulum autophagy protects against sepsis myocardial injury in mice.

Aging (Albany NY) 2021 Mar 26;13. Epub 2021 Mar 26.

Intensive Care Unit, The Second Affiliated Hospital of Harbin Medical University, Harbin, PR China.

Reticulophagy regulator 1 (RETEG1, also known as FAM134B) plays a crucial role in endoplasmic reticulum autophagy. We aimed to explore the effect of FAM134B-mediated endoplasmic reticulum autophagy in sepsis myocardial injury in mice. Sepsis myocardial injury mice were established via cecal ligation and puncture procedures. Read More

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Enhanced IL-6 and IL-12B Gene Expression After SARS-CoV-2 Infection in Leprosy Patients May Increase the Risk of Neural Damage.

Am J Trop Med Hyg 2021 Apr 5. Epub 2021 Apr 5.

2Programa de Pós-Graduação em Ciências Médicas, Faculdade Medicina, Universidade de Brasília (UnB) Brasília, Brazil.

Experts have called attention to the possible negative impact of the coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome on the progression of leprosy-related disabilities. We assessed the frequency of reactional states in patients co-infected with Mycobacterium leprae and severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 (SARS-CoV-2). We consecutively included patients during the first peak of the COVID-19 epidemic in Brazil and analyzed the expressions of genes encoding interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12A, IL-12B, and tumor necrosis factor-α in peripheral blood mononuclear cells. Read More

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Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats.

Open Life Sci 2021 16;16(1):128-141. Epub 2021 Feb 16.

Department of Neurosurgery, Chongqing Traditional Chinese Medicine Hospital, No. 6 Panxi 7 Branch Road, Jiangbei District, Chongqing 400021, People's Republic of China.

Our current research aims to examine whether protocatechuic acid (PCA) can be used as a therapeutic agent for the development of cerebral aneurysm (CA) and to elucidate the mechanisms behind this. We assessed the effects of PCA at 50 and 100 mg/kg on the activation of signaling pathways for tissue necrosis factor (TNF)-α/nuclear factor (NF)-κB/nuclear factor erythroid 2 (Nrf-2) on progression and development in an elastase-induced CA model, accompanied by a high-salt diet to induce hypertension. The expression of inflammatory cytokines, chemokines, tumor necrosis factor-α, interleukins (IL)-8, IL-17, IL-6, IL-1β, and matrix metalloproteinase (MMP)-2 and MMP-9 was analyzed by ELISA, western blot, and reverse transcriptase quantative polymerase chain reaction. Read More

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February 2021

Differential impacts of trail and ultra-trail running on cytokine profiles: An observational study.

Clin Hemorheol Microcirc 2021 Apr 1. Epub 2021 Apr 1.

Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon, Université de Lyon, Lyon, France.

Background: Endurance running events are known to cause inflammation and result in increased cytokine production. However, the effects of ultramarathons on cytokine profiles are not well characterized.

Objective: The aim of this study was to describe and compare the effects of a trail (40 km) race and an ultra-trail (171 km) race on leukocyte concentrations and cytokine profiles. Read More

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The association of Candida and antifungal therapy with pro-inflammatory cytokines in oral leukoplakia.

Clin Oral Investig 2021 Apr 4. Epub 2021 Apr 4.

Department of Biostatistics, All India Institute of Medical Sciences New Delhi, New Delhi, India.

Objectives: To study the association of Candida and antifungal therapy with pro-inflammatory cytokines (PIC) in oral leukoplakia (OL).

Materials And Methods: A prospective observational study where immunocompetent adult subjects with OL (30 homogenous (HL), 30 non-homogenous (NHL)) and 30 age and sex-matched healthy controls (C) with no predisposing factors for oral Candida infection were recruited. Sterile cotton swabs and ophthalmic sponges were used to sample the lesion surface in OL and buccal mucosa in C, for direct microscopy and culture for Candida and to determine levels of PIC (IL-6, IL-8. Read More

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Activation of alpha7 nicotinic acetylcholine receptor protects bovine endometrial tissue against LPS-induced inflammatory injury via JAK2/STAT3 pathway and COX-2 derived prostaglandin E.

Eur J Pharmacol 2021 Mar 31;900:174067. Epub 2021 Mar 31.

College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, PR China.

Bovine endometritis is one of the major postpartum diseases associated with infertility and subfertility, decreasing the benefit of dairy industry. It is important to develop alternate therapies for endometritis in the context of drug residues in the milk and hormone disorder in the estrous cycle. α7 nicotine acetylcholine receptor has been identified as the core of 'cholinergic anti-inflammatory pathway (CAP)', which is a potential drug target to inflammatory diseases. Read More

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The impact of polyphenols extracted from Tricholoma matsutake on UVB-induced photoaging in mouse skin.

