679,837 results match your criteria iii cases


Extracellular electron transfer influences the transport and retention of ferrihydrite nanoparticles in quartz sand coated with Shewanella oneidensis biofilm.

J Hazard Mater 2021 May 5;417:126023. Epub 2021 May 5.

Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.

Microbial biofilm has been found to impact the mobility of nanoparticles in saturated porous media by altering physicochemical properties of collector surface. However, little is known about the influence of biofilm's biological activity on nanoparticle transport and retention. Here, the transport of ferrihydrite nanoparticles (FhNPs) was studied in quartz sands coated with biofilm of Shewanella oneidensis MR-1 that is capable of reducing Fe(III) through extracellular electron transfer (EET). Read More

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Sodium fluoride causes oxidative damage to silkworm (Bombyx mori) testis by affecting the oxidative phosphorylation pathway.

Ecotoxicol Environ Saf 2021 May 11;218:112229. Epub 2021 May 11.

School of Biotechnology, Southwest University, Chongqing, China. Electronic address:

Bombyx mori was used to study the molecular mechanism of fluoride induced reproductive toxicity. In our previous study, we confirmed the physiological and biochemical effects of NaF on reproductive toxicity, and we found that the molecular mechanism of NaF induced reproductive damage may be associated with the oxidative phosphorylation pathway. To further study the function of NaF exposure on the oxidative phosphorylation pathway in the testis in Bombyx mori, and the relationship between oxidative phosphorylation and oxidative stress, we measured the changes in the main ROS (O and HO) in the testis, the activity of the main electron transport chain complex enzymes in the oxidative phosphorylation pathway and the transcription levels of the corresponding genes; we additionally performed pathological observations of the silkworm testis after exposure to 200 mg/L NaF solution for different times. Read More

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Associations between malignancy and cardiovascular complications following emergency laparotomy - A retrospective cohort study.

Surg Oncol 2021 May 5;38:101591. Epub 2021 May 5.

Center for Surgical Science, Department of Surgery, Zealand University Hospital, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.

Background: Systemic inflammation in patients with malignant disease has been associated with increased risk of cardiovascular events. The pro-inflammatory perturbations following surgical trauma may further promote adverse perioperative cardiovascular events and increase the risk of patients with cancer undergoing major surgery. Our objective was to estimate the association between malignant disease and postoperative cardiovascular complications. Read More

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Multidisciplinary treatment strategy for locally advanced gastric cancer: A systematic review.

Surg Oncol 2021 May 11;38:101599. Epub 2021 May 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Multidisciplinary management of patients with locally advanced gastric cancer (LAGC) remains unstandardized worldwide. We performed a systemic review to summarize the advancements, regional differences, and current recommended multidisciplinary treatment strategies for LAGC.

Methods: Eligible studies were identified through a comprehensive search of PubMed, Web of Science, Cochrane Library databases and Embase. Read More

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Interactions between mercury and environmental factors: A chemometric assessment in seafood from an eutrophic estuary in southeastern Brazil.

Aquat Toxicol 2021 Apr 28;236:105844. Epub 2021 Apr 28.

Molecular and Analytical Laboratory Center, Department of Food Technology, Faculty of Veterinary, Universidade Federal Fluminense, Niterói, 24230-340, Brazil; Chemistry Institute, Food Science Program, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-909, Brazil; National Institute of Health Quality Control, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.

Guanabara Bay (GB) is an estuary in Brazil, constantly the target of pollutants, such as mercury (Hg). Thus, our study aimed to evaluate (i) total mercury (THg) content in shrimp and squid species from GB; (ii) associate THg content to contamination in swimming crabs; (iii) explore potential differences between species, and size; (iv) correlate abiotic water data to the determined THg contents; (v) verify if Hg concentrations are below acceptable limits. Swimming crabs showed greater Hg contamination compared to other species. Read More

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Examining cognitive and behavioural symptoms across binge/purge profiles in adolescents with eating disorders.

Eat Behav 2021 May 1;42:101516. Epub 2021 May 1.

Discipline of Psychology, School of Population Health, Curtin University, Perth, Australia; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, United States; Division of Pediatrics, School of Medicine, The University of Western Australia, Perth, Australia.

Binge eating and purging profiles may vary in adolescents with eating disorders and this may potentially be a function of a range of cognitive and behavioural constructs. The aim was to determine whether cognitive and behavioural symptoms differed among purging profiles in 229 adolescent females (M age = 15.45). Read More

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Hydro-social dynamics of miningscapes: Obstacles to implementing water protection legislation in Mongolia.

J Environ Manage 2021 May 12;292:112767. Epub 2021 May 12.

Vrije Universiteit Amsterdam - Institute for Environmental Studies (IVM), the Netherlands.

