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Seroepidemiology of TORCH Infections among 1.7 Million Women of Childbearing Age in Rural China: A Population-Based Cross-Sectional Study.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Department of Clinical Laboratory Medicine, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China.

We conducted a national seroepidemiological study of the TORCH (Toxoplasma gondii [TOX], Rubella [RV], Cytomegalovirus [CMV], and Herpes Simplex Virus) in rural women to provided updated baseline data on TORCH prevalence. A total of 1,541,329 women of childbearing age were gathered from 2010 to 2012 in China. Of these, 858,072 women were tested positive for anti-RV IgG antibodies, 602,251 women were tested positive for anti-CMV antibodies, and 40,055 women were tested positive for anti-TOX antibodies. Read More

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September 2021

Longitudinal clinico-serological analysis of anti-nucleocapsid and anti-receptor binding domain of spike protein antibodies against SARS-CoV-2.

Int J Infect Dis 2021 Sep 17. Epub 2021 Sep 17.

ICMR-National Institute of Virology, Pune, Maharashtra, Pin 411021, India. Electronic address:

Objectives: Monitoring the antibody responses to SARS-CoV-2 infection and its correlation to clinical spectrum of disease is critical in understanding the disease progression and protection against re-infection. We assessed the nucleocapsid (N) and receptor-binding-domain of spike (SRBD) protein specific IgG and neutralizing antibody (NAb) responses in COVID-19 patients up to 8 months and its correlation with diverse disease spectrum.

Methods: During the first wave of SARS-CoV-2 pandemic, from 284 COVID-19 patients, 608 samples were collected up to 8 months post infection. Read More

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September 2021

Nosocomial Covid-19 Infection in Women Undergoing Elective Cesarean Sections: A prospective cohort study.

Am J Obstet Gynecol MFM 2021 Sep 17:100490. Epub 2021 Sep 17.

Zucker School of Medicine at Hofstra/Northwell and Northwell Health, New Hyde Park, NY.

Background: The Covid-19 pandemic placed Obstetricians in the difficult position of continuing to perform elective cesarean sections without knowledge of the risk of nosocomial spread of the Covid-19 virus.

Objectives: To determine the nosocomial infection rate in women undergoing elective cesarean section at two academic institutions.

Design: This non-randomized prospective cohort trial evaluated patients undergoing elective cesarean section during the reopening phase of the Covid-19 pandemic in New York State at two large volume Labor and Delivery Units. Read More

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September 2021

Study of antiphospholipid antibodies by enzyme immunoassay and chemiluminescent methods in patients with antiphospholipid syndrome and systemic lupus erythematosus (preliminary data).

Klin Lab Diagn 2021 Sep;66(9):546-551

V.A. Nasonova Research Institute of Rheumatology, Laboratory of Vascular Rheumatology.

Antiphospholipid antibodies (aPL) are a family of different autoantibodies that lead to recurrent vascular thrombosis of any localization and caliber, and/or obstetric pathology - fetal loss. Serological markers of antiphospholipid syndrome (APS) include only three types of aPL - lupus anticoagulant (VA), antibodies to cardiolipin (aCL) classes IgG and IgM, antibodies to β2-glycoprotein1 (aβ2GP1) classes IgG and IgM. Medium and high levels of aCL and aß2HP1 (IgG and / or IgM) were selected as serological markers of APS in the 2006 classification criteria. Read More

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September 2021

Expanding the clinical spectrum of anti-IgLON5 disease: A multicenter retrospective study.

Eur J Neurol 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: We conducted this study to describe detailed clinical characteristics, ancillary test results and treatment response of a group of Chinese patients with anti-IgLON5 disease.

Methods: We recruited 13 patients with positive IgLON5 antibodies in serum and/or cerebrospinal fluid from nine tertiary referral centers. Patients were enrolled from February 2017 to July 2021. Read More

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September 2021

Does reactogenicity after a second injection of the BNT162b2 vaccine predict spike IgG antibody levels in healthy Japanese subjects?

PLoS One 2021 20;16(9):e0257668. Epub 2021 Sep 20.

Department of Laboratory and Transfusion Medicine, Hospital of University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.

Background: Adverse reactions are more common after the second injection of messenger RNA vaccines such as Pfizer/BioNTech's BNT162b2. We hypothesized that the degree and severity of reactogenicity after the second injection reflects the magnitude of antibody production against the SARS CoV-2 virus spike protein (spike IgG).

