1,024 results match your criteria il-33 gene


Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Pathology.

J Pathol 2021 07;254(4):303-306

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

The 2021 Annual Review Issue of The Journal of Pathology contains 14 invited reviews on current research areas of particular importance in pathology. The subjects included here reflect the broad range of interests covered by the journal, including both basic and applied research fields but always with the aim of improving our understanding of human disease. This year, our reviews encompass the huge impact of the COVID-19 pandemic, the development and application of biomarkers for immune checkpoint inhibitors, recent advances in multiplexing antigen/nucleic acid detection in situ, the use of genomics to aid drug discovery, organoid methodologies in research, the microbiome in cancer, the role of macrophage-stroma interactions in fibrosis, and TGF-β as a driver of fibrosis in multiple pathologies. Read More

View Article and Full-Text PDF

Immune and Repair Responses in Joint Tissues and Lymph Nodes after Knee Arthroplasty Surgery in Mice.

J Bone Miner Res 2021 Jun 2. Epub 2021 Jun 2.

Research Institute, Hospital for Special Surgery, New York, NY, USA.

The importance of a local tissue immune response in healing injured tissues such as skin and lung is well established. Little is known about whether sterile wounds elicit lymph node (LN) responses and inflammatory responses after injury of musculoskeletal tissues that are mechanically loaded during the repair response. We investigated LN and tissue immune responses in a tibial implant model of joint replacement surgery where wounded tissue is subjected to movement and mechanical loading postoperatively. Read More

View Article and Full-Text PDF

Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver.

Cells 2021 May 24;10(6). Epub 2021 May 24.

Research Center for Endocrine and Metabolic Diseases, School of Medicine, Chungnam National University, 282 Munhwaro, Daejeon 35015, Korea.

Interleukin-4 (IL-4) and IL-13 are the major T helper 2 (Th2) cytokines, and they are involved in the regulation of metabolism in the adipose tissue. The liver contains diverse innate and adaptive immune cells, but it remains to be determined whether Th2 cytokines modulate energy metabolism in the liver. Here, using gene expression data from the Gene Expression Omnibus (GEO) and the BXD mouse reference population, we determined that the Th2 cytokines IL-4 and IL-13 increase the secretion of fibroblast growth factor 21 (FGF21) in the liver. Read More

View Article and Full-Text PDF

Proinflammatory Interleukin-33 Induces Dichotomic Effects on Cell Proliferation in Normal Gastric Epithelium and Gastric Cancer.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Health Sciences, Università degli Studi di Milano, 20133 Milano, Italy.

Interleukin (IL)-33 is a member of the interleukin (IL)-1 family of cytokines linked to the development of inflammatory conditions and cancer in the gastrointestinal tract. This study is designed to investigate whether IL-33 has a direct effect on human gastric epithelial cells (GES-1), the human gastric adenocarcinoma cell line (AGS), and the gastric carcinoma cell line (NCI-N87) by assessing its role in the regulation of cell proliferation, migration, cell cycle, and apoptosis. Cell cycle regulation was also determined in ex vivo gastric cancer samples obtained during endoscopy and surgical procedures. Read More

View Article and Full-Text PDF

Effects of Deacetylasperulosidic Acid on Atopic Dermatitis through Modulating Immune Balance and Skin Barrier Function in HaCaT, HMC-1, and EOL-1 Cells.

Molecules 2021 May 30;26(11). Epub 2021 May 30.

Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

The medicinal plant noni () is widely dispersed throughout Southeast Asia, the Caribbean, and Australia. We previously reported that fermented Noni could alleviate atopic dermatitis (AD) by recovering Th1/Th2 immune balance and enhancing skin barrier function induced by 2,4-dinitrochlorobenzene. Noni has a high deacetylasperulosidic acid (DAA) content, whose concentration further increased in fermented noni as an iridoid constituent. Read More

View Article and Full-Text PDF

Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin.

Exp Biol Med (Maywood) 2021 May 22:15353702211012417. Epub 2021 May 22.

Department of Pathology, Faculty of Medicine, Trakya University, Edirne 22030, Turkey.

