2,438 results match your criteria iii dissemination


A content analysis of the tweets of e-cigarette proponents in Australia.

Health Promot J Austr 2021 Jun 18. Epub 2021 Jun 18.

The George Institute for Global Health.

Issue Addressed: Social media sites have become platforms for public discourse on e-cigarettes, providing proponents with an opportunity to disseminate favourable information about the devices. Research examining the information being presented by Australian proponents of e-cigarettes is limited. Accordingly, this study explored the Twitter feeds of Australian proponents of e-cigarettes to determine the nature of the e-cigarette-related content being disseminated. Read More

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Evaluating adults' health-related values and preferences about unprocessed red meat and processed meat consumption: protocol for a cross-sectional mixed-methods study.

F1000Res 2020 11;9:346. Epub 2020 May 11.

Iberoamerican Cochrane Centre, Biomedical Research Institute San Pau (IIB Sant Pau), Barcelona, Spain.

People need to choose from a wide range of foods, and in addition to availability and accessibility, people's values and preferences largely determine their daily food choices. Given the potential adverse health consequences of red and processed meat and the limited knowledge on individuals' health-related values and preferences on the topic, such data would be useful in the development of recommendations regarding meat consumption. We will perform a cross-sectional mixed methods study. Read More

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Implementation of a multidisciplinary antimicrobial stewardship programme in a Philippine tertiary care hospital: an evaluation by repeated point prevalence surveys.

J Glob Antimicrob Resist 2021 Jun 9. Epub 2021 Jun 9.

Makati Medical Center, Makati, Philippines.

Objectives: Optimising antimicrobial prescribing in hospitals through antimicrobial stewardship (AMS) is essential in addressing the global threat of antimicrobial resistance. The objective of this study was to evaluate the impact of a hospital-wide programme, delivered by a multidisciplinary AMS team, on antimicrobial prescribing outcomes.

Methods: The AMS programme consisted of a combination of persuasive, restrictive, and structural components and was implemented in two phases. Read More

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Caregiver-mediated interventions to support self-regulation among infants and young children (0-5 years): a protocol for a realist review.

BMJ Open 2021 06 10;11(6):e046078. Epub 2021 Jun 10.

School of Psychological Sciences, The University of Western Australia, Crawley, Western Australia, Australia.

Introduction: Self-regulation is a modifiable protective factor for lifespan mental and physical health outcomes. Early caregiver-mediated interventions to promote infant and child regulatory outcomes prevent long-term developmental, emotional and behavioural difficulties and improve outcomes such as school readiness, educational achievement and economic success. To harness the population health promise of these programmes, there is a need for more nuanced understanding of the impact of these interventions. Read More

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SporTRIA study-a multicentre trial protocol for excretion kinetics of triamcinolone acetonide following sport-related intra-articular injections in knees: definitions of the washout periods.

BMJ Open 2021 06 9;11(6):e047548. Epub 2021 Jun 9.

Université de Lorraine, CHRU-Nancy, University Centre of Sports Medicine and Adapted Physical Activity, Centre Hospitalier Régional Universitaire de Nancy, Nancy, Lorraine, France.

Introduction: Intra-articular (IA) and peri-articular glucocorticoid (GC) injections are common in sports medicine. However, from 1 January 2022, all injectable GC routes (including IA administration) will be prohibited in-competition by World Anti-Doping Agency (WADA). Owing to these rules, an IA GC treatment out-of-competition could result in an adverse analytical finding in-competition if the washout period is not clearly defined. Read More

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Neonatal hypoxic-ischemic encephalopathy diagnosis and treatment: a National Survey in China.

BMC Pediatr 2021 06 5;21(1):261. Epub 2021 Jun 5.

Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 200032, China.

Background: Neonatal hypoxic-ischemic encephalopathy (HIE) affects as many as 100,000 infants each year in China. Therapeutic hypothermia reduces HIE related mortality and long-term neurodevelopmental disabilities. National guidelines for HIE management were published a decade ago. Read More

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Monitoring of Palliative Care Symptoms and Concerns in Specialized Palliative Home Care Using an Electronic Version of the Integrated Palliative care Outcome Scale (Palli-MONITOR): protocol for a mixed-methods study.

