17,831 results match your criteria iga igm

Effect of dietary phytobiotic mixture on growth performance, nutrient utilization, and immunity in weaned piglets.

Trop Anim Health Prod 2021 Sep 20;53(5):459. Epub 2021 Sep 20.

Department of Animal Nutrition, West Bengal University of Animal and Fishery Sciences, Belgachia, Kolkata, 700037, India.

This study investigated the effects of dietary phytobiotic mixture on growth performance, blood profiles, immune response, and fecal microorganisms in weaned piglets. Twenty four weaned crossbred piglets were equally divided into four groups in a completely randomized design. The animals in 4 groups were fed a basal diet added with (1) no antibiotics and phytobiotics (CON), (2) bacitracin (0. Read More

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September 2021

Editorial: The B-Side of B Cells.

Front Immunol 2021 3;12:758164. Epub 2021 Sep 3.

Department of Clinical Internal Sciences, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

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September 2021

Direct immunofluorescence analysis of oral Tzanck smears for pemphigus vulgaris: A diagnostic test.

J Oral Pathol Med 2021 Sep 18. Epub 2021 Sep 18.

Department of Oral Medicine, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, Beijing, China.

Background: Pemphigus vulgaris (PV) is a rare and potentially fatal autoimmune blistering disease. Direct immunofluorescence (DIF) is an important method for PV diagnosis, but oral tissue biopsy for DIF analysis is difficult to perform because of the fragile characteristics of oral mucosa. However, no well-designed diagnostic studies addressing the validity of DIF analysis of oral Tzanck smears for the diagnosis of PV exist. Read More

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September 2021

COVID-19 mRNA vaccine and antibody response in lactating women: a prospective cohort study.

BMC Pregnancy Childbirth 2021 Sep 17;21(1):632. Epub 2021 Sep 17.

Centro Hospitalar Universitário de Lisboa Central (CHULC), Lisboa, Portugal.

Background: Immunological protection via breastfeeding is well known. The immunological profile of human milk changes during lactation. No clinical trials have been conducted in lactating women with the newest mRNA vaccines against SARS- CoV-2. Read More

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September 2021

Prevalence and association of mycoplasma infection in the development of coronary artery disease.

Braz J Biol 2021 10;83:e246385. Epub 2021 Sep 10.

Danyang Hospital Affiliated to Nantong University, Danyang People's Hospital of Jiangsu Province, Department of Clinical Laboratory, Nantong, Jiangsu, China.

Coronary heart disease (CHD) has been associated with significant morbidity and mortality worldwide. Although remain controversial, several studies have demonstrated the association of M. pneumoniae infections with atherosclerosis. Read More

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September 2021

Serological assessment of SARS-CoV-2 infection during the first wave of the pandemic in Louisville Kentucky.

Sci Rep 2021 09 14;11(1):18285. Epub 2021 Sep 14.

James Graham Brown Cancer Center, University of Louisville School of Medicine, University of Louisville, Louisville, KY, USA.

Serological assays intended for diagnosis, sero-epidemiologic assessment, and measurement of protective antibody titers upon infection or vaccination are essential for managing the SARS-CoV-2 pandemic. Serological assays measuring the antibody responses against SARS-CoV-2 antigens are readily available. However, some lack appropriate characteristics to accurately measure SARS-CoV-2 antibodies titers and neutralization. Read More

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September 2021

Reflexing Suspicious β-Region Findings on Capillary Serum Protein Electrophoresis to Immunofixation or Immunosubtraction for Detecting Monoclonal Proteins.

Am J Clin Pathol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Objectives: Monoclonal immunoglobulins (M-proteins) that migrate in the β region on serum protein electrophoresis (SPEP) are often cloaked by this region's normal constituents. The present study interrogates the utility of using both quantitative and qualitative alterations in β-region bands for detection of β-migrating M-proteins.

Methods: Consecutive SPEP cases analyzed by capillary electrophoresis were searched to identify the initial workup on 1,841 patients with increased total β regions, suspicious β-region findings resulting in reflex immunofixation (IFE), or immunosubtraction (ISUB). Read More

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September 2021

MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19.

J Mass Spectrom Adv Clin Lab 2021 Aug 9;21:31-41. Epub 2021 Sep 9.

Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, United States.

More than a year after the COVID-19 pandemic was declared, the need still exists for accurate, rapid, inexpensive and non-invasive diagnostic methods that yield high specificity and sensitivity towards the current and newly emerging SARS-CoV-2 strains. Compared to the nasopharyngeal swabs, several studies have established saliva as a more amenable specimen type for early detection of SARS-CoV-2. Considering the limitations and high demand for COVID-19 testing, we employed MALDI-ToF mass spectrometry in the analysis of 60 gargle samples from human donors and compared the resultant spectra against COVID-19 status. Read More

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SARS-CoV-2 Antibody Isotypes in Systemic Lupus Erythematosus Patients Prior to Vaccination: Associations With Disease Activity, Antinuclear Antibodies, and Immunomodulatory Drugs During the First Year of the Pandemic.