Chronic kidney disease is a major global public health problem. The peptide hormones adropin and spexin modulate many physiological functions such as energy balance and glucose, lipid and protein metabolism. However, it is unclear whether these peptides may exert effects on renal damage, tissue remodeling, and inflammatory conditions. Read More

View Article and Full-Text PDF

Mapping Rora expression in resting and activated CD4+ T cells.

PLoS One 2021 18;16(5):e0251233. Epub 2021 May 18.

EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom.

The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an emphasis on Th2 cells, both in vitro as well as in the context of several in vivo type 2 infection models. We dissect the function of Rora using overexpression and a CD4-conditional Rora-knockout mouse, as well as a RORA-reporter mouse. Read More

View Article and Full-Text PDF

TLR7 Agonist Suppresses ILC2-mediated Inflammation via IL-27-producing Interstitial Macrophages.

Am J Respir Cell Mol Biol 2021 May 18. Epub 2021 May 18.

Keio University School of Medicine, Pulmonary Medicine, Shinjuku-ku, Japan.

Group 2 innate lymphoid cells (ILC2s) play an important role in the pathophysiology of asthma via the robust production of type 2 cytokines. Recent studies have demonstrated that Toll-like receptor 7 (TLR7) signaling skews toward a type 1 inflammatory response in asthma, which may lead to the development of novel treatment strategies. However, the effect of TLR7 signaling on ILC2-dependent non-allergic eosinophilic inflammation remains unclear. Read More

View Article and Full-Text PDF

Adipose-mesenchymal stromal cells suppress experimental Sjögren syndrome by IL-33-driven expansion of ST2 regulatory T cells.

iScience 2021 May 16;24(5):102446. Epub 2021 Apr 16.

Mucosal Immunology Section, NIDCR, NIH, Bethesda, MD 20892, USA.

Adipose-derived mesenchymal stromal cells (ADSCs) play important roles in the alleviation of inflammation and autoimmune diseases. Interleukin-33 (IL-33), a member of the IL-1 family, has been shown to regulate innate and adaptive immunity. However, it is still unknown whether ADSCs regulate immune responses via IL-33. Read More

View Article and Full-Text PDF

Colonic epithelial cathelicidin (LL-37) expression intensity is associated with progression of colorectal cancer and presence of CD8 T cell infiltrate.

J Pathol Clin Res 2021 May 14. Epub 2021 May 14.

Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.

Colorectal cancer (CRC) remains a leading cause of cancer mortality. Here, we define the colonic epithelial expression of cathelicidin (LL-37) in CRC. Cathelicidin exerts pleotropic effects including anti-microbial and immunoregulatory functions. Read More

View Article and Full-Text PDF

Epigenetic regulation of epithelial dectin-1 through an IL-33-STAT3 axis in allergic disease.

Allergy 2021 May 12. Epub 2021 May 12.

Department of Otolaryngology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Allergic diseases arise in susceptible individuals in part because of decrements in protective pathways. The mechanism by which these anti-inflammatory molecules become repressed remains unclear. We have previously reported that epithelial dectin-1 prevents aberrant type 2 responses and is downregulated in the epithelium of allergic patients. Read More

View Article and Full-Text PDF

Role of IL-36γ/IL-36R Signaling in Corneal Innate Defense Against Candida albicans Keratitis.

Invest Ophthalmol Vis Sci 2021 May;62(6):10

Departments of Ophthalmology and Anatomy and Cell Biology Wayne State University School of Medicine, Detroit, Michigan, United States.

Purpose: Interleukin (IL)-36 cytokines have been shown to play either beneficial or detrimental roles in the infection of mucosal tissues in a pathogen-dependent manner, but their involvement in fungal keratitis remains elusive. We herein investigated their expression and function in mediating corneal innate immunity against Candida albicans infection.

Methods: Gene expression in mouse corneas with or without C. Read More

View Article and Full-Text PDF

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.

Nat Commun 2021 05 5;12(1):2538. Epub 2021 May 5.

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.