BMJ Open 2021 06 1;11(6):e042266. Epub 2021 Jun 1.

Department of Palliative Medicine, University Hospital, LMU Munich, Munich, Germany.

Introduction: Over the last decades, patient-reported outcome (PRO) measures have been developed to better understand the patient's perspective and enable patient-centred care. In palliative care, the Integrated Palliative care Outcome Scale (IPOS) is recommended as a PRO tool. Its implementation in specialised palliative home care (SPHC) would benefit from an electronic version validated for the setting. Read More

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Determinants of clinical practice guidelines' utilization for the management of musculoskeletal disorders: a scoping review.

BMC Musculoskelet Disord 2021 Jun 1;22(1):507. Epub 2021 Jun 1.

UMR1295, Toulouse III University, Inserm, Equipe EQUITY, Equipe constitutive du CERPOP, Toulouse, France.

Context: Many clinical practice guidelines have been developed for the management of musculoskeletal disorders (MSDs). However, there is a gap between evidence-based knowledge and clinical practice, and reasons are poorly understood. Understanding why healthcare providers use clinical practice guidelines is essential to improve their implementation, dissemination, and adherence. Read More

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Diagnostic Performance of Ag-RDTs and NAAT for SARS-CoV2 Identification in Symptomatic Patients in Catalonia.

Viruses 2021 05 14;13(5). Epub 2021 May 14.

Sub-Directorate General of Surveillance and Response to Public Health Emergencies, Public Health Agency of Catalonia, Generalitat of Catalonia, 08005 Barcelona, Spain.

The use of rapid antigenic tests (Ag-RDTs) to diagnose a SARS-CoV-2 infection has become a common practice recently. This study aimed to evaluate performance of Abbott Panbio Ag-RDTs with regard to nucleic acid amplification testing (NAAT) in the early stages of the disease. A cohort of 149,026 infected symptomatic patients, reported in Catalonia from November 2020 to January 2021, was selected. Read More

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Neuroendocrine Factors in Melanoma Pathogenesis.

Cancers (Basel) 2021 May 10;13(9). Epub 2021 May 10.

Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Melanoma is one of the most aggressive skin cancers with a sharp rise in incidence in the last decades, especially in young people. Recognized as a significant public health issue, melanoma is studied with increasing interest as new discoveries in molecular signaling and receptor modulation unlock innovative treatment options. Stress exposure is recognized as an important component in the immune-inflammatory interplay that can alter the progression of melanoma by regulating the release of neuroendocrine factors. Read More

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Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression.

Cancers (Basel) 2021 May 22;13(11). Epub 2021 May 22.

Cancer Research Center (IBMCC-CSIC-USAL), University Hospital of Salamanca (IBSAL), 37007 Salamanca, Spain.

Multiple myeloma (MM) is a hematological malignancy of plasma cells that proliferate and accumulate within the bone marrow (BM). Work from many groups has made evident that the complex microenvironment of the BM plays a crucial role in myeloma progression and response to therapeutic agents. Within the cellular components of the BM, we will specifically focus on mesenchymal stromal cells (MSCs), which are known to interact with myeloma cells and the other components of the BM through cell to cell, soluble factors and, as more recently evidenced, through extracellular vesicles. Read More

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Comprehensive Scanning of Prophages in : Distribution, Diversity, Antibiotic Resistance Genes, and Linkages with CRISPR-Cas Systems.

mSystems 2021 Jun 1:e0121120. Epub 2021 Jun 1.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.

Prophage integration, release, and dissemination exert various effects on host bacteria. In the genus , they may cause bacteriophage contamination during fermentation and even regulate bacterial populations in the gut. However, little is known about their distribution, genetic architecture, and relationships with their hosts. Read More

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interferes with classical endocytic trafficking and replicates in a specialized replication-permissive niche in non-phagocytic cells.

J Bacteriol 2021 Jun 1:JB0050520. Epub 2021 Jun 1.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.

