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Opening Wedge High Tibial Osteotomy with High Hinge Position Risks Lateral Hinge Fracture in Males with Posterolateral Tibial Condyle Protrusion.

Arthroscopy 2022 Aug 9. Epub 2022 Aug 9.

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Purpose: The primary aim of this study was to evaluate the 3D morphology of the proximal tibia around the osteotomy plane in open-wedge high tibial osteotomy (OWHTO), focusing on the posterolateral (PL) and posteromedial (PM) tibial condyles, and to clarify the changes in morphological parameters due to differences in patient characteristics and hinge position. The secondary aim was to examine whether morphological features were associated with insufficient osteotomy, which increases the risk of lateral hinge fracture (LHF).

Methods: The PL and PM anteroposterior distance, asymmetry ratio, and discrepancy between PL and PM distances along the tibial osteotomy plane were measured. Read More

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Core Decompression Versus Nonoperative Management of Osteonecrosis of the Ankle: A Systematic Review.

Surg Technol Int 2022 08 12;41. Epub 2022 Aug 12.

Center for Joint Preservation and Replacement, Sinai Hospital of Baltimore, Rubin Institute for Advanced Orthopedics, Baltimore, Maryland.

Introduction: The purpose of this study is to investigate the efficacy of core decompression for treating osteonecrosis of the ankle, including the distal tibia and talus, compared to nonoperative management. A systematic review was performed to specifically evaluate: (1) clinical results (patient-reported pain as well as functional scores, physician clinical reported assessment); (2) radiographic outcomes (i.e. Read More

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Correlation between endoscopic resection outcomes and endosonographic findings in gastric tumors with muscularis propria origin.

Medicine (Baltimore) 2022 Aug;101(32):e29947

Gastroenterologic Division, Department of Internal Medicine, Presbyterian Medical Center, Jeonju City, South Korea.

Endoscopic resection is an effective treatment for subepithelial tumors arising from the muscularis propria layer of the stomach. However, the invasion pattern revealed by the pathological examination of tumor specimens is often not consistent with the findings of preprocedural endoscopic ultrasounds (EUS). We compared the real growing patterns of tumors, as evaluated on histopathological examination, with their EUS images, and analyzed the outcomes of endoscopic resections in relation to the EUS findings. Read More

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The Effect of Sarcopenia and Metabolic PET-CT Parameters on Survival in Locally Advanced Non-Small Cell Lung Carcinoma.

Nutr Cancer 2022 Aug 12:1-10. Epub 2022 Aug 12.

Department of Nuclear Medicine, Recep Tayyip Erdogan University Education and Research Hospital, Rize, Turkey.

The treatment of stage III non-small cell lung cancer (NSCLC) is complex. Here, we aimed to examine the prognostic utility of sarcopenia and metabolic muscle volumes and evaluate their relationship with oncological treatments in patients with locally advanced NSCLC. Patients with unresectable stage III NSCLC were evaluated retrospectively. Read More

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The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia.

Front Pharmacol 2022 26;13:886514. Epub 2022 Jul 26.

Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz, INiBICA, Hospital Universitario Puerta del Mar, Cádiz, Spain.

There is evidence that in schizophrenia, imbalances in inflammatory and oxidative processes occur during pregnancy and in the early postnatal period, generating interest in the potential therapeutic efficacy of anti-inflammatory and antioxidant compounds. Mangiferin is a polyphenolic compound abundant in the leaves of that has robust antioxidant and anti-inflammatory properties, making it a potential candidate for preventive or co-adjuvant therapy in schizophrenia. Hence, this study set-out to evaluate the effect of mango leaf extract (MLE) in a model of schizophrenia based on maternal immune activation, in which Poly I:C (4 mg/kg) is administered intravenously to pregnant rats. Read More

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Preferentially Expressed Antigen in Melanoma Immunohistochemistry Labeling in Uveal Melanomas.

Ocul Oncol Pathol 2022 Jun 11;8(2):133-140. Epub 2022 Mar 11.

Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Introduction: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and despite treatment of the primary tumor, approximately 15%-50% of patients will develop metastatic disease. Based on gene expression profiling (GEPs), UM can be categorized as Class 1A (low metastatic risk), Class 1B (intermediate metastatic risk), or Class 2 (high metastatic risk). PReferentially expressed Antigen in MElanoma (PRAME) status is an independent prognostic UM biomarker and a potential target for immunotherapy in metastatic UM. Read More

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Clinical Significance of Detection of Peripheral Blood VASP Level in Lung Cancer Patients.

