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Prediction of diabetic protein markers based on an ensemble method.

Front Biosci (Landmark Ed) 2021 Jul;26(7):207-221

School of Opto-electronic and Communication Engineering, Xiamen University of Technology, 361024 Xiamen, Fujian, China.

: A diabetic protein marker is a type of protein that is closely related to diabetes. This kind of protein plays an important role in the prevention and diagnosis of diabetes. Therefore, it is necessary to identify an effective method for predicting diabetic protein markers. Read More

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Coupled harmonic oscillator models for correlated plasmons in one-dimensional and quasi-one-dimensional systems.

J Phys Condens Matter 2021 Aug 2. Epub 2021 Aug 2.

Department of Physics, National University of Singapore, Kent Ridge, SINGAPORE 119260, Singapore, 119260, SINGAPORE.

A new phenomenon of correlated plasmons was first observed in the insulating phase of the Sr1-xNb1-yO3+ family [T. C. Asamara et al. Read More

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Non-structural protein 5 (NS5) as a target for antiviral development against established and emergent flaviviruses.

Curr Opin Virol 2021 Jul 30;50:30-39. Epub 2021 Jul 30.

Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil; Department of NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, D-37077 Göttingen, Germany. Electronic address:

Flaviviruses are among the most critical pathogens in tropical regions and cause a growing number of severe diseases in developing countries. The development of antiviral therapeutics is crucial for managing flavivirus outbreaks. Among the ten proteins encoded in the flavivirus RNA, non-structural protein 5, NS5, is a promising drug target. Read More

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Coordination and harmonization of a marine plastic debris monitoring program for beaches in the Wider Caribbean Region: Identifying strategic pathways forward.

Mar Pollut Bull 2021 Jul 30;171:112767. Epub 2021 Jul 30.

Closing the Circle: Marine Debris, Sargassum and Marine Spatial Planning Programme, World Maritime University, Malmö, Sweden. Electronic address:

An aim of the United Nations Decade of Ocean Science is to quantify marine plastic debris in the marine environment. This study analyzes peer-reviewed articles on marine debris monitoring conducted on beaches in the Wider Caribbean Region, with a focus on marine plastic debris. Governance and funding regimes for monitoring events were assessed to determine strategies needed for coordinated and harmonized marine plastic debris monitoring in the Wider Caribbean Region. Read More

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Identifying molecular insight of synergistic complexities for SARS-CoV-2 infection with pre-existing type 2 diabetes.

Comput Biol Med 2021 Jul 23;136:104668. Epub 2021 Jul 23.

Healthy Ageing Theme, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia; WHO Collaborating Centre on eHealth, UNSW Digital Health, School of Public Health and Community Medicine, Faculty of Medicine, UNSW Sydney, NSW, 2052, Australia. Electronic address:

The ongoing COVID-19 outbreak, caused by SARS-CoV-2, has posed a massive threat to global public health, especially to people with underlying health conditions. Type 2 diabetes (T2D) is lethal comorbidity of COVID-19. However, its pathogenetic link remains unclear. Read More

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Knockout of FER decreases cadmium concentration in roots of Arabidopsis thaliana by inhibiting the pathway related to iron uptake.

Sci Total Environ 2021 Jul 28;798:149285. Epub 2021 Jul 28.

State Key Laboratory of Plant Physiology and Biochemistry, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Identifying the genes that affect cadmium (Cd) accumulation in plants is a prerequisite for minimizing dietary Cd uptake from contaminated edible parts of plants by genetic engineering. This study showed that Cd stress inhibited the expression of FERONIA (FER) gene in the roots of wild-type Arabidopsis. Knockout of FER in fer-4 mutants downregulated the Cd-induced expression of several genes related to iron (Fe) uptake, including IRT1, bHLH38, NRAMP1, NRAMP3, FRO2 andFIT. Read More

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A global review of seed enhancement technology use to inform improved applications in restoration.

Sci Total Environ 2021 Jul 16;798:149096. Epub 2021 Jul 16.

School of Biological Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009, Australia; Kings Park Science, Department of Biodiversity Conservation and Attractions, 2 Kattidj Close, Kings Park, Western Australia, 6005, Australia.

Seed-based restoration often experiences poor success due to a range of edaphic and biotic issues. Seed enhancement technologies (SETs) are a novel approach that can alleviate these pressures and improve restoration success. Broadly, SETs have been reviewed for agricultural and horticultural purposes, for specific types of SETs such as coating or priming, or for focal ecosystems. Read More

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MIR spectroscopy versus MALDI-ToF-MS for authenticity control of honeys from different botanical origins based on soft independent modelling by class analogy (SIMCA) - A clash of techniques?