Front Immunol 2021 27;12:724047. Epub 2021 Aug 27.

Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection/Rheumatology, Linköping University, Linköping, Sweden.

Objectives: Impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic on individuals with arthritis has been highlighted whereas data on other rheumatic diseases, e.g., systemic lupus erythematosus (SLE), are scarce. Read More

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September 2021

Post-COVID syndrome. A case series and comprehensive review.

Autoimmun Rev 2021 Sep 10:102947. Epub 2021 Sep 10.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

The existence of a variety of symptoms with a duration beyond the acute phase of COVID-19, is referred to as post-COVID syndrome (PCS). We aimed to report a series of patients with PCS attending a Post-COVID Unit and offer a comprehensive review on the topic. Adult patients with previously confirmed SARS-CoV-2 infection and PCS were systematically assessed through a semi-structured and validated survey. Read More

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September 2021

Determinants and Reference Ranges of Serum Immunoglobulins in Middle-Aged and Elderly Individuals: a Population-Based Study.

J Clin Immunol 2021 Sep 10. Epub 2021 Sep 10.

Department of Internal Medicine, Division of Allergy & Clinical Immunology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Purpose: In clinical practice, currently one reference range for serum immunoglobulin (Ig) A, G, and M is applied to all adults, although various factors may influence Ig serum levels. Population-based data on determinants of IgA, IgG, and IgM and recommendations for subgroup specific reference ranges are lacking. We aimed to provide an overview of determinants of IgA, IgG, and IgM in community-dwelling middle-aged and elderly individuals and explore determinants that influence Ig reference ranges. Read More

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September 2021

Antibody response to the first dose of AZD1222 vaccine in COVID-19 convalescent and uninfected individuals in Bangladesh.

Expert Rev Vaccines 2021 Sep 15:1-10. Epub 2021 Sep 15.

Gonoshasthaya-RNA Molecular Diagnostic & Research Center, Dhanmondi, Dhaka, Bangladesh.

Background: Vaccination with the Oxford-AstraZeneca COVID-19 vaccine (AZD1222) initially started in the UK and quickly implemented around the Globe, including Bangladesh. Up to date, more than nine million doses administrated to the Bangladeshi public.

Method: Herein, we studied the antibody response to the first dose of AZD1222 in 86 Bangladeshi individuals using in-house ELISA kits. Read More

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September 2021

The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency.

J Clin Med 2021 Aug 25;10(17). Epub 2021 Aug 25.

Institute of Biology, University of Szczecin, Felczaka 3c St., 71-412 Szczecin, Poland.

Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency disease (PID), with an estimated occurrence from about 1:3000 to even 1:150, depending on population. sIgAD is diagnosed in adults and children after the 4th year of age, with immunoglobulin A level below 0.07 g/L and normal levels of IgM and IgG. Read More

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hIgDFc-Ig inhibits B cell function by regulating the BCR-Syk-Btk-NF-κB signalling pathway in mice with collagen-induced arthritis.

Pharmacol Res 2021 Sep 6:105873. Epub 2021 Sep 6.

Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei 230032, Anhui Province, China; Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China; Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Hefei, China; Anti-inflammatory Immune Drugs Collaborative Innovation Center, Anhui Province, Hefei, China. Electronic address:

Rheumatoid arthritis (RA) is an autoimmune disease targeting the synovium. Previous studies have found that IgD may be a potential target for the treatment of RA. We designed a new type of fusion protein, hIgDFc-Ig (DG), to block the binding of IgD to IgD receptor (IgDR). Read More

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September 2021

Long-Term Persistence and Relevant Therapeutic Impact of High-Titer Viral-Neutralizing Antibody in a Convalescent COVID-19 Plasma Super-Donor: A Case Report.

Front Immunol 2021 23;12:690322. Epub 2021 Aug 23.

Department of Research, Technological Innovation & Advanced Diagnostics, Regina Elena National Cancer Institute - IRCCS, Rome, Italy.

A convalescent, non-severe, patient with COVID-19 was enrolled as a hyper-immune plasma voluntary donor by the Immuno-Hematology and Transfusion Unit of the Regina Elena National Cancer Institute in Rome, under the TSUNAMI national study criteria. During a nearly 6-month period (May-October 2020), the patient was closely monitored and underwent four hyperimmune plasma collections. Serum SARS-CoV-2 (anti-S + anti-N) IgG and IgM, anti-S1 IgA, and neutralizing titers (NTs) were measured. Read More

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September 2021

Efficacy of Low-Temperature Plasma-Assisted Unilateral/Bilateral Tonsillectomy and Adenoidectomy in Children with Obstructive Sleep Apnea Hypopnea Syndrome.

