1,949 results match your criteria iga vasculitis


New-Onset and Relapsed Kidney Histopathology Following COVID-19 Vaccination: A Systematic Review.

Vaccines (Basel) 2021 Oct 29;9(11). Epub 2021 Oct 29.

Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

Introduction: The introduction of COVID-19 vaccination programs has become an integral part of the major strategy to reduce COVID-19 numbers worldwide. New-onset and relapsed kidney histopathology have been reported following COVID-19 vaccination, sparking debate on whether there are causal associations. How these vaccines achieve an immune response to COVID-19 and the mechanism that this triggers kidney pathology remains unestablished. Read More

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October 2021

Avacopan: First Approval.

Authors:
Arnold Lee

Drugs 2021 Nov 26. Epub 2021 Nov 26.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Avacopan (TAVNEOS™) is a complement 5a receptor (C5aR) antagonist developed by ChemoCentryx for the treatment of autoimmune diseases including anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis. The therapeutic effects of avacopan are attributed to the inhibition of C5aR activity on neutrophils, however, the exact mechanism of therapeutic efficacy in patients with ANCA-associated vasculitis has not been established. In September 2021, avacopan received its first approval in Japan for the treatment of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), the two most common forms of ANCA-associated vasculitis, where it is being commercialized by Kissei Pharmaceutical through a partnership with Vifor Pharma. Read More

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November 2021

Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis.

Pathobiology 2021 Nov 23:1-6. Epub 2021 Nov 23.

Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan.

Introduction: IgA vasculitis is a systemic disease that results from the entrapment of circulating IgA-containing immune complexes in small-vessel walls in the skin, kidneys, and gastrointestinal tract. An excessive formation of neutrophil extracellular traps (NETs) is involved in the pathogenesis of vasculitis, especially in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. This study aimed to clarify whether NETs are implicated in IgA vasculitis. Read More

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November 2021

Epidemiology and Clinical Characteristics of Henoch-Schönlein Purpura Associated with Epstein-Barr Virus Infection.

Mediterr J Hematol Infect Dis 2021 1;13(1):e2021064. Epub 2021 Nov 1.

Medical department, The first people's Hospital of Guangshui, China.

Background: Henoch-Schönlein purpura (HSP) is an immune-mediated vasculitis, and the formation of immune complexes may be triggered by exposure to Epstein-Barr virus (EBV) infection.

Methods: We performed a five-year case-control study to evaluate the epidemiology and clinical characteristics of HSP associated with EBV infection.

Results: The incidence of EBV-triggered HSP was 4. Read More

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November 2021

Post-COVID-19 vaccination IgA Vasculitis in an Adult.

J Cutan Pathol 2021 Nov 14. Epub 2021 Nov 14.

Department of Dematology, Yale University School of Medicine.

Leukocytoclastic vasculitis has been reported in the setting of COVID-19 infection and post-COVID-19 vaccination. We report a case of post-COVID-19 vaccination IgA vasculitis with IgA immune deposits in the skin and renal involvement; SARS-CoV spike protein immunohistochemical staining was negative. IgA vasculitis with skin and renal involvement is a potential reaction to COVID-19 vaccination. Read More

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November 2021

Antineutrophil cytoplasmic antibody positivity and cutaneous IgA vasculitis in a patient with antisynthetase syndrome.

JAAD Case Rep 2021 Dec 20;18:26-28. Epub 2021 Oct 20.

Department of Dermatology, University of Texas Health Science Center at Houston, Houston, Texas.

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December 2021

[Who can pretend knowing how to treat adult IgA vasculitis? What are the futures challenges?]

Rev Med Interne 2021 Nov 11. Epub 2021 Nov 11.

Service de Néphrologie, Hôpital Saint Louis, AP-HP, France.

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November 2021

Clinical predictive model for the 1-year remission probability of IgA vasculitis nephritis.

Int Immunopharmacol 2021 Nov 11;101(Pt B):108341. Epub 2021 Nov 11.

Department of Nephrology, West China Hospital, Sichuan University, No. 37, Guoxue alley, Chengdu, Sichuan Zipcode: 610000, China. Electronic address:

Purpose: Early remission of Immunoglobulin A vasculitis nephritis (IgAVN) substantially affects its prognosis. In this work, a multivariate model to predict the 1-year remission probability of patients with IgAVN was developed on the basis of clinical laboratory data.

Methods: Data of 187 patients with IgAVN confirmed by renal biopsy were retrospectively assessed. Read More

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November 2021

IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment.