Methods And Results: Blood samples were obtained from 67 Japanese healthcare workers three weeks after the first injection and two weeks after the second injection of the BNT162b2 vaccine to measure spike IgG levels. Read More

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September 2021

Immunological assessment of SARS-CoV-2 infection in pregnancy from diagnosis to delivery: A multicentre prospective study.

PLoS One 2021 20;16(9):e0253090. Epub 2021 Sep 20.

UCD School of Medicine, National Maternity Hospital, Dublin, Ireland.

Background: Background Population-based data on SARS-CoV-2 infection in pregnancy and assessment of passive immunity to the neonate, is lacking. We profiled the maternal and fetal response using a combination of viral RNA from naso-pharyngeal swabs and serological assessment of antibodies against SARS-CoV-2.

Methods: This multicentre prospective observational study was conducted between March 24th and August 31st 2020. Read More

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September 2021

HSP70i to subdue autoimmunity and support anti-tumor responses.

Cell Stress Chaperones 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.

Developing immunosuppressive therapies for autoimmune diseases comes with a caveat that immunosuppression may promote the risk of developing other conditions or diseases. We have previously shown that biolistic delivery of an expression construct encoding inducible HSP70 (HSP70i) with one amino acid modification in the dendritic cell (DC) activating moiety 435-445 (HSP70i) to mouse skin resulted in significant immunosuppressive activity of autoimmune vitiligo, associated with fewer tissue infiltrating T cells. To prepare HSP70i as a potential therapeutic for autoimmune vitiligo, in this study we evaluated whether and how biolistic delivery of HSP70i in mice affects anti-tumor responses. Read More

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September 2021

Effect of dietary phytobiotic mixture on growth performance, nutrient utilization, and immunity in weaned piglets.

Trop Anim Health Prod 2021 Sep 20;53(5):459. Epub 2021 Sep 20.

Department of Animal Nutrition, West Bengal University of Animal and Fishery Sciences, Belgachia, Kolkata, 700037, India.

This study investigated the effects of dietary phytobiotic mixture on growth performance, blood profiles, immune response, and fecal microorganisms in weaned piglets. Twenty four weaned crossbred piglets were equally divided into four groups in a completely randomized design. The animals in 4 groups were fed a basal diet added with (1) no antibiotics and phytobiotics (CON), (2) bacitracin (0. Read More

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September 2021

Fabrication of hydrophilic zwitterionic microspheres via inverse suspension polymerization for the enrichment of N-glycopeptides.

Mikrochim Acta 2021 Sep 20;188(10):348. Epub 2021 Sep 20.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.

A kind of zwitterionic microsphere was prepared via one-step inverse suspension polymerization employing 3-[N,N-dimethyl-[2-(2-methylpropyl-2-enyloxy) ethyl] ammonium] propane-1-sulfonate (MSA) and N,N-methylene bisacrylamide (BIS) as the precursors. The preparation conditions were carefully investigated and optimized by regulating the content of total monomers, ratio of MSA to BIS, ratio of water to oil, and content of stabilizer. The properties of microspheres were characterized by helium ion microscopy (HIM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), N adsorption/desorption measurement, and water contact angle measurement. Read More

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September 2021

Clinical characteristics and incidence of toxoplasmosis after autologous hematopoietic stem cell transplantation: A retrospective study and literature review.

Transpl Infect Dis 2021 Sep 20. Epub 2021 Sep 20.

Department of Hematology, Nagano Red Cross Hospital, Nagano City, Nagano, Japan.

Background: Toxoplasmosis is a rare but life-threatening infection occurring in immunocompromised hosts, including allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. However, thus far, the clinical features and incidence of toxoplasmosis in autologous HSCT (auto-HSCT) recipients remain unknown. This retrospective survey aimed to analyze 152 patients who received auto-HSCT between 1998 and 2017. Read More

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September 2021

COVID-19 associated Sub-acute invasive pulmonary aspergillosis.

Mycoses 2021 Sep 19. Epub 2021 Sep 19.

Department of Anaesthesia and Critical Care, All India institute of Medical Sciences, New Delhi.

Background: Though invasive pulmonary aspergillosis is a well known complication of COVID-19 pneumonia, indolent forms of aspergillosis have been rarely described.

Methods: We prospectively collected the clinico-radio-microbiological data of 10 patients of subacute invasive pulmonary aspergillosis (SAIA), who presented to our hospital with recent history of COVID-19 pneumonia along with cavitary lung disease, positive IgG (against Aspergillus) with or without positive respiratory samples for Aspergillus spp.