J Cosmet Dermatol 2021 Apr 3. Epub 2021 Apr 3.

Foshan Conney Allan Biotechnology Co. Ltd, Foshan, CN, China.

Background: Despite Tricholoma matsutake has been used as natural health products with multiple medicinal properties, detailed information about its polyphenolic composition as sources of anti-photoaging agents remains to be determined.

Objective: To investigate the impact of polyphenols extracted from Tricholoma matsutake (TME) on Ultraviolet B (UVB)-induced skin photoaging.

Materials And Methods: Various factors of oxidative stress and inflammation as well as histological and immunohistochemical analysis in the mouse dorsal skin were determined after UVB radiation. Read More

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The Independent Role of Body Mass Index (BMI) and Severity of Depressive Symptoms on Biological Changes of Women Affected by Overweight/Obesity.

Int J Environ Res Public Health 2021 Mar 12;18(6). Epub 2021 Mar 12.

Department of Mental Health, ASST Rhodense, 20024 Rho, Italy.

: Both obesity and depression are medical conditions associated with severe disability and biological abnormalities. Our aim was to study associations between Body Mass Index (BMI), depression and biological changes in women affected by overweight or obesity. : Depressive symptoms were evaluated by the Beck Depression Inventory II (BDI-II) questionnaire in 200 women affected by overweight/obesity (mean age of the sample 52. Read More

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Curcumin Alleviates LPS-Induced Oxidative Stress, Inflammation and Apoptosis in Bovine Mammary Epithelial Cells via the NFE2L2 Signaling Pathway.

Toxins (Basel) 2021 Mar 12;13(3). Epub 2021 Mar 12.

Key Laboratory of Zoonosis Research, Ministry of Education, Department of Animal Science, College of Animal Sciences, Jilin University, Changchun 130062, China.

Lipopolysaccharide (LPS) is an endotoxin, which may cause immune response and inflammation of bovine mammary glands. Mastitis impairs animal health and results in economic loss. Curcumin (CUR) is a naturally occurring diketone compound, which has attracted widespread attention as a potential anti-inflammatory antioxidant. Read More

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Cytokine Signature of Dengue Patients at Different Severity of the Disease.

Int J Mol Sci 2021 Mar 12;22(6). Epub 2021 Mar 12.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.

Clinical presentations of dengue fever (DF) are diverse and non-specific, causing unpredictable progression and outcomes. Its progression and severity have been associated with cytokine levels alteration. In this study, dengue patients were classified into groups following the 2009 WHO dengue classification scheme to investigate the cytokine signature at different severity of the disease: dengue without warning sign symptoms (A); dengue with warning signs (B); severe dengue (C); other fever (OF) and healthy (Healthy). Read More

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Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2.

Int J Mol Sci 2021 Mar 30;22(7). Epub 2021 Mar 30.

Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.

The IL-1 family cytokine IL-33 activates and re-shapes mast cells (MCs), but whether and by what mechanisms it elicits cytokines in MCs from human skin remains poorly understood. The current study found that IL-33 activates CCL1, CCL2, IL-5, IL-8, IL-13, and TNF-α, while IL-1β, IL-6, IL-31, and VEGFA remain unaffected in cutaneous MCs, highlighting that each MC subset responds to IL-33 with a unique cytokine profile. Mechanistically, IL-33 induced the rapid (1-2 min) and durable (2 h) phosphorylation of p38, whereas the phosphorylation of JNK was weaker and more transient. Read More

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Effects of Different Dialysis Strategies on Inflammatory Cytokine Profile in Maintenance Hemodialysis Patients with COVID-19: A Randomized Trial.

J Clin Med 2021 Mar 30;10(7). Epub 2021 Mar 30.

Department of Internal Medicine, University of Genova, 16132 Genova, Italy.

Uncontrolled inflammation plays a relevant role in the pathogenesis of coronavirus disease-19 (COVID-19). Here, we studied the time trend of inflammatory markers in a population of hemodialysis (HD) patients affected by COVID-19, undergoing two different dialysis approaches. In a prospective study, thirty-one maintenance HD patients with COVID-19 were randomized to expanded HD (HDx), performed using a medium cut-off membrane, or standard treatment using a protein-leaking dialyzer (PLD). Read More

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Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function.

Int J Mol Sci 2021 Mar 23;22(6). Epub 2021 Mar 23.

G.E.R.N. Research Center for Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Medical Center-Albert-Ludwigs-University of Freiburg, 79085 Freiburg im Breisgau, Germany.