Group 2 innate lymphoid cells (ILC2s) play a critical role in protection against helminths and in diverse inflammatory diseases by responding to soluble factors such as the alarmin IL-33, that is often overexpressed in cancer. Nonetheless, regulatory factors that dictate ILC2 functions remain poorly studied. Here, we show that peroxisome proliferator-activated receptor gamma (PPARγ) is selectively expressed in ILC2s in humans and in mice, acting as a central functional regulator. Read More

View Article and Full-Text PDF

Na/H Exchanger Regulatory Factor 1 Mediates the Pathogenesis of Airway Inflammation in a Murine Model of House Dust Mite-Induced Asthma.

J Immunol 2021 May 5;206(10):2301-2311. Epub 2021 May 5.

Department of Physiology, Michigan State University, East Lansing, MI

Na/H exchanger regulatory factor 1 (NHERF1), a class I PDZ-binding protein, regulates G protein-coupled receptor signaling in some cell types. NHERF1 also functions as a scaffolding protein and activates non-G protein-coupled receptor signaling pathways, thereby contributing to the pathogenesis of various diseases. Although we have previously shown that NHERF1 regulates mast cell functions, there is little information regarding the role of NHERF1 in other immune cells. Read More

View Article and Full-Text PDF

Epithelial miR-206 targets CD39/extracellular ATP to upregulate airway IL-25 and TSLP in type 2-high asthma.

JCI Insight 2021 Jun 8;6(11). Epub 2021 Jun 8.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The epithelial cell-derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) initiate type 2 inflammation in allergic diseases, including asthma. However, the signaling pathway regulating these cytokines expression remains elusive. Since microRNAs are pivotal regulators of gene expression, we profiled microRNA expression in bronchial epithelial brushings from type 2-low and type 2-high asthma patients. Read More

View Article and Full-Text PDF

Repeated exposure of house dust mite induces progressive airway inflammation in mice: Differential roles of CCL17 and IL-13.

Pharmacol Res Perspect 2021 May;9(3):e00770

Discovery Immunology, Janssen Research & Development, LLC, Spring House, PA, USA.

We conducted a systematic evaluation of lung inflammation indued by repeated intranasal exposure (for 10 consecutive days) to a human aeroallergen, house dust mite (HDM) in BALB/c mice. Peak influx of neutrophils, monocytes/lymphocytes, and eosinophils was observed in bronchoalveolar lavage (BAL) on days 1, 7 and 11, respectively, and normalized to baseline by day 21. Peak elevations of Th2, myeloid-derived cytokines/chemokines and serum IgE were seen both in BAL and lung tissue homogenates between days 7 and 11, and declined thereafter; however, IL-33 levels remained elevated from day 7 to day 21. Read More

View Article and Full-Text PDF

NLRP3-Inflammasome Inhibition during Respiratory Virus Infection Abrogates Lung Immunopathology and Long-Term Airway Disease Development.

Viruses 2021 04 16;13(4). Epub 2021 Apr 16.

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

Respiratory syncytial virus (RSV) infects most infants by two years of age. It can cause severe disease leading to an increased risk of developing asthma later in life. Previously, our group has shown that RSV infection in mice and infants promotes IL-1β production. Read More

View Article and Full-Text PDF

Interleukin-33 modulates lipopolysaccharide-mediated inflammatory response in rat primary astrocytes.

Neuroreport 2021 May;32(8):694-701

Department of Anesthesiology, Xiangya Hospital.

Astrocytes have a crucial role in the modulation of the neuroinflammatory response. However, the underlying mechanisms have yet to be fully defined. Interleukin-33 (IL-33) is constitutively expressed in astrocytes, which has been found to orchestrate inflammatory responses in a large variety of immune-mediated and inflammatory diseases of the nervous system. Read More

View Article and Full-Text PDF

Immunoregulatory Effects of Somatic Extract of on Airway Inflammations in Murine Model.

Iran J Parasitol 2020 Oct-Dec;15(4):500-510

Victor Caeiro Laboratory of Parasitology, MED-Mediterranean Institute for Agriculture, Environment and Development, Department of Veterinary Medicine, IIFA, University of Évora, Pólo da Mitra, Évora, Portugal.