Evid Based Complement Alternat Med 2022 31;2022:1703339. Epub 2022 Jul 31.

Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang 050030, Hebei Province, China.

This paper explores the relationship between the clinical value of vasodilator-stimulated phosphoprotein (VASP) in lung cancer tissue and its diagnosis and severity. Totally 100 patients who were clinically diagnosed with lung cancer from January 2018 to December 2020 were enrolled in our study. They were assigned into two groups according to the presence of lymph node metastasis. Read More

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A Closer Look at the Environmental Impact of Solar and Wind Energy.

Glob Chall 2022 Aug 22;6(8):2200016. Epub 2022 Jun 22.

Department of Thermal and Fluid Engineering University Carlos III of Madrid Avda. De la Universidad 30, Leganés Madrid 28913 Spain.

Moving towards a sustainable society implies constant improvement in the way energy is supplied and consumed, with wider implementation of solar and wind energy facilities in stand-alone or hybrid configurations. The goal of this work is to evaluate the lifecycle performance (construction and operation-related impact) of large-scale solar and wind energy systems and to compare it with conventional coal and natural gas fossil fuel plants under similar conditions. Environmental analyses of energy conversion systems today usually neglect the construction-related environmental impact of fossil fuel plants, because it is significantly smaller than the impact related to the operation of the plant. Read More

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The neoadjuvant chemotherapy responses and survival rates of patients with different molecular subtypes of breast cancer.

Am J Transl Res 2022 15;14(7):4648-4656. Epub 2022 Jul 15.

Department of Thyroid and Breast III, Cangzhou Central Hospital Cangzhou, Hebei, China.

Objective: The purpose of this study was to evaluate the effect of neoadjuvant chemotherapy (NAC) on the responses and survival rates of patients with different molecular subtypes of breast cancer.

Methods: A retrospective analysis was conducted on 284 breast cancer patients who underwent NAC in our hospital from January 2017 to January 2019. The patients were classified into the Luminal A (n=87), Luminal B (n=78), human epidermal growth factor receptor 2 positive (HER-2, n=66), and triple-negative (TN, n=53) breast cancer subtypes. Read More

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Efficacy and safety of nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure ventilation in neonatal respiratory distress syndrome: a systematic review and meta-analysis.

Transl Pediatr 2022 Jul;11(7):1242-1250

Neonatal Department, Haikou Maternal and Child Health Hospital, Haikou, China.

Background: The efficacies of nasal continuous positive airway pressure (NCPAP) and nasal intermittent positive pressure ventilation (NIPPV) in neonatal respiratory distress syndrome (RDS) are controversial. The reasons for controversy may be the selection bias of research objects and the small sample size.

Methods: Literature retrieval was performed in PubMed, EMBASE, Medline, Central, China National Knowledge Infrastructure (CNKI), Wanfang and China Science Digital Library (CSDL) databases. Read More

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Pilot Study of Combination Gemogenovatucel-T (Vigil) and Durvalumab in Women With Relapsed BRCA-wt Triple-Negative Breast or Ovarian Cancer.

Clin Med Insights Oncol 2022 6;16:11795549221110501. Epub 2022 Aug 6.

Medical Affairs, Gradalis, Inc., Carrollton, TX, USA.

Background: Gemogenovatucel-T (Vigil) is a triple-function autologous tumor cell immunotherapy which expresses granulocyte-macrophage colony-stimulating factor and decreases expression of furin and downstream TGF-β1 and TGF-β2. Vigil has suggested survival benefit in frontline maintenance ovarian cancer patients who are BRCA-wt. In addition, Vigil demonstrates relapse-free and overall survival advantage in homologous recombination-proficient patients with OC. Read More

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Real-Time People Re-Identification and Tracking for Autonomous Platforms Using a Trajectory Prediction-Based Approach.

Sensors (Basel) 2022 Aug 5;22(15). Epub 2022 Aug 5.

Faculty of Automatic Control and Computers, University Politehnica of Bucharest, 060042 Bucharest, Romania.

Currently, the importance of autonomous operating devices is rising with the increasing number of applications that run on robotic platforms or self-driving cars. The context of social robotics assumes that robotic platforms operate autonomously in environments where people perform their daily activities. The ability to re-identify the same people through a sequence of images is a critical component for meaningful human-robot interactions. Read More

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Experimental Study Regarding Long Range LiDAR Capabilities in Sensing Safety Distance for Vehicle Application.