() is an intracellular pathogen within a broad spectrum of hosts. Essential to virulence is its ability to invade and replicate inside host cells, yet the survival mechanisms and the nature of the replicative compartment remain unknown. Here, we characterized its intracellular lifestyle in non-phagocytic cells and showed that intracellular replication of in non-phagocytic cells is dependent on its type III secretion system but not type VI secretion system. Read More

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What Cognitive Mechanism, When, Where, and Why? Exploring the Decision Making of University and Professional Rugby Union Players During Competitive Matches.

Front Psychol 2021 12;12:609127. Epub 2021 May 12.

Research Centre for Sport Coaching, Carnegie School of Sport, Leeds Beckett University, Leeds, United Kingdom.

Over the past 50 years decision making research in team invasion sport has been dominated by three research perspectives, , , and . Recently, attempts have been made to integrate perspectives, as conceptual similarities demonstrate the decision making process as an interaction between a players perception of game information and the individual and collective capability to act on it. Despite this, no common ground has been found regarding what connects perception and action during performance. Read More

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[Innovative transformation of the health system through a preventive transition].

Rev Epidemiol Sante Publique 2021 May 27. Epub 2021 May 27.

Bordeaux Population Health Research Center. UMR 1219 CIC-EC 1401, Université de Bordeaux, Bordeaux, France; Département Prévention, CHU, Bordeaux, France.

Given today's evolution of the healthcare system, organizational transformations, technological developments and major challenges, innovation has taken on primordial importance. In this context and with considerable support, many experimentations have taken place. Unfortunately, few have managed to scale up. Read More

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Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinson's disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: The 'Exenatide-PD3' study.

BMJ Open 2021 05 28;11(5):e047993. Epub 2021 May 28.

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK

Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder with substantial morbidity. No disease-modifying treatments currently exist. The glucagon like peptide-1 receptor agonist exenatide has been associated in single-centre studies with reduced motor deterioration over 1 year. Read More

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Digital storytelling methodologies: Recommendations for a participatory approach to engaging underrepresented communities in counseling psychology research.

J Couns Psychol 2021 Apr;68(3):271-285

University of Minnesota, Twin Cities.

While counseling psychologists made substantial proposals to advance qualitative research since the special issue on related methods was published 15-years ago (Haverkamp, Morrow, & Ponterotto, 2005), the field continues to demonstrate an overreliance on quantitative methods. Though important for producing knowledge we can depend on, excessive use of these methods poses a barrier for counseling psychologists to address the needs of the communities that are at the core of our discipline's values-those who are marginalized and underserved in society. In alignment with our values of social justice, advocacy, and empowerment, we propose counseling psychologists adopt a methodology within a critical paradigm to better address issues of inequality and inequity when working with underrepresented communities, such as digital storytelling. Read More

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Pediatric Surgeons' Adoption of an Innovative Laparoscopic Technique for Inguinal Hernia Repair: A Mixed Methods Study.

J Laparoendosc Adv Surg Tech A 2021 May 27. Epub 2021 May 27.

Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

We studied adoption of an innovative laparoscopic technique for pediatric inguinal hernia repair by pediatric surgeons and pediatric urologists following dissemination of evidence for its benefits. This mixed methods study included children who received inguinal hernia repairs during 2017-2019 and their surgeons. We examined surgeons' adoption and use of the innovative technique and rates of ipsilateral recurrence and metachronous contralateral repair. Read More

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[Implications on the scientific production of COVID-19.]

Rev Esp Salud Publica 2021 May 27;95. Epub 2021 May 27.

Biblioteca Nacional de Ciencias de la Salud. Instituto de Salud Carlos III. Madrid. España.

The impact and the universality of the pandemic by SARS-CoV-2 has caused the need to have information quickly and accessible for the benefit of decision-making among healthcare professionals. In 10 months the scientific production on this new coronavirus has exceeded the number of 66 thousand articles, according to the LitCovid database, created by the National Library of Medicine, doubling and tripling every few weeks. This same urgency has characterized some of the main features of this voluminous production, in addition to its continuous and exponential growth, such as greater dissemination in open access and preprint repositories, a certain acceleration in the manuscript review process by editorials and an abundance of opinion articles, recommendations or comments compared to a smaller number of original articles with clinical data from large groups of patients. Read More

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Comparison of delivery catheter-based and stylet-based right ventricular lead placement at the right ventricular septum under fluoroscopic guidance judged by cardiac CT (Mt. FUJI): a study protocol for the Mt. FUJI randomised controlled trial.