Background: The immunomodulatory role of many parasites is well-documented. The current study designed to assess the immunoregulatory effects of the somatic extract (SE) of on murine model of airway inflammations.

Methods: The experiment was performed in department of parasitology of Tarbiat Mo-dares University, Tehran, Iran from November 2018 to May 2019. Read More

View Article and Full-Text PDF

Regulation of osteoclastogenesis by mast cell in rheumatoid arthritis.

Arthritis Res Ther 2021 04 21;23(1):124. Epub 2021 Apr 21.

Division of Rheumatology, Department of Internal Medicine, Research Institute of Medical Science, Konkuk University School of Medicine, 120-1 Neungdong-ro, Gwangjin-gu, Seoul, 05030, South Korea.

Background: In the pathogenesis of rheumatoid arthritis (RA), the role of mast cells has not been revealed clearly. We aimed to define the inflammatory and tissue-destructive roles of mast cells in rheumatoid arthritis (RA).

Methods: Serum and synovial fluid (SF) concentration levels of tryptase, chymase, and histamine were quantified using ELISA. Read More

View Article and Full-Text PDF

Genetic Association of Interleukin 33/ST2 Polymorphisms With Behcet's Uveitis.

Front Immunol 2021 25;12:589639. Epub 2021 Mar 25.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Interleukin (IL)33, a member of the IL1 superfamily, functions as a nuclear factor and mediates biological effects by interacting with the ST2 receptor. Recent studies have described IL33 as an emerging pro-inflammatory cytokine in the immune system, and / gene polymorphisms have been implicated in the pathogenesis of various immune diseases. However, the underlying mechanisms of in Behcet's disease (BD) remain to be defined. Read More

View Article and Full-Text PDF

A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression.

Cell Rep 2021 Apr;35(2):108997

Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA; Department of Neurology, University of California Irvine, Irvine, CA, USA. Electronic address:

Despite the well-accepted view that chronic inflammation contributes to the pathogenesis of Duchenne muscular dystrophy (DMD), the function and regulation of eosinophils remain an unclear facet of type II innate immunity in dystrophic muscle. We report the observation that group 2 innate lymphoid cells (ILC2s) are present in skeletal muscle and are the principal regulators of muscle eosinophils during muscular dystrophy. Eosinophils were elevated in DMD patients and dystrophic mice along with interleukin (IL)-5, a major eosinophil survival factor that was predominantly expressed by muscle ILC2s. Read More

View Article and Full-Text PDF

CDX2 regulates interleukin-33 gene expression in intestinal epithelial cells (LS174T).

FEBS Open Bio 2021 Jun 2;11(6):1638-1644. Epub 2021 May 2.

Department of Science and Environment, Roskilde University, Denmark.

Dysregulation of interleukin-33 (IL-33) has been implicated in the pathogenesis of several autoimmune and inflammatory diseases, but few studies have examined transcriptional regulation of the IL33 gene. In the intestines, gene regulation is controlled by a transcription factor network of which the intestinal-specific transcription factor CDX2 is a key component. In this study, we investigated whether CDX2 regulates IL33 mRNA expression. Read More

View Article and Full-Text PDF

The central role of IL-33/IL-1RL1 pathway in asthma: From pathogenesis to intervention.

Pharmacol Ther 2021 Apr 2;225:107847. Epub 2021 Apr 2.

University of Groningen, University Medical Centre Groningen, Department of Pathology and Medical Biology, Laboratory of Experimental Pulmonology and Inflammation Research (EXPIRE), Groningen, the Netherlands; University of Groningen University Medical Centre Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands. Electronic address:

Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor, Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma. In response to cellular damage, IL-33 is released from barrier tissues as an 'alarmin' to activate the innate immune response. IL-33 drives type 2 responses by inducing signalling through its receptor IL-1RL1 in several immune and structural cells, thereby leading to type 2 cytokine and chemokine production. Read More

View Article and Full-Text PDF

IL-13 modulates ∆Np63 levels causing altered expression of barrier- and inflammation-related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis.

Immun Inflamm Dis 2021 Apr 1. Epub 2021 Apr 1.

Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

Background: Barrier disruption and an excessive immune response in keratinocytes are now considered to have important roles in the pathophysiology of atopic dermatitis (AD). Furthermore, disturbed keratinocyte differentiation is considered to underlie AD. ΔNp63, a p53-like transcription factor, is a major regulator of keratinocyte differentiation. Read More

View Article and Full-Text PDF

Long-acting muscarinic antagonist regulates group 2 innate lymphoid cell-dependent airway eosinophilic inflammation.

Allergy 2021 Mar 31. Epub 2021 Mar 31.

Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Background: Tiotropium bromide, a long-acting muscarinic antagonist, reduces the frequency of exacerbation in patients with moderate to severe asthma, but its underlying mechanism is not clear. Asthma exacerbations are associated with exposure to external stimuli, and group 2 innate lymphoid cells (ILC2s) are considered to be involved in the pathophysiology of asthma exacerbation. We investigated whether tiotropium modulates airway inflammation through ILC2 functions. Read More

View Article and Full-Text PDF

IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway.

Mol Med Rep 2021 May 24;23(5). Epub 2021 Mar 24.

Department of Clinical Laboratory, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250012, P.R. China.

Gastric cancer (GC) remains one of the commonest malignant tumors and the second leading cause of cancer‑related deaths worldwide. IL‑33 is highly expressed in tumor tissues and serum of patients with GC. However, the function of the IL‑33 and IL‑33 receptor ST2 in the malignant progression of GC is yet to be elucidated. Read More

View Article and Full-Text PDF

Analysis and validation of human targets and treatments using a hepatocellular carcinoma-immune humanized mouse model.

Hepatology 2021 Mar 18. Epub 2021 Mar 18.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 138673, Singapore, Singapore.

Background & Aims: Recent development of multiple treatments for human hepatocellular carcinoma (HCC) has allowed us to select combination therapy to enhance the effectiveness of monotherapy. Optimal selection of therapies bases on both HCC and its microenvironment. Therefore, it is critical to develop and validate new pre-clinical animal models for testing clinical therapeutic solutions. Read More

View Article and Full-Text PDF

Shenlian extract protects against ultrafine particulate matter-aggravated myocardial ischemic injury by inhibiting inflammation response via the activation of NLRP3 inflammasomes.

Environ Toxicol 2021 Jul 17;36(7):1349-1361. Epub 2021 Mar 17.

Artemisinin Research Center, China Academy of Chinese Medical Sciences, Beijing, China.

Air pollution is a growing public health burden associated with several negative health effects, especially cardiovascular disease. Shenlian extract (SL), a traditional Chinese medicine, has the effects of clearing heat-toxin and promoting blood circulation for removing blood stasis, and it has long been used to treat cardiovascular diseases and atherosclerosis. This study explored the underlying action mechanism of SL against ultrafine particle-induced myocardial ischemic injury (UFP-MI) through network pharmacology prediction and experimental verification. Read More

View Article and Full-Text PDF

Interleukin-1 Blockade in Polygenic Autoinflammatory Disorders: Where Are We now?

Front Pharmacol 2020 26;11:619273. Epub 2021 Jan 26.

Department of Paediatric and Adult Rheumatology, University Hospital Motol, Prague, Czechia.

Polygenic autoinflammatory diseases (AIDs), such as systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease, Kawasaki disease, idiopathic recurrent pericarditis (IRP), Behçet's Syndrome, Crystal-induced arthropatihes such as gout or Calcium pyrophosphate deposition disease are characterized by the overexpression of inflammasome-associated genes, leading to a dysregulation of the innate immune response. The IL-1 cytokine family (IL-1α, IL-1β, IL-1Ra, IL-18, IL-36Ra, IL-36α, IL-37, IL-36β, IL-36g, IL-38, IL-33) was defined to be principally responsible for the inflammatory nature of polygenic AIDs. Several clinical trials were initiated, and IL-1 blockade has been proven to cause a rapid reduction of clinical symptoms and normalization of laboratory parameters in the majority of cases. Read More

View Article and Full-Text PDF
January 2021