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 23;263:120225. Epub 2021 Jul 23.

Institute for Instrumental Analytics and Bioanalytics, Mannheim University of Applied Sciences, Paul-Wittsack-Straße 10, 68163 Mannheim, Germany. Electronic address:

In this study, highly reproducible MIR spectroscopy and highly sensitive MALDI-ToF-MS data were directly compared for the metabolomic profiling of monofloral and multifloral honey samples from three different botanical origins canola, acacia, and honeydew. Subsequently, three different classification models were applied to the data of both techniques, PCA-LDA, PCA- kNN, and soft independent modelling by class analogy (SIMCA) as class modelling technique. All monofloral external test set samples were classified correctly by PCA-LDA and SIMCA with both data sets, while multifloral test set samples could only be identified as outliers by the SIMCA technique, which is a crucial aspect in the authenticity control of honey. Read More

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Thiol-disulphide independent in-cell trapping for the identification of peroxiredoxin 2 interactors.

Redox Biol 2021 Jul 25;46:102066. Epub 2021 Jul 25.

VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, B-1050, Brussels, Belgium; Brussels Center for Redox Biology, Vrije Universiteit Brussel, B-1050, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, B-1050, Brussels, Belgium. Electronic address:

Hydrogen peroxide (HO) acts as a signalling molecule by oxidising cysteine thiols in proteins. Recent evidence has established a role for cytosolic peroxiredoxins in transmitting HO-based oxidation to a multitude of target proteins. Moreover, it is becoming clear that peroxiredoxins fulfil their function in organised microdomains, where not all interactors are covalently bound. Read More

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Age estimation from sternebral fusion in an Indian population - A computed tomographic evaluation.

Leg Med (Tokyo) 2021 Jul 26;53:101951. Epub 2021 Jul 26.

Department of Anthropology, Panjab University, Chandigarh 160014, India. Electronic address:

Forensic age estimation is a crucial aspect of the human identification process. Sternebral fusion is one of the skeletal indicators of age that has not been thoroughly researched for the purpose of age estimation. The present study was conducted with the aim of assessing the utility of each of the sternebral fusion in age estimation, and to ascertain if these fusion stages can help in identifying whether an individual has attained the medicolegally significant ages of 16 and 18 years. Read More

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Computational design and analysis of modular cells for large libraries of exchangeable product synthesis modules.

Metab Eng 2021 Jul 30. Epub 2021 Jul 30.

Department of Chemical and Biomolecular Engineering, The University of Tennessee, Knoxville, TN, United States; Center for Bioenergy Innovation, Oak Ridge National Laboratory Oak Ridge, TN, United States. Electronic address:

Microbial metabolism can be harnessed to produce a large library of useful chemicals from renewable resources such as plant biomass. However, it is laborious and expensive to create microbial biocatalysts to produce each new product. To tackle this challenge, we have recently developed modular cell (ModCell) design principles that enable rapid generation of production strains by assembling a modular (chassis) cell with exchangeable production modules to achieve overproduction of target molecules. Read More

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Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study.

Lancet Oncol 2021 Jul 30. Epub 2021 Jul 30.

Sarah Cannon Research Institute, Nashville, TN, USA; Tennessee Oncology, Nashville, TN, USA.

Background: Systemic therapies for metastatic biliary tract cancers are few, and patients have a median overall survival of less than 1 year. MyPathway evaluates the activity of US Food and Drug Administration-approved therapies in non-indicated tumours with potentially actionable molecular alterations. In this study, we present an analysis of patients with metastatic biliary tract cancers with HER2 amplification, overexpression, or both treated with a dual anti-HER2 regimen, pertuzumab plus trastuzumab, from MyPathway. Read More

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A systems-level study reveals host-targeted repurposable drugs against SARS-CoV-2 infection.

Mol Syst Biol 2021 Aug;17(8):e10239

Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Understanding the mechanism of SARS-CoV-2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as potential therapeutics against COVID-19. These were deduced from the gene expression signature of SARS-CoV-2-infected A549 cells screened against Connectivity Map and prioritized by network proximity analysis with respect to disease modules in the viral-host interactome. Read More

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A clustering approach to identify multidimensional poverty indicators for the bottom 40 percent group.

PLoS One 2021 2;16(8):e0255312. Epub 2021 Aug 2.

Center for Artificial Intelligence Technology, Faculty of Information Science & Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.

The Multidimensional Poverty Index (MPI) is an income-based poverty index which measures multiple deprivations alongside other relevant factors to determine and classify poverty. The implementation of a reliable MPI is one of the significant efforts by the Malaysian government to improve measures in alleviating poverty, in line with the recent policy for Bottom 40 Percent (B40) group. However, using this measurement, only 0. Read More

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Normalisation process theory and the implementation of a new glaucoma clinical pathway in hospital eye services: Perspectives of doctors, nurses and optometrists.