Yi Qiao Jie Chen

Med Sci Monit 2021 Sep 9;27:e930792. Epub 2021 Sep 9.

Department of Otorhinolaryngology, National Children's Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).

BACKGROUND The aim of this study was to investigate the efficacy of low-temperature plasma-assisted bilateral or unilateral tonsillectomy (LTPABT or LTPAUT) and adenoidectomy in treatment of children with obstructive sleep apnea hypopnea syndrome (OSAHS). MATERIAL AND METHODS The present observational cohort study included a total of 244 children with OSAHS during December 2017 to December 2018. The patients were divided into the LTPABT group, the LTPAUT group, and the control group that received traditional bilateral tonsillectomy and adenoidectomy. Read More

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September 2021

A study on fungal defensin against multidrug-resistant Clostridium perfringens and its treatment on infected poultry.

Appl Microbiol Biotechnol 2021 Sep 7. Epub 2021 Sep 7.

Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.

In the present study, we aimed to investigate the antibacterial activity and mechanisms of plectasin-derived peptide NZ2114 in vitro and its therapeutic effects in vivo on broilers challenged with Clostridium perfringens. In vitro assay showed that NZ2114 had potent (minimal inhibitory concentration, 0.91 μM) and rapid antibacterial activity (99. Read More

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September 2021

Effects of Combined Supplementation of Extract and on the Growth Performance, Immune Responses, Antioxidant Capacity, Intestinal Morphology, and Microbial Composition in Weaned Piglets.

Front Vet Sci 2021 18;8:708597. Epub 2021 Aug 18.

Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

Because the use of antibiotics is forbidden, piglets experience a considerable weanling stress, resulting in increased incidence of diarrhea and death. extract or benzoic acid have anti-inflammatory, antioxidant, and antimicrobial activities that makes them potential antibiotic alternatives. The objective of this study was to evaluate the potential effects of feed supplemented with extract and benzoic acid on growth performance, immunity, antioxidant capacity, intestinal morphology, and microflora in weaned piglets. Read More

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Detection of Anti-SARS-CoV-2-S2 IgG Is More Sensitive Than Anti-RBD IgG in Identifying Asymptomatic COVID-19 Patients.

Front Immunol 2021 19;12:724763. Epub 2021 Aug 19.

Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.

Characterizing the serologic features of asymptomatic SARS-CoV-2 infection is imperative to improve diagnostics and control of SARS-CoV-2 transmission. In this study, we evaluated the antibody profiles in 272 plasma samples collected from 59 COVID-19 patients, consisting of 18 asymptomatic patients, 33 mildly ill patients and 8 severely ill patients. We measured the IgG against five viral structural proteins, different isotypes of immunoglobulins against the Receptor Binding Domain (RBD) protein, and neutralizing antibodies. Read More

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September 2021

Different Profiles of Antibodies and Cytokines Were Found Between Severe and Moderate COVID-19 Patients.

Front Immunol 2021 19;12:723585. Epub 2021 Aug 19.

Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

Objectives: Our objective was to determine the antibody and cytokine profiles in different COVID-19 patients.

Methods: COVID-19 patients with different clinical classifications were enrolled in this study. The level of IgG antibodies, IgA, IgM, IgE, and IgG subclasses targeting N and S proteins were tested using ELISA. Read More

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September 2021

Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study.

BMC Immunol 2021 Sep 6;22(1):61. Epub 2021 Sep 6.

Translational Oncology and Urology Research (TOUR), School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital, 3rd Floor, Bermondsey Wing, London, SE1 9RT, UK.

Background: Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explored the reciprocity between the humoral immune system and inflammation and assessed how external socio-demographic factors may influence these interactions. From the AMORIS cohort, 5513 individuals were identified with baseline measurements of serum humoral immune [immunoglobulin G, A & M (IgG, IgA, IgM)] and inflammation (C-reactive protein (CRP), albumin, haptoglobin, white blood cells (WBC), iron and total iron-binding capacity) markers measured on the same day. Read More

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September 2021

Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism.

Virol J 2021 09 5;18(1):180. Epub 2021 Sep 5.

Imunologia de Doenças Virais, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.

Background: Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in recent studies, including the gastrointestinal tract and liver. The host innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through their pattern recognition receptor (PRRs). Read More

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September 2021

The Effects of Oral Administration of Molybdenum Fertilizers on Immune Function of Nanjiang Brown Goat Grazing on Natural Pastures Contaminated by Mixed Heavy Metal.

Biol Trace Elem Res 2021 Sep 4. Epub 2021 Sep 4.

College of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China.