Numerous studies have assembled a complex picture, in which extracellular stimuli and intracellular signaling pathways modulate the chondrocyte phenotype. Because many diseases are mechanobiology-related, this review asked to what extent phenotype regulators control chondrocyte function through the cytoskeleton and cytoskeleton-regulating signaling processes. Such information would generate leverage for advanced articular cartilage repair. Read More

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Inhalationally Administered Semifluorinated Alkanes (SFAs) as Drug Carriers in an Experimental Model of Acute Respiratory Distress Syndrome.

Pharmaceutics 2021 Mar 23;13(3). Epub 2021 Mar 23.

Department of Anaesthesiology and Critical Care Medicine, University Hospital Mannheim, Faculty of Medicine, University of Heidelberg, Theodor-Kutzer Ufer 1-3, 68165 Mannheim, Germany.

Aerosol therapy in patients suffering from acute respiratory distress syndrome (ARDS) has so far failed in improving patients' outcomes. This might be because dependent lung areas cannot be reached by conventional aerosols. Due to their physicochemical properties, semifluorinated alkanes (SFAs) could address this problem. Read More

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Effect of on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice.

Nutrients 2021 Mar 4;13(3). Epub 2021 Mar 4.

Department of Anatomy, College of Korean Medicine, Kyung Hee University, 26, Kyunghee dae-ro, Dongdaemun-gu, Seoul 02447, Korea.

(CP), or Korean red pinecone, is a cluster of fruit. CP has also been verified in several studies to have anti-oxidation, anti-fungal, anti-bacterial, and anti-melanogenic effects. However, anti-inflammatory effects have not yet been confirmed in the inflammatory responses of pinecones to allergic contact dermatitis. Read More

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Associations between Dietary Patterns and Inflammatory Markers during Pregnancy: A Systematic Review.

Nutrients 2021 Mar 4;13(3). Epub 2021 Mar 4.

School of Nursing, University of Rochester, Rochester, NY 14642, USA.

Elevated inflammation in pregnancy has been associated with multiple adverse pregnancy outcomes and potentially an increased susceptibility to future chronic disease. How maternal dietary patterns influence systemic inflammation during pregnancy requires further investigation. The purpose of this review was to comprehensively evaluate studies that assessed dietary patterns and inflammatory markers during pregnancy. Read More

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Efficacy of Alpinumisoflavone Isolated from Fruit in Tumor Necrosis Factor-α-Induced Damage of Human Dermal Fibroblasts.

Antioxidants (Basel) 2021 Mar 25;10(4). Epub 2021 Mar 25.

College of Korean Medicine, Gachon University, Seongnam 13120, Korea.

The skin is an important organ in the human body that protects the body from environmentally hazardous substances. Reactive oxygen species (ROS) cause inflammatory reactions and degradation of the extracellular matrix leading to skin aging and various cutaneous lesions. This study evaluated the potential of isoflavones isolated from fruit to prevent TNF-α-induced skin inflammation in normal human dermal fibroblasts (HDFs). Read More

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Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells.

Int J Mol Sci 2021 Mar 25;22(7). Epub 2021 Mar 25.

Grupo de Terapia Celular y Medicina Regenerativa, Departamento de Fisioterapia, Ciencias Biomédicas y Medicina, Universdidade da Coruña, 15006 A Coruña, Spain.

Mesenchymal stem cells have an important potential in the treatment of age-related diseases. In the last years, small extracellular vesicles derived from these stem cells have been proposed as cell-free therapies. Cellular senescence and proinflammatory activation are involved in the loss of therapeutic capacity and in the phenomenon called inflamm-aging. Read More

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Antioxidant and Anti-Inflammatory Properties of Recombinant BGN4 Expressing Antioxidant Enzymes.

Microorganisms 2021 Mar 13;9(3). Epub 2021 Mar 13.

Department of Food and Nutrition, and Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea.

BGN4-SK (BGN4-SK), a recombinant strain which was constructed from BGN4 (BGN4) to produce superoxide dismutase (SOD) and catalase, was analyzed to determine its antioxidant and anti-inflammatory properties in vitro. Culture conditions were determined to maximize the SOD and catalase activities of BGN4-SK. The viability, intracellular radical oxygen species (ROS) levels, intracellular antioxidant enzyme activities, and pro-inflammatory cytokine levels were determined to evaluate the antioxidant and anti-inflammatory activities of BGN4-SK in human intestinal epithelial cells (HT-29) and murine macrophage cells (RAW 264. Read More

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Serum Concentration of Inflammatory Cytokines in Dogs with Suspected Acute Pancreatitis.

Vet Sci 2021 Mar 18;8(3). Epub 2021 Mar 18.

Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon-si 24341, Korea.

Acute pancreatitis is an acute inflammatory process in the pancreas that is common in dogs. This study was designed to compare cytokines between healthy dogs and dogs with suspected acute pancreatitis. For the canine cytokine antibody array, three healthy dogs and three dogs with suspected acute pancreatitis were included. Read More

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