Waterscapes with mining activities are often sites of water resource degradation and contestation. To prevent this, policy-makers deploy an increasing number of measures that purportedly align the interests of different water users. In Mongolia, mining-related protests led to the prohibition of mining in and close to rivers. Read More

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The role of age in treatment decisions for oral cavity squamous cell carcinoma: Analysis of the National Cancer Database.

Oral Oncol 2021 May 12;118:105330. Epub 2021 May 12.

Department of Otolaryngology - Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Background: The number of elderly patients with oral squamous cell carcinoma (OCSCC) is increasing as the elderly population increases. Unfortunately, evidence to guide the management of these patients is lacking.

Methods: Patients with OCSCC identified from the National Cancer Database (NCDB) were stratified into age-based cohorts. Read More

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Outcomes of Fludarabine, Melphalan and Total Body Irradiation as a Reduced Intensity Conditioning Regimen in Matched Donor Allogeneic Peripheral Blood Stem Cell Transplantation: Outcomes of Flu-Mel-TBI.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Oncology, Co-Director, Blood & Marrow Stem Cell Transplant Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, 4100 John R, HW04H0, Detroit, MI 48201. Electronic address:

Background: Fludarabine 30 mg/m/day x 5 and melphalan 140 mg/m x 1 (Flu-Mel140) is a commonly used RIC regimen. We hypothesized that addition of 200cGy total body irradiation (TBI) to Flu-Mel140 may improve antitumor activity and transplant outcomes.

Objectives: Primary objectives was overall survival (OS) at 3-year. Read More

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Early predictive factors of visual loss at 1-year in neovascular age-related macular degeneration under anti-VEGF in the GEFAL study.

Ophthalmol Retina 2021 May 12. Epub 2021 May 12.

Service d'Ophtalmologie, Hôpital Universitaire de la Croix-Rousse, Hospices Civils de Lyon, Université Lyon 1, Lyon, France; UMR-CNRS 5510 Matéis, Villeurbane, France.

Purpose: To evaluate early predictive factors of visual loss in patients treated with anti-vascular endothelial growth factor (VEGF) injections under as-needed regimen for neovascular age-related macular degeneration (AMD).

Design: Post-hoc analysis from the randomized controlled trial GEFAL, comparing ranibizumab versus bevacizumab for neovascular AMD.

Participants: 393 patients aged ≥50 years with neovascular AMD. Read More

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Deep Recurrent Model for Individualized Prediction of Alzheimer's Disease Progression.

Neuroimage 2021 May 12:118143. Epub 2021 May 12.

Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea; Department of Artificial Intelligence, Korea University, Seoul 02841, Republic of Korea.

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of developing AD in its earliest time. While many of the previous works considered cross-sectional analysis, more recent studies have focused on the diagnosis and prognosis of AD with longitudinal or time series data in a way of disease progression modeling. Read More

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Stable Lateral Meniscal Posterior Root Tears left in situ at time of Anterior Cruciate Ligament Reconstruction Are of Minimal Long Term Clinical Detriment.

Arthroscopy 2021 May 12. Epub 2021 May 12.

North Sydney Orthopaedic and Sports Medicine Centre, Sydney Australia; University of Notre Dame, School of Medicine, Sydney Australia. Electronic address:

Purpose: The purpose of this study was to compare long-term patient reported outcomes in patients undergoing ACL reconstruction with untreated stable LMPRT to those with an intact meniscus.

Methods: 492 subjects were followed for a minimum of 15-years post ACL reconstruction and evaluated by IKDC questionnaire. The integrity of the meniscus was classified at surgery. Read More

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A comparative study for phosphate adsorption on amorphous FeOOH and goethite (α-FeOOH): an investigation of relationship between the surface chemistry and structure.

Environ Res 2021 May 12:111223. Epub 2021 May 12.

Department of Civil Engineering, University of Louisiana at Lafayette, Lafayette, LA, 70504, USA. Electronic address:

Eutrophication is generally caused by excess nitrogen and phosphorus being released into surface waters by runoff. Developing adsorbents for adsorbing phosphate within soil buffer zones and/or water treatment columns may be effective methods to mitigate this problem. In this study, an amorphous FeOOH (AF) and a well-crystallized α-FeOOH (CF) was formulated to compare phosphate adsorption behavior. Read More

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What is the actual accuracy of clinical prediction models? The case of transition to psychosis.

Authors:
Joaquim Radua

Neurosci Biobehav Rev 2021 May 12. Epub 2021 May 12.

Imaging of Mood- and Anxiety-Related Disorders (IMARD) group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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Effects of different types of written vaccination information on COVID-19 vaccine hesitancy in the UK (OCEANS-III): a single-blind, parallel-group, randomised controlled trial.

Lancet Public Health 2021 May 12. Epub 2021 May 12.

Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Oxford, UK.

