11,355 results match your criteria iii 5-year

MRI-Guided Transurethral Ultrasound Ablation of Prostate Cancer: A Systematic Review.

J Endourol 2022 Jan 14. Epub 2022 Jan 14.

Mayo Clinic Florida, 23389, Jacksonville, Florida, United States;

Purpose: Magnetic resonance imaging-guided transurethral ultrasound ablation (TULSA) uses real-time MR thermometry feedback to target prostate disease. We systematically review the literature to synthesize efficacy, functional, and safety outcomes and assess the influence of planned ablation fraction on outcome.

Materials And Methods: PubMed, Embase, and the Cochrane Library were searched from inception to June 2021 following PRISMA guidelines. Read More

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January 2022

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

A 5-year multidisciplinary care outcomes in children with wilms' tumour managed at a tertiary centre: A retrospective observational study.

Afr J Paediatr Surg 2022 Apr-Jun;19(2):83-88

Pediatric Surgery Unit, Department of Surgery, Lagos University Teaching Hospital; Paediatric Surgery Unit, Department of Surgery, College of Medicine, University of Lagos & Pediatric Surgery Unit, Department of Surgery, Lagos University Teaching Hospital, Lagos, Nigeria.

Background: Over the last two decades, there has been significant improvement in the outcomes of children with Wilms' tumour (WT) in high income countries (HICs) with approximately 85% survival rate globally. This is partly attributable to a multi-disciplinary team approach to care and the evolution of more robust treatment measures. A previous review in our centre prior to multi-disciplinary team shows a survival rate of 31. Read More

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January 2022

Reappraisal of Grading in Intestinal-Type Sinonasal Adenocarcinoma: Tumor Budding as an Independent Prognostic Parameter.

Head Neck Pathol 2022 Jan 11. Epub 2022 Jan 11.

Department of Molecular Pathology, University Hospital of Zurich and University of Zurich, Zurich, Switzerland.

Since sinonasal intestinal-type adenocarcinomas (ITAC) show resemblance to colorectal adenocarcinomas, we aimed to investigate novel prognostic factors of outcome, with particular focus on the role of tumor budding (TB). Retrospective clinico-pathological single-institution study on consecutive ITAC patients between 1996 and 2020. Histopathological parameters including conventional subtypes and TB features (low, intermediate, high) were evaluated with the aid of pancytokeratin (AE1/AE3) immunohistochemical staining. Read More

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January 2022

Comparison of outcomes and side effects for neoadjuvant chemotherapy with weekly cisplatin and paclitaxel followed by chemoradiation vs. chemoradiation alone in stage IIB-IVA cervical cancer: study protocol for a randomized controlled trial.

Trials 2022 Jan 10;23(1):29. Epub 2022 Jan 10.

Department of Gynecology and Obstetrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, People's Republic of China.

Background: Currently, the standard treatment for locally advanced cervical cancer is concurrent chemoradiation (CCRT). The effect of neoadjuvant chemotherapy in advanced cervical cancer is controversial. Studies have shown that the addition of a weekly regimen of neoadjuvant chemotherapy (NACT) followed by CCRT may be superior to a thrice-weekly regimen of NACT and CCRT. Read More

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January 2022

Impact of Alternative Splicing Variants on Liver Cancer Biology.

Cancers (Basel) 2021 Dec 21;14(1). Epub 2021 Dec 21.

Experimental Hepatology and Drug Targeting (HEVEPHARM), Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain.

The two most frequent primary cancers affecting the liver, whose incidence is growing worldwide, are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), which are among the five most lethal solid tumors with meager 5-year survival rates. The common difficulty in most cases to reach an early diagnosis, the aggressive invasiveness of both tumors, and the lack of favorable response to pharmacotherapy, either classical chemotherapy or modern targeted therapy, account for the poor outcome of these patients. Alternative splicing (AS) during pre-mRNA maturation results in changes that might affect proteins involved in different aspects of cancer biology, such as cell cycle dysregulation, cytoskeleton disorganization, migration, and adhesion, which favors carcinogenesis, tumor promotion, and progression, allowing cancer cells to escape from pharmacological treatments. Read More

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December 2021

S100-stained perineural invasion is associated with worse prognosis in stage I/II colorectal cancer: Its possible association with immunosuppression in the tumor.