J Clin Med 2021 Oct 22;10(21). Epub 2021 Oct 22.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Patients with IgA vasculitis (IgAV), an immune complex-mediated disease, may exhibit kidney involvement-IgAV with nephritis (IgAVN). The kidney-biopsy histopathologic features of IgAVN are similar to those of IgA nephropathy, but little is known about histopathologic disease severity based on the interval between purpura onset and diagnostic kidney biopsy. We assessed kidney histopathology and clinical and laboratory data in a cohort of adult patients with IgAVN (n = 110). Read More

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October 2021

Relationship between Gd-IgA1 and TNFR1 in IgA nephropathy and IgA vasculitis nephritis in children - multicenter study.

Cent Eur J Immunol 2021 7;46(2):199-209. Epub 2021 Aug 7.

Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Aim Of The Study: To evaluate the relationship between serum Gd-IgA1 (sGd-IgA1) and serum and urine TNFR1 (sTNFR1, uTNFR1) levels as possible prognostic factors in IgA nephropathy (IgAN) and IgA vasculitis nephritis (IgAVN).

Material And Methods: From 299 patients from the Polish Registry of Pediatric IgAN and IgAVN, 60 children (24 IgAN and 36 IgAVN) were included in the study. The control group consisted of 20 healthy children. Read More

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Hemorrhagic bullous IgA vasculitis (Schönlein-Henoch purpura), does it have a worse prognosis?

Reumatol Clin (Engl Ed) 2021 Nov 6;17(9):549-551. Epub 2021 Apr 6.

Unidad de Reumatología Pediátrica, Hospital Universitario 12 de Octubre, Madrid, Spain; Departamento de Salud Pública y Materno-Infantil, Universidad Complutense de Madrid, Madrid, Spain.

Haemorrhagic bullous form of IgA vasculitis (IgAV), or Schönlein-Henoch purpura, is an unusual presentation of the disease in paediatric patients (<2%). Blistering eruptions can sometimes be very striking, leading to hospital admissions and administration of high-dose steroids and even immunosuppressants. Review of the literature, however, does not suggest that this clinical form carries a worse prognosis than the other forms of IgAV. Read More

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November 2021

Coronavirus disease 2019-associated immunoglobulin A vasculitis/Henoch-Schönlein purpura: A case report and review.

J Dermatol 2021 Nov 5. Epub 2021 Nov 5.

Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona, USA.

Immunoglobulin A (IgA) vasculitis or Henoch-Schönlein purpura is a predominantly pediatric disease occurring after a triggering viral or bacterial infection. Conversely, drug exposure is the most common inciting event in adult cases of IgA vasculitis. Recently, data has suggested a temporal association between coronavirus disease 2019 (COVID-19) and the development of IgA vasculitis in children and adults. Read More

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November 2021

Immune mediated events timely associated with COVID-19 vaccine. A comment on article by Badier, et al.: "IgA vasculitis in adult patients following vaccination by ChadOx1 nCoV-19".

Autoimmun Rev 2021 Nov 2:102989. Epub 2021 Nov 2.

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Internal Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

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November 2021

Patient reported outcomes in systemic vasculitis.

Curr Opin Rheumatol 2022 Jan;34(1):33-38

Rheumatology Department, Bristol Royal Infirmary, University Hospitals Bristol and Weston NHS Foundation Trust.

Purpose Of Review: This review paper evaluates the use of patient reported outcome (PROs) in systemic vasculitis and the increasing incorporation of these measures in the evaluation of clinical outcomes and healthcare provision.

Recent Findings: Generic PROs such as the SF-12, SF-36, EQ-5D have been used to evaluate health-related quality of life (HRQOL) across the spectrum of vasculitis; including giant cell arteritis, antineutrophil cytoplasmic antibody (ANCA)-related vasculitis and immunoglobulin A vasculitis (IgA) vasculitis. More recently disease-specific PROs have been developed including the associated vasculitis (AAV)-PRO and GCA-PRO, whilst further work is ongoing including a Steroid-PRO. Read More

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January 2022

Successful Treatment of IgA Vasculitis With Prolonged Cutaneous Manifestation With Colchicine in a 10-Year-Old Boy.

Mod Rheumatol Case Rep 2021 Nov 3. Epub 2021 Nov 3.

Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Hokkaido, Japan.

We report a 10-year-old boy with IgA vasculitis (IgAV) with prolonged cutaneous manifestations who was successfully treated with colchicine. At the age of 9, he was diagnosed as having IgAV by typical purpura, abdominal pain, and hematochezia. Initially, his severe gastrointestinal manifestation subsided by prednisolone 60 mg/day and intravenous methylprednisolone pulse therapy. Read More

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November 2021

Impact of the COVID-19 pandemic on the frequency of the pediatric rheumatic diseases.