PLoS One 2021 2;16(8):e0255564. Epub 2021 Aug 2.

School of Healthcare Sciences, Cardiff University, Cardiff, Wales.

Background: Normalisation process theory reports the importance of contextual integration in successfully embedding novel interventions, with recent propositions detailing the role that 'plasticity' of intervention components and 'elasticity' of an intended setting contribute. We report on the introduction of a clinical pathway assessing patient non-responsiveness to treatment for glaucoma and ocular hypertension. The aim of this study was to assess the feasibility of implementing the Cardiff Model of Glaucoma Care into hospital eye services, identifying any issues of acceptability for staff through the filter of normalisation process theory. Read More

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Machine learning prediction of dropping out of outpatients with alcohol use disorders.

PLoS One 2021 2;16(8):e0255626. Epub 2021 Aug 2.

Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Background: Alcohol use disorder (AUD) is a chronic disease with a higher recurrence rate than that of other mental illnesses. Moreover, it requires continuous outpatient treatment for the patient to maintain abstinence. However, with a low probability of these patients to continue outpatient treatment, predicting and managing patients who might discontinue treatment becomes necessary. Read More

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Dynamic SOFA score assessments to predict outcomes after acute admission of octogenarians to the intensive care unit.

PLoS One 2021 2;16(8):e0253077. Epub 2021 Aug 2.

Department of Anesthesia and Critical Care, CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France.

Background: Identifying which octogenarians could benefit most from continuing critical care is challenging. We aimed to see if responses to therapies using the sequential organ failure assessment (SOFA) score on day 4 after unplanned admission to the intensive care unit (ICU) could be associated with short-term mortality.

Methods: In this prospective observational cohort study, data from 4 ICUs in a University Hospital included SOFA scores on admission and day 4, along with preadmission measurements of frailty, comorbidities, nutritional status and number of medications. Read More

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Cardiac risk stratification in cancer patients: A longitudinal patient-patient network analysis.

PLoS Med 2021 Aug 2;18(8):e1003736. Epub 2021 Aug 2.

Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America.

Background: Cardiovascular disease is a leading cause of death in general population and the second leading cause of mortality and morbidity in cancer survivors after recurrent malignancy in the United States. The growing awareness of cancer therapy-related cardiac dysfunction (CTRCD) has led to an emerging field of cardio-oncology; yet, there is limited knowledge on how to predict which patients will experience adverse cardiac outcomes. We aimed to perform unbiased cardiac risk stratification for cancer patients using our large-scale, institutional electronic medical records. Read More

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Saved information is remembered less well than deleted information, if the saving process is perceived as reliable.

Memory 2021 Aug 2:1-10. Epub 2021 Aug 2.

Department of Psychology, University of California, Santa Cruz, CA, USA.

Prior research has shown that people are more likely to remember information that is deleted from a computer than information that is saved on a computer, presumably because saving serves as a form of cognitive offloading. Given recent concerns about the robustness and replicability of this "Google Effect," we conducted two experiments seeking to replicate and extend the phenomenon by identifying a potential boundary condition for when it is observed. In Experiment 1, we replicated the Google Effect, but only when participants experienced a practice phase demonstrating the reliability of the saving process. Read More

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OsaR (PA0056) functions as a repressor of the gene encoding an important motility regulator in .

J Bacteriol 2021 Aug 2:JB0014521. Epub 2021 Aug 2.

The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, China.

FleQ plays a crucial role in motility and biofilm formation by regulating flagellar and exopolysaccharide biosynthesis in . It has been reported that the expression of FleQ is transcriptionally downregulated by the virulence factor regulator Vfr. Herein we demonstrated that a LysR-type transcriptional regulator, OsaR, is also capable of binding to the promoter region of and repressing its transcription. Read More

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Identifying small ORFs in prokaryotes with ribosome profiling.

J Bacteriol 2021 Aug 2:JB0029421. Epub 2021 Aug 2.

Department of Molecular Biology & Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Small proteins encoded by ORFs shorter than 50 codons (sORFs) are often overlooked by annotation engines and are difficult to characterize using traditional biochemical techniques. Ribosome profiling has tremendous potential to empirically improve the annotations of prokaryotic genomes. Recent improvements in ribosome profiling methods for bacterial model organisms have revealed many new sORFs in well-characterized genomes. Read More

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Democracies Linked To Greater Universal Health Coverage Compared With Autocracies, Even In An Economic Recession.

Health Aff (Millwood) 2021 Aug;40(8):1234-1242

Thomas J. Bollyky is the director of the Global Health Program, Council on Foreign Relations.