BMJ Open 2021 05 26;11(5):e046782. Epub 2021 May 26.

Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Introduction: Pacing-induced cardiomyopathy occasionally occurs in patients undergoing pacemaker implantation. Although compared with right ventricular (RV) apical pacing, RV septal pacing can attenuate left ventricular dyssynchrony; the success rate of lead placement on the RV septum using the stylet system is low. Additionally, no randomised controlled trial has addressed the issue regarding the accuracy of RV lead placement on the RV septum using the stylet and delivery catheter systems. Read More

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Comparison of short-term outcomes and quality of life in totally laparoscopic distal gastrectomy and totally robotic distal gastrectomy for clinical stage I-III gastric cancer: study protocol for a multi-institutional randomised clinical trial.

BMJ Open 2021 05 25;11(5):e043535. Epub 2021 May 25.

Department of General Surgery & Institute of General Surgery, Chinese PLA General Hospital, Beijing, China

Introduction: Laparoscopic distal gastrectomy (LDG) is regarded as a standard treatment for patients with clinical stage I-III gastric cancer. With the popularisation of the robotic system in the 21st century, robotic distal gastrectomy has been increasingly applied, and its potential advantages over LDG have been proved by several studies. Intraperitoneal anastomosis is a hot topic in research as it highlights the superiority of minimally invasive surgery and is safe and feasible. Read More

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Laparoscopic complete mesocolic excision with central vascular ligation for splenic flexure colon cancer: short- and long-term outcomes.

Surg Endosc 2021 May 24. Epub 2021 May 24.

Department of Surgery, Kindai University Faculty of Medicine, 377-2, Ohnohigashi, Osaka Sayama, Osaka, 589-8511, Japan.

Background: Complete mesocolic excision (CME) with central vascular ligation (CVL) for colon cancer is an essential procedure for improved oncologic outcomes after surgery. Laparoscopic surgery for splenic flexure colon cancer was recently adopted due to a greater understanding of surgical anatomy and improvements in surgical techniques and innovative surgical devices.

Methods: We retrospectively analyzed the data of patients with splenic flexure colon cancer who underwent laparoscopic CME with CVL at our institution between January 2005 and December 2017. Read More

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Providing trial results to participants in phase III pragmatic effectiveness RCTs: a scoping review.

Trials 2021 May 24;22(1):361. Epub 2021 May 24.

Health Services Research Unit, Health Sciences Building, Foresterhill, Aberdeen, UK.

Background: There is an ethical imperative to offer the results of trials to those who participated. Existing research highlights that less than a third of trials do so, despite the desire of participants to receive the results of the trials they participated in. This scoping review aimed to identify, collate, and describe the available evidence relating to any aspect of disseminating trial results to participants. Read More

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Development of a Core Outcome Set for the Benefits and Adverse Events of Acute Heart Failure in Clinical Trials of Traditional Chinese Medicine and Western Medicine: A Study Protocol.

Front Med (Lausanne) 2021 7;8:677068. Epub 2021 May 7.

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Beijing University of Chinese Medicine Affiliated Dongzhimen Hospital, Beijing, China.

To identify a minimum set of efficacy and adverse events for patients with acute heart failure (AHF) among different stakeholders in clinical trials of traditional Chinese medicine and Western medicine. First, we will develop a preliminary long list of outcomes that includes efficacy and adverse events/reactions via three steps: (i) systematic reviews of efficacy and safety outcomes for clinical trials of AHF; (ii) drugs included in the National Medical Insurance Catalog, the National Essential Medicines Catalog, and the WHO Essential Medicines List will be collected and safety outcomes extracted from the package inserts; and (iii) patients' or caregivers' semi-structured interviews will be carried out to add new viewpoints to the list. Second, after merging outcomes and grouping them under different outcome domains, questionnaires for health professionals and patients will be separately developed. Read More

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COVID-19 fake news diffusion across Latin America.