Result: The mean age of presentation of SAIA was 50. Read More

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September 2021

A single dose of SARS-CoV-2 FINLAY-FR-1A vaccine enhances neutralization response in COVID-19 convalescents, with a very good safety profile: An open-label phase 1 clinical trial.

Lancet Reg Health Am 2021 Dec 15;4:100079. Epub 2021 Sep 15.

Finlay Vaccine Institute, 21st Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.

Background: As a first step towards a vaccine protecting COVID-19 convalescents from reinfection, we evaluated FINLAY-FR-1A vaccine in a clinical trial.

Methods: Thirty COVID-19 convalescents aged 22-57 years were studied: convalescents of mild COVID-19, asymptomatic convalescents, both with PCR-positive at the moment of diagnosis; and individuals with subclinical infection detected by viral-specific IgG. They received a single intramuscular injection of the FINLAY-FR-1A vaccine (50 µg of the recombinant dimeric receptor binding domain). Read More

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December 2021

Bilateral neuroretinits and exudative retinal detachment with multifocal subretinal deposits secondary to Bartonella henselae infection.

Am J Ophthalmol Case Rep 2021 Dec 7;24:101201. Epub 2021 Sep 7.

Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY, USA.

Purpose: to describe a case of bilateral neuroretinitis with bullous retinal detachment and multiple subretinal lesions, in a 10-year-old immunocompetent girl.

Observations: A broad workup for infectious, inflammatory and masquerade etiologies was done for the patient, resulting in positive IgM and IgG for Bartonella henselae. The patient demonstrated improvement in the visual acuity, and rapid resolution of the retinal detachment and subretinal lesions in both eyes in response to systemic rifampin, doxycycline and corticosteroids. Read More

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December 2021

Rat Hepatitis E Virus: Presence in Humans in South-Western France?

Front Med (Lausanne) 2021 3;8:726363. Epub 2021 Sep 3.

Virology Laboratory, National Reference Centre of Hepatitis E Viruses, Federal Institute of Biology, University Hospital, Toulouse, France.

Hepatitis E Virus (HEV) is one of the most common causes of hepatitis worldwide, and South-Western France is a high HEV seroprevalence area. While most cases of HEV infection are associated with the species Orthohepevirus-A, several studies have reported a few cases of HEV infections due to Orthohepevirus-C (HEV-C) that usually infects rats. Most of these human cases have occurred in immunocompromised patients. Read More

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September 2021

Seroepidemiological survey of brucellosis and Q fever among high-risk occupations in northeast of Iran for first time.

Iran J Microbiol 2021 Jun;13(3):325-336

Department of Quality Control, Razi Vaccine and Serum Research Institute, Agricultural Research Education And Extention Organization, Mashhad Branch, Mashhad, Iran.

Background And Objectives: Brucellosis and Q fever are considered as occupational hazards to people in contact with domestic animals or their carcasses. The present cross-sectional study was carried out to determine the seroprevalence of brucellosis and Q fever among professions at risk in the North Khorasan Province, northeastern Iran during 2020.

Materials And Methods: In this study, 185 sera samples were collected from butchers, slaughterhouse workers, farmers, and veterinarians in different counties of the province. Read More

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Assessment of seroprevalence of in blood donors applied to the blood center of Gazi university hospital.

Iran J Microbiol 2021 Apr;13(2):243-247

Department of Medical Microbiology, School of Medicine, Lokman Hekim University, Ankara, Turkey.

Background And Objectives: Toxoplasmosis is a life-threatening zoonotic infection in immunosuppressive individuals. Determining the prevalence and seropositivity rates of toxoplasmosis in asymptomatic blood donors is crucial in terms of the risk status of the transmission of this infection to the blood recipients.

Materials And Methods: In this study, the presence and level of the specific IgG and IgM antibodies in blood donors was investigated by electrochemiluminescence immunoassay (ECLIA). Read More

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Monitoring Specific IgM and IgG Production Among Severe COVID-19 Patients Using Qualitative and Quantitative Immunodiagnostic Assays: A Retrospective Cohort Study.

Front Immunol 2021 3;12:705441. Epub 2021 Sep 3.

Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

The purpose of this study is to monitor specific anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) IgG and IgM antibody production in patients with severe forms of coronavirus disease 2019 (COVID-19) using various commercially available quantitative and qualitative tests. The sera of 23 confirmed COVID-19 patients were processed for anti-SARS-CoV-2 IgG and IgM detection. Three different immunoassays, viz. Read More

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September 2021

Cytokine Profiles Associated With Worse Prognosis in a Hospitalized Peruvian COVID-19 Cohort.

Front Immunol 2021 1;12:700921. Epub 2021 Sep 1.

Grupo Enfermedades Emergentes, Universidad Científica del Sur, Lima, Peru.

Cytokines, chemokines and growth factors present different expression profiles related to the prognosis of COVID-19. We analyzed clinical parameters and assessed the expression of these biomarkers in patients with different disease severity in a hospitalized Peruvian cohort to determine those associated with worse prognosis. We measured anti-spike IgG antibodies by ELISA and 30 cytokines by quantitative suspension array technology in 123 sera samples. Read More

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September 2021

Genome-Wide DNA Methylation Profile in Whole Blood of Patients With Chronic Spontaneous Urticaria.

Front Immunol 2021 3;12:681714. Epub 2021 Sep 3.

Department of Dermatology, The First Hospital of China Medical University, National Health Commission Key Laboratory of Immunodermatology, Key Laboratory of Immunodermatology of Ministry of Education, Shenyang, China.

Background: Chronic spontaneous urticaria (CSU) is a common autoimmune skin disease. Little is known about the role of epigenetics in the pathogenesis of CSU. This study aimed to investigate genome-wide DNA methylation profile in whole blood of patients with CSU. Read More

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September 2021

Fermented Cottonseed Meal as a Partial Replacement for Soybean Meal Could Improve the Growth Performance, Immunity and Antioxidant Properties, and Nutrient Digestibility by Altering the Gut Microbiota Profile of Weaned Piglets.

Front Microbiol 2021 1;12:734389. Epub 2021 Sep 1.

College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

The study investigated the impact of fermented cottonseed meal (FCSM) on growth performance, immunity and antioxidant properties, nutrient digestibility, and gut microbiota of weaned piglets by replacing soybean meal with FCSM in the diet. The experimental piglets were fed with either the soybean meal diet (SBM group) or fermented cottonseed meal diet (FCSM group) for 14days after weaning. The digestibility of dry matter (DM), organic matter (OM), crude protein (CP), gross energy (GE), amino acids and nitrogen was higher in the FCSM diet than those in the SBM diet (<0. Read More

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September 2021

Neonatal Immune Neutropenia due to Isoantibodies against the Granulocyte Receptor FcγRIIIb.

Transfus Med Hemother 2021 Aug 25;48(4):259-262. Epub 2021 Feb 25.

Department of Neonatology, Service of Pediatrics, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.

Introduction: Neonatal neutropenia is often secondary to sepsis, low birth weight, pregnancy-induced maternal hypertension, and other conditions.

Case Report: We report a case of asymptomatic isoimmune neutropenia in a pair of preterm twins. Genotyping confirmed that the mother was negative for HNA-1a, 1b, and 1c, consistent with an FcγRIIIb deficiency. Read More

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Seroconversion in septic ICU patients presenting with COVID-19: necessary but not sufficient.

Arch Med Res 2021 Sep 6. Epub 2021 Sep 6.

UR 7426 "Pathophysiology of Injury-Induced Immunosuppression" (Université Claude-Bernard Lyon 1 - Hospices Civils de Lyon - bioMérieux) / Joint Research Unit HCL-bioMérieux, Edouard Herriot Hospital, Lyon, France; Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, 69437, Lyon, France. Electronic address:

Background: As COVID-19 pandemic and vaccination effects progress, research now focuses on adaptive immunological response to SARS-CoV-2. Few studies specifically investigated intensive care unit (ICU) patients, and little is known about kinetics of humoral response in such critically ill patients. In this context, the main objective of the present work was to perform a longitudinal analysis of the humoral response in critically ill COVID-19 patients with prolonged ICU stays in regard with initial inflammatory response, disease severity and mortality. Read More

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September 2021

Effects of enzymatic hydrolysis on the allergenicity of natural cow milk based on a BALB/c mouse model.

J Dairy Sci 2021 Sep 15. Epub 2021 Sep 15.