Sensors (Basel) 2022 Jul 31;22(15). Epub 2022 Jul 31.

Electrical Motors and Drives Laboratory, National Institute for Research and Development in Electrical Engineering ICPE-CA, 030138 Bucharest, Romania.

The safety of vehicles is one of the major goals of driving automation. The safety distance is longer for rail vehicles such as trams because of the adherence limitations of the wheel-to-rail system. The major issues of fixed frontal sensing are fake target detection, blind spots related to rail slopes, curves, and random changes in the target's illumination or reflectivity. Read More

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Gait Characteristics and Cognitive Function in Middle-Aged Adults with and without Type 2 Diabetes Mellitus: Data from ENBIND.

Sensors (Basel) 2022 Jul 30;22(15). Epub 2022 Jul 30.

School of Engineering, Trinity College Dublin, D08 XW7X Dublin, Ireland.

Type 2 Diabetes Mellitus (T2DM) in midlife is associated with a greater risk of dementia in later life. Both gait speed and spatiotemporal gait characteristics have been associated with later cognitive decline in community-dwelling older adults. Thus, the assessment of gait characteristics in uncomplicated midlife T2DM may be important in selecting-out those with T2DM at greatest risk of later cognitive decline. Read More

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A Novel Polysaccharide from Alleviates Thrombosis Induced by Carrageenan in Mice.

Molecules 2022 Jul 28;27(15). Epub 2022 Jul 28.

School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150006, China.

The increasing incidence of cardiovascular diseases has created an urgent need for safe and effective antithrombotic agents. In this study, we aimed to elucidate the structural characteristics and antithrombotic activity of a novel polysaccharide isolated from fruiting bodies. The purified polysaccharide AAP-b2 (12. Read More

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Effects of Botanical Ingredients Addition on the Bioactive Compounds and Quality of Non-Alcoholic and Craft Beer.

Plants (Basel) 2022 Jul 28;11(15). Epub 2022 Jul 28.

Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.

Special beers, known as artisanal, are progressively gaining consumer preference, opening up competition, and acquiring more space in the market. Considering that, exploration for new formulations is justified and plants represent a source of novel compounds with promising antioxidant activity for this beer segment. This paper aims to evaluate the current knowledge on the role of botanical ingredients on the final yield of bioactive compounds in special beer, and how these molecules generally affect the sensory profile. Read More

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Swin Transformer Improves the IDH Mutation Status Prediction of Gliomas Free of MRI-Based Tumor Segmentation.

J Clin Med 2022 Aug 8;11(15). Epub 2022 Aug 8.

Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Deep learning (DL) could predict isocitrate dehydrogenase (IDH) mutation status from MRIs. Yet, previous work focused on CNNs with refined tumor segmentation. To bridge the gap, this study aimed to evaluate the feasibility of developing a Transformer-based network to predict the IDH mutation status free of refined tumor segmentation. Read More

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Quantum Biochemistry Screening and In Vitro Evaluation of Metalloproteinase Inhibitors.

Int J Mol Sci 2022 Aug 2;23(15). Epub 2022 Aug 2.

Laboratory of Immunoparasitology, Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.

Leishmanolysin, also known as major promastigote protease (PSP) or gp63, is the most abundant surface glycoprotein of spp., and has been extensively studied and recognized as the main parasite virulence factor. Characterized as a metalloprotease, gp63 can be powerfully inactivated in the presence of a metal chelator. Read More

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Dual Costimulatory and Coinhibitory Targeting with a Hybrid Fusion Protein as an Immunomodulatory Therapy in Lupus Nephritis Mice Models.

Int J Mol Sci 2022 Jul 29;23(15). Epub 2022 Jul 29.

Experimental Nephrology Laboratory, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

Systemic lupus erythematosus is a complex autoimmune disorder mostly mediated by B-cells in which costimulatory signals are involved. This immune dysregulation can cause tissue damage and inflammation of the kidney, resulting in lupus nephritis and chronic renal failure. Given the previous experience reported with CTLA4-Ig as well as recent understanding of the PD-1 pathway in this setting, our group was encouraged to evaluate, in the NZBWF1 model, a human fusion recombinant protein (Hybri) with two domains: CTLA4, blocking the CD28-CD80 costimulatory pathway, and PD-L2, exacerbating the PD-1-PD-L2 coinhibitory pathway. Read More

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Reliability and Validity of a Chinese Version of the Cohen-Mansfield Agitation Inventory-Short Form in Assessing Agitated Behavior.