Pathol Int 2022 Jan 10. Epub 2022 Jan 10.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

Perineural invasion (PNI) is known as a poor prognostic factor in colorectal cancer (CRC). Although histopathological evaluation of PNI is usually conducted on hematoxylin and eosin (HE)-stained sections (HE-PNI), it remains controversial whether PNI can be precisely evaluated only by HE-staining, and its concise mechanisms causing worse prognosis remains elusive. In this study, we examined the impact of PNI evaluated by S-100-immunostaining (S100-PNI) on postoperative mortality in 279 consecutive CRC patients and further investigated its association with the tumor immune microenvironment. Read More

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January 2022

Subthalamic Nucleus Stimulation in Parkinson's Disease: 5-Year Extension Study of a Randomized Trial.

Mov Disord Clin Pract 2022 Jan 18;9(1):48-59. Epub 2021 Oct 18.

Department of Neurology Oslo University Hospital Oslo Norway.

Background: In Parkinson's disease (PD) long-term motor outcomes of subthalamic nucleus deep brain stimulation (STN-DBS) are well documented, while comprehensive reports on non-motor outcomes are fewer and less consistent.

Objective: To report motor and non-motor symptoms after 5-years of STN-DBS.

Methods: We performed an open 5-year extension study of a randomized trial that compared intraoperative verification versus mapping of STN using microelectrode recordings. Read More

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January 2022

Effects of WeChat platform-based health management on health and self-management effectiveness of patients with severe chronic heart failure.

World J Clin Cases 2021 Dec;9(34):10576-10584

Department of Emergency Medicine, Zhuji People's Hospital of Zhejiang Province, Zhuji 311800, Zhejiang Province, China.

Background: Epidemiological studies have found that the prevalence of chronic heart failure in China is 0.9%, the number of people affected is more than 4 million, and the 5-year survival rate is even lower than that of malignant tumors.

Aim: To determine the impact of WeChat platform-based health management on severe chronic heart failure patients' health and self-management efficacy. Read More

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December 2021

Functional Outcome of Pipkin Type III Fracture Managed by Osteosynthesis through Trochanteric Flip Osteotomy in a Young Patient after 5 Years Follow-Up - A Case Report and Literature Review.

J Orthop Case Rep 2021 Aug;11(8):101-106

Department of Orthopaedics, Sancheti Institute for Orthopedics and Rehabilitation, Pune, Bihar, India.

Introduction: Femoral head fractures are uncommon. A femoral head fracture associated with an ipsilateral neck of femur fracture is classified as a Pipkin's Type III fracture and is exceedingly rare. It is a high-energy injury associated with an extremely poor prognosis. Read More

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Nomogram Predicting Overall Survival in Patients with FIGO II to III Squamous Cell Cervical Carcinoma Under Radical Radiotherapy: A Retrospective Analysis Based on 2018 FIGO Staging.

Cancer Manag Res 2021 29;13:9391-9400. Epub 2021 Dec 29.

Department of Gynecological Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, People's Republic of China.

Purpose: To present a nomogram to predict overall survival in patients with FIGO-2018 II to III squamous cell cervical carcinoma undergoing radical radiotherapy.

Patients And Methods: Patients diagnosed with FIGO-2018 II to III squamous cell cervical cancer between December 2013 and December 2014 were analyzed retrospectively. The optimal cutoff point for tumor length and width were determined by R package. Read More

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December 2021

Obstetric outcomes after conservative management of ovarian borderline tumors in women of reproductive age: A single center experience.

Eur J Obstet Gynecol Reprod Biol 2021 Dec 30;269:126-131. Epub 2021 Dec 30.

Department of Gynecologic Oncology, The Maria Sklodowska-Curie National Research Institute of Oncology, 5 Roentgen Street, 02-781 Warsaw, Poland.

Objective: The main goal of fertility-sparing treatment is pregnancy followed by live birth (i.e., successful pregnancy). Read More

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December 2021

Validation of the 2021 FIGO staging schema for advanced vulvar cancer.

