3,788 results match your criteria identity heart


Influenza vaccination in congenital heart disease in the pre-COVID19 era: Coverage rate, patient characteristics and outcome.

Can J Cardiol 2021 May 4. Epub 2021 May 4.

Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium.

Background: Influenza vaccination is the most commonly recommended immune prevention strategy. However, data on influenza vaccination in patients with congenital heart disease (CHD) is scarce. In this study, our goals were to (i) measure vaccination coverage rates (VCR) for influenza in a large cohort of children, adolescents and adults with CHD, (ii) identity patient characteristics as predictors for vaccination, and (iii) investigate the impact of influenza vaccination on hospitalization. Read More

View Article and Full-Text PDF

Sweating the big stuff: Arousal and stress as functions of self-uncertainty and identification.

Psychophysiology 2021 May 7:e13836. Epub 2021 May 7.

Department of Psychological Sciences, Texas Tech University, Lubbock, TX, USA.

Groups serve a variety of crucial functions, one of which is the provision of an identity and belief system that impart self-referent information, thereby reducing self-uncertainty. Entitative groups are more attractive for highly uncertain participants seeking groups for identification and self-uncertainty reduction than less entitative groups. The purpose of the current study was to explore how self-uncertainty impacts physiological arousal and stress responses. Read More

View Article and Full-Text PDF

A comprehensive formula for computing corrected QT intervals in patients with wide QRS.

J Electrocardiol 2021 Apr 17;66:139-147. Epub 2021 Apr 17.

Cardiology Department, Hospital Universitario Central de Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain. Electronic address:

Background: There is increasing interest in developing appropriate methods for correction of the QT intervals in patients with prolonged depolarization of the ventricles. From an experimental model of controlled heart rate and QRS widening, we aimed to develop a new formula with better performance.

Methods: After exclusions, incremental pacing was performed (AAI mode; 50-120 bpm) in 17 patients admitted for self-expanding aortic valve implantation in two different phases: before and immediately after the release of the prosthesis. Read More

View Article and Full-Text PDF

Influence of Stress, Gender, and Minority Status on Cardiovascular Disease Risk in the Hispanic/Latino Community: Protocol for a Longitudinal Observational Cohort Study.

JMIR Res Protoc 2021 May 6;10(5):e28997. Epub 2021 May 6.

Department of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, United States.

Background: Hispanic/Latino sexual and gender minorities (SGM) are the fastest growing ethnic group of SGM in the United States. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among Hispanics/Latinos. SGM inequities in CVD risk have been identified as early as young adulthood, and minority stress has been identified as a potential mediator. Read More

View Article and Full-Text PDF

Evolution of Reproductive Behavior.

Genetics 2020 Jan;214(1):49-73

Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.

Behaviors associated with reproduction are major contributors to the evolutionary success of organisms and are subject to many evolutionary forces, including natural and sexual selection, and sexual conflict. Successful reproduction involves a range of behaviors, from finding an appropriate mate, courting, and copulation, to the successful production and (in oviparous animals) deposition of eggs following mating. As a consequence, behaviors and genes associated with reproduction are often under strong selection and evolve rapidly. Read More

View Article and Full-Text PDF
January 2020

Evolution of Reproductive Behavior.

Genetics 2020 Jan;214(1):49-73

Laboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.

Behaviors associated with reproduction are major contributors to the evolutionary success of organisms and are subject to many evolutionary forces, including natural and sexual selection, and sexual conflict. Successful reproduction involves a range of behaviors, from finding an appropriate mate, courting, and copulation, to the successful production and (in oviparous animals) deposition of eggs following mating. As a consequence, behaviors and genes associated with reproduction are often under strong selection and evolve rapidly. Read More

View Article and Full-Text PDF
January 2020

The Role of Cell Tracing and Fate Mapping Experiments in Cardiac Outflow Tract Development, New Opportunities through Emerging Technologies.

J Cardiovasc Dev Dis 2021 Apr 26;8(5). Epub 2021 Apr 26.

Department Anatomy & Embryology, Leiden University Medical Center, 2300RC Leiden, The Netherlands.

Whilst knowledge regarding the pathophysiology of congenital heart disease (CHDs) has advanced greatly in recent years, the underlying developmental processes affecting the cardiac outflow tract (OFT) such as bicuspid aortic valve, tetralogy of Fallot and transposition of the great arteries remain poorly understood. Common among CHDs affecting the OFT, is a large variation in disease phenotypes. Even though the different cell lineages contributing to OFT development have been studied for many decades, it remains challenging to relate cell lineage dynamics to the morphologic variation observed in OFT pathologies. Read More

View Article and Full-Text PDF

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients.