Int J Environ Res Public Health 2022 Aug 1;19(15). Epub 2022 Aug 1.

Department of Nursing, Kaohsiung Municipal United Hospital, Kaohsiung 80457, Taiwan.

Background: Patients with dementia often present agitated behaviors. The Cohen-Mansfield Agitation Inventory-short form (CMAI-SF) is one of the most widely used instruments to evaluate agitated behaviors that affect patients' quality of life and impose burden on caregivers. However, there is no simplified Chinese version of the CMAI-SF (C-CMAI-SF) in clinical settings. Read More

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Effects of a Home-Based Exercise Program on Health-Related Quality of Life and Physical Fitness in Dementia Caregivers: A Randomized Controlled Trial.

Int J Environ Res Public Health 2022 Jul 29;19(15). Epub 2022 Jul 29.

Department of Didactic of Musical, Plastic and Body Expression, Faculty of Sport Sciences, University of Extremadura, 10071 Cáceres, Spain.

Regular exercise can be an effective health-promotion strategy to improve the physical and mental health of informal caregivers. A randomized controlled trial study was designed to evaluate the effects of a 9-month home-based exercise intervention on health-related quality of life (HRQoL) and physical fitness in female family caregivers of persons with dementia. Fifty-four female caregivers were randomly assigned to two groups for the 9-month study period. Read More

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Nine-Year Trends in Atrial Fibrillation Prevalence among Romanian Adult Hypertensives: A Post-Hoc Analysis of SEPHAR II-IV Surveys.

Int J Environ Res Public Health 2022 Jul 28;19(15). Epub 2022 Jul 28.

Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Objectives: There are limited epidemiological data regarding atrial fibrillation (AF) in hypertensive (HT) Romanian adults. We sought to evaluate AF prevalence trends in the SEPHAR surveys (Study for Evaluation of Prevalence of Hypertension and Cardiovascular Risk in an Adult Population in Romania) during a nine-year interval (2012-2016-2021).

Methods: Three consecutive editions of a national epidemiological survey regarding HT included representative samples of subjects stratified by age, gender and area of residence (SEPHAR II-IV-in total, 5422 subjects, mean age 48. Read More

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Mutated Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma.

Cells 2022 Jul 30;11(15). Epub 2022 Jul 30.

Department of Experimental Medicine, University of Genoa, Via De Toni 14, 16132 Genova, Italy.

Fanconi Anaemia (FA) is a rare recessive genetic disorder characterized by a defective DNA repair mechanism. Although aplastic anaemia is the principal clinical sign in FA, patients develop a head and neck squamous cell carcinoma (HNSCC) with a frequency 500-700 folds higher than the general population, which appears more aggressive, with survival of under two years. Since FA gene mutations are also associated with a defect in the aerobic metabolism and an increased oxidative stress accumulation, this work aims to evaluate the effect of mutation on the energy metabolism and the relative mitochondrial quality control pathways in an HNSCC cellular model. Read More

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Distribution patterns of arterial affection and the influence of glucocorticoids on F-fluorodeoxyglucose positron emission tomography/CT in patients with giant cell arteritis.

RMD Open 2022 Aug;8(2)

Department of Internal Medicine III, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany

Background: Giant cell arteritis (GCA) with the involvement of extracranial vessels is increasingly coming into focus. Isolated aortic involvement in the acute phase of GCA is probably more frequent than estimated because only a minority of patients show typical symptoms. F-fluorodeoxyglucose positron emission tomography/CT (PET/CT) is a reliable imaging tool to diagnose patients with extracranial GCA. Read More

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Use of sequentially inoculation of Saccharomyces cerevisiae and Hanseniaspora uvarum strains isolated from honey by-products to improve and stabilize the quality of mead produced in Sicily.

Food Microbiol 2022 Oct 27;107:104064. Epub 2022 May 27.

Department of Agricultural, Food and Forest Science, University of Palermo, Viale Delle Scienze Bldg. 5, Ent. C, 90128, Palermo, Italy.