Int J Gynecol Cancer 2022 Jan 7. Epub 2022 Jan 7.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Objective: The International Federation of Gynecology and Obstetrics (FIGO) revised the vulvar cancer staging schema in 2021. Previous stage IIIA-B diseases were reclassified based on nodal size (≤5 mm for stage IIIA compared with >5 mm for stage IIIB), and previous stage IVA1 disease based on non-osseous organ extension was reclassified to stage IIIA whereas osseous extension remained as stage IVA. This study sought to validate the 2021 FIGO vulvar cancer staging schema. Read More

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January 2022

Disparities in Cancer Specific and Overall Survival Outcomes in African Americans with Renal Cell Carcinoma: Analysis from the International Marker Consortium for Renal Cancer (INMARC).

Urology 2022 Jan 4. Epub 2022 Jan 4.

Department of Urology, UC San Diego School of Medicine, La Jolla, USA. Electronic address:

Objective: To investigate association of African-American race and survival in Renal Cell Carcinoma (RCC).

Methods: We queried the International Marker Consortium for Renal Cancer (INMARC) database for patients who underwent partial or radical (RN) nephrectomy. The cohort was divided into African American (AA) and Non-African American (NAA) patients. Read More

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January 2022

Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance).

J Clin Oncol 2022 Jan 7:JCO2101784. Epub 2022 Jan 7.

Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT.

Purpose: Current tools in predicting survival outcomes for patients with colon cancer predominantly rely on clinical and pathologic characteristics, but increasing evidence suggests that diet and lifestyle habits are associated with patient outcomes and should be considered to enhance model accuracy.

Methods: Using an adjuvant chemotherapy trial for stage III colon cancer (CALGB 89803), we developed prediction models of disease-free survival (DFS) and overall survival by additionally incorporating self-reported nine diet and lifestyle factors. Both models were assessed by multivariable Cox proportional hazards regression and externally validated using another trial for stage III colon cancer (CALGB/SWOG 80702), and visual nomograms of prediction models were constructed accordingly. Read More

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January 2022

Real-World Treatment Patterns, Survival, and Costs for Ovarian Cancer in Canada: A Retrospective Cohort Study Using Provincial Administrative Data.

J Health Econ Outcomes Res 2021 9;8(2):114-121. Epub 2021 Dec 9.

London Health Sciences Centre.

In 2020, approximately 3100 Canadian women were diagnosed with ovarian cancer (OC), with 1950 women dying of this disease. Prognosis for OC remains poor, with 70% to 75% of cases diagnosed at an advanced stage and an overall 5-year survival of 46%. Current standard of care in Canada involves a combination of cytoreductive surgery and platinum-based chemotherapy. Read More

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December 2021

Internal fixation versus endoprosthetic replacement of the proximal femur for metastatic bone disease: Single institutional outcomes.

J Orthop 2021 Nov-Dec;28:86-90. Epub 2021 Nov 8.

Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA.

Purpose: This study compared internal fixation (IF) to proximal femur replacement (PFR) for proximal femoral metastasis.

Methods: Between 2005 and 2019, 113 lesions underwent IF ( = 94) or PFR ( = 19). Revision risk was calculated with mortality as a competing event. Read More

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November 2021

Positron Emission Tomography-Driven Strategy in Advanced Hodgkin Lymphoma: Prolonged Follow-Up of the AHL2011 Phase III Lymphoma Study Association Study.

J Clin Oncol 2022 Jan 6:JCO2101777. Epub 2022 Jan 6.

Department of Hematology, University Hospital F. Mitterrand and Inserm UMR 1231, Dijon, France.

Purpose: The AHL2011 study (ClinicalTrials.gov identifier: NCT01358747) demonstrated that a positron emission tomography (PET)-driven de-escalation strategy after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) provides similar progression-free survival (PFS) and overall survival (OS) and reduces early toxicity compared with a nonmonitored standard treatment. Here, we report, with a prolonged follow-up, the final study results. Read More

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January 2022

Anthracycline, taxane, and trastuzumab-based neoadjuvant chemotherapy in HER2-positive early breast cancer: phase II trial.

Tumori 2022 Jan 6:3008916211067568. Epub 2022 Jan 6.

Department of Internal Medicine and Medical Specialties (DiMI), School of Medicine, University of Genoa, Genoa, Italy.