Mineral development and metal smelting seriously polluted the surrounding groundwater and soil, threatening human health through the food chain. To investigate the effects of different sources of molybdenum (Mo) fertilizers on immune function of Nanjiang brown goats grazing on natural pastures under compound pollutions, fertilizing experiment was carried out in Liangshan Yi Nationality Prefecture of the Western Sichuan Plateau, China. Eighteen square hectometers of polluted meadows were fenced and were randomly divided into three groups (3 replications/group and 2 hm/replication). Read More

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September 2021

The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis.

Mol Med 2021 09 3;27(1):97. Epub 2021 Sep 3.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330000, Jiangxi, People's Republic of China.

Background/aim: N-Acetylcysteine (NAC) demonstrates applications in the prevention of exacerbation of chronic obstructive pulmonary disease (COPD). COPD is often characterized by fibrosis of the small airways. This study aims at investigating the physiological mechanisms by which NAC might mediate the pulmonary fibrosis in COPD. Read More

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September 2021

An association between immune status and chest CT scores in COVID-19 patients.

Int J Clin Pract 2021 Sep 3:e14767. Epub 2021 Sep 3.

Division of Pediatric Allergy and Immunology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.

Background: The characteristic features of the immune responses of COVID-19 patients and how they reflect lung involvement have not been clearly elucidated.

Aim: The aim of this study was to examine the immune status and the correlations thereof with chest CT scores and lung involvement of patients with COVID-19.

Methods: In this retrospective and single-center study, 72 patients with laboratory-confirmed COVID-19 were recruited. Read More

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September 2021

Longitudinal analysis of human humoral responses after vaccination with a live attenuated V. cholerae vaccine.

PLoS Negl Trop Dis 2021 Sep 3;15(9):e0009743. Epub 2021 Sep 3.

Division of Infectious Disease, Department of Pediatrics, Emory University, School of Medicine, Atlanta, Georgia, United States of America.

Vibrio cholerae is a bacterial pathogen which causes the severe acute diarrheal disease cholera. Given that a symptomatic incident of cholera can lead to long term protection, a thorough understanding of the immune response to this pathogen is needed to identify parameters critical to the generation and durability of immunity. To approach this, we utilized a live attenuated cholera vaccine to model the response to V. Read More

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September 2021

Immunomodulatory effect of the combined use of Vetosporin Zh probiotic and Gumi-malysh biologically active additive.

Vet World 2021 Jul 26;14(7):1915-1921. Epub 2021 Jul 26.

Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection, Federal State Budgetary Educational Establishment of Higher Education "Bashkir State Agrarian University," Ufa, Russia.

Background And Aim: Various means and methods, including probiotics and biologically active additives, have been developed and proposed for production to increase the immunobiological reactivity of the body, regardless of the etiology of its decrease. This study aimed to find out the immune status of calves during the preweaning period in association with Vetosporin Zh, Normosil, and Gumi-malysh.

Materials And Methods: The research object was 30-day-old calves of black-and-white Holstein breed. Read More

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Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected individuals on antiretroviral therapy during the first South African infection wave.

Clin Infect Dis 2021 Sep 2. Epub 2021 Sep 2.

HIV Pathogenesis Programme, University of KwaZulu-Natal, Durban, South Africa.

Background: There is limited understanding of SARS-CoV-2 pathogenesis in African populations with a high burden of infectious disease comorbidities such as HIV. The kinetics, magnitude and duration of virus-specific antibodies and the underlying B cell responses in people living with HIV (PLWH) in sub-Saharan Africa have not been fully characterized.

Methods: We longitudinally followed SARS-CoV-2 infected individuals in Durban, KwaZulu-Natal, South Africa and characterized SARS-CoV-2 receptor binding domain-specific IgM, IgG and IgA antibodies weekly for a month, and then at 3 months post diagnosis. Read More

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September 2021

High proportion of drug-resistant isolates in adult community-acquired pneumonia from Northeast India: A hospital-based study.

Lung India 2021 Sep-Oct;38(5):460-465

Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Background: Empirical antibiotic therapy is the mainstay of management of adult community-acquired pneumonia (CAP) globally. Knowledge of prevalent pathogen (bacterial) profile and drug susceptibility pattern is very essential for appropriate management of CAP cases, which again calls for regular update of pathogen profile in a given locality. This study was to identify the bacterial etiology of CAP cases and their antibiotic susceptibility pattern. Read More

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September 2021

Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice.

Mil Med Res 2021 08 31;8(1):47. Epub 2021 Aug 31.

Infectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.

SARS-CoV-2 is a newly identified member of the coronavirus family that has caused the Coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2 has disrupted the lives and livelihoods of millions worldwide. As of 23 August 2021, a total of 211,373,303 COVID-19 cases have been confirmed globally with a death toll of 4,424,341. Read More

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