Mead is a beverage produced by alcoholic fermentation of honey-must. The starter yeasts that are commonly used for the alcoholic fermentation of honey-must are oenological Saccharomyces cerevisiae strains. The objective of the present work was, for the first time, to apply yeasts of honey by-products origin to evaluate the influences the taste-olfactory attributes of mead. Read More

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October 2022

A systematic review and meta-analysis of GLASS staging system in the endovascular treatment of chronic limb threatening ischemia.

J Vasc Surg 2022 Aug 8. Epub 2022 Aug 8.

Department of Vascular Surgery, Aristotle University of Thessaloniki, AHEPA University General Hospital, Thessaloniki, Greece.

Objectives: To evaluate the application of the Global Anatomic Staging System (GLASS) in the endovascular treatment of chronic limb threatening ischemia (CLTI).

Methods: We performed a systematic research between June 2019 and February 2022, including articles investigating the relationship of GLASS classification with the outcomes of endovascular interventions in the treatment of CLTI. Data from the included studies were pooled and meta-analyzed. Read More

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Successful same-day discharge in 88% of patients after unicompartmental knee arthroplasty: a systematic review and meta-analysis.

Knee Surg Sports Traumatol Arthrosc 2022 Aug 11. Epub 2022 Aug 11.

Department of Orthopaedic Surgery and Computer Assisted Surgery Center, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY, 10021, USA.

Purpose: The purpose of this study was to evaluate the effectiveness of day-case unicompartmental knee arthroplasty (UKA) by assessment of successful same-day discharge (SDD), readmission, complication and reoperation rates in the recent literature.

Methods: For this systematic review and meta-analysis, PubMed, Embase and Cochrane Library were comprehensively searched to identify all eligible studies reporting outcomes of day-case UKA. Studies with intended same-day home discharge after UKA were included. Read More

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LIBRETTO-432, a phase III study of adjuvant selpercatinib or placebo in stage IB-IIIA fusion-positive non-small-cell lung cancer.

Future Oncol 2022 Aug 11. Epub 2022 Aug 11.

Department of Medicine, Memorial Sloan-Kettering Cancer Center & Weill Cornell Medical College, New York, NY 10065, USA.

Selpercatinib, a first-in-class, highly selective and potent central nervous system-active RET kinase inhibitor demonstrated clinically meaningful activity with manageable toxicity in pretreated and treatment-naive advanced/metastatic fusion-positive non-small-cell lung cancer (NSCLC). LIBRETTO-432 is a global, randomized, double-blind, phase III trial evaluating selpercatinib versus placebo in stage IB-IIIA, fusion-positive NSCLC, previously treated with definitive surgery or radiation; participants must have undergone available anti-cancer therapy (including chemotherapy or durvalumab) or not be suitable for it, per investigator's discretion. The primary end point is investigator-assessed event-free survival (EFS) in the primary analysis population (stage II-IIIA fusion-positive NSCLC). Read More

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Healthcare costs of a telemonitoring programme for heart failure: indirect deterministic data linkage analysis.

ESC Heart Fail 2022 Aug 10. Epub 2022 Aug 10.

Cardiology Department, Rangueil University Hospital, Toulouse, France.

Aims: We aim to evaluate the costs associated with healthcare resource consumption for chronic heart failure (HF) management in patients allocated to telemonitoring versus standard of care (SC).

Methods And Results: OSICAT-ECO involved 745 patients from the OSICAT trial (NCT02068118) who were successfully linked to the French national healthcare database through an indirect deterministic data linkage approach. OSICAT compared a telemonitoring programme with SC follow-up in adults hospitalized for acute HF ≤ 12 months. Read More

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Antenatal Magnesium Sulfate for Preterm Neuroprotection: A Single-Center Experience from Kuwait Tertiary NICU.

Biomed Hub 2022 May-Aug;7(2):80-87. Epub 2022 Jun 30.

Department of Pediatrics, Farwaniya Hospital, Ministry of Health of Kuwait, Kuwait City, Kuwait.

Objectives: The study aimed to evaluate the impact of antenatal exposure of magnesium sulfate (MgSO) on short- and long-term outcomes in preterm neonates born less than 32 weeks gestation.

Methods: Single-center retrospective cohort study of 229 neonates born between 24 and 32 weeks gestation was conducted from January 2018 through December 2018 in a level III neonatal care unit in Kuwait. Antenatal MgSO exposure was collected from the medical records, and the indication was for neuroprotection effect. Read More

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