Soc Netw Anal Min 2021 19;11(1):47. Epub 2021 May 19.

Federal University of Sao Paulo, Av. Cesare Mansueto Giulio Lattes, 1201 São José dos Campos, Brazil.

Fact-checking verifies a multitude of claims and remains a promising solution to fight fake news. The spread of rumors, hoaxes, and conspiracy theories online is evident in times of crisis, when fake news ramped up across platforms, increasing fear and confusion among the population as seen in the COVID-19 pandemic. This article explores fact-checking initiatives in Latin America, using an original Markov-based computational method to cluster topics on tweets and identify their diffusion between different datasets. Read More

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VALUE study: a protocol for a qualitative semi-structured interview study of IVF add-ons use by patients, clinicians and embryologists in the UK and Australia.

BMJ Open 2021 05 21;11(5):e047307. Epub 2021 May 21.

Oncology and Metabolism, The University of Sheffield, Sheffield, UK.

Introduction: For couples undergoing assisted reproduction, a plethora of adjuncts are available; these are known as 'add-ons'. Most add-ons are not supported by good quality randomised trial evidence of efficacy, with some proven to be ineffective. However, estimates suggest that over 70% of fertility clinics provide at least one add-on, often at extra cost to the patient. Read More

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Continuous enteral nutrition compared with a maximal gastric vacuity strategy at the time of extubation in the intensive care unit: protocol for a non-inferiority cluster randomised trial (the Ambroisie Project).

BMJ Open 2021 05 20;11(5):e041799. Epub 2021 May 20.

Intensive Resuscitation Medicine, CHRU Tours, Tours, France.

Introduction: Fasting is frequently imposed to patients before extubation in the intensive care unit based on scheduled surgery guidelines. This practice has never been evaluated among critically ill patients and may delay extubation, increase nursing workload and reduce caloric intake. We are hypothesising that continuous enteral nutrition until extubation represents a safe alternative compared with fasting prior to extubation in the intensive care unit. Read More

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Neutrophil extracellular traps promote gastric cancer metastasis by inducing epithelial‑mesenchymal transition.

Int J Mol Med 2021 Jul 20;48(1). Epub 2021 May 20.

The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.

The risks of tumor recurrence following the successful resection of the primary tumor have been known for decades; however, the precise mechanisms underlying treatment failures remain unknown. The formation of neutrophil extracellular traps (NETs) has increasingly been demonstrated to be associated with thrombi formation in cancer patients, as well as with the development and metastasis of cancer. The present study demonstrated that the level of peripheral blood NETs in patients with gastric cancer (GC) was associated with tumor progression, and patients with stage III/IV disease exhibited significant differences compared with the healthy controls and patients with stage I/II disease, which may be associated with an increased risk of metastasis. Read More

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Point-of-care haemoglobin testing in African hospitals: a neglected essential diagnostic test.

Br J Haematol 2021 Jun 15;193(5):894-901. Epub 2021 May 15.

Kenya Medical Research Institute (KEMRI), Wellcome Trust Research Programme, Kilifi, Kenya.

Owing to the rapid turnaround time in the assessment of haemoglobin level by point-of-care tests (POC Hb), these have grown in popularity and scope in large parts of the world. However, whilst POC testing for malaria and HIV remains has been integrated into patient management in Africa, the use of POC haemoglobin testing remains neglected by health services. The main users of transfusions (paediatric, maternity and trauma services) present largely as emergencies. Read More

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Efficacy of a Web-Enabled, School-Based, Preventative Intervention to Reduce Bullying and Improve Mental Health in Children and Adolescents: Study Protocol for a Cluster Randomized Controlled Trial.

Front Pediatr 2021 26;9:628984. Epub 2021 Apr 26.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Centro de Investigación Biomédica en Red (CIBER) de Salud Mental (CIBERSAM), School of Medicine, Universidad Complutense, Madrid, Spain.

Bullying is a major preventable risk factor for mental disorders. Available evidence suggests school-based interventions reduce bullying prevalence rates. This study aims to test the efficacy of a web-enabled, school-based, multicomponent anti-bullying intervention to prevent school bullying and to assess its effects on mental health and quality of life. Read More

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