Cell Stem Cell 2021 Apr 21. Epub 2021 Apr 21.

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA, USA. Electronic address:

Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age-equivalent neuronal model. AD patient-derived iNs exhibit strong neuronal transcriptome signatures characterized by downregulation of mature neuronal properties and upregulation of immature and progenitor-like signaling pathways. Read More

View Article and Full-Text PDF

Intersectionality and heart failure: what clinicians and researchers should know and do.

Curr Opin Support Palliat Care 2021 Jun;15(2):141-146

Faculty of Nursing, University of Alberta, Edmonton, Canada.

Purpose Of Review: To review the application of intersectionality to heart failure. Intersectionality refers to the complex ways in which disenfranchisement and privilege intersect to reproduce and influence health and social outcomes.

Recent Findings: Intersectionality challenges approaches that focus on a single or small number of socio-demographic characteristics, such as sex or age. Read More

View Article and Full-Text PDF

Influence of Tissue Technology on Pannus Formation on Bioprosthetic Heart Valves.

Cardiovasc Eng Technol 2021 Apr 20. Epub 2021 Apr 20.

Cardiac Surgery, Department of Cardiovascular Sciences, University Hospitals Leuven, Leuven, Belgium.

Purpose: Bioprosthetic heart valves have several modes of failure. Tissue degeneration and calcification are the major modes of failure with the highest focus of attention, however pannus formation can also be problematic. We studied the effect of a new tissue technology with the absence of any glutaraldehyde-based storage solution and a stable aldehyde capping process on pannus formation. Read More

View Article and Full-Text PDF

Toxicological investigations in a death involving 2-MAPB.

Forensic Sci Med Pathol 2021 Apr 20. Epub 2021 Apr 20.

Governmental Institute of Legal Medicine and Forensic Sciences, Turmstraße 21, 10559, Berlin, Germany.

New psychoactive substances are becoming increasingly popular. However, there is a lack of mass spectral information on parent substances and their corresponding metabolites as well as fatal concentrations in body liquids and tissues. Only very few clinical reports and user reports exist. Read More

View Article and Full-Text PDF

Cultural socialization in childhood: Analysis of parent-child conversations with a direct observation measure.

J Fam Psychol 2021 Mar;35(2):138-148

Department of Medical Social Sciences, and Innovations in Developmental Sciences.

Cultural factors influence the development of all children. Yet, current knowledge of explicit cultural socialization processes in childhood remains limited, mainly by failing to incorporate the experiences of young children. To address this critical gap, the authors introduce the OMERS-Peds task, an observational measurement designed to systematically identify and compare the content of cultural messages passed down from caregivers to offspring during early school age years. Read More

View Article and Full-Text PDF

Association between erythema nodosum/ erythema induratum of Bazin and Mycobacterium tuberculosis infection in Koreans.

Indian J Dermatol Venereol Leprol 2021 Mar 2:1-5. Epub 2021 Mar 2.

Department of Dermatology Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Background: Erythema nodosum and erythema induratum of Bazin are similar inflammatory diseases of the lower extremities. These are clinically distinguishable entities, though overlap can occur. Both diseases are reported to be related to Mycobacterium tuberculosis infection, but it is very difficult to identify Mycobacterium tuberculosis in skin lesions. Read More

View Article and Full-Text PDF

Effects of Nursing Education Using Films on Perception of Nursing, Satisfaction With Major, and Professional Nursing Values.

J Nurs Res 2021 Apr 16. Epub 2021 Apr 16.

PhD, RN, Associate Manager, Department of Prevention and Public Relations & Research and Development Team, Korea Center on Gambling Problems, Seoul, Republic of Korea PhD, RN, Associate Professor, Department of Nursing, Wonkwang University, Iksan, Republic of Korea.

Background: Cinenurducation, a film-based approach to nursing education that incorporates student-centered, problem-solving, experiential, and reflective learning strategies, allows students to experience a variety of indirect experiences and improves critical thinking and self-reflection through discussion.

Purpose: The aims of this study were, first, to employ a cinenurducation approach to help instill a proper professional nursing identity in second-year nursing students and, second, to examine the effects of this approach on the perception of nursing, satisfaction with major, and professional nursing values of the participants.

Methods: An experimental, pretest-and-posttest design was used to test the primary variables, including perception of nursing, satisfaction with major, and professional nursing values. Read More

View Article and Full-Text PDF

Intracerebral electrical stimulation to understand the neural basis of human face identity recognition.

Eur J Neurosci 2021 Apr 18. Epub 2021 Apr 18.