Rheumatol Int 2021 Nov 2. Epub 2021 Nov 2.

Department of Pediatrics, Division of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey.

The impact of the COVID-19 pandemic, and implemented restrictions on the frequency of pediatric rheumatic diseases remain unknown, while they have probably prevented common infections in children. We present the effects of the COVID-19 on our pediatric rheumatology practice in a main referral center. We retrospectively reviewed the medical records of patients presenting to pediatric rheumatology department in 4 years before March 2020 and compared it to the pandemic year (March 2020-March 2021). Read More

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November 2021

Henoch-Schönlein Purpura Following the First Dose of COVID-19 Viral Vector Vaccine: A Case Report.

Vaccines (Basel) 2021 Sep 25;9(10). Epub 2021 Sep 25.

Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

A 76 year-old female came to our observation one week after the vaccination with ChAdOx1 nCoV-19 AZD1222 for the onset of purpuric rash on her gluteal and legs regions associated with coxalgia and episodes of macrohaematuria. Henoch-Schönlein purpura (HSP) was diagnosed on the basis of the revised criteria developed by the European League Against Rheumatism, the Paediatric Rheumatology International Trials Organization, and the Paediatric Rheumatology European Society (EULAR/PRINTO/PRES). HSP is a common IgA-mediated small vessel vasculitis, typical of childhood, that affects several systems and is characterized by a tetrad of dermatological, abdominal, joint, and renal manifestations. Read More

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September 2021

In Every Man, There Is a Child: Henoch-Schönlein Purpura in an Adult With Liver Cirrhosis.

Cureus 2021 Sep 25;13(9):e18270. Epub 2021 Sep 25.

Internal Medicine, St. Peter's University Hospital, New Brunswick, USA.

Henoch-Schönlein purpura (HSP), also known as immunoglobulin A (IgA) vasculitis, is a small-vessel vasculitis characterized by IgA deposits in various organs in the body producing a unique constellation of symptoms. This disease predominantly affects the skin (palpable purpura), joints (arthritis/arthralgia), gut (abdominal pain), and kidneys (nephritic syndrome-IgA nephropathy [IgAN]). The pathogenesis of HSP in children is usually secondary to an immune reaction after viral infections. Read More

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September 2021

Immunoglobulin A Vasculitis in a Japanese Patient with Complete Familial Mediterranean Fever Carrying MEFV Exon 10 Mutation.

Tohoku J Exp Med 2021 10;255(2):157-162

Department of Rheumatology, Fukushima Medical University School of Medicine.

Immunoglobulin A (IgA) vasculitis is a systemic small-vessel vasculitis involving the skin, kidney, joints, and gastrointestinal tract. Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by periodic fever, peritonitis, pleuritis, or arthritis. It is well known that FMF may coexist with vasculitis, especially small and medium vessel vasculitis. Read More

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October 2021

"Comb and Target signs" in abdominal CT in patients with purpura.

Eur J Intern Med 2021 Oct 21. Epub 2021 Oct 21.

Division of General Medicine, Department of Comprehensive Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama 330-8503, Japan.

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October 2021

Immunoglobulin A Glycosylation and Its Role in Disease.

Exp Suppl 2021 ;112:433-477

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.

Human IgA is comprised of two subclasses, IgA1 and IgA2. Monomeric IgA (mIgA), polymeric IgA (pIgA), and secretory IgA (SIgA) are the main molecular forms of IgA. The production of IgA rivals all other immunoglobulin isotypes. Read More

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November 2021

Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever.

Medicina (Kaunas) 2021 Oct 1;57(10). Epub 2021 Oct 1.

Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.

Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease with autosomal recessive transmission, characterized by periodic fever attacks with self-limited serositis. Secondary amyloidosis due to amyloid A renal deposition represents the most fearsome complication in up to 8.6% of patients. Read More

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October 2021

IgA vasculitis nephritis clinical course and kidney biopsy - national study in children.

Pediatr Rheumatol Online J 2021 Oct 7;19(1):150. Epub 2021 Oct 7.

Department of Paediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

The aim of the study was to investigate the relationship between the severity of typical clinical symptoms, severity of histopathological lesions in kidney biopsies in IgA vasculitis nephritis (IgAVN) and to propose indications for kidney biopsy in children.

Material And Methods: This retrospective study enrolled 106 patients, included in the IgAVN registry of Polish children, diagnosed by kidney biopsy. Renal and extrarenal symptoms at onset of the disease were analyzed. Read More

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October 2021

Assessment of Clinical and Laboratory Use of the Cutaneous Direct Immunofluorescence Assay.

