443 results match your criteria il-33 measured

[Menthol promotes cytokine secretion in human bronchial epithelial BEAS-2B cells by activating transient receptor potential melastatin 8 (TRPM8)].

Yixin Hu Minchao Li

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Jul;37(7):577-584

Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. *Corresponding author, E-mail:

Objective To explore the role of transient receptor potential melastatin 8 (TRPM8) in the expression of airway epithelial-derived cytokines interleukin 25 (IL-25), IL-33 and thymic stromal lymphopoietin (TSLP) in human bronchial epithelial BEAS-2B cells induced by menthol and its related signal transduction mechanism. Methods BEAS-2B cells were treated with 2 mmol/L menthol for 1, 2, 3 and 4 hours. The groups with the higher expression of IL-25, IL-33, TSLP or Ca were chosen to carry out the following experiments. Read More

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Inflammatory cytokines and appetite in older hospitalized patients.

Appetite 2021 Jun 14:105470. Epub 2021 Jun 14.

Department of Geriatric Medicine, Marien Hospital Herne, Ruhr-Universität Bochum, Germany.

It has already been confirmed that the decline in appetite during disease is a common issue and the biologic players of inflammation such as cytokines may serve as mediators of this effect. This study aimed to investigate the association of appetite with individual cytokines that could be involved in the inflammation-associated loss of appetite in acutely ill older hospitalized patients. 191 patients (mean age 81. Read More

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Soluble ST2 is increased in systemic lupus erythematous and is a potential marker of lupus nephritis.

Clin Exp Rheumatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, Belgium.

Objectives: To investigate the role of the interleukin IL-33/ST2 axis in systemic lupus erythematosus (SLE).

Methods: Serum concentrations of IL-33 and sST2 were measured by sandwich ELISA in SLE patients (n=111) compared to sex- and age-matched healthy controls (n=36). The serum concentrations of IL-33 and sST2 were correlated with various clinical and biological parameters. Read More

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Anti-IgE therapy inhibits chemotaxis, proliferation and transformation of circulating fibrocytes in patients with severe allergic asthma.

Respirology 2021 Jun 9. Epub 2021 Jun 9.

Pulmonary Medicine Research Center, Taipei Medical University, Taipei, Taiwan.

Background And Objective: Circulating fibrocytes act as precursors of myofibroblasts, contribute to airway remodelling in chronic asthma and migrate to injured tissues by expressing CXCR4 and CCR7. Anti-IgE therapy improves severe allergic asthma (SAA) control and airway remodelling in T2-high SAA. The effects of anti-IgE therapy on fibrocyte activities were investigated in this study. Read More

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Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma.

Exp Mol Med 2021 Jun 2. Epub 2021 Jun 2.

Department of Pulmonary, Allergy and Critical Care Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Asthma is a chronic eosinophilic inflammatory disease with an increasing prevalence worldwide. Endocannabinoids are known to have immunomodulatory biological effects. However, the contribution of oleoylethanolamide (OEA) to airway inflammation remains to be elucidated. Read More

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Less airway inflammation and goblet cell metaplasia in an IL-33-induced asthma model of leptin-deficient obese mice.

Respir Res 2021 Jun 1;22(1):166. Epub 2021 Jun 1.

Department of Respiratory Medicine, Tokyo Women's Medical University, Tokyo, 162-8666, Japan.

Background: Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulatory effect. Read More

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IL-16 and BCA-1 Serum Levels Are Associated with Disease Severity of Infection.

Pathogens 2021 May 20;10(5). Epub 2021 May 20.

The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.

infection (CDI) is associated with a high risk for complications and death, which requires identifying severe patients and treating them accordingly. We examined the serum level of six cytokines and chemokines (IL-16, IL-21, IL-23, IL-33, BCA-1, TRAIL) and investigated the association between them and patients' disease severity. Concentrations of six cytokines and chemokines were measured using the MILLIPLEXMAP kit (Billerica, MA, USA) in serum samples attained from CDI patients within 24-48 h after laboratory confirmation of presence. Read More

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Ginsenoside Rh1 attenuates ovalbumin-induced asthma by regulating Th1/Th2 cytokines balance.