Background: The effectiveness of the COVID-19 vaccination programme depends on mass participation: the greater the number of people vaccinated, the less risk to the population. Concise, persuasive messaging is crucial, particularly given substantial levels of vaccine hesitancy in the UK. Our aim was to test which types of written information about COVID-19 vaccination, in addition to a statement of efficacy and safety, might increase vaccine acceptance. Read More

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Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.

Lancet 2021 May 12. Epub 2021 May 12.

MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, London, UK.

Background: Ovarian cancer continues to have a poor prognosis with the majority of women diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) to determine if population screening can reduce deaths due to the disease. We report on ovarian cancer mortality after long-term follow-up in UKCTOCS. Read More

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Exploring specific predictors of psychosis onset over a 2-year period: A decision-tree model.

Early Interv Psychiatry 2021 May 15. Epub 2021 May 15.

Department of Social Studies, Faculty of Social Sciences, University of Stavanger, Stavanger, Norway.

Aim: The fluctuating symptoms of clinical high risk for psychosis hamper conversion prediction models. Exploring specific symptoms using machine-learning has proven fruitful in accommodating this challenge. The aim of this study is to explore specific predictors and generate atheoretical hypotheses of onset using a close-monitoring, machine-learning approach. Read More

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Outbreak of equine pythiosis in a southeastern region of Brazil: environmental isolation and phylogeny.

Transbound Emerg Dis 2021 May 15. Epub 2021 May 15.

UNESP Univ Estadual Paulista, School of Veterinary Medicine and Animal Science, Brazil.

Pythiosis is a disease caused by the oomycete Pythium insidiosum, mainly reported in equines, dogs, and humans and directly transmitted through contaminant zoospores in aquatic environments. We report the first outbreak of equine pythiosis in five equines. Wound samples were submitted for diagnostic testing including mycological culture and nested PCR. Read More

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Air pollution-induced tanning of human skin.

Br J Dermatol 2021 May 15. Epub 2021 May 15.

IUF - Leibniz Research Institute of Environmental Medicine, Düsseldorf, Germany.

Background: Melanism is more frequent in animals living in polluted areas at urban-industrial sites. Given that a growing part of the human population is exposed to elevated air pollution levels, we wondered if environmental pollutants might affect melanogenesis in human skin likewise. Epidemiological studies in Caucasians and East Asians indeed showed that exposure to traffic-related air pollutants such as Diesel Exhaust Particles (DEP) is associated with more clinical signs of hyperpigmentation. Read More

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Epidemiology of biopsy-proven glomerulonephritis in the past 25 years in the North-Eastern area of Romania.

Int Urol Nephrol 2021 May 15. Epub 2021 May 15.

Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. Parhon' University Hospital, and "Grigore T. Popa" University of Medicine, Iasi, Romania.

Purpose: The aim of this retrospective study was: to analyze the epidemiological patterns of the kidney disease based on clinical and histological features in a single-center in the N-E region of Romania, between 2011 and 2019 and to compare the biopsy results with the others periods, as well as the results from other countries.

Methods: We studied 442 renal biopsies. The indications for renal biopsy were represented by the clinical features: nephrotic syndrome, nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology. Read More

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Children with ASD: A Pilot Study.

J Autism Dev Disord 2021 May 15. Epub 2021 May 15.

Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, 28029, Madrid, Spain.

While advances in intensive neonatal care have greatly improved survival rates among preterm infants, incidence of neurodevelopmental disorders in this group is still high, with autism spectrum disorder (ASD) being one of the most frequent. To this end, we conducted a social-communication intervention aimed at investigating efficacy in social-communicative skills. Eighteen children (preterm and full-term with ASD and preterm children) aged 18 through 20 months participated in the study. Read More

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Periprosthetic joint infection is the main reason for failure in patients following periprosthetic fracture treated with revision arthroplasty.

Arch Orthop Trauma Surg 2021 May 15. Epub 2021 May 15.

Bioengineering Laboratory, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.

Introduction: Periprosthetic fracture after primary total hip and knee arthroplasty (THA; TKA) can be challenging, requiring open reduction internal fixation (ORIF), revision, or both. The aim of this study was to evaluate the outcomes and risk factors associated with re-revision surgery following failed revision arthroplasty for periprosthetic fracture.

Methods: A total of 316 consecutive THA patients and 79 consecutive TKA patients underwent a revision for periprosthetic fracture, of which 68 THA patients (21. Read More

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Efficacy and safety of the EMS Swiss LithoClast® Trilogy for PCNL: results of the European multicentre prospective study on behalf of European Section of UroTechnology.

World J Urol 2021 May 15. Epub 2021 May 15.

Department of Urology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ, UK.