Objective: Neoadjuvant chemotherapy has become the preferred treatment in HER2-positive early breast cancer. Several trials investigated the neoadjuvant efficacy of dual HER2 blockade with anthracycline-free chemotherapy, whereas few data are available on single-agent trastuzumab and anthracycline-based regimens, which represent the standard of care in the adjuvant setting. This phase II, single-arm trial assessed anthracycline-based chemotherapy and trastuzumab as neoadjuvant treatment for high-risk HER2-positive breast cancer. Read More

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January 2022

Prognostic Significance of Preoperative Serum Carcinoembryonic Antigen Varies with Lymph Node Metastasis Status in Colorectal Cancer.

J Oncol 2021 27;2021:4487988. Epub 2021 Dec 27.

Central Laboratory, Fujian Medical University Cancer Hospital& Fujian Cancer Hospital, Fuzhou, China.

Background: Preoperative serum level of carcinoembryonic antigen (pCEA) is generally recognized as a prognostic factor for colorectal cancer (CRC), but the stage-specific role of pCEA in colorectal cancer remains unclear.

Objective: We investigated the prognostic significance of pCEA levels in different tumor stages of nonmetastatic CRC patients.

Methods: Six hundred and fifteen CRC patients at stage I-III were retrospectively analyzed. Read More

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December 2021

Clinical features and treatment outcomes of resected large cell neuroendocrine carcinoma of the lung.

Radiat Oncol J 2021 Dec 8;39(4):288-296. Epub 2021 Dec 8.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a high-grade lung neuroendocrine tumor with a poor prognosis, similar to small cell lung cancer (SCLC). However, it remains unclear whether to treat LCNEC as non-small-cell lung cancer (NSCLC) or as SCLC. We reviewed our experiences to suggest appropriate treatment strategy for resected pulmonary LCNEC. Read More

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December 2021

Clinical Significance of Surgical Resection Timing from Endoscopic Stenting for Left-Sided Large-Bowel Obstruction in Colorectal Cancer.

Dig Dis Sci 2022 Jan 4. Epub 2022 Jan 4.

Department of Surgery, Ajou University School of Medicine, 164, World cup-ro, Yeongtong-gu, Suwon, 16499, Korea.

Background: The optimal interval between self-expanding metallic stent (SEMS) insertion and surgery remains controversial in malignant left-sided large-bowel obstruction (MLLO), especially with respect to oncologic aspects.

Aims: The aim of this study is to examine whether the time interval to surgery is related to oncologic outcomes.

Methods: Prospectively collected database of MLLO between January 2005 and December 2017 were reviewed. Read More

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January 2022

Varicocelectomy in adolescents - Does it safeguard future fertility? A single centre experience.

J Pediatr Urol 2021 Dec 5. Epub 2021 Dec 5.

Department of Urology, Ramaiah Medical College and Hospital, Bangalore 560054, India. Electronic address:

Background: There is paucity of literature comparing varicocelectomy to observant management amongst adolescent boys with hormonal and semen abnormalities resulting from high grade unilateral varicoceles and consequent testicular volume loss. Furthermore, it is not known whether surgical correction in such adolescents improves paternity rates in future compared to their non-operated cohort.

Objective: The primary objective was to compare adolescent boys with unilateral high grade varicocele with associated ipsilateral testicular volume loss who were operated versus those who were not, in relation to their fertility markers (hormonal, semen parameters, and testicular volume) over a 5 year follow up period. Read More

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December 2021

Radiographic vs. MRI vs. arthroscopic assessment and grading of knee osteoarthritis - are we using appropriate imaging?

J Exp Orthop 2022 Jan 3;9(1). Epub 2022 Jan 3.

Wrightington, Wigan & Leigh NHS Foundation Trust, Wigan Lane, Wigan, WN1 2NN, UK.

Purpose: Radiographs and MRI scans are commonly used imaging techniques in the assessment of knee osteoarthritis. However, it currently remains uncertain how good a representation of the actual condition of the knee joint these investigations provide. By comparing them against arthroscopic findings the aim of our study was to conclude how accurate these imaging techniques are at grading knee osteoarthritis. Read More

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January 2022

Real-World Survival Outcomes Based on Mutation Status in Chinese Patients With Lung Adenocarcinoma After Complete Resection: Results From the ICAN Study.