Biosci Biotechnol Biochem 2021 May 31. Epub 2021 May 31.

Department of Geriatrics, Hangzhou Red Cross Hospital, Xiacheng District, Hangzhou City, Zhejiang Province, 310000, China.

Ginsenoside Rh1 (Rh1) has anti-inflammatory effects in asthma mice, but the underlying mechanism remains unclear. BALB/c mice were sensitized and challenged with ovalbumin (OVA) to construct asthma model. Mice received Rh1 or Tiotropium Bromide 0. Read More

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The effect of erythrocyte transfusion on macrophage pyroptosis and inflammation in a sepsis model.

Adv Clin Exp Med 2021 May 25. Epub 2021 May 25.

Department of Anesthesiology, Shanghai Gongli Hospital, The Second Military Medical University, China.

Background: Sepsis is one of most common causes of death in the intensive care unit (ICU) due to infection and inflammation. The Duffy antigen receptor for chemokines (DARC) regulates pro-inflammatory cytokines, thus playing an important role in inflammation.

Objectives: This study aimed to elucidate the correlation among erythrocyte transfusion, macrophage pyroptosis and inflammation in the progression of sepsis. Read More

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Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin.

Exp Biol Med (Maywood) 2021 May 22:15353702211012417. Epub 2021 May 22.

Department of Pathology, Faculty of Medicine, Trakya University, Edirne 22030, Turkey.

Chronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance and glucose, lipid and protein metabolism. However, it is unclear whether these peptides may exert effects on renal damage, tissue remodeling, and inflammatory conditions. Read More

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Mapping Rora expression in resting and activated CD4+ T cells.

PLoS One 2021 18;16(5):e0251233. Epub 2021 May 18.

EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.

The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an emphasis on Th2 cells, both in vitro as well as in the context of several in vivo type 2 infection models. We dissect the function of Rora using overexpression and a CD4-conditional Rora-knockout mouse, as well as a RORA-reporter mouse. Read More

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Efficacy of parasternal block to decrease intraoperative opioid use in coronary artery bypass surgery via sternotomy: a randomized controlled trial.

Reg Anesth Pain Med 2021 May 14. Epub 2021 May 14.

Clinical Research Department, CMC Ambroise Paré, Neuilly-sur-Seine, France.

Objective: This study aims to assess the effect of a preoperative parasternal plane block (PSB) on opioid consumption required to maintain hemodynamic stability during sternotomy for coronary artery bypass graft surgery.

Methods: This double-blind, randomized, placebo-controlled trial prospectively enrolled 35 patients scheduled for coronary artery bypass graft surgery under general anesthesia with propofol and remifentanil. Patients were randomized to receive preoperative PSB using either ropivacaine (PSB group) or saline solution (placebo group) (1:1 ratio). Read More

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Aggravation of airway inflammation in RSV-infected asthmatic mice following infection-induced alteration of gut microbiota.

Ann Palliat Med 2021 May 10;10(5):5084-5097. Epub 2021 May 10.

Department of Traditional Chinese Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: This study aimed to confirm the relationship between asthma, respiratory syncytial virus (RSV) infection, and the gut environment by analyzing the alterations in the gut microbiota of RSV-infected asthmatic mice.

Methods: Twenty-four male BALB/c mice were randomly separated into a control group (CON), ovalbumin (OVA) group, and an OVA + RSV group, (n=8 mice/group). At the end of experiments, we evaluated the RSV-infected asthma model using Wright-Giemsa staining, histopathology and immunoglobulin E (IgE) level using enzyme-linked immunosorbent assays (ELISA). Read More

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The presence of Tularemia infection in patients with Japanese spotted fever.

J Dermatol 2021 May 5. Epub 2021 May 5.

Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.

In our previous study, by measuring serum cytokine levels in the acute and recovery stage of Japanese spotted fever (JSF), IFN-ɤ and IL-6 were proved to be the critical immunological cytokines against Rickettsia japonica (R. japonica) infection. Tularemia is an infectious disorder caused by tick biting or contact with infected animals, and is also known as rabbit fever. Read More

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Molecular hydrogen alleviates asthma through inhibiting IL-33/ILC2 axis.

Inflamm Res 2021 May 14;70(5):569-579. Epub 2021 Apr 14.