Purpose: PCNL requires a lithotrite to efficiently break stones, and some devices include active suction to remove the fragments. We set out to determine the efficacy and safety of the Swiss LithoClast® Trilogy, in a prospective European multicentre evaluation and compared it to published stone clearance rates for Trilogy based on surface area (68.9 mm/min) and using the 3D calculated stone volume (526. Read More

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Growth of Flavobacterium columnare Genomovars in the Presence or Lack of Supplemental Cations.

Curr Microbiol 2021 May 15. Epub 2021 May 15.

National Center for Cool and Cold Water Aquaculture USDA/ARS, 11861 Leetown Rd., Kearneysville, WV, 25430, USA.

Flavobacterium columnare is a problematic pathogen for the aquaculture industry where isolates are classified by genomovars. Suspended growth in a low nutrient media, like tryptone yeast extract salts, is a common method used for laboratory study. The presence of calcium and magnesium is the factor contributing to growth, virulence, and biofilm formation for F. Read More

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Long-term cardiovascular outcomes after orlistat therapy in patients with obesity: a nationwide, propensity-score matched cohort study.

Eur Heart J Cardiovasc Pharmacother 2021 May 15. Epub 2021 May 15.

Department of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.

Aims: The rising prevalence of obesity and its associated comorbidities represent a growing public health issue; in particular, obesity is known to be a major risk factor for cardiovascular disease. Despite the evidence behind the efficacy of orlistat in achieving weight loss in patients with obesity, no study thus far has quantified its long-term effect on cardiovascular outcomes. The purpose of this study is to explore long-term cardiovascular outcomes after orlistat therapy. Read More

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Risk factors for return to work in colorectal cancer survivors.

Cancer Med 2021 May 14. Epub 2021 May 14.

Division of Environmental Health and Occupational Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background: The increasing incidence of colorectal cancer among individuals in the productive age-group has adversely affected the labor force and increased healthcare expenses in recent years. Return to work (RTW) is an important issue for these patients. In this study, we explored the factors that influence RTW and investigated the influence of RTW on survival outcomes of patients with colorectal cancer. Read More

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Inhibition of the interaction between fibronectin and dermatopontin by Clostridium perfringens fibronectin-binding proteins.

Microbiol Immunol 2021 May 15. Epub 2021 May 15.

Department of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama-shi, Okayama, 700-0005, Japan.

Fibronectin (Fn) is an approximately 450 kDa glycoprotein that is comprised of 12 type I, 2 type II, and 15-17 type III modules. Fibrillation of Fn is important for tissue reconstitution and wound healing. We previously reported that Clostridium perfringens produces several Fn-binding proteins (Fbps), two of which, FbpA and FbpB, bind to III -C (a fragment of Fn derived from the carboxyl-terminal two-thirds of the first type III module). Read More

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Metabolic Flux Analysis of Simultaneous Production of Vitamin B and Propionic Acid in a Coupled Fermentation Process by Propionibacterium freudenreichii.

Appl Biochem Biotechnol 2021 May 15. Epub 2021 May 15.

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.

The metabolic processes involved in simultaneous production of vitamin B and propionic acid by Propionibacterium freudenreichii are very complicated. To further investigate the regulatory mechanism of this metabolism, a simplified metabolic network was established. The effects of glucose feeding, propionic acid removal, and 5,6-dimethylbenzimidazole (DMB) addition on the metabolic flux distribution were investigated. Read More

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Fatigue is independently associated with functional status limitations in older adults with gastrointestinal malignancies-results from the CARE registry.

Support Care Cancer 2021 May 15. Epub 2021 May 15.

Institute for Cancer Outcomes & Survivorship, University of Alabama At Birmingham, Birmingham, AL, USA.

Purpose: Fatigue is a component of frailty and may undermine functional well-being and independent living. The prevalence of fatigue and its impact on functional limitations among older adults with cancer remains understudied.

Methods: Using participants enrolled in the Cancer and Aging Resilience Evaluation (CARE), a prospective registry of patients (≥ 60 years) with cancer, who underwent a geriatric assessment (GA) at the first visit with oncology, we examined the presence of fatigue based on self-report of moderate to severe fatigue on PROMIS global health 10-item instrument at the time of GA. Read More

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High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia.

Virchows Arch 2021 May 14. Epub 2021 May 14.

Institute of Clinical and Preventive Medicine, Faculty of Medicine, University of Latvia, 19 Raina Blvd, Riga, 1006, Latvia.

The use of Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Assessment based on Intestinal Metaplasia (OLGIM) staging system is recommended for identifying subjects at risk for developing gastric cancer; usually high-risk lesions are considered only as stages III and IV. Accumulating evidence suggests that incomplete intestinal metaplasia (IM) is important in the development of gastric cancer. Our aim has been to identify the prevalence of incomplete IM in patients with low-risk OLGA/OLGIM stages among a high-risk general population. Read More

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