College of Food Science, Shenyang Agricultural University, Shenyang 100866, P. R. China. Electronic address:

Cow milk allergy is one of the most prevalent food allergies worldwide, particularly in infants and children. To the best of our knowledge, minimal research exists concerning the antigenicity of cow milk (CM). This study was performed to evaluate the allergenicity of enzymatically hydrolyzed cow milk (HM) in a BALB/c mouse model. Read More

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September 2021

Universal fluorescence nanoprobes to enhance the sensitivity of immunochromatographic assay for detection of 17β-estradiol in milk.

Food Chem 2021 Sep 1;370:131027. Epub 2021 Sep 1.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu 214122, PR China. Electronic address:

The pollution caused by estrogens in the environment and food has received increasing attention. It is still challenging for on-site immunochromatographic assay (ICA) detection of estrogens. The performance of the prepared probes plays a decisive role in the sensitivity and stability of the ICA system. Read More

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September 2021

Safety and Immunogenicity of an Inactivated SARS-CoV-2 Vaccine in a Subgroup of Healthy Adults in Chile.

Clin Infect Dis 2021 Sep 19. Epub 2021 Sep 19.

Hospital Clínico Félix Bulnes, Santiago, Chile.

Background: The development of effective vaccines against COVID-19 is a global priority. CoronaVac is an inactivated SARS-CoV-2 vaccine with promising safety and immunogenicity profiles. This article reports safety and immunogenicity results obtained for healthy Chilean adults aged ≥18 in a phase 3 clinical trial. Read More

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September 2021

Potential of recombinant LiHyQ, a novel Leishmania infantum protein, for the diagnosis of canine visceral leishmaniasis and as a diagnostic and prognostic marker for human leishmaniasis and human immunodeficiency virus co-infection: a preliminary study.

Acta Trop 2021 Sep 16:106126. Epub 2021 Sep 16.

Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30.130-100, Minas Gerais, Brazil; Departamento de Patologia Clínica, COLTEC, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil. Electronic address:

Laboratory diagnosis of leishmaniasis shows variable efficacy in detecting infected mammalian hosts and there is a need to identify suitable antigens to improve the accuracy of diagnostic tests. In the present study, a L. infantum hypothetical protein called LiHyQ was evaluated for the diagnosis of tegumentary (TL) and visceral (VL) leishmaniasis using canine and human samples. Read More

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September 2021

Direct immunofluorescence analysis of oral Tzanck smears for pemphigus vulgaris: A diagnostic test.

J Oral Pathol Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.

Background: Pemphigus vulgaris (PV) is a rare and potentially fatal autoimmune blistering disease. Direct immunofluorescence (DIF) is an important method for PV diagnosis, but oral tissue biopsy for DIF analysis is difficult to perform because of the fragile characteristics of oral mucosa. However, no well-designed diagnostic studies addressing the validity of DIF analysis of oral Tzanck smears for the diagnosis of PV exist. Read More

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September 2021

Evaluation of the performance of 25 SARS-CoV-2 serological rapid diagnostic tests using a reference panel of plasma specimens at the Uganda Virus Research Institute.

Int J Infect Dis 2021 Sep 15. Epub 2021 Sep 15.

Uganda Virus Research Institute, P.O. Box 49, Plot 51-59, Nakiwogo Road, Entebbe, Uganda; Medical Research Council/Uganda Virus Research Institute & London School of Hygiene and Tropical Medicine, Uganda Research Unit, P.O. Box 49, Plot 1-59, Nakiwogo Road, Entebbe, Uganda. Electronic address:

Introduction: Serological testing is needed to better understand the epidemiology of the SARS-CoV-2 virus. Rapid Diagnostic Tests (RDTs) have been developed to detect specific antibodies, IgM and IgG, to the virus. We evaluated the performance of 25 of these RDTs. Read More

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September 2021

Acute myocarditis after COVID-19 vaccination with mRNA-1273 in a patient with former SARS-CoV-2 infection.

ESC Heart Fail 2021 Sep 18. Epub 2021 Sep 18.

Department of Medicine I, Jena University Hospital, Friedrich Schiller University Jena, Am Klinikum 1, Jena, 07747, Germany.

We describe a case of a 20-year-old healthy man developing chest pain and classical symptoms of vaccine reactogenicity 12 h after receiving the first dose of mRNA-1273 (Moderna). Cardiac troponin T was increased, and subepicardial inflammation and focal contractile dysfunction were detected by cardiac magnetic resonance imaging and echocardiography. We confirmed the diagnosis of acute myocarditis by endomyocardial biopsy demonstrating significant infiltration of monocytes and T lymphocytes. Read More

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September 2021