Department of Respiratory Medicine, Changhai Hospital, Navy Medical University, Shanghai, 200433, China.

Background: Asthma is one of the most common noninfectious chronic diseases characterized by type II inflammation. This study aimed to investigate the effects of molecular hydrogen on the pathogenesis of asthma.

Methods: OVA sensitized asthma mouse model and house dust mite treated 16HBE cellular model were established and hydrogen/oxygen mixture was used to treat asthmatic mice and 16HBE cells. Read More

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IL-33 in Mental Disorders.

Medicina (Kaunas) 2021 Mar 26;57(4). Epub 2021 Mar 26.

School and Operative Unit of Allergy and Clinical Immunology, Policlinico "G. Martino", Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Mental disorders are common in the general population; every year about 25% of the total European population is affected by a mental condition. The prevalence of psychiatric disorders might be underestimated. Emerging evidence highlights the role of immune response as a key factor in MDs. Read More

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Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study.

Mol Med 2021 03 26;27(1):29. Epub 2021 Mar 26.

Department of Anaesthesiology, Division of Emergencies and Critical Care, Oslo University Hospital Ullevål, Oslo, Norway.

Background: Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma. Read More

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IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway.

Mol Med Rep 2021 May 24;23(5). Epub 2021 Mar 24.

Department of Clinical Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250012, P.R. China.

Gastric cancer (GC) remains one of the commonest malignant tumors and the second leading cause of cancer‑related deaths worldwide. IL‑33 is highly expressed in tumor tissues and serum of patients with GC. However, the function of the IL‑33 and IL‑33 receptor ST2 in the malignant progression of GC is yet to be elucidated. Read More

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Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients.

PLoS One 2021 23;16(3):e0248853. Epub 2021 Mar 23.

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

Hyperglycemia during sepsis is associated with increased organ dysfunction and higher mortality. The role of the host immune response in development of hyperglycemia during sepsis remains unclear. We performed a retrospective analysis of critically ill adult septic patients requiring mechanical ventilation (n = 153) to study the relationship between hyperglycemia and ten markers of the host injury and immune response measured on the first day of ICU admission (baseline). Read More

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Analysis and validation of human targets and treatments using a hepatocellular carcinoma-immune humanized mouse model.

Hepatology 2021 Mar 18. Epub 2021 Mar 18.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.

Background & Aims: Recent development of multiple treatments for human hepatocellular carcinoma (HCC) has allowed us to select combination therapy to enhance the effectiveness of monotherapy. Optimal selection of therapies bases on both HCC and its microenvironment. Therefore, it is critical to develop and validate new pre-clinical animal models for testing clinical therapeutic solutions. Read More

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Immunoinflammatory Biomarkers in Serum Are Associated with Disease Severity in Atopic Dermatitis.

Dermatology 2021 Mar 17:1-8. Epub 2021 Mar 17.

Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: A growing body of evidence links various biomarkers to atopic dermatitis (AD). Still, little is known about the association of specific biomarkers to disease characteristics and severity in AD.

Objective: To explore the relationship between various immunological markers in the serum and disease severity in a hospital cohort of AD patients. Read More

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Association between plasma interleukin-33 level and acute exacerbation of chronic obstructive pulmonary disease.

BMC Pulm Med 2021 Mar 15;21(1):86. Epub 2021 Mar 15.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpodaero, Seochogu, Seoul, 06591, Republic of Korea.

Background: The role of interleukin (IL)-33 in patients with chronic obstructive pulmonary disease (COPD) has not been well elucidated. The aim of this study is to analyze the association between plasma IL-33 level and acute exacerbation of COPD.

Methods: Plasma IL-33 was measured in 62 COPD patients during their stable state. Read More

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IL-33 Is Involved in the Anti-Inflammatory Effects of Butyrate and Propionate on TNFα-Activated Endothelial Cells.

Int J Mol Sci 2021 Feb 28;22(5). Epub 2021 Feb 28.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands.

Short-chain fatty acids (e.g., butyrate and propionate) are able to diminish endothelial cell activation. Read More

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February 2021

Chamaecyparis obtusa Essential Oil Inhibits House Dust Mite Induced Nasal Epithelial Cell Activation and Immune Responses.