JAMA Dermatol 2021 Nov;157(11):1343-1348

Massachusetts General Physician Organization Dermatopathology Associates, Newton, Massachusetts.

Importance: Dermatologists submit direct immunofluorescence (DIF) biopsies on a daily basis, using an assay detecting immunoreactant deposition with a panel that has traditionally comprised immunoglobulin (Ig) G, IgA, IgM, C3, and fibrin, with or without albumin antibodies.

Objectives: To evaluate and compare the frequency of immunoreactants in DIF biopsies submitted over an 8-year period and assess use by dermatologists based on clinical impression.

Design, Setting, And Participants: A quality improvement study was conducted in a community outreach reference laboratory associated with a large academic medical center. Read More

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November 2021

The pathogenesis of COVID-19-induced IgA nephropathy and IgA vasculitis: A systematic review.

J Taibah Univ Med Sci 2021 Sep 28. Epub 2021 Sep 28.

Department of Medicine, Mayo Hospital, King Edward Medical University, Lahore, Pakistan.

Objective: IgA nephropathy (IgAN) and IgA vasculitis (IgAV) are part of a similar clinical spectrum. Both clinical conditions occur with the coronavirus disease 2019 (COVID-19). This review aims to recognize the novel association of IgAN and IgAV with COVID-19 and describe its underlying pathogenesis. Read More

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September 2021

Changes of Peripheral Blood Lymphocyte Subsets and Immune Function in Children with Henoch-Schonlein Purpura Nephritis.

Iran J Immunol 2021 09;18(3):259-267

Department of Pediatrics, The Second Hospital of HeBei Medical University, ShiJiaZhuang 050000, China.

Background: Purpuric nephritis is the most common secondary glomerular disease in childhood. Its prevalence in children has been steadily rising in recent years.

Objective: To explore the characteristics and pathogenesis of changes in peripheral blood lymphocyte subsets and immune function in children with Henoch-Schonlein purpura nephritis. Read More

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September 2021

Clinical features of lupus enteritis: a single-center retrospective study.

Orphanet J Rare Dis 2021 09 26;16(1):396. Epub 2021 Sep 26.

Department of Rheumatology and Immunology, Suining Central Hospital, No.127, West Desheng Rd., Chuanshan District, Suining, Sichuan Province, China.

Background: Lupus enteritis (LEn) is a rare complication of systemic lupus erythematosus (SLE). Timely diagnosis and treatment of LEn are necessary to prevent the most serious consequences - intestinal perforation, gastrointestinal bleeding, and death. We compared the clinical features of SLE patients with and without LEn. Read More

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September 2021

Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases.

Kidney Int 2021 10;100(4):753-779

Cochrane Kidney and Transplant, Sydney, New South Wales, Australia; Sydney School of Public Health, The University of Sydney, Sydney, New South Wales, Australia.

The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is to assist clinicians caring for individuals with glomerulonephritis (GN), both adults and children. The scope includes various glomerular diseases, including IgA nephropathy and IgA vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil cytoplasmic antibody (ANCA) vasculitis, lupus nephritis, and anti-glomerular basement membrane antibody GN. Read More

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October 2021

Value of second opinion subspecialty radiology consultation in suspected abdominal medium vessel vasculitis.

Abdom Radiol (NY) 2021 12 22;46(12):5763-5771. Epub 2021 Sep 22.

Department of Radiology, Diagnostic Imaging, St. Joseph's Healthcare Hamilton, McMaster University, 50 Charlton Ave. E, Hamilton, ON, L8N 4A6, Canada.

Purpose: To perform a descriptive analysis of individuals with suspected Polyarteritis nodosa (PAN) referred for second opinion imaging consultation.

Methods: A retrospective observational cohort study was performed at a single institution. A consecutive sample was performed of individuals who underwent a second opinion CT or MR angiography subspecialty radiologist consultation between January 2008 and September 2019 for suspected abdominal medium vessel vasculitis. Read More

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December 2021

The Involvement of Neutrophil Extracellular Traps in Disease Activity Associated With IgA Vasculitis.

Front Immunol 2021 3;12:668974. Epub 2021 Sep 3.

Department of Pediatrics, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.

Objectives: This aim of this study was to determine whether neutrophil extracellular traps (NETs) are involved in the pathogenesis of IgA vasculitis (IgAV) and investigate whether the circulating NETs levels are associated with disease activity in children.

Methods: We performed a case-control study and collected blood samples from 193 children with different stages of IgAV (61 were at the onset stage, 64 at the remission stage, 43 at the active stage, and 25 were undergoing drug withdrawal). A total of 192 healthy children were recruited as controls. Read More

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October 2021