Université de Lorraine, CNRS, CRAN, F-54000, Nancy, France.

Recognizing people's identity by their faces is a key function in the human species, supported by regions of the ventral occipito-temporal cortex (VOTC). In the last decade, there have been several reports of perceptual face distortion during direct electrical stimulation (DES) with subdural electrodes positioned over a well-known face-selective VOTC region of the right lateral middle fusiform gyrus (LatMidFG; i.e. Read More

View Article and Full-Text PDF

Donor cell memory confers a metastable state of directly converted cells.

Cell Stem Cell 2021 Apr 7. Epub 2021 Apr 7.

Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster 48149, Germany; Faculty of Medicine, University of Münster, Münster 48149, Germany. Electronic address:

Generation of induced oligodendrocyte progenitor cells (iOPCs) from somatic fibroblasts is a strategy for cell-based therapy of myelin diseases. However, iOPC generation is inefficient, and the resulting iOPCs exhibit limited expansion and differentiation competence. Here we overcome these limitations by transducing an optimized transcription factor combination into a permissive donor phenotype, the pericyte. Read More

View Article and Full-Text PDF

Pitx genes in development and disease.

Cell Mol Life Sci 2021 Apr 12. Epub 2021 Apr 12.

Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, 97331, USA.

Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential in specifying spatial and temporal cell identity and as a result, their mutations often cause severe developmental defects. Pitx genes belong to the PRD class of the highly evolutionary conserved homeobox genes in all animals. Read More

View Article and Full-Text PDF

Single cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes.

Cardiovasc Res 2021 Apr 11. Epub 2021 Apr 11.

Department of Pathology and Laboratory Medicine.

Aims: The precise cellular identity and molecular features of non-myocytes (nonCM) in a mammalian heart at a single cell level remain elusive. Depiction of epigenetic landscape with transcriptomic signatures using the latest single-cell multi-omics has the potential to unravel the molecular programs underlying the cellular diversity of cardiac non-myocytes. Here, we characterized the molecular and cellular features of cardiac nonCM populations in the adult murine heart at the single cell level. Read More

View Article and Full-Text PDF

Redeveloping a Digital Sexual Health Intervention for Adolescents to Allow for Broader Dissemination: Implications for HIV and STD Prevention.

AIDS Educ Prev 2021 04;33(2):89-102

North Carolina State University, Department of Computer Science, Raleigh, North Carolina.

HIV/STDs and unintended pregnancy persist among adolescents in the United States; thus, effective sexual health interventions that can be broadly disseminated are necessary. Digital health interventions are highly promising because they allow for customization and widespread reach. The current project involved redeveloping and expanding HEART (Health Education and Relationship Training)-a brief, digital sexual health intervention efficacious at improving safer sex knowledge, self-efficacy, and behavior-onto an open-source platform to allow for greater interactivity and accessibility while reducing long-term program costs. Read More

View Article and Full-Text PDF

Sibling Relationships of Adolescents with Congenital Heart Disease.

Int J Environ Res Public Health 2021 03 8;18(5). Epub 2021 Mar 8.

College of Nursing, The Catholic University of Korea, Seoul 03722, Korea.

Adolescents with congenital heart disease (CHD) continuously need family support because of their repeated follow ups, treatments, and complications. However, sibling relationships have not been well studied among adolescents with CHD. The purpose of the present study was to explore the relationships between adolescents with CHD and their siblings, and to examine these relationships according to birth order and age. Read More

View Article and Full-Text PDF

Agromyces laixinhei sp. nov. isolated from bat feces in China.

J Microbiol 2021 May 29;59(5):467-475. Epub 2021 Mar 29.

Department of Epidemiology, Shanxi Medical University School of Public Health, Taiyuan, Shanxi, 030001, China.

Three rod-shaped, Gram-stain-positive, and catalase-positive, phenotypically closely related isolates (HY052, HY050, and HY045) were obtained from fecal samples collected from bats in Guangxi province and Chongqing city of China. Circular, smooth, light-yellow colonies appeared on brain heart infusion plate after 24-48 h incubation at 28°C. The optimal pH for growth was between 6. Read More

View Article and Full-Text PDF

Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement.

Sports Med 2021 Mar 24. Epub 2021 Mar 24.

European Federation of Sports Medicine Associations (EFSMA), Lausanne, Switzerland.