J Oleo Sci 2021 ;70(3):431-438

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Catholic University of Daegu.

Essential oils extracted from plants contain protective volatile compounds and are known to processes antibacterial, antifungal, anti-oxidative, and anti-inflammatory effects. This study was conducted to explore the immunomodulatory effects of essential oil extracted from Chamaecyparis obtusa (EOCO) on house dust mite-induced mucosal inflammation. Cultured primary nasal epithelial cells were stimulated with Dermatophagoides pteronyssinus (DP), and Dermatophagoides farina (DF) for 48 h. Read More

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January 2021

A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis.

Asian Pac J Allergy Immunol 2021 Feb 21. Epub 2021 Feb 21.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.

Background: Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD). Although AIP and IgG4-RD are characterized by multiple organ involvement including salivary glands, lung, and kidney, co-occurrence of chronic rhinosinusitis (CRS) and AIP/IgG4-RD has been poorly defined.

Objective: We explored molecular mechanism accounting for the co-occurrence of CRS and AIP/IgG4-RD. Read More

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February 2021

The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization.

Cancer Biol Med 2021 Feb;18(1):172-183

Key Laboratory of Pathobiology, Ministry of Education, Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun 130000, China.

Objective: Macrophages are a major component of the tumor microenvironment. M1 macrophages secrete pro-inflammatory factors that inhibit tumor growth and development, whereas tumor-associated macrophages (TAMs) mainly exhibit an M2 phenotype. Our previous studies have shown that the interleukin-33/ST2 (IL-33/ST2) axis is essential for activation of the M1 phenotype. Read More

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February 2021

Relationship Between Semen IL-6, IL-33 and Malondialdehyde Generation in Human Seminal Plasma and Spermatozoa.

Reprod Sci 2021 Feb 23. Epub 2021 Feb 23.

Department of Molecular and Developmental Medicine, University of Siena, 53100, Siena, Italy.

Cytokines are physiological seminal components and their abnormal levels, reported in different pathological conditions, negatively influence the sperm function. We analysed the relationship between interleukin (IL)-6 and IL-33 levels and lipid peroxidation (LPO), measured both in semen and sperm lysate, in 44 human semen samples. The semen analysis was performed following the WHO guidelines. Read More

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February 2021

Role of the IL-33/ST2 axis in cigarette smoke-induced airways remodelling in chronic obstructive pulmonary disease.

Thorax 2021 Feb 15. Epub 2021 Feb 15.

Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China

Background: Efficient therapy and potential prophylaxis are confounded by current ignorance of the pathogenesis of airway remodelling and blockade in COPD.

Objective: To explore the role of the IL-33/ST2 axis in cigarette smoke (CS) exposure-induced airways remodelling.

Methods: C57BL/6, BALB/c and mice exposed to CS were used to establish an animal surrogate of COPD (air-exposed=5~8, CS-exposed=6~12). Read More

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February 2021

Glucagon-like peptide 1 receptor (GLP-1R) agonist relieved asthmatic airway inflammation via suppression of NLRP3 inflammasome activation in obese asthma mice model.

Pulm Pharmacol Ther 2021 Apr 12;67:102003. Epub 2021 Feb 12.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Background: Obesity is a correctable factor for uncontrolled bronchial asthma. However, the effects of glucagon-like peptide-1 receptor (GLP-1R) agonist, a recently approved antiobestic drug, on airway hyperresponsiveness (AHR) and immune responses are not known.

Methods: Mice were fed with high-fat diet (HFD, 60% fat) for 8 weeks to induce obesity. Read More

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Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults.

J Transl Med 2021 02 4;19(1):52. Epub 2021 Feb 4.

Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.

Background: Interleukin-33 (IL-33) plays a pivotal role in regulating innate immune response and metabolic homeostasis. However, whether its circulating level is correlated with obesity and metabolic disorders in humans remains largely unknown. We aimed to address this gap by determining IL-33 serum level and its downstream type 2 inflammatory cytokines interleukin-5 (IL-5) and interleukin-13 (IL-13) in overweight/obese population, and analyzing the specific associations between IL-33 and obesity metabolic phenotypes. Read More

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February 2021