Despite widespread recognition that universal health coverage is a political choice, the roles that a country's political system plays in ensuring essential health services and minimizing financial risk remain poorly understood. Identifying the political determinants of universal health coverage is important for continued progress, and understanding the roles of political systems is particularly valuable in a global economic recession, which tests the continued commitment of nations to protecting their health of its citizens and to shielding them from financial risk. We measured the associations that democracy has with universal health coverage and government health spending in 170 countries during the period 1990-2019. Read More

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Importance of addressing malnutrition in cancer and implementation of a quality improvement project in a gastrointestinal cancer clinic.

Nutr Clin Pract 2021 Aug 2. Epub 2021 Aug 2.

Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Malnutrition is exceedingly common in cancer patients, with some of the highest rates seen in gastrointestinal (GI) malignancies. Malnutrition and cachexia in cancer patients is associated with worse quality of life, poor treatment tolerance, and increased morbidity and mortality. The importance of early recognition of malnutrition in cancer patients is key, and numerous screening tools have been validated to aid practitioners in this diagnosis. Read More

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Profiles of urine and blood metabolomics in autism spectrum disorders.

Metab Brain Dis 2021 Aug 2. Epub 2021 Aug 2.

Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, 110 Inthawarorot Road, Sriphum, Muang, Chiang Mai, 50200, Thailand.

Early diagnosis and treatment for autism spectrum disorder (ASD) pose challenges. The current diagnostic approach for ASD is mainly clinical assessment of patient behaviors. Biomarkers-based identification of ASD would be useful for pediatricians. Read More

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Diagnostic accuracy of the Berlin questionnaire and the NoSAS score in detecting risk for obstructive sleep apnea in rotating shift workers.

Sleep Breath 2021 Aug 2. Epub 2021 Aug 2.

Health and Nutrition, Federal University of Ouro Preto, Ouro Preto, MG, 35400-000, Brazil.

Background: Data on the validity of tools for sleep apnea risk detection in rotating shift workers are limited. The aim was to evaluate the Berlin questionnaire (BQ) and the Neck, Obesity, Snoring, Age, Sex (NoSAS) score for the detection of obstructive sleep apnea risk in shift workers.

Methods: This cross-sectional study included male rotating shift workers, drivers of heavy off-road machinery in an iron ore extraction company. Read More

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Revisiting vimentin: a negative surrogate marker of molecularly defined oligodendroglioma in adult type diffuse glioma.

Brain Tumor Pathol 2021 Aug 2. Epub 2021 Aug 2.

Department of Pathology, Seoul National University Hospital, College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, South Korea.

Vimentin is a marker of epithelial-mesenchymal transformation and indicates poor prognosis in various cancers, but its role in diffuse gliomas remains unknown. We investigated the vimentin expression of diffuse gliomas according to the upcoming 2021 WHO classification, its variations due to mutational status, and its prognostic effects. We analyzed vimentin immunohistochemistry in 315 gliomas: a test set (n = 164) and a validation set (n = 151). Read More

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A 3D spheroid-specific role of Wnt/β-catenin and Eph-Ephrin in nasopharyngeal carcinoma cells.

J Cell Sci 2021 Aug 2. Epub 2021 Aug 2.

School of Biomedical Sciences, University of Hong Kong, Sassoon Road, Hong Kong.

One of the greatest unmet needs hindering the successful treatment of nasopharyngeal carcinomas (NPC) is the lack of representative, physiological, and cost-effective models. Although Epstein-Barr virus (EBV) infection is consistently present in NPC, most studies have focused on EBV-negative NPC. For the first time, 3D spheroids model of EBV-positive and -negative NPC cells were established and analyzed as compared to classical 2D culture in various aspects of tumor phenotype and drugs response. Read More

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Gas-Phase UV Spectroscopy of Chemical Intermediates Produced in Solution: Oxidation Reactions of Phenylhydrazines by DDQ.

J Phys Chem A 2021 Aug 2. Epub 2021 Aug 2.

Department of Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima 739-8526, Japan.

In this study, we demonstrated cold gas-phase spectroscopy of chemical intermediates produced in solution. Herein, we combined an electrospray ion source with a T-shaped solution mixer for introducing chemical intermediates in solution into the gas phase. Specifically, the oxidation reaction of 2-(4-nitrophenyl)hydrazinecarboxaldehyde (NHCA) by 2,3-dichloro-5,6-dicyano--benzoquinone (DDQ) was initiated by mixing the methanol solutions of NHCA and DDQ in the T-shaped mixer, and the chemical species were injected into the vacuum apparatus for ultraviolet photodissociation (UVPD) spectroscopy. Read More

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