JTO Clin Res Rep 2022 Jan 25;3(1):100257. Epub 2021 Nov 25.

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China.

Introduction: The adjuvant treatment of patients with resected lung adenocarcinoma (LUAD) remains unstandardized. We analyzed the survival outcomes of these patients based on mutation status and adjuvant chemotherapy treatment.

Methods: This noninterventional real-world study (ICAN) enrolled Chinese patients with resected stages I to III LUAD from April 8, 2010, to December 31, 2010. Read More

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January 2022

Stratified Prognostic Value of Pathological Response to Preoperative Treatment in yp II/III Rectal Cancer.

Front Oncol 2021 16;11:795137. Epub 2021 Dec 16.

Department of Gastroenterology, Peking University First Hospital, Beijing, China.

Aim: Accumulated studies have verified that tumor regression is associated with the prognosis of rectal cancer. However, stratified analysis within a certain stage is still unknown. The purpose of our study was to assess the impact of pathologic response on the survival of stageII and III rectal cancer patients after neoadjuvant chemoradiotherapy (nCRT). Read More

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December 2021

A personalized decision aid for prostate cancer shared decision making.

BMC Med Inform Decis Mak 2021 Dec 31;21(1):374. Epub 2021 Dec 31.

Stanford University Radiation Oncology, Stanford, CA, USA.

Background: A shared decision-making model is preferred for engaging prostate cancer patients in treatment decisions. However, the process of assessing an individual's preferences and values is challenging and not formalized. The purpose of this study is to develop an automated decision aid for patient-centric treatment decision-making using decision analysis, preference thresholds and value elicitations to maximize the compatibility between a patient's treatment expectations and outcome. Read More

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December 2021

Transcriptomic profiling of adjuvant colorectal cancer identifies three key prognostic biological processes and a disease specific role for granzyme B.

PLoS One 2021 31;16(12):e0262198. Epub 2021 Dec 31.

Oncology Biomarker Development, Genentech Inc., South San Francisco, California, United States of America.

Background: Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with a 5% 5-year survival rate for metastatic disease, yet with limited therapeutic advancements due to insufficient understanding of and inability to accurately capture high-risk CRC patients who are most likely to recur. We aimed to improve high-risk classification by identifying biological pathways associated with outcome in adjuvant stage II/III CRC.

Methods And Findings: We included 1062 patients with stage III or high-risk stage II colon carcinoma from the prospective three-arm randomized phase 3 AVANT trial, and performed expression profiling to identify a prognostic signature. Read More

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December 2021

Malignant extracranial germ cell tumours: A first national report by the South African Children's Cancer Study Group.

Pediatr Blood Cancer 2021 Dec 31:e29543. Epub 2021 Dec 31.

Paediatric Haematology Oncology, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, University of Stellenbosch, Tygerberg Hospital, Cape Town, South Africa.

Objective: To determine the overall survival (OS) and prognostic factors influencing outcomes in children and adolescents with malignant extracranial germ cell tumours (MEGCTs) in preparation for the development of a harmonised national treatment protocol.

Methods: A retrospective folder review was undertaken at nine South African paediatric oncology units to document patient profiles, tumour and treatment-related data and outcomes for all children with biopsy-proven MEGCTs from birth up to and including 16 years of age.

Results: Between 1 January 2000 and 31 December 2015, 218 patients were diagnosed with MEGCTs. Read More

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December 2021

HIV-infection impact on outcomes of deep-brain stimulation of the subthalamic nucleus for Parkinson's disease.

Eur J Neurol 2021 Dec 30. Epub 2021 Dec 30.

Department of Neurology, Rothschild Foundation Hospital, Paris, France.

Background And Purpose: Middle-aged persons living with HIV (PLHIVs) experience heightened risk for more concomitant age-related comorbidities, acknowledged as signs of poorer deep-brain stimulation of the subthalamic nucleus (STN-DBS) prognosis, at younger-than-expected ages. To assess the beneficial and adverse effects of STN-DBS in PLHIVs with Parkinson's disease (PD-PLHIVs).

Methods: We retrospectively included 9 PD-PLHIVs with sustained virological control. Read More

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December 2021