Sport is historically designated by the binary categorization of male and female that conflicts with modern society. Sport's governing bodies should consider reviewing rules determining the eligibility of athletes in the female category as there may be lasting advantages of previously high testosterone concentrations for transwomen athletes and currently high testosterone concentrations in differences in sex development (DSD) athletes. The use of serum testosterone concentrations to regulate the inclusion of such athletes into the elite female category is currently the objective biomarker that is supported by most available scientific literature, but it has limitations due to the lack of sports performance data before, during or after testosterone suppression. Read More

View Article and Full-Text PDF

Visions by Women in Molecular Imaging Network: Antiracism and Allyship in Action.

Mol Imaging Biol 2021 Jun 22;23(3):301-309. Epub 2021 Mar 22.

Baker Heart and Diabetes Institute, Melbourne, Australia.

Recent events in America in 2020 have stimulated a worldwide movement to dismantle anti-Black racism in all facets of our lives. Anti-Black racism is, as defined by the Movement for Black Lives, a "term used to specifically describe the unique discrimination, violence, and harm imposed on and impacting Black people specifically." In science, technology, engineering, and mathematics (STEM), we have yet to achieve the goal and responsibility to ensure that the field reflects the diversity of our lived experiences. Read More

View Article and Full-Text PDF

Mechanical stimulation enhances development of scaffold-free, 3D-printed, engineered heart tissue grafts.

J Tissue Eng Regen Med 2021 May 2;15(5):503-512. Epub 2021 Apr 2.

Division of Cardiac Surgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

Current efforts to engineer a clinically relevant tissue graft from human-induced pluripotent stem cells (hiPSCs) have relied on the addition or utilization of external scaffolding material. However, any imbalance in the interactions between embedded cells and their surroundings may hinder the success of the resulting tissue graft. Therefore, the goal of our study was to create scaffold-free, 3D-printed cardiac tissue grafts from hiPSC-derived cardiomyocytes (CMs), and to evaluate whether or not mechanical stimulation would result in improved graft maturation. Read More

View Article and Full-Text PDF

ACE2 as a key target for treatment of COVID-19 related cardiovascular diseases: current progress and prospect.

Curr Drug Targets 2021 Mar 19. Epub 2021 Mar 19.

Department of Pharmacy at the Second Affiliated Hospital, and Department of Pharmacology (The Key Laboratory of Cardiovascular Research, Ministry of Education) at College of Pharmacy, Harbin Medical University, Harbin. China.

ACE2 has long been known as an injury protective protein, it can protect a variety of organ damage such as heart, liver, kidney and lung. Especially in cardiovascular diseases, ACE2, as a negative regulator of RAAS, is an extremely important protective factor that mainly plays a role by converting Ang Ⅱ to Ang-(1-7). Nevertheless, with the recent outbreak of COVID-19, it was exposed that another identity of ACE2 is the entry receptor for SARS-CoV-2, which previously served as the entry receptor for SARS. Read More

View Article and Full-Text PDF

Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2.

Cell Discov 2020 Mar 16;6(1):14. Epub 2020 Mar 16.

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.

Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. Read More

View Article and Full-Text PDF

A case of mistaken identity: pseudoaneurysm masquerading as pericardial effusion following premature ventricular contraction ablation.

Eur Heart J Cardiovasc Imaging 2021 Mar 13. Epub 2021 Mar 13.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

View Article and Full-Text PDF

A Novel Disease Entity in Search of Its Own Identity - Takotsubo Syndrome. Is It Really "Cardiomyopathy"?

Circ Rep 2020 Jul 15;2(8):446-448. Epub 2020 Jul 15.

Department of Cardiology and Aging Science, Kochi Medical School Nankoku Japan.

The term "takotsubo cardiomyopathy" is commonly used in clinical practice. However, there is conceptual problem with the term "cardiomyopathy" in this context because "cardiomyopathy" implies a primary and chronic myocardial disease of unknown etiology. In this study we reviewed the literature related to takotsubo cardiomyopathy to investigate whether it is appropriate to use the term "cardiomyopathy" for this condition. Read More

View Article and Full-Text PDF

Deciphering the Role of Wnt and Rho Signaling Pathway in iPSC-Derived ARVC Cardiomyocytes by In Silico Mathematical Modeling.

Int J Mol Sci 2021 Feb 18;22(4). Epub 2021 Feb 18.

Department of Clinical and Experimental Medicine, Magna Græcia University, 88100 Catanzaro, Italy.

Arrhythmogenic Right Ventricular cardiomyopathy (ARVC) is an inherited cardiac muscle disease linked to genetic deficiency in components of the desmosomes. The disease is characterized by progressive fibro-fatty replacement of the right ventricle, which acts as a substrate for arrhythmias and sudden cardiac death. The molecular mechanisms underpinning ARVC are largely unknown. Read More

View Article and Full-Text PDF
February 2021